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    Florence, SC Retail Properties & Spaces for Lease

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    14 listings
    Two-Unit Retail Conversion Opportunity
    $2,500/Mo
    2,304 SF
    Two-Unit Retail Conversion Opportunity

    225 W Lucas St, Florence, SC 29501

    Two storefront units with restaurant conversion-ready features on a high-traffic corridor near I-95.
    • Two‑unit commercial property built in 1983 at 225 W Lucas St (front) and 223 W Lucas St (rear), Florence, SC 29501
    • Front unit currently a convenience store and includes natural gas access, a commercial hood vent, take‑out window, and seating area for restaurant conversion
    • Rear unit has a liquor store permit application underway (223 W Lucas St), positioning dual revenue streams on one site
    • Property sits on the US‑52/Lucas Street Corridor with an average daily traffic count of 24,700 vehicles
    • Located just minutes from I‑95 and surrounded by 5,000+ hotel rooms
    Updated: May 10
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    Industrial Flex Building with Bay Doors
    $5,000/Mo
    11,390 SF
    Industrial Flex Building with Bay Doors

    374 Darlington St., Florence, SC 29501

    Flexible industrial space with multiple bay doors and front office area for vehicle, equipment, and service operations.
    • Year built: 1951
    • Downtown Florence, SC commercial property with multiple bay doors
    • Versatile open space suitable for vehicle, equipment, or flexible commercial use
    • Front office space plus restrooms for staff and clients
    • Rent listed at $5,000/month
    Updated: Oct 11, 2025
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    Retail Spaces in CrossRoads Center
    $18,134/Mo
    95,840 SF
    Retail Spaces in CrossRoads Center

    Retail spaces available in high-traffic Florence commercial corridor.

    2522, 2524, 2528 David H McLeod Blvd, Florence, SC 29501

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    Retail Space in Regional Destination
    $22 SF/Yr
    2,800 SF
    Retail Space in Regional Destination

    Retail space available in premier shopping center, built in 2015.

    112-120 Woody Jones Blvd, Florence, SC

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    Warehouse with Showroom and Yard
    Contact for pricing
    Warehouse with Showroom and Yard

    Single tenant building with showroom, warehouse, and fenced yard.

    511 Irby Street, Florence, SC 29501

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    Florence Warehouse in West End
    $90 SF/Yr
    36,360 SF
    Florence Warehouse in West End

    Warehouse in Florence's West End District, near major retailers.

    2295 Hoffmeyer Rd, Florence, SC 29501

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    Retail Space in Regional Destination
    $25 SF/Yr
    2,400 SF
    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination, built in 2015.

    104 Woody Jones Blvd, Florence, SC

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    Retail Space in Florence, SC
    Contact for pricing
    8,000 SF
    Retail Space in Florence, SC

    8,000 SF retail space available for lease.

    2600 David H Mcleod Blvd, Florence, SC

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    Retail Space in Regional Destination
    $22 SF/Yr
    4,475 SF
    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination near major highways.

    110 Woody Jones Blvd, Florence, SC

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    Retail Space in Five Points
    $25 SF/Yr
    2,700 SF
    Retail Space in Five Points

    End-cap retail space in a high-traffic area for lease.

    1939 Hoffmeyer Rd, Florence, SC 29501

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    Established Commercial Complex on Second Loop
    Contact for pricing
    2,000 SF
    Established Commercial Complex on Second Loop

    Multi-tenant commercial complex with high visibility and convenient access.

    1800 2nd Loop Rd, Florence, SC 29501

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    Prime Outparcel Opportunities in Florence
    $1.00 SF/Yr
    Prime Outparcel Opportunities in Florence

    Outparcels available at I-95 interchange, ideal for hotels, restaurants.

    2939 N Williston Rd, Florence, SC 29506

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    Florence Commercial Space For Rent
    Contact for pricing
    Florence Commercial Space For Rent

    Commercial space suitable for office, professional, or retail use.

    2843 W Palmetto Street Suite C, Florence, SC 29501

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    Retail Space in Florence Mall
    Contact for pricing
    329,000 SF
    Retail Space in Florence Mall

    Prime retail space in regional shopping center, Florence, South Carolina.

    1945 W Palmetto St, Florence, SC 29501

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    Based on your search, we've compiled 49 Potential Opportunities for your consideration. Besides 14 Active listings in Florence, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 27 Properties for Sales.

    Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail Space Near Walmart
    $26 SF/Yr
    1,200 SF
    Retail Space Near Walmart

    Retail space available February 2026 near Walmart Supercenter.

