Add Listing
    Florence, SC
    For Sale
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Property Types
    • Retail
    • Office
    • Residential Income
    • Restaurants
    • Industrial
    • Mixed-Use
    • Hospitality
    • Health Care
    • Sports & Entertainment
    • Land
    • Agricultural
    • Specialty
    Price
    Price
    $
    $

    Florence, SC Commercial Real Estate for Sale

    Notify Me
    List
    Map
    Timmonsville, SC Darlington, SC Coward, SC
    103 results
    Historic Downtown Office Building
    $2,700,000
    16,304 SF

    Historic Downtown Office Building

    248-260 W Evans st., Florence, SC 29501

    Historic office building with multiple suites and ample on-site parking in downtown Florence.

    • 16,000 SF historic building built in 1939 in Downtown Florence
    • Tenant space includes a law firm (13,759 SF) with 23 offices, 7 bathrooms, 8 boardrooms/meeting spaces, kitchen, library, and reception/waiting area
    • Additional tenants include H&R Block (1,977 SF) and Smith Hair Studio (568 SF)
    • Set on 1.47 acres with over 100 parking spaces
    • Heating includes electric and heat pump; cooling is central air
    Updated: Mar 14
    View details
    Office Property with Parking
    $250,000
    1,405 SF

    Office Property with Parking

    2228 W Palmetto St., Florence, SC 29501

    Office space on a 0.31-acre lot with parking and strong visibility along W Palmetto St in Florence.

    • Commercial property located along high‑traffic W Palmetto St in Florence
    • Wood frame construction with wood flooring
    • Central air and heat pump heating
    • Generous lot with ample space for parking, expansion, or business use
    • Suitable for uses such as a tax office, professional services, or small business operations
    Updated: May 4
    View details
    Remodeled Medical Office Building
    $320,000
    2,165 SF

    Remodeled Medical Office Building

    Turnkey, fully remodeled office building with five rooms and private patient or work-ready treatment configurations.

    910 W Evans st, Florence, SC 29501
    View details
    Fully Occupied Retail Center
    $1,650,000
    15,450 SF

    Fully Occupied Retail Center

    Retail center in good condition with high traffic count.

    823-817 S Cashua Drive, Florence, SC 29501
    View details
    Vacant Specialty Commercial Building
    $265,000
    2,422 SF

    Vacant Specialty Commercial Building

    Vacant specialty building sold as-is, with access via a Sentri lockbox at the back door near a small patio.

    818 S Cashua Drive, Florence, SC 29501
    View details
    Day Care Center For Sale
    $285,000
    2,067 SF

    Day Care Center For Sale

    Existing day care center offered as-is with special showing requirements and lockbox access on the back door.

    822 S Cashua, Florence, SC 29501
    View details
    Buildable Retail Development Land
    $1,500,000
    7.27 Acres

    Buildable Retail Development Land

    Level, buildable two-parcel land package suited for a range of retail and service-oriented development uses.

    3312 Meadors Road, Florence, SC 29501
    View details
    Development-Ready Commercial Land Site
    $980,000
    4.76 Acres

    Development-Ready Commercial Land Site

    4.76-acre B3-zoned parcel on a four-lane corridor with SCDOT-reported traffic near major daily-use anchors.

    917 S Cashua Drive, Florence, SC 29501
    View details
    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    7,517 SF office building on 1.34 acres in Florence.

    1706 Second Loop Rd., Florence, SC 29501
    View details
    Commercial Land Opportunity
    $129,900
    4.00 Acres

    Commercial Land Opportunity

    4-acre commercial land in Florence County, positioned in a high-traffic area for a wide range of business uses.

    W Leggs Cir, Florence, SC 29501
    View details
    B-6 Zoned Commercial Land Opportunity
    $47,900
    840 SF

    B-6 Zoned Commercial Land Opportunity

    B-6 zoned parcel suited for a range of commercial development options.

