Lee County, FL Mixed-use properties for sale

Updated: Sep 18

Waterfront Mixed-Use Property

3269 Stringfellow Road, St James City, FL 33956

$625,000

0.30 AC lot

C‑1 zoning on a 0.298‑acre waterfront lot
100' x 130' lot with canal access
Office/shop area with tile flooring and 1/2 bath
2‑bedroom, 1‑bath apartment with equipped kitchen
Detached 2‑car garage with additional shop/storage space

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Updated: Jun 3

Mixed-Use Property with Residential Units

2251 GRAND Avenue, Fort Myers, FL 33901

$1,200,000

4,688 sqft 0.15 AC lot

4,688‑square‑foot mixed‑use property with two residential condominium units and ground‑floor commercial space
Upstairs residences include a renovated 3‑bedroom, 2‑bath unit and a renovated 2‑bedroom, 2‑bath unit
Ground floor is configured as a music studio
Approximately 10 dedicated parking spaces in a fully fenced lot
CI zoning and block construction

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Shopping Center with Pylon Signage

12709-12731 McGregor Blvd, Fort Myers, FL 33919

$4,970,000

3.72 AC lot

Neighborhood center with access from College Pkwy and McGregor Blvd, parking, landscaping, and a varied commercial tenant mix.

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Multi-Tenant Mixed-Use Building

50 Mildred Dr, Fort Myers, FL 33901

$800,000

5,835 sqft 0.38 AC lot

Commercial-intensive zoning and Mildred Drive access support varied retail, office, flex, and trade-oriented uses.

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Commercial Land with Boulevard Exposure

1698 Estero Boulevard, Fort Myers Beach, FL 33931

$1,300,000

0.11 AC lot

Commercial land along Fort Myers Beach’s primary corridor, near Gulf beaches, dining, retail, lodging, and entertainment.

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Mixed-Use Property with Lake Views

2430 Palm Ridge Road, Sanibel, FL 33957

$2,989,000

0.99 AC lot

Three buildings combine leased commercial suites with remodeled apartments and residential outlooks over the lake.

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Two-Story Mixed-Use Building

19011 San Carlos Boulevard, Fort Myers Beach, FL 33931

$1,075,000

0.20 AC lot

Freestanding commercial property with three upstairs apartments, shared laundry, storage areas, and a ground-level space requiring refurbishment.

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Two-Story Mixed-Use Property

3724 Del Prado Blvd S, Cape Coral, FL 33904

$2,195,000

6,062 sqft

Freestanding commercial building with an operating restaurant, three service-retail suites, separate entrances, and on-site parking.

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Two-Story Mixed-Use Building

917 SE 47th Terrace, Cape Coral, FL 33904

$2,100,000

0.14 AC lot

Flexible commercial building with event, office, classroom, kitchen, and storage areas across two separately accessible levels.

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Multi-Tenant Mixed-Use Property

16251 N Cleveland Ave, North Fort Myers, FL 33903

$3,350,000

2.57 AC lot

Nine tenants occupy space approved for office, medical office, and retail uses.

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Office, Retail & Flex Portfolio

1328 Lafayette St & 1323-1325, 1403 Miramar St, Cape Coral, FL 33904

$3,350,000

14,893 sqft

The assemblage combines adaptable buildings with conditioned office and warehouse areas and roll-up door access.

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Gulfside Commercial Land

2096 ESTERO Boulevard, Fort Myers Beach, FL 33931

$2,999,000

0.40 AC lot

Commercial land on Estero Boulevard with public water and sewer service.

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Mixed-Use Building with 3 Apartments

1161 Estero Boulevard, Fort Myers Beach, FL 33931

$3,600,000

0.17 AC lot

Two-story property combines residential rentals with street-level commercial space in a pedestrian-oriented beach setting.

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Renovated Commercial Property on Fowler Street

2730 Fowler St, Fort Myers, FL 33901

$999,000

6,200 sqft 0.46 AC lot

Fully renovated commercial building with flexible space in Fort Myers.

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Mixed-Use Property with Two Condos

2251 Grand Avenue, Fort Myers, FL 33901

$1,999,999

0.15 AC lot

Renovated residential units occupy the upper level above a flexible ground-floor commercial studio.

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Mixed-Use Duplex with Commercial Space

2826 Santa Barbara Boulevard, Cape Coral, FL 33914

$429,000

0.23 AC lot

MR zoning supports a combined commercial and residential configuration with public utilities and fenced grounds.

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Prime Mixed-Use Development Opportunity

2915 Estero Boulevard, Fort Myers Beach, FL 33931

$1,095,000

4,748 sqft 0.11 AC lot

Cleared lot on Estero Blvd, steps from the Gulf.

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Mixed-Use Coastal Development Site

2915 ESTERO BOULEVARD, Fort Myers Beach, FL 33931

$1,095,000

Cleared parcel with CO zoning and public water, sewer, and electric available on site.

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Storefront Building with Bakery

1615 Se 47th Ter, Cape Coral, FL 33904

$1,072,000

3,634 sqft

Flexible SC-zoned commercial building with an existing bakery occupant and adaptable space for multiple business configurations.

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Three-Parcel Commercial Land Assemblage

1003 LEELAND HEIGHTS Boulevard W, Lehigh Acres, FL 33936

$2,900,000

0.25 AC lot

Corner assemblage combines a commercial parcel with two tenant-occupied residential properties along Leeland Heights Boulevard W.

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Waterfront Mixed-Use Property

St James City, FL 33956

$625,000

0.30 AC lot

Office and shop space adjoins a two-bedroom apartment, with a detached garage and canal access.

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Market Place Residential Land

1626 NW 2nd Avenue, Cape Coral, FL 33993

$1,749,000

5.18 AC lot

Commercial land in Cape Coral’s Market Place Residential District supports retail, office, service, residential, and mixed-use development concepts.

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Commercial Mixed-Use Assemblage

13160, 13170, 13180 & 13192 North Cleveland Avenue, North Fort Myers, FL 33903

$7,000,000

35,935 sqft

Four parcels combine existing retail and commercial improvements under CG, C-1A, and C-2 zoning.

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Two-Level Office Building

905 Fitzhugh Street, Sanibel, FL 33957

$1,095,000

0.26 AC lot

Commercial building with an open lower level and flexible upper-floor configuration in Town Center Limited zoning.

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Lee County, FL Mixed-Use Properties Market Trends and Statistics

Explore 72 mixed-use properties for sale in Lee County, FL, showcased through 45 active listings on our real estate platform. These investment opportunities span a total of 194,763 square feet of properties for sale, with an estimated market value of $96,175,998.

Sale prices for multi use buildings in Lee County, FL start at $258,000, averaging $2,530,947, and reaching up to $11,800,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Featured Lee County Real Estate Agencies

Realmo connects you with licensed Lee County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

Priceless Realty

1425 Del Prado Blvd Cape Coral, FL 33990

Phone: 12397707121

www.pricelessrealty.com

Jones & Co. Realty

9403 Cypress Lake Dr. Suite 3 Fort Myers, FL 33919

Phone: 12394155881

www.jonesandcorealty.com

Starlink Realty

1567 Hayley Lane, Suite 205 Fort Myers, FL 33907

Phone: 12396937263