Lafayette County, FL Commercial Real Estate for Sale

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Commercial Building with Acreage
Updated: Sep 8, 2025
Commercial Building with Acreage

130 NE Clyde Avenue, Mayo, FL 32066

$860,000
2,623 sqft 1.46 AC lot
2019‑built 2,623 SF brick building on a 1.46‑acre lot
Central air conditioning and electric heating
Asphalt shingle roof
Public water and septic tank sewer
Blacktop driveway with driveway parking
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Row Crop Farmland with 3-Side Road Access
Updated: Jun 26
Row Crop Farmland with 3-Side Road Access

4844 N CR 53, Mayo, FL 32066

$570,000
75.04 AC lot
75‑acre agricultural property with road frontage on 3 sides in the Day, FL area of Lafayette County
Zoned RSF‑MH1 and Rural Residential with future land use identified as higher density
Mostly flat topography; no flood zone or designated wetlands reported per FEMA maps
Currently used for row crop farming and under lease for the next few years
Water source: well and an irrigation well on the property
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Recreation Land Tract
Recreation Land Tract

NE Sage Rd, Mayo, FL 32066

$239,900
20.00 AC lot

20-acre parcel outside Mayo, FL, suitable for residential build, farming uses, or private hunting and recreation.

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Prime Commercial Property in Mayo
Prime Commercial Property in Mayo

130 NE CLYDE Ave, Mayo, FL 32066

$1,005,000
2,623 sqft 1.46 AC lot

1.46-acre property with 2,623 sq ft building in Mayo.

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Residential Land Lot
Residential Land Lot

SW DOE Road, Mayo, FL 32066

Contact for pricing
1.00 AC lot

Residentially zoned 1-acre lot in Lafayette County, offered for sale in Mayo, FL.

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Nearly 44-Acre Land Parcel
Nearly 44-Acre Land Parcel

464 NE Morning Glory Rd., Mayo, FL 32066

$300,000
43.44 AC lot

Large land parcel in a peaceful rural community.

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Corner Land Parcel For Sale
Corner Land Parcel For Sale

939 NW HAROLD WINBURN RD, Mayo, FL 32066

$4,500,000

Corner land parcel available west of Mayo on HWY 27.

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211.62 Acres of Farmland
211.62 Acres of Farmland

003 Brushy Hammock Road, Mayo, FL 32066

$634,860
211.00 AC lot

211.62 acres of diverse farmland with recreational opportunities.

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45.66 Acres of Farmland
45.66 Acres of Farmland

004 Brushy Hammock Road, Mayo, FL 32066

$228,300
45.00 AC lot

Escape to your natural paradise with this diverse acreage.

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40-Acre Rural Escape Land
40-Acre Rural Escape Land

002 Brushy Hammock Road, Mayo, FL 32066

$200,100
40.01 AC lot

40-acre land with diverse mixture of pine and hardwoods.

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Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 10 Active listings in Lafayette County, FL, we suggest exploring several alternatives: similar 62 Off-Market properties to explore as potential leads

Off-Market Properties in Lafayette County, FL

Consider similar Off-Market properties in Lafayette County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

305 Main St
VEHICLE SALES, RENTALS

305 Main St, Mayo, FL 32066-4036

Value Estimation by Request
2,471 sqft
View details
172 Main St
RETAIL STORES (PERSONAL SERVICES)

172 Main St, Mayo, FL 32066-4095

Value Estimation by Request
8,028 sqft
View details
530 Fletcher Ave
RESTAURANT

530 Fletcher Ave, Mayo, FL 32066-4907

Value Estimation by Request
3,344 sqft
View details
294 Main St
GROCERY, SUPERMARKET

294 Main St, Mayo, FL 32066

Value Estimation by Request
12,351 sqft
View details
224 Clyde Ave
NURSERY, GREENHOUSE, FLORIST

224 Clyde Ave, Mayo, FL 32066

Value Estimation by Request
1,975 sqft
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Main St
VACANT COMMERCIAL LAND

Main St, Mayo, FL 32066

Value Estimation by Request
View details
8540 Main St
WHOLESALE OUTLET, DISCOUNT STORE

8540 Main St, Mayo, FL 32066

$575,000
Estimated value
16,400 sqft 2.11 AC lot
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325 Main St
STORE/OFFICE (MIXED USE)

325 Main St, Mayo, FL 32066

Value Estimation by Request
3,024 sqft
View details
757 State Rd 51
OFFICE BUILDING

757 State Rd 51, Mayo, FL 32066-6609

$2,200,000
Estimated value
646 sqft 8.10 AC lot
View details
116 Clark Ave
STORE/OFFICE (MIXED USE)

116 Clark Ave, Mayo, FL 32066

Value Estimation by Request
1,535 sqft
View details
253 Bloxham St
MANUFACTURING (LIGHT)

253 Bloxham St, Mayo, FL 32066

Value Estimation by Request
3,072 sqft
View details
968 State Rd 51
VEHICLE SALES, RENTALS

968 State Rd 51, Mayo, FL 32066-6611

Value Estimation by Request
5,298 sqft 3.45 AC lot
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536 Nwnw Cir
VACANT COMMERCIAL LAND

536 Nwnw Cir, Mayo, FL 32066

Value Estimation by Request
5.00 AC lot
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4485 County Rd 53
OFFICE BUILDING

4485 County Rd 53, Mayo, FL 32066-2834

Value Estimation by Request
4,296 sqft
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Lafayette County, FL Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Lafayette County, FL, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 5,246 square feet of properties for sale, with an estimated market value of $8,538,160.

Sale prices for business properties in Lafayette County, FL start at $200,100, averaging $948,684, and reaching up to $4,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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