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    Florence County, SC Mixed-use Properties for Sale

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    6 properties
    Historic Mixed-Use Building in Florence
    Updated: Sep 10, 2025
    Historic Mixed-Use Building in Florence

    248,258, and 268 W. Evans St., Florence, SC 29501

    $2,700,000
    13 sqft
    Prime downtown Florence location in a thriving area.
    Expansive 16,000 sq ft historic building with limitless potential.
    Currently generating income with existing tenants (Law Firm, H&R Block, Smith Hair Studio).
    Includes 1.47 acres of land, offering room for growth and development.
    Features a substantial amount of parking with over 100 spaces, a rare amenity for downtown.
    View details
    Versatile Commercial Building on Acreage
    Updated: Mar 5
    Versatile Commercial Building on Acreage

    511 Irby Street, Florence, SC 29501

    $500,000
    1.09 AC lot
    1.09 acre lot
    Single tenant building
    Ample showroom and warehouse space
    Features two (2) rollup doors
    Totally fenced in
    View details
    Downtown Lake City Commercial Building
    Downtown Lake City Commercial Building

    112 E Main St, Lake City, SC 29560

    Contact for pricing
    2,500 sqft

    2,500 sq ft commercial building in downtown Lake City.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Versatile Commercial Parcel Near Downtown
    Versatile Commercial Parcel Near Downtown

    121 N Lawson St, Florence, SC 29501

    Contact for pricing
    67,518 sqft 1.55 AC lot

    Office, showroom, and warehouse space less than one mile from Downtown.

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    Evans Street Commercial Redevelopment Opportunity
    Evans Street Commercial Redevelopment Opportunity

    617 W Evans St, Florence, SC 29501

    Contact for pricing
    1,200 sqft 0.75 AC lot

    Standalone building on Evans Street with redevelopment potential.

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    Johnsonville Investment Opportunity
    Johnsonville Investment Opportunity

    212 Maple Street, Johnsonville, SC 29555

    Contact for pricing

    Prime property in Johnsonville, SC, with development potential.

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    Based on your search, we've compiled 54 Potential Opportunities for your consideration. Besides 6 Active listings in Florence County, SC, we suggest exploring several alternatives: similar 44 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Florence Area Investment Opportunity
    Florence Area Investment Opportunity

    5723 E National Cemetery Rd, Florence, SC 29506

    $32,725

    Prime land in Florence, SC, with development potential.

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    Cleared Lot in Marion, SC
    Cleared Lot in Marion, SC

    Phillips St., Marion, SC 29571

    Contact for pricing
    0.18 AC lot

    0.18-acre cleared lot ready for building in Marion, SC.

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    Multiplex-Ready Residential Development Land
    Multiplex-Ready Residential Development Land

    Rice Street, Latta, SC 29565

    $45,000
    3.88 AC lot

    Nearly 4 acres in Latta with city water and sewer, offering flexible development options for residential or small multifamily uses.

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    Multifamily-Ready Residential Land
    Multifamily-Ready Residential Land

    W Rice Street, Latta, SC 29565

    $45,000
    3.88 AC lot

    Nearly 4 acres in Latta with dual access points and city water and sewer available.

    View details

    Off-Market Properties in Florence County, SC

    Consider similar Off-Market properties in Florence County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1505 Palmetto St
    OFFICE/RESIDENTIAL (MIXED USE)

    1505 Palmetto St, Florence, SC 29501-4131

    $150,000
    Estimated value
    1,057 sqft 0.23 AC lot
    View details
    1388 Blackwell Ml Rd
    OFFICE/RESIDENTIAL (MIXED USE)

    1388 Blackwell Ml Rd, Johnsonville, SC 29555-6224

    $135,000
    Estimated value
    2,340 sqft 0.07 AC lot
    View details
    1459 Palmetto St
    OFFICE/RESIDENTIAL (MIXED USE)

