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    Florence County, SC Commercial Land for Sale

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    71 properties
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    Vacant Farm-Zoned Development Land
    Updated: Jul 8
    Vacant Farm-Zoned Development Land

    1714 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    4.03 AC lot
    4.04‑acre vacant parcel on one of Florence’s most active commercial corridors
    Zoned Farm Vacant (FV), offering flexibility for future development options
    Convenient access to West Second Loop Road
    Surrounded by an established commercial medical facility at 1706 2nd Loop Road and a shopping plaza across the way
    Generous acreage for new construction, parking, and site planning
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    Commercial Land with Water and Sewer
    Updated: May 16
    Commercial Land with Water and Sewer

    Cale Yarborough HWY, Timmonsville, SC 29161

    $225,000
    3.03 AC lot
    Commercial property located immediately off Exit 150 at the intersection of I‑95 and Cale Yarborough Highway
    Easement provides access to a smaller rear section, creating additional income‑producing lease potential
    Rear section could be leased for uses such as a cellular tower, utility installation, billboard placement, or other small commercial leases
    Public water and sewer available to the property
    Site supports a range of commercial development including retail, hospitality, restaurants, travel services, fuel stations, storage, or mixed‑use
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    Buildable Retail Development Land
    Buildable Retail Development Land

    3312 Meadors Road, Florence, SC 29501

    $1,500,000
    7.27 AC lot

    Level, buildable two-parcel land package suited for a range of retail and service-oriented development uses.

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    Florence Commercial Development Opportunity
    Florence Commercial Development Opportunity

    2621 West Palmetto Street, Florence, SC 29501

    $1,200,000
    4.54 AC lot

    4.54 acre commercial parcel on high-traffic corridor.

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    Development-Ready Commercial Land Site
    Development-Ready Commercial Land Site

    917 S Cashua Drive, Florence, SC 29501

    $980,000
    4.76 AC lot

    4.76-acre B3-zoned parcel on a four-lane corridor with SCDOT-reported traffic near major daily-use anchors.

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    Prime Commercial Land Opportunity
    Prime Commercial Land Opportunity

    791 S Ron McNair Blvd., Lake City, SC 29560

    $599,000
    2.90 AC lot

    2.9-acre commercial site in Lake City, SC.

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    Cleared Level Commercial Land Lot
    Cleared Level Commercial Land Lot

    207 S Irby St., Florence, SC 29501

    $750,000
    0.52 AC lot

    Level, cleared commercial lot with utilities available in Florence, SC.

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    Commercial Land with Bus Terminal
    Commercial Land with Bus Terminal

    611 S Irby St, Florence, SC 29501

    $395,000
    5,500 sqft 1.05 AC lot

    1.05-acre site with 5,500 SF bus terminal building.

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    Corner Commercial Development Lot
    Corner Commercial Development Lot

    360 S Ron McNair Blvd, Lake City, SC 29560

    $59,900
    1,200 sqft 0.12 AC lot

    Corner commercial lot on a major route between Florence and Charleston, suited for office, retail, or restaurant development.

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    Commercial Land Opportunity
    Commercial Land Opportunity

    W Leggs Cir, Florence, SC 29501

    $129,900
    4.00 AC lot

    4-acre commercial land in Florence County, positioned in a high-traffic area for a wide range of business uses.

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    Prime Commercial Site on Highway
    Prime Commercial Site on Highway

    791 S Ron McNair Blvd, Lake City, SC 29560

    $599,000
    2.90 AC lot

    Development opportunity in high-traffic commercial corridor near industrial area.

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    B-6 Zoned Commercial Land Opportunity
    B-6 Zoned Commercial Land Opportunity

    720 S Barringer Street, Florence, SC 29506

    $47,900
    840 sqft 0.17 AC lot

    B-6 zoned parcel suited for a range of commercial development options.

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    Flat Corner Commercial Land
    Flat Corner Commercial Land

    635 N Coit St., Florence, SC 29501

    $275,000
    0.91 AC lot

    Commercially zoned flat, buildable corner lot with utilities available.

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    Vacant Commercial Development Land
    Vacant Commercial Development Land

    1714 W 2nd Loop Rd., Florence, SC 29501

    $1,650,000

    A 4.04-acre vacant parcel zoned Farm Vacant (FV) with convenient access to W 2nd Loop Road.

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    Florence Commercial Land For Sale
    Florence Commercial Land For Sale

    Presbyterian Road, Florence, SC 29501

    $792,792
    1.82 AC lot

    1.82 acre commercial land near I-95 in Florence, SC.

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    Lake City Commercial Parking Lot
    Lake City Commercial Parking Lot

    0.47 Acres-TBD Sumter St., Lake City, SC 29560

    $160,000
    0.47 AC lot

    0.47 acre commercial lot with rental income potential.

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    Zoned NZ Development Land
    Zoned NZ Development Land

    Pygatt Rd/ 2222 1/2 W Cummings Rd, Effingham, SC 29541

    $170,000

    Commercial land zoned NZ, offering flexible development possibilities for land and office-oriented endeavors.

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    Commercial Redevelopment Land Parcel
    Commercial Redevelopment Land Parcel

    2931 Republic Avenue, Florence, SC 29501

    $75,000
    0.97 AC lot

    Nearly one-acre commercial-zoned lot in Florence, SC, sold as-is with an abandoned structure on-site.

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    Commercial Land For Sale
    Commercial Land For Sale

    2819 E Palmetto Street, Florence, SC 29501

    $166,000
    1.98 AC lot

    1.98 acre commercial land with utilities in Florence, SC.

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    Florence Commercial Land For Sale
    Florence Commercial Land For Sale

    Presbyterian Road, Florence, SC 29501

    $396,396
    0.91 AC lot

    0.91 acre commercial land parcel in Florence, South Carolina.

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    South Irby Street Commercial Lot
    South Irby Street Commercial Lot

    623 South Irby Street, Florence, SC 29501

    $255,000
    0.46 AC lot

    0.46 acre lot suitable for retail or office development.

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    Commercial Land at Signalized Intersection
    Commercial Land at Signalized Intersection

    2365 Pamplico Hwy., Florence, SC 29505

    $525,000
    0.89 AC lot

    Unzoned commercial parcel with high-visibility access on Pamplico Highway, suited for a range of development concepts.

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    Prime Commercial Lot in Florence
    Prime Commercial Lot in Florence

    3104 Hoffmeyer Road, Florence, SC 29501

    $1,600,000
    4.12 AC lot

    Strategically located 4.12-acre commercial lot in a high-growth area.

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    Corner Commercial Land Parcel
    Corner Commercial Land Parcel

    360 N Dargan St, Florence, SC 29501

    $75,000
    0.10 AC lot

    Corner lot zoned Commercial, suited for development or placement of a new commercial use in Florence.

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    Florence County, SC Commercial Land Market Trends and Statistics

    Explore 72 commercial land for sale in Florence County, SC, showcased through 71 active listings on our real estate platform. These investment opportunities span a total of 13,636 square feet of properties for sale, with an estimated market value of $3,912,700.

    Sale prices for commercial lots in Florence County, SC start at $47,900, averaging $558,957, and reaching up to $2,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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