    1211 Retail Row, Hartsville, SC 29550

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    Retail Space For Lease
    $4 SF/Yr
    28,000 SF
    Retail Space For Lease

    28,000 SF retail space on 4.48 AC available.

    1404 N Main St, Marion, SC

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    Retail Strip Center Storefront
    Contact for pricing
    Retail Strip Center Storefront

    1,200 SF storefront for lease in a retail strip center with strong visibility and signage opportunities.

    1217 S FOURTH ST, Hartsville, SC 29550

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    Retail Space in Marion Center
    Contact for pricing
    1,300 SF
    Retail Space in Marion Center

    Retail and restaurant opportunities available in Marion Towne Center.

    2523-2565 US 76, Marion, SC

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    Similar Spaces for Sale in Florence, SC

    Consider Similar Space for Sale. We found 27 Spaces matching your search parameters.

    Fully Occupied Retail Center
    $1,650,000
    15,450 SF
    Fully Occupied Retail Center

    Retail center in good condition with high traffic count.

    823-817 S Cashua Drive, Florence, SC 29501

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    Buildable Retail Development Land
    $1,500,000
    7.27 Acres
    Buildable Retail Development Land

    Level, buildable two-parcel land package suited for a range of retail and service-oriented development uses.

    3312 Meadors Road, Florence, SC 29501

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    Freestanding Retail Showroom and Warehouse
    $799,000
    15,541 SF
    Freestanding Retail Showroom and Warehouse

    Freestanding retail property combines showroom and warehouse space on a hard-corner site with approximately 174 feet of frontage.

    2803 West Palmetto Street, Florence, SC 29501

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    Florence Commercial Development Opportunity
    $1,200,000
    4.54 Acres
    Florence Commercial Development Opportunity

    4.54 acre commercial parcel on high-traffic corridor.

    2621 West Palmetto Street, Florence, SC 29501

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    Former Convenience Store Investment Property
    $125,000
    2,400 SF
    Former Convenience Store Investment Property

    Fixer-upper retail property with 150' frontage, great investment potential.

    1134 E Howe Springs Road, Florence, SC 29505

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    NNN Leased Plasma Investment Property
    $3,370,000
    17,174 SF
    NNN Leased Plasma Investment Property

    NNN leased investment property in Florence, South Carolina.

    1933 2nd Loop Rd, Florence, SC 29501

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    Turnkey Fish Market Opportunity
    $250,900
    2,499 SF
    Turnkey Fish Market Opportunity

    Profitable, equipped fish market for sale in Florence, SC.

    1401 W Darlington Street, Florence, SC 29501

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    Showroom and Warehouse on Irby
    $500,000
    6,120 SF
    Showroom and Warehouse on Irby

    Single tenant building with showroom and warehouse on 1.09-acre lot.

    511 Irby Street, Florence, SC 29501

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    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF
    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501

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    Standalone Industrial Building on Harrell
    $189,000
    40,000 SF
    Standalone Industrial Building on Harrell

    Industrial building suitable for fabrication, automotive, contractor, or storage.

    120 N Guerry St, Florence, SC 29501

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Development Ready Outparcel in Myrtle Beach
    $95,000 SF/Yr
    Development Ready Outparcel in Myrtle Beach

    1.17 acre commercial land with high traffic counts.

    1028 Glenforest Rd., Myrtle Beach, SC 29579

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    Commercial Land in Murrells Inlet
    $2,500/Mo
    Commercial Land in Murrells Inlet

    1.49 acres of commercial land for lease.

    Inlet Square Dr., Murrells Inlet, SC 29576

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    Commercial Land in Southern Pines
    $3,500/Mo
    Commercial Land in Southern Pines

    1.297-acre commercial land site for lease in a high-traffic area.

    Pinehurst Avenue, Southern Pines, NC 28387

    View details
    Land Lease Opportunity in Waxhaw
    $8,000/Mo
    Land Lease Opportunity in Waxhaw

    5.341-acre commercial land for lease in a high-growth area.

    5325 Waxhaw Marvin Road, Waxhaw, NC 28173

    View details

    Florence, SC Retail properties & Spaces Market Trends and Statistics

    Explore Retail properties & Spaces leasing options in Florence, SC with 14 listings featured on our commercial real estate exchange. The current inventory includes 158,269 square feet of properties with an estimated lease value of $204 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Florence, SC begin at $2 SF/Yr, with an average of $25 SF/Yr and extend to $90 SF/Yr.
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