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    Florence County, SC Commercial Real Estate for Lease

    38 results
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    Versatile Commercial Space in Florence
    $5,000 / Mo
    11,390 SF

    Versatile Commercial Space in Florence

    374 Darlington St, Florence, SC 29501

    Commercial property with bay doors, ideal for automotive or warehouse.

    • Prime Downtown Florence, SC location
    • Multiple bay doors for easy access and operations
    • Versatile space suitable for automotive, warehouse, or service‑related businesses
    • Abundant open space for vehicles, equipment, or flexible use
    • Dedicated office space for administrative functions
    Updated: Oct 11, 2025
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    Restaurant Space Near I-95
    $7,680 / Mo
    4,190 SF

    Restaurant Space Near I-95

    3751 W Palmetto St, Florence, SC 29501

    Restaurant space for lease with high visibility and traffic.

    • High traffic location with 36,300 vehicles daily on I‑95 and 17,800 vehicles daily on US‑76.
    • Excellent visibility and accessibility with copious road frontage, two driveway entrances, and ample parking.
    • Located off I‑95 Exit 157.
    • Surrounded by established national brands (McDonald’s, Waffle House, etc.).
    • 4,190 SF restaurant space available for lease.
    Updated: Sep 2, 2025
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    Restaurant Space Near I-95
    $7,680 / Mo
    4,190 SF

    Restaurant Space Near I-95

    Restaurant space for lease with high visibility and traffic.

    3751 W Palmetto St, Florence, SC 29501
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    Office Space Near Timrod Park
    $700 / Mo
    150 SF

    Office Space Near Timrod Park

    Flexible office spaces in historic building near Timrod Park.

    720 S Coit St, Florence, SC 29501
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    Lake City Retail/Office Building
    $10 SF/Yr
    11,000 SF

    Lake City Retail/Office Building

    Retail/office building in Lake City available through 1/31/2032.

    231 Kelley St, Lake City, SC 29560
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    146,270 SF Industrial Warehouse
    Contact for pricing
    146,270 SF

    146,270 SF Industrial Warehouse

    Industrial warehouse with versatile use options and strategic prime location.

    729 White Oak Dr, Johnsonville, SC 29555
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    Retail Space in Florence, SC
    Contact for pricing

    Retail Space in Florence, SC

    Located at a busy intersection with high visibility and access.

    Florence, SC 29501
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    Industrial Building Near I-95
    Contact for pricing
    30,000 SF

    Industrial Building Near I-95

    30,000 SF industrial space for lease near I-95.

    Enterprise Dr, Florence, SC 29501
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    Retail Space in Regional Destination
    Contact for pricing
    4,475 SF

    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination near major highways.

    110 Woody Jones Blvd, Florence, SC 29501
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    Retail Space in Regional Destination
    Contact for pricing
    2,400 SF

    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination, built in 2015.

    104 Woody Jones Blvd, Florence, SC 29501
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    Retail Space in Regional Destination
    Contact for pricing
    2,800 SF

    Retail Space in Regional Destination

    Retail space available in premier shopping center, built in 2015.

    112-120 Woody Jones Blvd, Florence, SC 29501
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    Retail Space in Lake City
    Contact for pricing
    1,200 SF

    Retail Space in Lake City

    Retail spaces available in a busy Lake City shopping center.

    252 Kelley St, Lake City, SC 29560
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    Retail Space in Florence, SC
    Contact for pricing
    8,000 SF

    Retail Space in Florence, SC

    8,000 SF retail space available for lease.

    2600 David H Mcleod Blvd, Florence, SC 29501
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    Prime Land for Lease
    Contact for pricing

    Prime Land for Lease

    Strategically located land parcel with high visibility and access.

    3335 Sneed Rd, Florence, SC 29501
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    Industrial Space in Florence, SC
    Contact for pricing
    200,000 SF

    Industrial Space in Florence, SC

    100,000 SF Class B industrial space available for lease.

    4501 E Palmetto St, Florence, SC 29506
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    Downtown Florence Flex Space
    $7 SF/Yr
    9,880 SF

    Downtown Florence Flex Space

    9,880 SF Flex Warehouse For Lease

    312 Railroad Ave, Florence, SC 29506
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    Claussen Retail Center Space Available
    $12 SF/Yr
    47,905 SF

    Claussen Retail Center Space Available

    Grocery-anchored retail space in Florence, SC.

    2332 Pamplico Hwy, Florence, SC 29505
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    Downtown Florence Office Suite A
    $226 SF/Yr
    1,400 SF

    Downtown Florence Office Suite A

    1400 sq ft Executive Office Space for Lease

    620 Evans St, Florence, SC 29501
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    Florence Office Space For Lease
    $10 SF/Yr
    2,300 SF

    Florence Office Space For Lease

    2300 sq ft Flex Space, I-95 Access

    1092 Church St, Florence, SC 29506
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    Florence Office Space: 7,145 SF
    $22 SF/Yr
    74,186 SF

    Florence Office Space: 7,145 SF

    Prime Florence Office: Modern, Customizable Space

    2701 Alex Lee Blvd, Florence, SC 29506
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    Downtown Florence Mixed-Use Gem
    $25 SF/Yr
    7,748 SF

    Downtown Florence Mixed-Use Gem

    Historic District, prime location, flexible space.

    127 Evans St, Florence, SC 29501
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    West End District Warehouse
    $90 SF/Yr
    36,360 SF

    West End District Warehouse

    36,360 SF Warehouse, Prime Location

    2295 Hoffmeyer Rd, Florence, SC 29501
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    620 Evans St
    $216 SF/Yr
    3,000 SF

    620 Evans St

    Office Properties & Spaces

    620 Evans St, Florence, SC 29501
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    Prime Florence Office Space
    $26 SF/Yr
    3,600 SF

    Prime Florence Office Space

    Class A Office, 1,800 SF Available

    609 2Nd Loop Rd, Florence, SC 29505
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    Florence County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Florence County, SC with 151 listings featured on our commercial real estate exchange. The current inventory includes 29,735,972,640 square feet of properties with an estimated lease value of $1,019 /Mo.

    Estimated lease rates for Commercial real estate in Florence County, SC begin at $4 SF/Yr, with an average of $53 SF/Yr and extend to $226 SF/Yr.
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    Browse Commercial real estate for Lease Near Florence, SC

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