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    Florence, SC

    Florence, SC Commercial Real Estate for Sale

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    Timmonsville, SC Effingham, SC Darlington, SC Marion, SC Coward, SC Hartsville, SC Latta, SC Pamplico, SC
    92 properties
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    Professional Office Building
    Updated: Oct 6
    Professional Office Building

    608 Gregg Avenue, Florence, SC 29150

    $575,000
    3,132 sqft
    Ten offices, reception area, lobby, break room, and four bathrooms
    Separate exits serve both the upper and lower floors
    Adjacent to the 45,000‑square‑foot Francis Marion University Medical Consortium on Gregg Avenue
    Updated plumbing, electrical, HVAC units, air handlers, and roof
    CCTV cameras and crawlspace moisture barrier
    View details
    Heavy Truck Repair Shop
    Updated: May 19
    Heavy Truck Repair Shop

    N Cashua Dr., Florence, SC 29501

    $580,000
    1,000 sqft 2.00 AC lot
    Established heavy truck and mobile repair franchise serving commercial fleets and roadside service customers
    Contracts in place with 16 national and regional commercial fleet accounts
    Sale includes equipment, inventory, operational systems, trade secrets, customer relationships, and training
    Mobile service capability supports fleet assistance throughout the Florence market
    1,000‑square‑foot facility situated on 2 acres
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    Historic Office Building
    Historic Office Building

    248-260 W Evans st., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    Established professional layout with multiple occupants, meeting rooms, reception space, and dedicated parking in downtown Florence.

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    10-Office Building with Updated Interiors
    10-Office Building with Updated Interiors

    608 Gregg Avenue, Florence, SC 29150

    $575,000
    3,132 sqft

    Two-level office property features renovated common areas, new building systems, and proximity to the Francis Marion Medical Consortium.

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    Church Property with Classrooms
    Church Property with Classrooms

    111 Williams Blvd., Florence, SC 29501

    $350,000
    2,968 sqft 2.00 AC lot

    A roughly two-acre site includes a sanctuary, educational rooms, and central air conditioning.

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    Fully Occupied Shopping Center
    Fully Occupied Shopping Center

    823-817 S Cashua Drive, Florence, SC 29501

    $1,550,000
    15,450 sqft

    Two connected buildings provide an established retail configuration with GC zoning and a Walmart Neighborhood Market across S. Cashua Drive.

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    Medical Office with Exam Rooms
    Medical Office with Exam Rooms

    1706 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    8,291 sqft 1.34 AC lot

    Brick medical facility with exam rooms, administrative offices, covered patient arrival, and dedicated on-site parking.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    260 W Evans St, Florence, SC 29501

    $2,700,000
    16,000 sqft 1.47 AC lot

    A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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    Vacant Specialty Property
    Vacant Specialty Property

    818 S Cashua Drive, Florence, SC 29501

    $265,000
    2,422 sqft 0.37 AC lot

    Vacant brick building with mixed flooring, heat pump heating, and central air conditioning.

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    Day Care Center with Frontage
    Day Care Center with Frontage

    822 S Cashua, Florence, SC 29501

    $285,000
    2,067 sqft 0.60 AC lot

    Existing daycare facility with direct frontage on S Cashua and an as-is sale condition.

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    Historic Downtown Florence Building For Sale
    Historic Downtown Florence Building For Sale

    248,258, and 268 W. Evans St., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    16,000 SF historic building in downtown Florence for sale.

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    Commercial Land Along Four-Lane Corridor
    Commercial Land Along Four-Lane Corridor

    917 S Cashua Drive, Florence, SC 29501

    $850,000
    4.76 AC lot

    High, level parcel near retail, grocery, restaurant, and service businesses along a four-lane commercial corridor.

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    Cleared Commercial Land
    Cleared Commercial Land

    207 S Irby St., Florence, SC 29501

    $699,000
    0.52 AC lot

    Level, cleared parcel with utilities available for commercial development.