    1459 Palmetto St, Florence, SC 29501-4173

    $375,000
    Estimated value
    1,519 sqft 0.46 AC lot
    View details
    245 Moore St
    OFFICE/RESIDENTIAL (MIXED USE)

    245 Moore St, Lake City, SC 29560-2532

    $90,000
    Estimated value
    0.37 AC lot
    View details
    Main St
    OFFICE/RESIDENTIAL (MIXED USE)

    Main St, Timmonsville, SC 29161

    Value Estimation by Request
    1.28 AC lot
    View details
    119 Thomas St
    OFFICE/RESIDENTIAL (MIXED USE)

    119 Thomas St, Lake City, SC 29560-2638

    $165,000
    Estimated value
    2,613 sqft 0.11 AC lot
    View details
    209 Mclendon St
    OFFICE/RESIDENTIAL (MIXED USE)

    209 Mclendon St, Timmonsville, SC 29161-1913

    $85,000
    Estimated value
    1,352 sqft 0.51 AC lot
    View details
    101 Kershaw St
    OFFICE/RESIDENTIAL (MIXED USE)

    101 Kershaw St, Timmonsville, SC 29161-1425

    $795,000
    Estimated value
    33,345 sqft 3.91 AC lot
    View details
    2702 Irby St
    OFFICE/RESIDENTIAL (MIXED USE)

    2702 Irby St, Florence, SC 29505-3434

    $115,000
    Estimated value
    2,541 sqft 0.53 AC lot
    View details
    501 Ron Mcnair Blvd
    OFFICE/RESIDENTIAL (MIXED USE)

    501 Ron Mcnair Blvd, Lake City, SC 29560-3820

    $125,000
    Estimated value
    1,155 sqft 0.19 AC lot
    View details
    174 Ron Mcnair Blvd
    OFFICE/RESIDENTIAL (MIXED USE)

    174 Ron Mcnair Blvd, Lake City, SC 29560-3260

    $65,000
    Estimated value
    1,024 sqft 1.30 AC lot
    View details
    Runway Dr
    OFFICE/RESIDENTIAL (MIXED USE)

    Runway Dr, Timmonsville, SC 29161

    Value Estimation by Request
    1.00 AC lot
    View details
    546 Church St
    OFFICE/RESIDENTIAL (MIXED USE)

    546 Church St, Lake City, SC 29560-3817

    $115,000
    Estimated value
    2,862 sqft 0.68 AC lot
    View details
    1506 Palmetto St
    OFFICE/RESIDENTIAL (MIXED USE)

    1506 Palmetto St, Florence, SC 29501-4132

    $260,000
    Estimated value
    2,978 sqft 0.40 AC lot
    View details
    1107 Evans St
    OFFICE/RESIDENTIAL (MIXED USE)

    1107 Evans St, Florence, SC 29506-2739

    $165,000
    Estimated value
    2,216 sqft 0.30 AC lot
    View details
    1115 Cheves St
    OFFICE/RESIDENTIAL (MIXED USE)

    1115 Cheves St, Florence, SC 29506-2709

    $215,000
    Estimated value
    0.39 AC lot
    View details
    State Hwy 51
    OFFICE/RESIDENTIAL (MIXED USE)

    State Hwy 51, Effingham, SC 29541

    $145,000
    Estimated value
    1,236 sqft 6.19 AC lot
    View details
    3808 Railroad Ave
    OFFICE/RESIDENTIAL (MIXED USE)

    3808 Railroad Ave, Coward, SC 29530-5432

    $170,000
    Estimated value
    3,000 sqft 0.25 AC lot
    View details

    Florence County, SC Mixed-Use Properties Market Trends and Statistics

    Explore 50 mixed-use properties for sale in Florence County, SC, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 71,231 square feet of properties for sale, with an estimated market value of $3,200,000.

    Sale prices for multi use buildings in Florence County, SC start at $500,000, averaging $1,600,000, and reaching up to $2,700,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Featured Florence County Real Estate Agencies

    Realmo connects you with licensed Florence County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com

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