    720 S Barringer Street, Florence, SC 29506
    View details
    Commercial Land with Bus Terminal
    $395,000
    5,500 SF

    Commercial Land with Bus Terminal

    1.05-acre site with 5,500 SF bus terminal building.

    611 S Irby St, Florence, SC 29501
    View details
    Florence Area Investment Opportunity
    Contact for pricing

    Florence Area Investment Opportunity

    Prime land in Florence, SC, with development potential.

    5723 E National Cemetery Rd, Florence, SC 29506
    View details
    Florence Commercial Land For Sale
    $792,792
    1.82 Acres

    Florence Commercial Land For Sale

    1.82 acre commercial land near I-95 in Florence, SC.

    Presbyterian Road, Florence, SC 29501
    View details
    Commercial Corner Land Parcel
    $125,000
    0.10 Acres

    Commercial Corner Land Parcel

    Corner lot in Commercial zoning, suited for buyers looking to develop on a small in-fill site.

    360 N Dargan St, Florence, SC 29501
    View details
    Commercial Property on Pamplico Highway
    $395,000
    0.90 Acres

    Commercial Property on Pamplico Highway

    Approximately 1.2 acre commercial property for sale or lease.

    111 Pamplico Highway, Florence, SC 29501
    View details
    Agricultural Land Tract
    $525,000
    83.54 Acres

    Agricultural Land Tract

    Large agriculturally zoned land available for sale along Timmonsville Highway in the Florence area.

    Timmonsville Hwy, Florence, SC 29532
    View details
    McLeod Physician Associates For Sale
    $1,384,320
    2,666 SF

    McLeod Physician Associates For Sale

    2,666 SF medical office in Florence, SC for sale.

    1540 American Dr, Florence, SC
    View details
    Florence Commercial Development Opportunity
    $1,200,000
    4.54 Acres

    Florence Commercial Development Opportunity

    4.54 acre commercial parcel on high-traffic corridor.

    2621 West Palmetto Street, Florence, SC 29501
    View details
    Florence Commercial Land For Sale
    $396,396
    0.91 Acres

    Florence Commercial Land For Sale

    0.91 acre commercial land parcel in Florence, South Carolina.

    Presbyterian Road, Florence, SC 29501
    View details
    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF

    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501
    View details
    Medical Office Building Near MUSC
    $2,200,000
    7,950 SF

    Medical Office Building Near MUSC

    Medical office building near MUSC campus with ample parking.

    1929 Mountain Laurel Court, Florence, SC
    View details
    Downtown Florence Business Technology Center
    $12,000,000
    119,567 SF

    Downtown Florence Business Technology Center

    Office building in downtown Florence with investment and value-add potential.

    187 E Evans St, Florence, SC
    View details
    Vacant Lot For Sale
    $39,900
    0.40 Acres

    Vacant Lot For Sale

    Empty lot available for development, zoning confirmation required.

    613 S Church St, Florence, SC 29506
    View details

    Florence, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 103 commercial real estate for sale in Florence, SC, showcased through 103 active listings on our real estate platform. These investment opportunities span a total of 911,833 square feet of properties for sale, with an estimated market value of $64,764,464.

    Sale prices for business properties in Florence, SC start at $47,900, averaging $1,506,150, and reaching up to $16,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
    Map

    Demographics Overview

    Population 92K
    Population Growth (5Y) -1.5%
    Median Household Income $61,793
    College Educated 17.4%

    High-Yield Neighborhoods for Investment

    Identify Florence submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    29505 $547.8K
    29501 $897.4K
    29506 $914.8K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Need Help?

    Reach out if you need assistance with Realmo tools or have questions about your listings

    Browse Commercial real estate for Sale Near Florence, SC

    Popular Searches in Florence, SC

    Popular Categories

    Most Searched ZIP Codes in Florence, SC

    • 29501
    • 29506
    • 29505

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!