Florence, SC Commercial Real Estate for Sale

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154 properties

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Updated: May 19

Heavy Truck Repair Shop

N Cashua Dr., Florence, SC 29501

$580,000

1,000 sqft 2.00 AC lot

Established heavy truck and mobile repair franchise serving commercial fleets and roadside service customers
Contracts in place with 16 national and regional commercial fleet accounts
Sale includes equipment, inventory, operational systems, trade secrets, customer relationships, and training
Mobile service capability supports fleet assistance throughout the Florence market
1,000‑square‑foot facility situated on 2 acres

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Updated: Mar 14

Historic Office Building

248-260 W Evans st., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

1939 construction with historic character
1.47‑acre downtown Florence office property
Over 100 on‑site parking spaces
Current occupants include a law firm, H&R Block, and Smith Hair Studio
23 offices, 7 bathrooms, and 8 boardrooms and meeting spaces

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Office Building with Central Air

2228 W Palmetto St., Florence, SC 29501

$225,000

1,405 sqft 0.31 AC lot

Wood-frame office property with wood flooring, heat-pump heating, and a central air-conditioning system.

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Historic Downtown Office Building

260 W Evans St, Florence, SC 29501

$2,700,000

16,000 sqft 1.47 AC lot

A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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Fully Occupied Shopping Center

823-817 S Cashua Drive, Florence, SC 29501

$1,550,000

15,450 sqft

Two connected retail buildings sit across from a Walmart Neighborhood Market.

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Medical Office with Exam Rooms

1706 2nd Loop Rd., Florence, SC 29501

$1,650,000

8,291 sqft 1.34 AC lot

Brick medical facility with exam rooms, administrative offices, covered patient arrival, and dedicated on-site parking.

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Vacant Specialty Property

818 S Cashua Drive, Florence, SC 29501

$265,000

2,422 sqft 0.37 AC lot

Vacant brick building with mixed flooring, heat pump heating, and central air conditioning.

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Historic Downtown Florence Building For Sale

248,258, and 268 W. Evans St., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

16,000 SF historic building in downtown Florence for sale.

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Day Care Center with Frontage

822 S Cashua, Florence, SC 29501

$285,000

2,067 sqft 0.60 AC lot

Existing daycare facility with direct frontage on S Cashua and an as-is sale condition.

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Commercial Land Along Four-Lane Corridor

917 S Cashua Drive, Florence, SC 29501

$850,000

4.76 AC lot

High, level parcel near retail, grocery, restaurant, and service businesses along a four-lane commercial corridor.

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Commercial Land with Utilities

3104 Hoffmeyer Road, Florence, SC 29501

$1,600,000

4 sqft

Public sewer is installed, with water, electricity, and high-speed internet available for future development.

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Remodeled Office Building

910 W Evans st, Florence, SC 29501

$300,000

2,165 sqft 0.27 AC lot

Five-room commercial layout with a kitchen, full bathroom, and additional half bath.

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Cleared Commercial Land

207 S Irby St., Florence, SC 29501

$699,000

0.52 AC lot

Level, cleared parcel with utilities available for commercial development.

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Historic Mixed-Use Building in Florence

248,258, and 268 W. Evans St., Florence, SC 29501

$2,700,000

13 sqft

16,000 sq ft historic building in Downtown Florence for sale.

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Unzoned Commercial Land Tract

880 Freedom Blvd, Florence, SC 29506

$1,900,000

59.44 AC lot

Large unzoned tract with existing water and sewer infrastructure and flexible land-use potential.

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Commercial Land Parcel

1714 2nd Loop Rd., Florence, SC 29501

$1,650,000

4.03 AC lot

Vacant tract with FV zoning and convenient access from 2nd Loop Road.

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Flex Space with Warehouse

600 S Irby St., Florence, SC 29501

Contact for pricing

8,400 sqft 0.71 AC lot

Office, showroom, warehouse, and storage areas support an established tire service operation.

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B-6 Zoned Commercial Land

720 S Barringer Street, Florence, SC 29506

$47,900

840 sqft 0.17 AC lot

Commercial parcel near two Florence medical centers, offered in its existing condition for redevelopment or other commercial plans.

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Chipotle Restaurant Property

2037 S. Irby Street, Florence, SC 29505

Contact for pricing

2,325 sqft

Brand-new corporate-guaranteed restaurant with an absolute NNN lease and long-term renewal options.

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Corner Commercial Land

635 N Coit St., Florence, SC 29501

$265,000

0.91 AC lot

Flat, buildable commercial site with utilities available at a prominent corner location.

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Office-Warehouse Flex Facility

1829 Habersham Square, Florence, SC 29501

Contact for pricing

5,000 sqft 0.81 AC lot

Office space with three private offices and a reception area complements a warehouse with two drive-in doors.

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Commercial Land Development Site

3312 Meadors Road, Florence, SC 29501

$1,500,000

7.27 AC lot

Level, buildable acreage near I-95 with utilities available nearby.

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Former Convenience Store Investment Property

1134 E Howe Springs Road, Florence, SC 29505

$125,000

2,400 sqft

Fixer-upper retail property with 150' frontage, great investment potential.

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Signalized-Intersection Commercial Land

2365 Pamplico Hwy., Florence, SC 29505

$525,000

0.89 AC lot

Unzoned commercial parcel with highway access near Florence’s medical district and retail corridor.

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Florence, SC Commercial Real Estate Market Trends and Statistics

Explore 154 commercial real estate for sale in Florence, SC, showcased through 154 active listings on our real estate platform. These investment opportunities span a total of 1,614,278 square feet of properties for sale, with an estimated market value of $33,845,497.

Sale prices for business properties in Florence, SC start at $32,725, averaging $914,743, and reaching up to $2,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 92K

Population Growth (5Y) -1.5%

Median Household Income $61,793

College Educated 17.4%

High-Yield Neighborhoods for Investment

Identify Florence submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
29505	$252.1K
29501	$749.5K
29506	$961.9K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Florence County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in Florence County

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