Lee County, FL Commercial Real Estate for Sale

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Updated: Mar 10

Tamiami Trail Commercial Building

1357 N Tamiami Trl, North Fort Myers, FL 33903

$1,750,000

8,126 sqft 0.83 AC lot

High‑visibility frontage on busy Tamiami Trail.
Flexible C2 zoning allows for office, medical office, or retail use.
Seller financing available (50% down, 3 yr balloon @9%).
Building size: 8,126 sq. ft.
Land size: 0.83 acres with fenced lot and signage.

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1357 N Tamiami Trl, North Fort Myers, FL 33903

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Est. Cap Rate

8%
Above avg (5.9%)
Est. NOI

$140K
Annual
Mortgage

$346K
Apr 2019
Last Sold

Apr 2019
$450K
Property Type

Office Building (Multi-Story)
Built 1950

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Updated: May 5

Retail/Flex/Office Building on Del Prado

4529 Del Prado Boulevard S, Cape Coral, FL 33904

$1,150,000

3,840 sqft 0.15 AC lot

High visibility location on Del Prado Boulevard South.
Flexible SC (South Cape) zoning with many permitted uses.
Potential for owner‑occupancy or investment with flexible purchase options.
Divisible into two units with showroom, office, and warehouse space.
Two warehouse spaces with overhead doors and alley access.

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Sanibel Commercial Building For Sale

2440 Palm Ridge Road, Sanibel, FL 33957

$2,700,000

4,066 sqft 0.63 AC lot

Income-producing commercial building in Sanibel's Central Business District.

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Office/Medical Suite with Spa Tenant

12545 New Brittany Boulevard, Fort Myers, FL 33907

$759,900

3,264 sqft 0.08 AC lot

Two updated office/medical units offer an income-leaning setup with a spa lease through 2028 and an available companion suite.

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Sanibel Island Commercial Property

2341 Palm Ridge Road, Sanibel, FL 33957

$1,495,000

2,827 sqft 0.08 AC lot

Highly visible commercial property in Sanibel's Town Center corridor.

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San Carlos Blvd Office Building

16048 SAN CARLOS BOULEVARD, Fort Myers, FL 33908

$1,100,000

3,960 sqft 0.69 AC lot

Class B office building on high-traffic San Carlos Blvd.

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C1 Flex Office and Industrial Site

3671 Fowler St, Fort Myers, FL 33901

$2,800,000

5,800 sqft 1.30 AC lot

Multiple building options on one C1-zoned site support businesses needing office space alongside flexible expansion.

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Restaurant Property with Fenced Yard

916 SE 14th Ave, Cape Coral, FL 33990

$1,498,000

5,000 sqft 0.52 AC lot

Restaurant property in a heavy industrial zoning district with a fully fenced yard for operations or adaptive reuse.

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North Fort Myers Commercial Opportunity

236 Pondella Road, North Fort Myers, FL 33903

$2,200,000

5,850 sqft 0.61 AC lot

Versatile commercial property with high visibility and multiple uses.

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Multi-Unit Professional Office Building

1314-1322 Lafayette Street, Cape Coral, FL 33904

$1,295,000

0.42 AC lot

Fully leased office building configured as five units, designed for professional tenants with potential to expand.

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Auto Repair Flex Facility

6100 Idlewild St, Fort Myers, FL 33966

$2,243,430

9,000 sqft 1.19 AC lot

9,000 SF auto repair and flex building with secure fenced yard, paint booth, and multiple grade-level doors.

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Restaurant on US 41 For Sale

1130 N TAMIAMI TRAIL, North Fort Myers, FL 33903

$1,200,000

3,460 sqft 0.81 AC lot

Freestanding restaurant with drive-thru and high visibility on US 41.

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Auto Repair Business For Sale

336 Gunnery Road S, Lehigh Acres, FL 33973

$1,500,000

4,300 sqft 0.61 AC lot

Auto repair business with property on high-traffic Gunnery Road.

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Renovated Commercial Property on Fowler Street

2730 Fowler Street, Fort Myers, FL 33901

$1,200,000

6,200 sqft 0.46 AC lot

Fully renovated commercial building with flexible space in Fort Myers.

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Two-Unit Mixed-Use Building

1615 SE 47th Terrace, Cape Coral, FL 33904

$1,072,000

0.22 AC lot

Good-condition two-unit property in the CRA district, zoned SC, currently with a bakery unit through August 2026.

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Leased Retail Center in Fort Myers

4434-4458 Cleveland Ave, Fort Myers, FL 33901

$5,500,000

22,170 sqft 2.10 AC lot

100% leased retail center with redevelopment upside.

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Single-Tenant Medical Office Building

16101 N Cleveland Ave Unit 251, North Fort Myers, FL 33903

$1,175,000

5,741 sqft

Single-tenant medical building is leased under a NNN structure through November 30, 2030.

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Corner Retail-Use Building

2730 Fowler Street, Fort Myers, FL 33901

$1,200,000

0.47 AC lot

Fully renovated corner property with flexible multi-unit configuration, strong frontage, and fenced rear lot for storage or operations.

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Office Building

3800 Via Del Rey, Bonita Springs, FL 34134

$1,545,000

12,570 sqft

For sale office building with an on-site income option structured as $15.00 PSF plus NNN.

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Professional Office with Canal Access

1218 Del Prado Boulevard S, Cape Coral, FL 33990

$749,000

0.24 AC lot

Three-office layout with a shared lobby, located at a signalized intersection with canal frontage for client-friendly access.

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Downtown Cape Coral Landmark Building

917 SE 47th Ter, Cape Coral, FL 33904

$2,100,000

8,600 sqft

Two-story, 8,600 SF building in Cape Coral's downtown district.

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Restaurant and Retail Building with Land

17650 San Carlos Boulevard, Fort Myers Beach, FL 33931

$5,799,000

3.51 AC lot

For-sale commercial property with a sizable building, open-air center, and extensive frontage on San Carlos Blvd.

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Office Building with Multiple Suites

3780 Via Del Rey, Bonita Springs, FL 34134

$1,150,000

12,570 sqft

Two office buildings offer combined flexibility for ownership or leasing across 5,210 and 7,360± SF.

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Restaurant Property with Fenced Yard

916 SE 14th Avenue, Cape Coral, FL 33990

$1,498,000

0.52 AC lot

Fenced yard and existing restaurant use in a heavy industrial zoning district create flexible options for operators and owners.

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Lee County, FL Commercial Real Estate Market Trends and Statistics

Explore 1698 commercial real estate for sale in Lee County, FL, showcased through 1698 active listings on our real estate platform. These investment opportunities span a total of 3,813,767 square feet of properties for sale, with an estimated market value of $618,837,813.

Sale prices for business properties in Lee County, FL start at $35,000, averaging $2,455,705, and reaching up to $22,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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