San Marcos, TX Medical Office Space for Rent & Lease

Updated: Oct 10, 2025

Multi-Suite Office Building

1224 N State Highway 123, San Marcos, TX 78666

$19 SF/Yr

12,325 sqft

Four office/professional suites available, individually or combined
Space 1: approximately 2,400 SF with six private offices, central workspace, two restrooms
Space 2: approximately 3,600 SF white‑box with five private rooms and two bathrooms
Space 3: approximately 2,400 SF with reception, waiting room, eleven private rooms, two bathrooms
Space 4: approximately 1,600 SF adaptable layout for retail, office, or service use

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Updated: Nov 25, 2025

Medical Office Space with Six Suites

715 W Hopkins Street, San Marcos, TX 78666

$3,583/Mo

MU zoning with former dental office layout
Four private offices, including three exam rooms, plus reception, break room, and x‑ray room
Six individual suites for lease, with suites ranging from 513 to 1,312 square feet
Several newly renovated suites with private restrooms and rear entry doors
Masonry construction with tile flooring; electric heating and electric cooling

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Second-Floor Office Suites

322 Cheatham St, San Marcos, TX 78666

$1,500/Mo

1,880 sqft

Second-floor office suites sized from 360–540 sq. ft. above a downtown wine bar with nearby park and river access.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 3 Active listings in San Marcos, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Class A Medical Office Space

1750 East Common Street, New Braunfels, TX 78130

$25 SF/Yr

18,600 sqft

New Class A medical/retail space for lease, ready for occupancy.

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Medical Office Building

1583 Common St, New Braunfels, TX 78130

Contact for pricing

804 sqft

Central medical office building with ample free-surface parking and convenient access to IH-35.

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Office Space in Kyle, TX

181 Kirkham Cir, Kyle, TX

Contact for pricing

1,101 sqft

Office space for rent in a park-like setting.

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Medical Office Space Available

4210 Benner Rd, Kyle, TX

Contact for pricing

6,133 sqft

Contemporary medical office space for lease in Kyle, Texas.

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Similar Spaces for Sale in San Marcos, TX

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Office Units with Dedicated Parking

400 Harvey Street, San Marcos, TX 78666

$450,000

1,972 sqft 0.24 AC lot

Office units zoned CD-5D with flexible space options and ample on-site parking for customers and staff.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land for Long-Term Lease

5538 E Paisano Drive, El Paso, TX 79905

$5,950/Mo

Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft

1.7 acre corner lot zoned for commercial, medical, residential.

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General Business Retail Development Site

Tift Avenue N, Tifton, GA 31794

$7,500/Mo

Approximately 0.66-acre commercial land parcel zoned GB General Business in Tifton.

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San Marcos, TX Medical Office Space Market Trends and Statistics

Explore Medical Office Space leasing options in San Marcos, TX with 3 listings featured on our commercial real estate exchange. The current inventory includes 14,205 square feet of properties with an estimated lease value of $28.57 SF/Yr.

Estimated lease rates for Medical Office Space in San Marcos, TX begin at $9.57 SF/Yr, with an average of $14.28 SF/Yr and extend to $19 SF/Yr.