San Marcos, TX Medical Office Space for Rent & Lease

Updated: Oct 10, 2025

Multi-Suite Flex Space

1224 N State Highway 123, San Marcos, TX 78666

$19 SF/Yr

12,325 sqft 0.94 AC lot

Four suites available individually or in combination, with configurations from 1,600 to 10,000 square feet
2,400‑square‑foot office suite with six private offices, two restrooms, central workspace, and storage
3,600‑square‑foot open commercial suite with five private rooms and two bathrooms
2,400‑square‑foot layout includes reception, waiting room, eleven private rooms, and two bathrooms
Located at 1224 N State Highway 123 near Texas State University

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Updated: Nov 25, 2025

Medical Office Suite with Exam Rooms

715 W Hopkins Street, San Marcos, TX 78666

$3,583/Mo

0.94 AC lot

Four private offices, including 3 exam rooms
Two restrooms, reception area, break room, and x‑ray room
Six individual suites available within the property
Additional suites range from 513 square feet up to 1,312 square feet
Suites can be combined for larger contiguous spaces

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Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 2 Active listings in San Marcos, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Space with Open Layout

New Braunfels, TX 78130

Contact for pricing

3,500 sqft

Finished second-floor suite includes open workspace, a conference room, and a break room for immediate occupancy.

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Class A Medical Office Space

1750 East Common Street, New Braunfels, TX 78130

$25 SF/Yr

18,600 sqft

New Class A medical/retail space for lease, ready for occupancy.

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Medical Office Space Available

135 Bunton Crk Rd, Kyle, TX 78640

Contact for pricing

4,265 sqft

Class A medical office space near Ascension Seton Hays Hospital.

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Medical Office Space Available

4210 Benner Rd, Kyle, TX

Contact for pricing

6,133 sqft 2.42 AC lot

Contemporary medical office space for lease in Kyle, Texas.

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Similar Spaces for Sale in San Marcos, TX

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

Freshly Painted Flex Space

400 Harvey Street, San Marcos, TX 78666

$395,000

1,972 sqft 0.24 AC lot

Adaptable commercial space with dedicated parking supports office, medical, retail, restaurant, and salon uses.

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Flexible Multi-Suite Office Units

1224 N State Highway 123, San Marcos, TX 78666

Contact for pricing

12,325 sqft

Four configurable suites support professional, medical, retail, and service-oriented operations with parking for staff and clients.

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San Marcos, TX Medical Office Space Lease Rates & Market Statistics

Explore 2 Medical Office Space listings for lease in San Marcos, TX on Realmo, a commercial real estate exchange covering the San Marcos area. The current inventory totals 12,325 square feet of properties.

Asking lease rates for Medical Office Space in San Marcos start at $19 SF/Yr, average $19 SF/Yr, and reach $19 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $19 SF/Yr, the local average runs 22% below Texas's state average of $24.33 SF/Yr.

San Marcos accounts for 10% of the 21 medical office space listings currently available across Hays County, where nearby markets include Austin and Kyle. Medical Office Space is one of the more limited space types in San Marcos, with just 2 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (21 listings) elsewhere in the San Marcos market.

San Marcos, TX Medical Office Space for Lease

1224 N State Highway 123, San Marcos, TX 78666

715 W Hopkins Street, San Marcos, TX 78666