Florence County, SC Office Spaces for Sale

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29 properties

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Updated: Jun 8

Remodeled Office Building

910 W Evans st, Florence, SC 29501

$300,000

2,165 sqft 0.27 AC lot

2,165‑square‑foot office building on a 0.27‑acre parcel
Comprehensive renovation included roof, HVAC, electrical, and plumbing upgrades
Five rooms suitable for private offices or treatment areas
Kitchen with new cabinets and granite countertops
One full bathroom plus an additional half bath

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910 W Evans st, Florence, SC 29501

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Est. Cap Rate

6.8%
Above avg (5.9%)
Est. NOI

$20K
Annual
Price @ 7% Cap

$289K
Suggested
Property Type

Single Family Residence
Built 1941

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Updated: Mar 14

Historic Office Building with Parking

248-260 W Evans st., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

16,304 SF historic office building built in 1939
1.47‑acre site
Central air cooling; electric and heat pump heating
Law firm space: 13,759 SF with 23 offices and 7 bathrooms
8 boardrooms and meeting spaces plus reception and waiting area

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Wood-Frame Office Building

2228 W Palmetto St., Florence, SC 29501

$225,000

1,405 sqft 0.31 AC lot

Wood-frame office building with heat pump heating and central air, positioned on a commercial lot along W Palmetto St.

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Medical Office Building with 13 Exam Rooms

1706 2nd Loop Rd., Florence, SC 29501

$1,650,000

8,291 sqft 1.34 AC lot

CI-zoned medical office facility with 13 exam rooms, covered patient drop-off, and 62 parking spaces.

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Freestanding Storefront Building

205 W Main St, Lake City, SC 29560

$700,000

5,410 sqft

Downtown setting near businesses, banks, restaurants, and public services supports multiple commercial use options.

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Historic Downtown Florence Building For Sale

248,258, and 268 W. Evans St., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

16,000 SF historic building in downtown Florence for sale.

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Historic Downtown Office Building

260 W Evans St, Florence, SC 29501

$2,700,000

16,000 sqft 1.47 AC lot

A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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Historic Mixed-Use Building in Florence

248,258, and 268 W. Evans St., Florence, SC 29501

$2,700,000

13 sqft

16,000 sq ft historic building in Downtown Florence for sale.

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Office-Warehouse Flex Facility

1829 Habersham Square, Florence, SC 29501

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5,000 sqft 0.81 AC lot

Office space with three private offices and a reception area complements a warehouse with two drive-in doors.

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Commercial Office Property with Parking

2228 W Palmetto St., Florence, SC 29501

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1,405 sqft

Office-focused commercial property along a high-traffic corridor, offering visibility, accessibility, and ample on-site parking.

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Historic Downtown Office Building

248-260 W Evans st., Florence, SC 29506

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16,304 sqft 1.47 AC lot

Historic office building in downtown Florence with multiple tenant suites and over 100 parking spaces.

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Two-Story Single-Tenant Medical Office

1604 E Cheves St, Florence, SC 29506

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16,444 sqft

Fee simple interest in a purpose-built two-story medical office building, single-tenant and leased to a neurosurgery practice.

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Freestanding Office Building For Sale

1221 West Evans Street, Florence, SC 29501

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1,085 sqft

Leased office building with immediate income potential in Florence.

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Freestanding Office Building with Parking

1500 West Evans Street, Florence, SC 29501

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2,523 sqft

Well-maintained brick office with private offices, reception, open workspace, and paved side and rear parking.

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Office/Retail Conversion Opportunity

2901 W Palmetto Street, Florence, SC 29501

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2,600 sqft 1.60 AC lot

2600 SF residence on 1.6 acres, suitable for conversion.

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Versatile Commercial Parcel Near Downtown

121 N Lawson St, Florence, SC 29501

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67,518 sqft 1.55 AC lot

Office, showroom, and warehouse space less than one mile from Downtown.

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Multi-Tenant Office Building

1465 Pamplico Hwy, Florence, SC 29505

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6,768 sqft

Office building offered for sale with approximately 6,768 SF and a stated 4.92% CAP.

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Downtown Florence Business Technology Center

187 E Evans St, Florence, SC

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119,567 sqft 3.29 AC lot

Office building in downtown Florence with investment and value-add potential.

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Historic Downtown Florence Commercial Property

329 N Irby St, Florence, SC 29501

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12,411 sqft 1.55 AC lot

Historic building in downtown Florence, suitable for commercial use.

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South Irby Street Commercial Lot

623 South Irby Street, Florence, SC 29501

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0.46 AC lot

0.46 acre lot suitable for retail or office development.

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Versatile Office Building For Sale

603 W Palmetto Street, Florence, SC 29501

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2,004 sqft

Functional office building in high traffic area, ideal for professionals.

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Timmonsville Medical Office Building

101 W Market St, Timmonsville, SC 29161

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1,978 sqft

Well-maintained building suitable for medical or business office.

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Industrial Warehouse with Development Potential

906 S Church St, Florence, SC 29506

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95,590 sqft 7.34 AC lot

95,590 SF industrial warehouse on 7.34 acres for sale.

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Johnsonville Investment Opportunity

212 Maple Street, Johnsonville, SC 29555

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Prime property in Johnsonville, SC, with development potential.

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Florence County, SC Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Florence County, SC, showcased through 29 active listings on our real estate platform. These investment opportunities span a total of 418,721 square feet of properties for sale, with an estimated market value of $14,265,000.

Sale prices for office spaces in Florence County, SC start at $225,000, averaging $1,585,000, and reaching up to $2,700,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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