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    Columbia, SC Aiken, SC Greenville, SC

    Florence County, SC Commercial Real Estate for Sale

    230 results
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    Industrial Building in Florence, SC
    $550,000
    67,518 SF

    Industrial Building in Florence, SC

    121 Lawson St, Florence, SC 29501

    Standalone industrial building suitable for various commercial and industrial uses.

    • Standalone industrial building with approximately 5,000 SF interior space plus 2,000 SF of covered area.
    • Light Industrial zoning supports a wide range of commercial and industrial uses.
    • Suitable for fabrication, automotive uses, contractor operations, or storage.
    • Includes interior office space.
    • Features include delivery door, lifts, loading dock, security system, 220/440 volts, and drive‑in door.
    Updated: Mar 3
    View details
    Historic Downtown Florence Commercial Building
    $2,700,000
    16,304 SF

    Historic Downtown Florence Commercial Building

    248-260 W Evans St, Florence, SC 29501

    16,000 SF historic building in thriving downtown Florence.

    • Prime downtown Florence location in a thriving area.
    • Large 16,000 sq ft historic building with limitless potential.
    • Significant parking available (over 100 spaces), rare for downtown.
    • Versatile space currently configured with multiple tenants (Law Firm, H&R Block, Hair Studio).
    • Spacious 1.47‑acre lot allows for growth and development.
    Updated: Mar 9
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    Established Auto Body Business For Sale
    $1,305,000
    4,125 SF

    Established Auto Body Business For Sale

    Turn-key auto body business with equipment, client roster, and real estate.

    803 Ranch Rd, Florence, SC 29506
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    Industrial Buildings with Power & Access
    $199,000
    40,000 SF

    Industrial Buildings with Power & Access

    Two industrial buildings ideal for fabrication, automotive, or storage.

    120 N Guerry St, Florence, SC 29501
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    Prime Commercial Development Site
    $980,000
    4.76 Acres

    Prime Commercial Development Site

    4.76-acre commercial land with high traffic exposure in Florence, SC.

    917 S Cashua Dr, Florence, SC 29501
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    Prime Commercial Lot on Highway
    $599,000
    2.90 Acres

    Prime Commercial Lot on Highway

    2.9-acre commercial site on S. Ron McNair Boulevard, Lake City.

    791 S Ron Mcnair Blvd, Lake City, SC 29560
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    Olanta Commercial Building on US 301
    $75,000
    1,500 SF

    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with restaurant and retail potential.

    405 N Jones Rd, Olanta, SC 29114
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    Vacant Corner Lot For Sale
    Contact for pricing

    Vacant Corner Lot For Sale

    Vacant corner lot to be sold via online auction.

    813 Chase St, Florence, SC 29501
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    Prime Commercial Land Near I-95
    $1,500,000
    7.27 Acres

    Prime Commercial Land Near I-95

    7.27 acres of commercial land near I-95 in Florence, SC.

    3312 Meadors Rd, Florence, SC 29501
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    Florence Commercial Building on Evans
    $79,000
    1,200 SF

    Florence Commercial Building on Evans

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
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    Downtown Lake City Commercial Lot
    $59,900
    0.12 Acres

    Downtown Lake City Commercial Lot

    Commercial lot in downtown Lake City, South Carolina.

    360 S Ron Mcnair Blvd, Lake City, SC 29560
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    Florence Commercial Lot For Sale
    $1,500,000
    4.02 Acres

    Florence Commercial Lot For Sale

    4.02 acre mixed-use lot with high visibility in Florence, SC.

    1714 2Nd Loop Rd, Florence, SC 29501
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    Commercial Property in Prime Location
    $265,000
    2,422 SF

    Commercial Property in Prime Location

    Commercial property for sale in a prime Florence location.

    818 S Cashua Dr, Florence, SC 29501
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    Unrestricted Acreage in Pamplico, SC
    $250,000
    77.00 Acres

    Unrestricted Acreage in Pamplico, SC

    77+ acres of unzoned land near Florence and Myrtle Beach.

    N Old River Rd, Pamplico, SC 29583
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    Riverfront Land with Development Potential
    $1,180,000
    215.00 Acres

    Riverfront Land with Development Potential

    215-acre riverfront tract ideal for recreation, agriculture, and investment.

    00 East Myrtle Beach Hwy, Johnsonville, SC 29555
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    Commercial Lot on Darlington Street
    $31,000
    0.19 Acres

    Commercial Lot on Darlington Street

    Vacant commercial lot with frontage on Darlington Street, Florence, SC.

    East Darlington St, Florence, SC 29506
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    Prime Land in Pamplico, SC
    $99,000
    2.00 Acres

    Prime Land in Pamplico, SC

    Two-acre commercial land with high visibility and road frontage.

    S Pamplico Hwy, Pamplico, SC 29583
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    Florence Commercial Land For Sale
    $396,396
    0.91 Acres

    Florence Commercial Land For Sale

    0.91 acre commercial land parcel in Florence, South Carolina.

    Presbyterian Rd, Florence, SC 29501
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    Florence Commercial Land For Sale
    $792,792
    1.82 Acres

    Florence Commercial Land For Sale

    1.82 acre commercial land near I-95 in Florence, SC.

    Tbd Presbyterian Rd, Florence, SC 29501
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    Vacant Land in Florence, SC
    Contact for pricing

    Vacant Land in Florence, SC

    Vacant lot sold via online auction. Buyer responsible for due diligence.

    813 N Dargan St, Florence, SC 29506
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    Commercial Lot on Darlington Street
    $31,000
    0.19 Acres

    Commercial Lot on Darlington Street

    Commercial lot with frontage on East Darlington Street, Florence, SC.

    East Darlington St, Florence, SC 29506
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    Florence Commercial Land For Sale
    $49,900
    0.17 Acres

    Florence Commercial Land For Sale

    B-6 zoned property with commercial and redevelopment options.

    720 S Barringer St, Florence, SC 29506
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    20 Acres Vacant Land
    $144,000
    20.00 Acres

    20 Acres Vacant Land

    20-acre tract suitable for small farm or recreational use.

    00 East Myrtle Beach Hwy, Johnsonville, SC 29555
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    25 Acres Near Great Pee Dee
    $180,000
    25.00 Acres

    25 Acres Near Great Pee Dee

    25-acre tract suitable for small farm or recreational use.

    00 East Myrtle Beach Hwy, Johnsonville, SC 29555
    View details

    Florence County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 133 commercial real estate for sale in Florence County, SC, showcased through 230 active listings on our real estate platform. These investment opportunities span a total of 52,053,329 square feet of properties for sale, with an estimated market value of $65,293,141.

    Sale prices for business properties in Florence County, SC start at $31,000, averaging $750,495, and reaching up to $16,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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