Lee County, FL Medical Office Space for Sale

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Updated: Mar 10

Tamiami Trail Commercial Building

1357 N Tamiami Trl, North Fort Myers, FL 33903

$1,750,000

8,126 sqft 0.83 AC lot

High‑visibility frontage on busy Tamiami Trail.
Flexible C2 zoning allows for office, medical office, or retail use.
Seller financing available (50% down, 3 yr balloon @9%).
Building size: 8,126 sq. ft.
Land size: 0.83 acres with fenced lot and signage.

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1357 N Tamiami Trl, North Fort Myers, FL 33903

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Est. Cap Rate

8%
Above avg (5.9%)
Est. NOI

$140K
Annual
Mortgage

$346K
Apr 2019
Last Sold

Apr 2019
$450K
Property Type

Office Building (Multi-Story)
Built 1950

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Updated: Apr 13

Office/Medical Suite with Spa Tenant

12545 New Brittany Boulevard, Fort Myers, FL 33907

$759,900

3,264 sqft 0.08 AC lot

Dual‑unit property offering flexibility for owner‑occupancy or investment, with one unit leased until 2028.
Zoned for office/medical use, increasing potential tenant pool.
Prime location in South Fort Myers within World Plaza, providing easy access to US41.
Seller's unit features 2 restrooms, 2 showers, a kitchen, a large conference area, several offices, and a reception/waiting area.
Both units are updated and well‑maintained.

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Church Building with Conversion Potential

3657 Central Avenue, Fort Myers, FL 33901

$1,100,000

0.76 AC lot

Well-maintained church building with kitchenette, multiple rooms, and flexible interior space for office, medical, education, or faith use.

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Concrete Block Medical Office Portfolio

3900 Broadway, Fort Myers, FL 33901

$3,400,000

2.72 AC lot

Four concrete block office buildings on 2.72 acres with strong occupancy, frontage on Broadway, and ample parking.

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Single-Tenant Medical Office Building

16101 N Cleveland Ave Unit 251, North Fort Myers, FL 33903

$1,175,000

5,741 sqft

Single-tenant medical building is leased under a NNN structure through November 30, 2030.

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Medical Office Building with Parking

331 Cape Coral Parkway W, Cape Coral, FL 33914

$1,350,000

0.47 AC lot

For sale office building with ample parking and original metal roof on a corner lot.

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Medical Office Space For Sale

22904 Lyden Drive, Estero, FL 33928

$1,750,000

3,651 sqft 0.04 AC lot

Newly constructed medical office space in a desirable Estero location.

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Two-Story Freestanding Medical Office

12731 New Brittany Blvd, Fort Myers, FL 33907

$4,900,000

1.69 AC lot

Two-story concrete block medical building with surgical buildout and flexible occupancy options for owner-users or investors.

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Freestanding Medical Office Building

6150 Diamond Centre Ct., Bldg. 100, Fort Myers, FL 33912

$1,350,000

4,100 sqft

Freestanding 4,100± SF building currently built out for rehabilitation therapy with multiple exam and therapy rooms.

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Medical Office Condo in Grey Shell

217 Del Prado Boulevard S, Cape Coral, FL 33990

$650,000

0.74 AC lot

Grey shell medical office condo with impact fees paid and concept plan available for a customized layout.

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Multi-Tenant Medical Office Building

16251 N Cleveland Ave, North Fort Myers, FL 33903

$3,350,000

2.57 AC lot

Multi-tenant commercial building with direct US-41 frontage, signalized access, and on-site parking for office and medical tenants.

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Office/Medical Condo with Spa Tenant

551-12545 New Brittany Blvd, Fort Myers, FL 33907

$759,900

3,264 sqft

Zoned for office/medical with one spa lease through 2028 and an updated unit ready for occupancy.

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Commercial Building with Tamiami Trail Frontage

1357 N Tamiami Trl, North Fort Myers, FL 33903

$1,750,000

0.83 AC lot

8,126 sq ft C-2 building on a fenced, sign-ready lot with direct N Tamiami Trail exposure.

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Remodeled Medical Office Park

68, 72, 76 Pondella Road, North Fort Myers, FL 33903

$1,699,000

1.62 AC lot

Three concrete block buildings offer two ADA-compliant suites per building with private entrances, restrooms, and individual utilities.

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Medical Office Flex Suite

2080 Collier Avenue, Fort Myers, FL 33901

$699,995

0.39 AC lot

Corner-lot medical office with 25 paved parking spaces, ADA-compliant bathrooms, and a conference room plus flex hall.

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Commercial Land with Office Building

5106 Lee Blvd, Lehigh Acres, FL 33971

$2,200,000

2.20 AC lot

2.2-acre CPD site with 450+ feet of road frontage and a one-story office/model home building.

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Built-Out Medical Office Suite

22904 Lyden Drive 1, Estero, FL 33928

$1,750,000

3,651 sqft

Turnkey medical office suite with reception, eight plumbing-equipped exam rooms, procedure room, and private physician’s office.

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Renovated Office Condo on Sanibel

1640 Periwinkle Way, Sanibel, FL 33957

$225,000

987 sqft 0.14 AC lot

Completely renovated office condo in the heart of Sanibel Island.

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NNN Heartland Dental Investment Opportunity

1701 Boy Scout Dr, Fort Myers, FL 33907

$3,288,000

3,961 sqft

NNN leased Heartland Dental with rental increases and prime location.

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Medical Office Suite with Terrace

4968 Royal Gulf Circle, Fort Myers, FL 33966

$399,000

0.03 AC lot

Medical office suite includes reception, three treatment rooms, flex space, kitchenette, and an outdoor terrace with ample parking.

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Turnkey Medical Office Building

2621 Cleveland Avenue, Fort Myers, FL 33901

$900,000

3,080 sqft

Street-front medical office with turnkey buildout and existing infrastructure, ready for continued or new healthcare use.

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Medical Office Building with Option to Split

3822 Broadway, Fort Myers, FL 33901

$2,950,000

0.80 AC lot

Freestanding medical office built out with multiple restrooms and shower options, plus covered patient drop-off and flexible suite separation.

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Renovated Office Building in Midtown

2080 Collier Avenue, Fort Myers, FL 33901

$699,995

2,384 sqft

Fully renovated office building in Fort Myers' Midtown corridor.

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Commercial Parcel for Medical Use

15100 & 15200 Elderberry Lane, Fort Myers, FL 33907

$1,600,000

2.45 AC lot

Zoned CC and positioned for medical office development with strong access off Summerlin Road and Gladiolus.

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Lee County, FL Medical Office Space Market Trends and Statistics

Explore 72 medical office space for sale in Lee County, FL, showcased through 51 active listings on our real estate platform. These investment opportunities span a total of 99,567 square feet of properties for sale, with an estimated market value of $24,906,795.

Sale prices for medical spaces in Lee County, FL start at $225,000, averaging $1,383,710, and reaching up to $3,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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