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    Commercial Land with Utilities
    Commercial Land with Utilities

    3104 Hoffmeyer Road, Florence, SC 29501

    $1,600,000
    4 sqft

    Public sewer is installed, with water, electricity, and high-speed internet available for future development.

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    Corner Commercial Land
    Corner Commercial Land

    TBD Hwy 51 Pamplico Hwy, Florence, SC 29505

    $250,000
    1.30 AC lot

    B-3-zoned parcel positioned at the intersection of Pamplico Hwy and E Broach Street in Florence.

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    Unzoned Commercial Land
    Unzoned Commercial Land

    880 Freedom Boulevard, Florence, SC 29506

    $1,800,000
    59.44 AC lot

    Unzoned commercial tract with water and sewer on site and flexibility for varied land-use plans.

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    Flex Space with Office and Shop
    Flex Space with Office and Shop

    120 W Freight Road, Florence, SC 29501

    Contact for pricing
    7,920 sqft 3.50 AC lot

    Office, warehouse, and shop areas are arranged across a multi-function commercial property.

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    Commercial Land Parcel
    Commercial Land Parcel

    1714 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    4.03 AC lot

    Vacant tract with FV zoning and convenient access from 2nd Loop Road.

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    Flex Space with Warehouse
    Flex Space with Warehouse

    600 S Irby St., Florence, SC 29501

    Contact for pricing
    8,400 sqft 0.71 AC lot

    Office, showroom, warehouse, and storage areas support an established tire service operation.

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    B-6 Zoned Commercial Land
    B-6 Zoned Commercial Land

    720 S Barringer Street, Florence, SC 29506

    $47,900
    840 sqft 0.17 AC lot

    Commercial parcel near two Florence medical centers, offered in its existing condition for redevelopment or other commercial plans.

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    Flexible Retail and Office Building
    Flexible Retail and Office Building

    821 2nd Loop Road, Florence, SC 29505

    Contact for pricing
    5,400 sqft

    New construction with adaptable suites, shell interiors, and on-site parking along a heavily traveled commercial corridor.

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    Corner Commercial Land
    Corner Commercial Land

    635 N Coit St., Florence, SC 29501

    $265,000
    0.91 AC lot

    Flat, buildable commercial site with utilities available at a prominent corner location.

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    Chipotle Restaurant Property
    Chipotle Restaurant Property

    2037 S. Irby Street, Florence, SC 29505

    Contact for pricing
    2,325 sqft

    Brand-new corporate-guaranteed restaurant with an absolute NNN lease and long-term renewal options.

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    Commercial Land Development Site
    Commercial Land Development Site

    3312 Meadors Road, Florence, SC 29501

    $1,500,000
    7.27 AC lot

    Level, buildable acreage near I-95 with utilities available nearby.

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    Florence, SC Commercial Real Estate Market Trends and Statistics

    Explore 92 commercial real estate for sale in Florence, SC, showcased through 92 active listings on our real estate platform. These investment opportunities span a total of 618,154 square feet of properties for sale, with an estimated market value of $36,261,497.

    Sale prices for business properties in Florence, SC start at $32,725, averaging $980,040, and reaching up to $5,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    Florence, SC CRE market trends — vacancy, lease rates and price per SF, updated monthly
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    Demographics Overview

    Population 92K
    Population Growth (5Y) -1.5%
    Median Household Income $61,793
    College Educated 17.4%

    High-Yield Neighborhoods for Investment

    Identify Florence submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    29505 $356.3K
    29506 $489.9K
    29501 $1.2M

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Florence County

    New Delisted

    Total CRE Inventory on Market (SF)

    How Realmo verifies these figures

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    Browse Commercial real estate for Sale Near Florence, SC

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    Most Searched ZIP Codes in Florence, SC

    • 29501
    • 29505
    • 29506
    • 29150

    Featured Florence Real Estate Agencies

    Realmo connects you with licensed Florence CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com
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