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    Florence County, SC Office Spaces for Sale

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    Columbia, SC Greenville, SC Spartanburg, SC
    27 results
    Remodeled Commercial Building Near Downtown
    $320,000
    2,165 SF
    Remodeled Commercial Building Near Downtown

    910 W Evans st, Florence, SC 29501

    Turnkey commercial property in prime location with excellent visibility.
    • Completely remodeled/rebuilt from the ground up with new roof, HVAC, electrical, and plumbing.
    • Prime location minutes from downtown Florence with excellent visibility and access.
    • Turnkey property suitable for a medical office, salon, law firm, or small business.
    • Five spacious rooms that can serve as private offices or treatment spaces.
    • Modern kitchen with brand‑new cabinets and granite countertops.
    Updated: Apr 24
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    Historic Downtown Florence Commercial Building
    $2,700,000
    16,304 SF
    Historic Downtown Florence Commercial Building

    248-260 W Evans st., Florence, SC 29501

    16,000 SF historic building in thriving downtown Florence.
    • Prime downtown Florence location in a thriving area.
    • Large 16,000 sq ft historic building with limitless potential.
    • Significant parking available (over 100 spaces), rare for downtown.
    • Versatile space currently configured with multiple tenants (Law Firm, H&R Block, Hair Studio).
    • Spacious 1.47‑acre lot allows for growth and development.
    Updated: Mar 9
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    Prime Commercial Property on Palmetto
    $250,000
    1,405 SF
    Prime Commercial Property on Palmetto

    High-visibility commercial property on a high-traffic street in Florence.

    2228 W Palmetto St., Florence, SC 29501

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    Florence Office Building For Sale
    $1,500,000
    7,517 SF
    Florence Office Building For Sale

    7,517 SF office building on 1.34 acres in Florence.

    1706 Second Loop Rd., Florence, SC 29501

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    Florence Commercial Building on Evans
    $79,000
    1,200 SF
    Florence Commercial Building on Evans

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501

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    Downtown Lake City Commercial Building
    $199,000
    2,500 SF
    Downtown Lake City Commercial Building

    2,500 sq ft commercial building in downtown Lake City.

    112 E Main St, Lake City, SC 29560

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    Olanta Commercial Building on US 301
    $60,000
    1,500 SF
    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with multiple business possibilities.

    405 N Jones Road, Olanta, SC 29114

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    McLeod Physician Associates For Sale
    $1,384,320
    2,666 SF
    McLeod Physician Associates For Sale

    2,666 SF medical office in Florence, SC for sale.

    1540 American Dr, Florence, SC

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    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF
    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501

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    Medical Office Building Near MUSC
    $2,200,000
    7,950 SF
    Medical Office Building Near MUSC

    Medical office building near MUSC campus with ample parking.

    1929 Mountain Laurel Court, Florence, SC

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    Downtown Florence Business Technology Center
    $12,000,000
    119,567 SF
    Downtown Florence Business Technology Center

    Office building in downtown Florence with investment and value-add potential.

    187 E Evans St, Florence, SC

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    Olanta Commercial Building on US 301
    $60,000
    1,500 SF
    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with multiple business possibilities.

    405 N Jones Road, Olanta, SC 29114

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    Standalone Industrial Building on Harrell
    $189,000
    40,000 SF
    Standalone Industrial Building on Harrell

    Industrial building suitable for fabrication, automotive, contractor, or storage.

    120 N Guerry St, Florence, SC 29501

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    Office/Retail Conversion Opportunity
    $400,000
    2,600 SF
    Office/Retail Conversion Opportunity

    2600 SF residence on 1.6 acres, suitable for conversion.

    2901 W Palmetto Street, Florence, SC 29501

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    Evans Street Commercial Redevelopment Opportunity
    $79,000
    1,200 SF
    Evans Street Commercial Redevelopment Opportunity

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501

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    Stand-Alone Office Building For Sale
    $250,000
    1,722 SF
    Stand-Alone Office Building For Sale

    Stand-alone office building with immediate occupancy in Lake City, SC.

    215 John St, Lake City, SC

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    Freestanding Office Building For Sale
    $199,000
    1,085 SF
    Freestanding Office Building For Sale

    Leased office building with immediate income potential in Florence.

    1221 West Evans Street, Florence, SC 29501

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    Timmonsville Medical Office Building
    $125,000
    1,968 SF
    Timmonsville Medical Office Building

    Well-maintained 2,000 SF building suitable for various office uses.

    101 Market St, Timmonsville, SC 29161

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    Historic Downtown Florence Building For Sale
    $2,800,000
    16,304 SF
    Historic Downtown Florence Building For Sale

    16,000 SF historic building in downtown Florence for sale.

    248,258, and 268 W. Evans St., Florence, SC 29501

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    Johnsonville Investment Opportunity
    Contact for pricing
    Johnsonville Investment Opportunity

    Prime property in Johnsonville, SC, with development potential.

    212 Maple Street, Johnsonville, SC 29555

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    South Irby Street Commercial Lot
    $255,000
    0.46 Acres
    South Irby Street Commercial Lot

    0.46 acre lot suitable for retail or office development.

    623 South Irby Street, Florence, SC 29501

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    Historic Downtown Florence Commercial Property
    $1,100,000
    12,411 SF
    Historic Downtown Florence Commercial Property

    Historic building in downtown Florence, suitable for commercial use.

    329 N Irby St, Florence, SC 29501

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    Versatile Office Building For Sale
    $262,500
    2,004 SF
    Versatile Office Building For Sale

    Functional office building in high traffic area, ideal for professionals.

    603 W Palmetto Street, Florence, SC 29501

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    Industrial Warehouse with Development Potential
    $2,190,000
    95,590 SF
    Industrial Warehouse with Development Potential

    95,590 SF industrial warehouse on 7.34 acres for sale.

    906 S Church St, Florence, SC 29506

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    Florence County, SC Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Florence County, SC, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 406,676 square feet of properties for sale, with an estimated market value of $28,846,720.

    Sale prices for office spaces in Florence County, SC start at $60,000, averaging $1,311,214, and reaching up to $12,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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