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    Florence County, SC Office Properties & Spaces for Sale

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    Columbia, SC Aiken, SC Greenville, SC
    27 results
    Remodeled Commercial Building Near Downtown
    $340,000
    2,165 SF

    Remodeled Commercial Building Near Downtown

    910 W Evans st, Florence, SC 29501

    Turnkey commercial property in prime location with excellent visibility.

    • Completely remodeled/rebuilt from the ground up with new roof, HVAC, electrical, and plumbing.
    • Prime location minutes from downtown Florence with excellent visibility and access.
    • Turnkey property suitable for a medical office, salon, law firm, or small business.
    • Five spacious rooms that can serve as private offices or treatment spaces.
    • Modern kitchen with brand‑new cabinets and granite countertops.
    Updated: Apr 1
    View details
    Historic Downtown Florence Commercial Building
    $2,700,000
    16,304 SF

    Historic Downtown Florence Commercial Building

    248-260 W Evans st., Florence, SC 29501

    16,000 SF historic building in thriving downtown Florence.

    • Prime downtown Florence location in a thriving area.
    • Large 16,000 sq ft historic building with limitless potential.
    • Significant parking available (over 100 spaces), rare for downtown.
    • Versatile space currently configured with multiple tenants (Law Firm, H&R Block, Hair Studio).
    • Spacious 1.47‑acre lot allows for growth and development.
    Updated: Mar 9
    View details
    Industrial Buildings with Power & Access
    $199,000
    40,000 SF

    Industrial Buildings with Power & Access

    Two industrial buildings ideal for fabrication, automotive, or storage.

    120 N Guerry Street, Florence, SC 29501
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    Florence Commercial Building on Evans
    $79,000
    1,200 SF

    Florence Commercial Building on Evans

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
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    Timmonsville Medical Office Building
    $125,000
    1,968 SF

    Timmonsville Medical Office Building

    Well-maintained 2,000 SF building suitable for various office uses.

    101 Market St, Timmonsville, SC 29161
    View details
    Downtown Lake City Commercial Building
    $199,000
    2,500 SF

    Downtown Lake City Commercial Building

    2,500 sq ft commercial building in downtown Lake City.

    112 E Main St, Lake City, SC 29560
    View details
    Olanta Commercial Building on US 301
    $60,000
    1,500 SF

    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with multiple business possibilities.

    405 N Jones Road, Olanta, SC 29114
    View details
    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    Office building with 7,517 square feet of space in Florence.

    1706 Second Loop Rd., Florence, SC 29501
    View details
    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF

    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501
    View details
    Downtown Florence Business Technology Center
    $12,000,000
    119,567 SF

    Downtown Florence Business Technology Center

    Office building in downtown Florence with investment and value-add potential.

    187 E Evans St, Florence, SC
    View details
    McLeod Physician Associates For Sale
    $1,384,320
    2,666 SF

    McLeod Physician Associates For Sale

    2,666 SF medical office in Florence, SC for sale.

    1540 American Dr, Florence, SC
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    Olanta Commercial Building on US 301
    $60,000
    1,500 SF

    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with multiple business possibilities.

    405 N Jones Road, Olanta, SC 29114
    View details
    Medical Office Building Near MUSC
    $2,200,000
    7,950 SF

    Medical Office Building Near MUSC

    Medical office building near MUSC campus with ample parking.

    1929 Mountain Laurel Court, Florence, SC
    View details
    Standalone Industrial Building on Harrell
    $189,000
    40,000 SF

    Standalone Industrial Building on Harrell

    Industrial building suitable for fabrication, automotive, contractor, or storage.

    120 N Guerry St, Florence, SC 29501
    View details
    Office/Retail Conversion Opportunity
    $400,000
    2,600 SF

    Office/Retail Conversion Opportunity

    2600 SF residence on 1.6 acres, suitable for conversion.

    2901 W Palmetto Street, Florence, SC 29501
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    Evans Street Commercial Redevelopment Opportunity
    $79,000
    1,200 SF

    Evans Street Commercial Redevelopment Opportunity

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
    View details
    Stand-Alone Office Building For Sale
    $250,000
    1,722 SF

    Stand-Alone Office Building For Sale

    Stand-alone office building with immediate occupancy in Lake City, SC.

    215 John St, Lake City, SC
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    Historic Downtown Florence Building For Sale
    $2,800,000
    16,304 SF

    Historic Downtown Florence Building For Sale

    16,000 SF historic building in downtown Florence for sale.

    248,258, and 268 W. Evans St., Florence, SC 29501
    View details
    Johnsonville Investment Opportunity
    Contact for pricing

    Johnsonville Investment Opportunity

    Prime property in Johnsonville, SC, with development potential.

    212 Maple Street, Johnsonville, SC 29555
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    South Irby Street Commercial Lot
    $255,000

    South Irby Street Commercial Lot

    0.46 acre lot suitable for retail or office development.

    623 South Irby Street, Florence, SC 29501
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    Versatile Office Building For Sale
    $262,500
    2,004 SF

    Versatile Office Building For Sale

    Functional office building in high traffic area, ideal for professionals.

    603 W Palmetto Street, Florence, SC 29501
    View details
    Timmonsville Medical Office Building
    $125,000
    1,978 SF

    Timmonsville Medical Office Building

    Well-maintained building suitable for medical or business office.

    101 W Market St, Timmonsville, SC 29161
    View details
    Historic Downtown Florence Commercial Property
    $1,100,000
    12,411 SF

    Historic Downtown Florence Commercial Property

    Historic building in downtown Florence, suitable for commercial use.

    329 N Irby St, Florence, SC 29501
    View details
    Industrial Warehouse with Development Potential
    $2,190,000
    95,590 SF

    Industrial Warehouse with Development Potential

    95,590 SF industrial warehouse on 7.34 acres for sale.

    906 S Church St, Florence, SC 29506
    View details

    Florence County, SC Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 27 office properties & spaces for sale in Florence County, SC, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 18,174,000 square feet of properties for sale, with an estimated market value of $148,873,000.

    Sale prices for office spaces in Florence County, SC start at $50,000, averaging $581,535, and reaching up to $15,640,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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