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    Lafayette County, FL Commercial Real Estate for Sale

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    Miami, FL Cape Coral, FL Tampa, FL
    13 listings
    Commercial Building with Acreage
    $860,000
    2,623 SF
    Commercial Building with Acreage

    130 NE Clyde Avenue, Mayo, FL 32066

    A 2,623 sq. ft. building on 1.46 acres in CG zoning, offering flexibility for a range of business uses.
    • 2019‑built 2,623 SF brick building on a 1.46‑acre lot
    • Central air conditioning and electric heating
    • Asphalt shingle roof
    • Public water and septic tank sewer
    • Blacktop driveway with driveway parking
    Updated: Sep 8, 2025
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    Childcare Facility in Mayo, Florida
    $385,000
    3,044 SF
    Childcare Facility in Mayo, Florida

    311 NE CRAWFORD ST, Mayo, FL 32066

    Established childcare facility with income potential in Mayo, Florida.
    • Established and income‑producing childcare facility.
    • Turnkey operation, fully set up for childcare.
    • Multiple classrooms and child‑friendly spaces.
    • Outdoor play areas designed for safety and engagement.
    • Convenient location amongst schools.
    Updated: Mar 19
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    Farm Property with Broiler Houses
    $1,995,000
    2,144 SF
    Farm Property with Broiler Houses

    Structured agricultural operation with eight broiler houses, litter storage, wells, and on-site living in A-3 zoning.

    1175 SW COUNTY ROAD 351, Mayo, FL 32066

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    Poultry Farm with Broiler Houses
    $1,995,000
    1,500 SF
    Poultry Farm with Broiler Houses

    Turnkey poultry operation with multiple broiler houses, farm utilities, litter storage, and an onsite home in Mayo, FL.

    1083 SW COUNTY ROAD 351, Mayo, FL 32066

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    Poultry Farm with Broiler Houses
    $1,750,000
    33.20 Acres
    Poultry Farm with Broiler Houses

    A-1 zoned poultry operation with seven broiler houses, on-site utilities, litter storage, and an owner/manager home.

    1083 SW COUNTY ROAD 351, Mayo, FL 32066

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    Broiler Farm with On-Site Home
    $1,750,000
    67.56 Acres
    Broiler Farm with On-Site Home

    Agricultural property featuring multiple broiler houses, litter storage, and supporting utilities with an on-site residence.

    1175 SW COUNTY ROAD 351, Mayo, FL 32066

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    Lafayette County Land For Sale
    $149,000
    18.10 Acres
    Lafayette County Land For Sale

    18 acres in Lafayette County, close to recreational opportunities.

    000 SW GRACELAND RD., Mayo, FL 32066

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    Nearly 44-Acre Land Parcel
    $300,000
    43.44 Acres
    Nearly 44-Acre Land Parcel

    Large land parcel in a peaceful rural community.

    464 NE Morning Glory Rd., Mayo, FL 32066

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    Corner Land Parcel For Sale
    $4,500,000
    Corner Land Parcel For Sale

    Corner land parcel available west of Mayo on HWY 27.

    939 NW HAROLD WINBURN RD, Mayo, FL 32066

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    211.62 Acres of Farmland
    $634,860
    211.00 Acres
    211.62 Acres of Farmland

    211.62 acres of diverse farmland with recreational opportunities.

    003 Brushy Hammock Road, Mayo, FL 32066

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    45.66 Acres of Farmland
    $228,300
    45.00 Acres
    45.66 Acres of Farmland

    Escape to your natural paradise with this diverse acreage.

    004 Brushy Hammock Road, Mayo, FL 32066

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    40-Acre Rural Escape Land
    $200,100
    40.01 Acres
    40-Acre Rural Escape Land

    40-acre land with diverse mixture of pine and hardwoods.

    002 Brushy Hammock Road, Mayo, FL 32066

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    Downtown Mayo Automotive Business For Sale
    $400,000
    Downtown Mayo Automotive Business For Sale

    Profitable auto shop with inventory and customer database included.

    305 W Main Street, Mayo, FL 32066

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    Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 13 Active listings in Lafayette County, FL, we suggest exploring several alternatives: similar 59 Off-Market properties to explore as potential leads

    Off-Market Properties in Lafayette County, FL

    Consider similar Off-Market properties in Lafayette County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    305 Main St
    VEHICLE SALES, RENTALS
    2,471 SF Lot: 0.00 Acres

    305 Main St, Mayo, FL 32066-4036

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    172 Main St
    RETAIL STORES (PERSONAL SERVICES)
    8,028 SF Lot: 0.00 Acres
    Value Estimation by Request

    172 Main St, Mayo, FL 32066-4095

    View details
    530 Fletcher Ave
    RESTAURANT
    3,344 SF Lot: 0.00 Acres
    Value Estimation by Request

    530 Fletcher Ave, Mayo, FL 32066-4907

    View details
    294 Main St
    GROCERY, SUPERMARKET
    12,351 SF Lot: 0.00 Acres
    Value Estimation by Request

    294 Main St, Mayo, FL 32066

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    224 Clyde Ave
    NURSERY, GREENHOUSE, FLORIST
    1,975 SF Lot: 0.00 Acres
    Value Estimation by Request

    224 Clyde Ave, Mayo, FL 32066

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    Main St
    VACANT COMMERCIAL LAND
    Lot: 0.00 Acres
    Value Estimation by Request

    Main St, Mayo, FL 32066

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    8540 Main St
    WHOLESALE OUTLET, DISCOUNT STORE
    16,400 SF Lot: 2.11 Acres
    Estimated value
    $575,000

    8540 Main St, Mayo, FL 32066

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    325 Main St
    STORE/OFFICE (MIXED USE)
    3,024 SF Lot: 0.00 Acres
    Value Estimation by Request

    325 Main St, Mayo, FL 32066

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    757 State Rd 51
    OFFICE BUILDING
    646 SF Lot: 8.10 Acres
    Estimated value
    $2,200,000

    757 State Rd 51, Mayo, FL 32066-6609

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    116 Clark Ave
    STORE/OFFICE (MIXED USE)
    1,535 SF Lot: 0.00 Acres
    Value Estimation by Request

    116 Clark Ave, Mayo, FL 32066

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    253 Bloxham St
    MANUFACTURING (LIGHT)
    3,072 SF Lot: 0.00 Acres
    Value Estimation by Request

    253 Bloxham St, Mayo, FL 32066

    View details

    Lafayette County, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in Lafayette County, FL, showcased through 13 active listings on our real estate platform. These investment opportunities span a total of 9,311 square feet of properties for sale, with an estimated market value of $5,235,000.

    Sale prices for business properties in Lafayette County, FL start at $385,000, averaging $1,308,750, and reaching up to $1,995,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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