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    Florence County, SC Office Spaces for Sale

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    15 properties
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    Historic Office Building
    Updated: Mar 14
    Historic Office Building

    248-260 W Evans st., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot
    1939 construction with historic character
    1.47‑acre downtown Florence office property
    Over 100 on‑site parking spaces
    Current occupants include a law firm, H&R Block, and Smith Hair Studio
    23 offices, 7 bathrooms, and 8 boardrooms and meeting spaces
    View details
    Medical Office with Exam Rooms
    Updated: Jul 10
    Medical Office with Exam Rooms

    1706 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    8,291 sqft 1.34 AC lot
    13 exam rooms plus an X‑ray room
    8,300 sq ft commercial facility on 1.34 acres
    CI zoning in Florence, SC
    62 parking spaces and a four‑bay carport
    Covered patient drop‑off area
    View details
    Freestanding Storefront Building
    Freestanding Storefront Building

    205 W Main St, Lake City, SC 29560

    $700,000
    5,410 sqft

    Downtown setting near businesses, banks, restaurants, and public services supports multiple commercial use options.

    View details
    Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads
    Historic Downtown Office Building
    Historic Downtown Office Building

    260 W Evans St, Florence, SC 29501

    $2,700,000
    16,000 sqft 1.47 AC lot

    A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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    Historic Downtown Florence Building For Sale
    Historic Downtown Florence Building For Sale

    248,258, and 268 W. Evans St., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    16,000 SF historic building in downtown Florence for sale.

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    Medical Office Building with Sinks
    Medical Office Building with Sinks

    102 West Market Street, Timmonsville, SC 29161

    Contact for pricing
    4,856 sqft 0.34 AC lot

    B-4-zoned office building with separate entrances, reception areas, and adaptable medical-office infrastructure.

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    Flexible Retail and Office Building
    Flexible Retail and Office Building

    821 2nd Loop Road, Florence, SC 29505

    Contact for pricing
    5,400 sqft

    New construction with adaptable suites, shell interiors, and on-site parking along a heavily traveled commercial corridor.

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    Office-Warehouse Flex Facility
    Office-Warehouse Flex Facility

    1829 Habersham Square, Florence, SC 29501

    Contact for pricing
    5,000 sqft 0.81 AC lot

    Office space with three private offices and a reception area complements a warehouse with two drive-in doors.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    248-260 W Evans st., Florence, SC 29506

    Contact for pricing
    16,304 sqft 1.47 AC lot

    Historic office building in downtown Florence with multiple tenant suites and over 100 parking spaces.

    View details
    Freestanding Office Building For Sale
    Freestanding Office Building For Sale

    1221 West Evans Street, Florence, SC 29501

    Contact for pricing
    1,085 sqft

    Leased office building with immediate income potential in Florence.

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    Freestanding Office Building with Parking
    Freestanding Office Building with Parking

    1500 West Evans Street, Florence, SC 29501

    Contact for pricing
    2,523 sqft

    Well-maintained brick office with private offices, reception, open workspace, and paved side and rear parking.

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    Office/Retail Conversion Opportunity
    Office/Retail Conversion Opportunity

    2901 W Palmetto Street, Florence, SC 29501

    Contact for pricing
    2,600 sqft 1.60 AC lot

    2600 SF residence on 1.6 acres, suitable for conversion.

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    Office Building with Efficiency Apartment
    Office Building with Efficiency Apartment

    1506 W Palmetto Street, Florence, SC 29501

    Contact for pricing

    Three main-level rooms and a den are complemented by a downstairs kitchen and dining area.

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    Historic Downtown Florence Commercial Property
    Historic Downtown Florence Commercial Property

    329 N Irby St, Florence, SC 29501

    Contact for pricing
    12,411 sqft 1.55 AC lot

    Historic building in downtown Florence, suitable for commercial use.

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    South Irby Street Commercial Lot
    South Irby Street Commercial Lot

    623 South Irby Street, Florence, SC 29501

    Contact for pricing
    0.46 AC lot

    0.46 acre lot suitable for retail or office development.

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    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 15 Active listings in Florence County, SC, we suggest exploring several alternatives: similar 57 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land Along Four-Lane Corridor
    Commercial Land Along Four-Lane Corridor

    917 S Cashua Drive, Florence, SC 29501

    $850,000
    4.76 AC lot

    High, level parcel near retail, grocery, restaurant, and service businesses along a four-lane commercial corridor.

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    Florence Area Investment Opportunity
    Florence Area Investment Opportunity

    5723 E National Cemetery Rd, Florence, SC 29506

    $32,725

    Prime land in Florence, SC, with development potential.

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    Commercial Land with Billboard
    Commercial Land with Billboard

    S Governor Williams Highway, Darlington, SC 29532

    $249,000
    4.79 AC lot

    Commercial-zoned acreage with an existing income-producing billboard and possible city annexation.

    View details
    Corner Commercial Land
    Corner Commercial Land

    360 S Ron McNair Blvd, Lake City, SC 29560

    $59,900
    1,200 sqft 0.12 AC lot

    Corner commercial parcel with brick construction, concrete flooring, and central air.

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    Off-Market Properties in Florence County, SC

    Consider similar Off-Market properties in Florence County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    316 Mcqueen St
    MEDICAL BUILDING

    316 Mcqueen St, Florence, SC 29501-4723

    Estimated value:
    $235,000
    1,470 sqft 0.18 AC lot
    View details
    511 Evans St
    OFFICE BUILDING

    511 Evans St, Florence, SC 29501-3407

    Estimated value:
    $160,000
    2,145 sqft
    View details
    511 Evans St
    OFFICE BUILDING

    511 Evans St, Florence, SC 29501-3407

    Estimated value:
    $130,000
    1,250 sqft 0.30 AC lot
    View details
    908 Evans St
    OFFICE BUILDING

    908 Evans St, Florence, SC 29501-3442

    Estimated value:
    $115,000
    1,430 sqft 0.27 AC lot
    View details
    3036 Caterpillar Ln
    OFFICE BUILDING

    3036 Caterpillar Ln, Florence, SC 29506-8109

    Estimated value:
    $300,000
    672 sqft 5.65 AC lot
    View details
    221 Rodgers Ave
    OFFICE BUILDING

    221 Rodgers Ave, Lake City, SC 29560-2151

    Estimated value:
    $270,000
    2,929 sqft 0.34 AC lot
    View details
    1530 Mclure Ct
    MEDICAL BUILDING

    1530 Mclure Ct, Florence, SC 29505-6174

    Estimated value: by Request
    10,148 sqft 1.22 AC lot
    View details
    1937 Palmetto St
    OFFICE BUILDING

    1937 Palmetto St, Florence, SC 29506-3606

    Estimated value:
    $460,000
    2,907 sqft 0.72 AC lot
    View details
    130 Acline St
    MEDICAL BUILDING

    130 Acline St, Lake City, SC 29560-2633

    Estimated value:
    $170,000
    2,052 sqft 0.22 AC lot
    View details

    Florence County, SC Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in Florence County, SC, showcased through 15 active listings on our real estate platform. These investment opportunities span a total of 112,488 square feet of properties for sale, with an estimated market value of $10,450,000.

    Sale prices for office properties in Florence County, SC start at $700,000, averaging $2,090,000, and reaching up to $2,700,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Featured Florence County Real Estate Agencies

    Realmo connects you with licensed Florence County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com
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