Lee County, FL Office Spaces for Sale

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Updated: Sep 9, 2025

Church-Configured Flex Facility

300 Leonard Boulevard N, Lehigh Acres, FL 33971

$1,000,000

3,850 sqft 0.65 AC lot

Large adaptable space (approx. 3,850 Sqft) suitable for various uses.
Excellent location with easy access to I‑75.
Located in the well‑maintained Leonard Industrial Center.
Security features include a fenced lot, electronic security gate, and on‑site security system.
Built in 2007, indicating relatively modern construction.

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This listing looks promising.

Here's a quick look at some key insights for

300 Leonard Boulevard N, Lehigh Acres, FL 33971

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Est. Cap Rate

6.6%
Above avg (5.9%)
Est. NOI

$66K
Annual
Mortgage

$193K
Jan 2021
Last Sold

Jan 2021
$218K

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Updated: May 5

Retail/Flex/Office Building on Del Prado

4529 Del Prado Boulevard S, Cape Coral, FL 33904

$1,150,000

3,840 sqft 0.15 AC lot

High visibility location on Del Prado Boulevard South.
Flexible SC (South Cape) zoning with many permitted uses.
Potential for owner‑occupancy or investment with flexible purchase options.
Divisible into two units with showroom, office, and warehouse space.
Two warehouse spaces with overhead doors and alley access.

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Office/Medical Suite with Spa Tenant

12545 New Brittany Boulevard, Fort Myers, FL 33907

$759,900

3,264 sqft 0.08 AC lot

Two updated office/medical units offer an income-leaning setup with a spa lease through 2028 and an available companion suite.

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Sanibel Island Commercial Property

2341 Palm Ridge Road, Sanibel, FL 33957

$1,495,000

2,827 sqft 0.08 AC lot

Highly visible commercial property in Sanibel's Town Center corridor.

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San Carlos Blvd Office Building

16048 SAN CARLOS BOULEVARD, Fort Myers, FL 33908

$1,100,000

3,960 sqft 0.69 AC lot

Class B office building on high-traffic San Carlos Blvd.

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C1 Flex Office and Industrial Site

3671 Fowler St, Fort Myers, FL 33901

$2,800,000

5,800 sqft 1.30 AC lot

Multiple building options on one C1-zoned site support businesses needing office space alongside flexible expansion.

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Multi-Unit Professional Office Building

1314-1322 Lafayette Street, Cape Coral, FL 33904

$1,295,000

0.42 AC lot

Fully leased office building configured as five units, designed for professional tenants with potential to expand.

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Two-Unit Mixed-Use Building

1615 SE 47th Terrace, Cape Coral, FL 33904

$1,072,000

0.22 AC lot

Good-condition two-unit property in the CRA district, zoned SC, currently with a bakery unit through August 2026.

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Professional Office with Canal Access

1218 Del Prado Boulevard S, Cape Coral, FL 33990

$749,000

0.24 AC lot

Three-office layout with a shared lobby, located at a signalized intersection with canal frontage for client-friendly access.

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C-1 Zoned Commercial Property

2959 Oleander Street, St James City, FL 33956

$750,000

0.22 AC lot

Small commercial site on Stringfellow Road, suited for retail, office, or marine-related neighborhood-serving uses.

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Class A Flex Building with 14-Foot Door

3820 Via Del Rey, Bonita Springs, FL 34134

$4,500,000

0.78 AC lot

Modern flex facility with high-end office buildout, reception, and a large garage/receiving bay.

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Remodeled Office Condo Suite

2401 First Street, Fort Myers, FL 33901

$995,000

5,874 sqft 0.29 AC lot

Third-floor office condo with 24-hour controlled access and potential rooftop terrace, with water included in CAM.

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End-Unit Office Condominium

25110 Bernwood Dr, Bonita Springs, FL 34135

$659,900

0.27 AC lot

Office condo with reception, kitchen, and full bath, plus front and rear parking in a business park setting.

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Cape Coral Commercial Land Available

617 SW 4th Street, Cape Coral, FL 33991

$190,000

15,000 sqft 0.34 AC lot

Commercial land in growing Pine Island Road District, Cape Coral.

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Church Building with Conversion Potential

3657 Central Avenue, Fort Myers, FL 33901

$1,100,000

0.76 AC lot

Well-maintained church building with kitchenette, multiple rooms, and flexible interior space for office, medical, education, or faith use.

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Mixed-Use Property with Fenced Parking

2251 GRAND AVENUE, Fort Myers, FL 33901

$1,200,000

4,688 sqft 0.15 AC lot

Three distinct income spaces upstairs residential and ground-floor studio, supported by dedicated fenced parking for tenants and visitors.

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Live-Work Property with Covered Space

2850 Packinghouse Road, Alva, FL 33920

$390,000

1.88 AC lot

Zoned AG-2 live-work site with multiple offices, remodeled restroom, and covered space for equipment or vehicles.

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Concrete Block Medical Office Portfolio

3900 Broadway, Fort Myers, FL 33901

$3,400,000

2.72 AC lot

Four concrete block office buildings on 2.72 acres with strong occupancy, frontage on Broadway, and ample parking.

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Medical Office Building with Parking

331 Cape Coral Parkway W, Cape Coral, FL 33914

$1,350,000

0.47 AC lot

For sale office building with ample parking and original metal roof on a corner lot.

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Waterfront Fort Myers Warehouse Opportunity

3131 E Riverside Drive, Fort Myers, FL 33916

$3,495,000

7,500 sqft 1.06 AC lot

Waterfront industrial warehouse with loading docks near Downtown Fort Myers.

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Medical Office Space For Sale

22904 Lyden Drive, Estero, FL 33928

$1,750,000

3,651 sqft 0.04 AC lot

Newly constructed medical office space in a desirable Estero location.

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Two-Story Freestanding Medical Office

12731 New Brittany Blvd, Fort Myers, FL 33907

$4,900,000

1.69 AC lot

Two-story concrete block medical building with surgical buildout and flexible occupancy options for owner-users or investors.

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Commercial Land Parcel with Existing Property

1010 NE 9th Street, Cape Coral, FL 33909

$995,000

0.23 AC lot

Two parcels sold together near NE 9th Street, offering space for expansion, parking, storage, or redevelopment subject to approvals.

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Industrial Warehouse with Office Suite

912 SE 8th Place, Cape Coral, FL 33990

$1,100,000

0.19 AC lot

Turnkey warehouse includes private offices, reception, conference room, and onsite industrial equipment for immediate operations.

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Lee County, FL Office Spaces Market Trends and Statistics

Explore 276 office spaces for sale in Lee County, FL, showcased through 276 active listings on our real estate platform. These investment opportunities span a total of 800,545 square feet of properties for sale, with an estimated market value of $165,458,094.

Sale prices for office spaces in Lee County, FL start at $110,000, averaging $1,705,753, and reaching up to $17,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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