Lee County, FL Commercial real estate for sale

Updated: Sep 1

Finished Office Units

8991 Daniels Center Dr, Fort Myers, FL 33912

$1,076,000

9,120 sqft

Two finished office units totaling 3,648 square feet
Each unit measures 1,824 square feet
CPD zoning supports medical, professional office, and retail uses
Units may be separated in the future by the buyer
Along the Daniels Parkway corridor west of I‑75

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Updated: Sep 24

Waterfront Short-Term Rental Property

12200/12210 SHOREVIEW Drive, Matlacha, FL 33993

$3,250,000

7,400 sqft 1.00 AC lot

12 furnished guest accommodations across two buildings
Approximately 7,400 square feet on about one acre
155 feet of waterfront and 5 boat slips
Renovated in 2025; includes a pool
Unit mix includes two studios, six 1‑bedroom units, three 2‑bedroom units, one 3‑bedroom unit, and a hotel‑style room used for laundry

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Waterfront Hospitality Property

12200/12210 Shoreview Dr, Matlacha, FL 33993

$3,250,000

12,400 sqft 1.00 AC lot

Two buildings provide furnished guest accommodations, with a pool and boat slips on a riverfront site.

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Multi-Tenant Mixed-Use Building

50 Mildred Dr, Fort Myers, FL 33901

$800,000

5,835 sqft 0.38 AC lot

Commercial-intensive zoning and Mildred Drive access support varied retail, office, flex, and trade-oriented uses.

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Furnished Specialty Property

10069 Antori Dr, Estero, FL 33928

$457,000

1,525 sqft 0.85 AC lot

The residence includes a den, screened lanai, and two-car garage, and is offered with its furnishings.

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Lake-View Specialty Property

3744 Costa Maya Way, Estero, FL 33928

$339,000

1,529 sqft 0.17 AC lot

Remodeled villa with a private-feeling layout, fenced backyard, and views of a lake and fountain.

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Automotive Property with Office

3426 Palm Beach Blvd, Fort Myers, FL 33916

$649,000

200 sqft 0.22 AC lot

C1-zoned site with blacktopped vehicle display and customer parking areas plus an on-site office building.

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Two-Story Mixed-Use Property

3724 Del Prado Blvd S, Cape Coral, FL 33904

$2,195,000

6,062 sqft

Freestanding commercial building with an operating restaurant, three service-retail suites, separate entrances, and on-site parking.

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Two-Story Retail Building

3724 Del Prado Boulevard S, Cape Coral, FL 33904

$2,195,000

0.57 AC lot

Multiple suites accommodate restaurant and service-retail operations along Del Prado Boulevard.

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Industrial Flex Space

6381 Corporate Park Cir, Fort Myers, FL 33966

$2,590,000

11,574 sqft 1.79 AC lot

The property combines industrial/flex, showroom, and office areas within an IL-zoned setting.

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Two-Story Professional Office Building

1323 Viscaya Parkway, Cape Coral, FL 33990

$1,250,000

4,865 sqft 0.34 AC lot

Commercially zoned office property with medical use potential, on-site parking, and an existing tax and accounting service occupant.

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Freestanding Restaurant with Drive-Through

1130 N TAMIAMI Trail, North Fort Myers, FL 33903

$950,000

3,460 sqft 0.81 AC lot

Built-out restaurant with drive-through service, substantial dining capacity, and direct US 41 access.

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Improved Flex Space with Overhead Doors

3535/3537 Dora Street, Fort Myers, FL 33916

$2,400,000

0.69 AC lot

Fenced commercial building with remodeled offices and updated building systems.

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Two-Story Bar & Pub Building

1313 SE 47th Terrace, Cape Coral, FL 33904

$1,350,000

5,920 sqft

Flexible hospitality layout with patio areas and the option to operate as one business or two separate units.

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Mixed-Use Property with Residential Units

2251 GRAND Avenue, Fort Myers, FL 33901

$1,200,000

4,688 sqft 0.15 AC lot

Two renovated upstairs residences complement flexible ground-floor commercial space.

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Waterfront Mixed-Use Property

3269 Stringfellow Road, St James City, FL 33956

$625,000

0.30 AC lot

C-1-zoned property combines office/shop space with a two-bedroom apartment and canal access.

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Standalone Office Building

16048 San Carlos Blvd, Fort Myers, FL 33908

$875,000

4,400 sqft

Four-suite professional office property with on-site parking, C1A zoning, and a mix of occupied and available space.

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Two-Unit Office Building

1224 & 1228 Lafayette Street, Cape Coral, FL 33904

$1,275,000

0.21 AC lot

Separate professional suites are occupied by architecture and civil engineering tenants.

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Fully Leased Medical Office Building

1435 SE 8th Terrace, Cape Coral, FL 33990

$3,000,000

10,255 sqft

The medical office property is fully leased and has undergone recent capital improvements.

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Two-Story Retail Building with Patios

1313 SE 47th Terrace, Cape Coral, FL 33904

$1,350,000

0.15 AC lot

Two-level commercial space with patio areas and a layout that can accommodate one or two businesses.

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Office, Retail & Flex Portfolio

1328 Lafayette St & 1323-1325, 1403 Miramar St, Cape Coral, FL 33904

$3,350,000

14,893 sqft

The assemblage combines adaptable buildings with conditioned office and warehouse areas and roll-up door access.

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Commercial Kitchen Shell

16541 San Carlos Boulevard, Fort Myers, FL 33908

$1,250,000

0.38 AC lot

Freestanding building undergoing renovation with upgraded electrical, HVAC, plumbing, roofing, drywall, and paint.

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Flex Space with Outdoor Storage

3890 Veronica S Shoemaker Boulevard, Fort Myers, FL 33916

$1,999,000

6,354 sqft 2.63 AC lot

A mix of office and operational space is paired with land for equipment, vehicles, or other outdoor needs.

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Flex Condominium with Showroom

17000 Alico Commerce Court, Fort Myers, FL 33967

$1,199,000

0.40 AC lot

Climate-controlled warehouse space pairs with finished office, conference, and storefront areas.

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Lee County, FL Commercial Real Estate Market Trends and Statistics

Explore 1979 commercial real estate for sale in Lee County, FL, showcased through 1979 active listings on our real estate platform. These investment opportunities span a total of 5,945,523 square feet of properties for sale, with an estimated market value of $1,519,576,036.

Sale prices for business properties in Lee County, FL start at $30,000, averaging $1,096,375, and reaching up to $27,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.