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    Florence County, SC Retail Properties & Spaces for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    15 results
    Two-Unit Retail Conversion Opportunity
    $2,500/Mo
    2,304 SF
    Two-Unit Retail Conversion Opportunity

    225 W Lucas St, Florence, SC 29501

    Two storefront units with restaurant conversion-ready features on a high-traffic corridor near I-95.
    • Two‑unit commercial property built in 1983 at 225 W Lucas St (front) and 223 W Lucas St (rear), Florence, SC 29501
    • Front unit currently a convenience store and includes natural gas access, a commercial hood vent, take‑out window, and seating area for restaurant conversion
    • Rear unit has a liquor store permit application underway (223 W Lucas St), positioning dual revenue streams on one site
    • Property sits on the US‑52/Lucas Street Corridor with an average daily traffic count of 24,700 vehicles
    • Located just minutes from I‑95 and surrounded by 5,000+ hotel rooms
    Updated: May 10
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    Industrial Flex Building with Bay Doors
    $5,000/Mo
    11,390 SF
    Industrial Flex Building with Bay Doors

    374 Darlington St., Florence, SC 29501

    Flexible industrial space with multiple bay doors and front office area for vehicle, equipment, and service operations.
    • Year built: 1951
    • Downtown Florence, SC commercial property with multiple bay doors
    • Versatile open space suitable for vehicle, equipment, or flexible commercial use
    • Front office space plus restrooms for staff and clients
    • Rent listed at $5,000/month
    Updated: Oct 11, 2025
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    Retail Spaces in CrossRoads Center
    $18,134/Mo
    95,840 SF
    Retail Spaces in CrossRoads Center

    Retail spaces available in high-traffic Florence commercial corridor.

    2522, 2524, 2528 David H McLeod Blvd, Florence, SC 29501

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    Retail Space in Lake City
    $12 SF/Yr
    1,200 SF
    Retail Space in Lake City

    Retail spaces available in a busy Lake City shopping center.

    252 Kelley St, Lake City, SC

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    Retail Space in Regional Destination
    $22 SF/Yr
    2,800 SF
    Retail Space in Regional Destination

    Retail space available in premier shopping center, built in 2015.

    112-120 Woody Jones Blvd, Florence, SC

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    Warehouse with Showroom and Yard
    Contact for pricing
    Warehouse with Showroom and Yard

    Single tenant building with showroom, warehouse, and fenced yard.

    511 Irby Street, Florence, SC 29501

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    Retail Space in Regional Destination
    $25 SF/Yr
    2,400 SF
    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination, built in 2015.

    104 Woody Jones Blvd, Florence, SC

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    Florence Warehouse in West End
    $90 SF/Yr
    36,360 SF
    Florence Warehouse in West End

    Warehouse in Florence's West End District, near major retailers.

    2295 Hoffmeyer Rd, Florence, SC 29501

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    Retail Space in Florence, SC
    Contact for pricing
    8,000 SF
    Retail Space in Florence, SC

    8,000 SF retail space available for lease.

    2600 David H Mcleod Blvd, Florence, SC

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    Retail Space in Regional Destination
    $22 SF/Yr
    4,475 SF
    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination near major highways.

    110 Woody Jones Blvd, Florence, SC

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    Retail Space in Five Points
    $25 SF/Yr
    2,700 SF
    Retail Space in Five Points

    End-cap retail space in a high-traffic area for lease.

    1939 Hoffmeyer Rd, Florence, SC 29501

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    Established Commercial Complex on Second Loop
    Contact for pricing
    2,000 SF
    Established Commercial Complex on Second Loop

    Multi-tenant commercial complex with high visibility and convenient access.

    1800 2nd Loop Rd, Florence, SC 29501

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    Prime Outparcel Opportunities in Florence
    $1.00 SF/Yr
    Prime Outparcel Opportunities in Florence

    Outparcels available at I-95 interchange, ideal for hotels, restaurants.

