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    Florence County, SC Commercial Real Estate for Sale

    208 results
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    Established Auto Body Business For Sale
    $1,305,000
    4,125 SF

    Established Auto Body Business For Sale

    803 Ranch Rd, Florence, SC 29506

    Turn-key auto body business with equipment, client roster, and real estate.

    • Established auto body business operating for over 30 years.
    • Turn‑key operation including all equipment, signage, business name, phone number, and client roster.
    • High‑visibility location with a long‑standing customer base.
    • Includes real estate and a profitable business.
    • Features 6 bays (2 upfront, 4 in the back).
    Updated: Jan 12
    View details
    Commercial Property on S Cashua Drive
    $638,800
    13,801 SF

    Commercial Property on S Cashua Drive

    818 Delmae Dr, Florence, SC 29501

    Three buildings on three lots near Walmart in Florence, SC.

    • Three combined lots on S Cashua Drive, near Walmart.
    • Includes three buildings: two houses, a large garage, and a renovated tobacco barn. One building currently operates as a day care center.
    • Three separate tax map ID numbers.
    • Includes "Bathroom 1" and "Bathroom 2".
    • One house built in 1962.
    Updated: Dec 17, 2025
    View details
    Versatile Building on Georgetown Highway
    $595,000
    22,000 SF

    Versatile Building on Georgetown Highway

    22,000 sqft building on 2.42 acres in Johnsonville, SC

    435 S Georgetown Hwy, Johnsonville, SC 29555
    View details
    Olanta Commercial Building on US 301
    $75,000
    1,500 SF

    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with restaurant and retail potential.

    405 N Jones Rd, Olanta, SC 29114
    View details
    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    Office building with 7,517 square feet of space in Florence.

    1706 2Nd Loop Rd, Florence, SC 29501
    View details
    Commercial Lot in Lake City
    $160,000
    0.47 Acres

    Commercial Lot in Lake City

    0.47 acre commercial lot with rental income potential.

    0.47 Acres-Tbd Sumter St, Lake City, SC 29560
    View details
    Timmonsville Warehouse: Prime Investment
    $290,000
    10,260 SF

    Timmonsville Warehouse: Prime Investment

    Spacious warehouse, income-producing, versatile.

    165 165 Main St, Timmonsville, SC 29161
    View details
    Johnsonville Commercial Building For Sale
    $150,000
    0.43 Acres

    Johnsonville Commercial Building For Sale

    High-traffic location, restaurant-ready, ample parking.

    115 Georgetown Hwy, Johnsonville, SC 29555
    View details
    Florence Commercial Building - Great Location
    $195,000
    3,332 SF

    Florence Commercial Building - Great Location

    Prime Commercial Space, 3,332 sq ft, 0.25 acre lot

    111 111 Laurel St, Florence, SC 29501
    View details
    Prime Timmonsville Commercial Building
    $125,000
    1,968 SF

    Prime Timmonsville Commercial Building

    High-traffic location, versatile space, great investment.

    101 Market St, Timmonsville, SC 29161
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    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive)
    $200,000
    1,520 SF

    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive)""""}"""

    Florence Commercial Corner Property

    702 Barringer St, Florence, SC 29506
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    Prime Florence Commercial Space
    $520,000
    3,900 SF

    Prime Florence Commercial Space

    High-traffic location, 3900 sq ft.

    181 181 Palmetto, Florence, SC 29506
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    Florence Commercial Property - High Traffic Area
    $400,000
    3,375 SF

    Florence Commercial Property - High Traffic Area

    Prime Commercial Land, Warehouse, & More

    710 Barringer St, Florence, SC 29506
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    Prime Florence Commercial Building
    $375,000
    3,000 SF

    Prime Florence Commercial Building

    Updated Bank Facility, 3000 sq ft, 0.72 acres

    1937 1937 Palmetto, Florence, SC 29501
    View details
    Florence Commercial Redevelopment Opportunity
    $275,000
    7,700 SF

    Florence Commercial Redevelopment Opportunity

    High-potential 7,700 SF building on 1.08 acres.

    4617 4617 Palmetto St, Florence, SC 29506
    View details
    Florence Commercial Building - Great Investment
    $199,000
    1,340 SF

    Florence Commercial Building - Great Investment

    High-traffic location, excellent income potential.

    603 603 Dargan St, Florence, SC 29506
    View details
    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive).
    $200,000
    1,350 SF

    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive).""""}"""

    Florence Commercial Property - High Traffic Area

    726 Barringer St, Florence, SC 29506
    View details
    Prime Florence Commercial Property
    Contact for pricing
    2,250 SF

    Prime Florence Commercial Property

    Established Business, High Traffic Area

    1416 Pamplico Hwy, Florence, SC 29505
    View details
    with lines out the door. Now
    $235,000
    2,216 SF

    with lines out the door. Now

    the community is eager for a new dining option

    625 625 Walnut St, Pamplico, SC 29583
    View details
    Johnsonville Commercial Building Investment
    $595,000
    22,000 SF

    Johnsonville Commercial Building Investment

    Huge Warehouse, Prime Location, High Potential

    435 Georgetown Hwy, Johnsonville, SC 29555
    View details
    Prime Timmonsville Commercial Property
    $585,000
    15,000 SF

    Prime Timmonsville Commercial Property

    Spacious Church Building, 1.23 Acres

    151 151 Byrd St, Timmonsville, SC 29161
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    Prime Florence Commercial Land
    $2,750,000
    1 SF

    Prime Florence Commercial Land

    7.96 Acres Near Hospital & Airport

    1700 Palmetto St, Florence, SC 29506
    View details
    High-Traffic Florence Commercial Lot
    $90,000
    0.34 Acres

    High-Traffic Florence Commercial Lot

    Prime Commercial Land, High Visibility

    732 Barringer St, Florence, SC 29506
    View details
    Pamplico Commercial Building - Great Potential
    $500,000
    9,270 SF

    Pamplico Commercial Building - Great Potential

    Large commercial space, ample parking, versatile.

    615 Walnut St, Pamplico, SC 29583
    View details

    Florence County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 3993 commercial real estate investment opportunities in Florence County, SC with 208 listings featured on our commercial real estate marketplace. The current inventory includes 396,932,341 square feet of properties with an estimated value of $854,152,421.

    Estimated prices for commercial real estate in Florence County, SC begin at $31,000, with an average of $565,663 and extend to $16,000,000.

    In Florence County, SC, current investment values show:

    • Retail properties positioned at $489,183
    • Shopping centers measuring $304,538
    • Shopping malls assessed at $298,178
    • Office Properties & Spaces calculated at $578,470
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