    2939 N Williston Rd, Florence, SC 29506

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    Florence Commercial Space For Rent
    Contact for pricing
    Florence Commercial Space For Rent

    Commercial space suitable for office, professional, or retail use.

    2843 W Palmetto Street Suite C, Florence, SC 29501

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    Retail Space in Florence Mall
    Contact for pricing
    329,000 SF
    Retail Space in Florence Mall

    Prime retail space in regional shopping center, Florence, South Carolina.

    1945 W Palmetto St, Florence, SC 29501

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    Based on your search, we've compiled 54 Potential Opportunities for your consideration. Besides 15 Active listings in Florence County, SC, we suggest exploring alternatives. Similar 35 Properties for Sales.

    Similar Spaces for Sale in Florence County, SC

    Consider Similar Space for Sale. We found 35 Spaces matching your search parameters.

    Fully Occupied Retail Center
    $1,650,000
    15,450 SF
    Fully Occupied Retail Center

    Retail center in good condition with high traffic count.

    823-817 S Cashua Drive, Florence, SC 29501

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    Buildable Retail Development Land
    $1,500,000
    7.27 Acres
    Buildable Retail Development Land

    Level, buildable two-parcel land package suited for a range of retail and service-oriented development uses.

    3312 Meadors Road, Florence, SC 29501

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    Prime Commercial Land Opportunity
    $599,000
    2.90 Acres
    Prime Commercial Land Opportunity

    2.9-acre commercial site in Lake City, SC.

    791 S Ron McNair Blvd., Lake City, SC 29560

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    Prime Commercial Site on Highway
    $599,000
    2.90 Acres
    Prime Commercial Site on Highway

    Development opportunity in high-traffic commercial corridor near industrial area.

    791 S Ron McNair Blvd, Lake City, SC 29560

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    Downtown Lake City Commercial Building
    $199,000
    2,500 SF
    Downtown Lake City Commercial Building

    2,500 sq ft commercial building in downtown Lake City.

    112 E Main St, Lake City, SC 29560

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    Olanta Commercial Building on US 301
    $60,000
    1,500 SF
    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with multiple business possibilities.

    405 N Jones Road, Olanta, SC 29114

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    Florence Commercial Development Opportunity
    $1,200,000
    4.54 Acres
    Florence Commercial Development Opportunity

    4.54 acre commercial parcel on high-traffic corridor.

    2621 West Palmetto Street, Florence, SC 29501

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    Lake City Commercial Parking Lot
    $160,000
    0.47 Acres
    Lake City Commercial Parking Lot

    0.47 acre commercial lot with rental income potential.

    0.47 Acres-TBD Sumter St., Lake City, SC 29560

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    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF
    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Development Ready Outparcel in Myrtle Beach
    $95,000 SF/Yr
    Development Ready Outparcel in Myrtle Beach

    1.17 acre commercial land with high traffic counts.

    1028 Glenforest Rd., Myrtle Beach, SC 29579

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    Commercial Land in Murrells Inlet
    $2,500/Mo
    Commercial Land in Murrells Inlet

    1.49 acres of commercial land for lease.

    Inlet Square Dr., Murrells Inlet, SC 29576

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    Commercial Land in Southern Pines
    $3,500/Mo
    Commercial Land in Southern Pines

    1.297-acre commercial land site for lease in a high-traffic area.

    Pinehurst Avenue, Southern Pines, NC 28387

    View details
    Land Lease Opportunity in Waxhaw
    $8,000/Mo
    Land Lease Opportunity in Waxhaw

    5.341-acre commercial land for lease in a high-growth area.

    5325 Waxhaw Marvin Road, Waxhaw, NC 28173

    View details

    Florence County, SC Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Florence County, SC with 15 listings featured on our commercial real estate exchange. The current inventory includes 159,469 square feet of properties with an estimated lease value of $216 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Florence County, SC begin at $2 SF/Yr, with an average of $24 SF/Yr and extend to $90 SF/Yr.
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