Add Listing
    Lake City, SC
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent / SF / Yr
    $
    $
    Size
    Property Size / SF

    Lake City, SC Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Kingstree, SC Johnsonville, SC Florence, SC
    Retail Space in Lake City
    $12 SF/Yr
    1,200 SF

    Retail Space in Lake City

    252 Kelley St, Lake City, SC

    Retail spaces available in a busy Lake City shopping center.

    • Anchored by KJ’s IGA Grocery, Roses, Dollar Tree, Hibbetts, Cato, It’s Fashion, and Subway.
    • Located in the heart of Lake City.
    • 146,000 sf Retail strip center.
    • Available space: 22,000 sf at $3.00 rent rate (NNN).
    • Available space: 1200 sf at $12.00 rent rate (NNN).
    Updated: Jun 27, 2025
    View details
    Lake City Retail/Office Building
    $10 SF/Yr
    11,000 SF

    Lake City Retail/Office Building

    231 Kelley St, Lake City, SC

    Retail/office building in Lake City available through 1/31/2032.

    • ±11,000 SF freestanding building.
    • Available through 1/31/2032.
    • Includes ±6,000 square feet of medical office space.
    • Includes ±5,000 square feet of shell space.
    • On‑site parking.
    Updated: Jul 30, 2024
    View details
    Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 2 Active listings in Lake City, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    146,270 SF Industrial Warehouse
    Contact for pricing
    146,270 SF

    146,270 SF Industrial Warehouse

    Industrial warehouse with versatile use options and strategic prime location.

    729 White Oak Dr, Johnsonville, SC 29555
    View details
    Industrial Warehouse with Rail Access
    Contact for pricing
    146,270 SF

    Industrial Warehouse with Rail Access

    146,270 sq ft warehouse for lease near rail line.

    729 White Oak Dr, Johnsonville, SC 29555
    View details
    Renovated Retail Space on US-52
    Contact for pricing
    22,800 SF

    Renovated Retail Space on US-52

    Anchor suite in renovated shopping center with high visibility.

    1611 S Irby St, Florence, SC 29505
    View details
    Retail Space at Claussen Shops
    Contact for pricing
    3,600 SF

    Retail Space at Claussen Shops

    Grocery-anchored retail space for lease with ample parking.

    2332 Pamplico Hwy, Florence, SC 29505
    View details

    Similar Spaces for Sale in Lake City, SC

    Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

    Prime Commercial Lot on Highway
    $599,000
    2.90 Acres

    Prime Commercial Lot on Highway

    2.9-acre commercial site on S. Ron McNair Boulevard, Lake City.

    791 S Ron McNair Blvd., Lake City, SC 29560
    View details
    78.4 Acres with Cropland
    $515,000
    78.40 Acres

    78.4 Acres with Cropland

    78.4-acre property featuring cropland, wetlands, and a 1,376-square-foot home.

    711 Cade Rd., Lake City, SC 29560
    View details
    Downtown Lake City Commercial Lot
    $59,900
    1,200 SF

    Downtown Lake City Commercial Lot

    Commercial lot in downtown Lake City, South Carolina.

    360 S Ron McNair Blvd, Lake City, SC 29560
    View details
    Prime Commercial Site on Highway
    $599,000
    2.90 Acres

    Prime Commercial Site on Highway

    Development opportunity in high-traffic commercial corridor near industrial area.

    791 S Ron McNair Blvd, Lake City, SC 29560
    View details
    Lake City Acreage For Sale
    $135,000
    13.32 Acres

    Lake City Acreage For Sale

    13.32 acres in Lake City, SC, ideal for development.

    13.32 Ac - 1014 W Highway 378 Bypass, Lake City, SC 29560
    View details
    Downtown Lake City Commercial Building
    $199,000
    2,500 SF

    Downtown Lake City Commercial Building

    2,500 sq ft commercial building in downtown Lake City.

    112 E Main St, Lake City, SC 29560
    View details
    6.83 Acres of Rural Land
    $80,000
    6.83 Acres

    6.83 Acres of Rural Land

    Vacant land perfect for building your dream home.

    1302 Bragdon Rd., Lake City, SC 29560
    View details
    Versatile Acreage in Lake City, SC
    $49,225
    19.60 Acres

    Versatile Acreage in Lake City, SC

    19.6-acre property ideal for recreation, investment, or building a home.

    TBD Green Rd., Lake City, SC 29560
    View details
    Commercial Lot in Lake City
    $160,000
    0.47 Acres

    Commercial Lot in Lake City

    0.47 acre commercial lot with rental income potential.

    0.47 Acres-TBD Sumter St., Lake City, SC 29560
    View details
    Commercial Lot in Downtown
    $59,900
    1,200 SF

    Commercial Lot in Downtown

    Commercial lot in a high-traffic downtown location.

    360 S Ron McNair Blvd, Lake City, SC 29560
    View details
    Commercial Land with Development Potential
    $200,000
    1.50 Acres

    Commercial Land with Development Potential

    Commercial land with frontage on US 52, development potential.

    356 S Ron McNair Blvd, Lake City, SC 29560
    View details
    Former Talon Zipper Plant
    $1,474,350
    105,000 SF

    Former Talon Zipper Plant

    Manufacturing/warehouse space on 20 acres near airport runway.

    701 South Ron McNair Boulevard |, Lake City, SC 29560
    View details
    Stand-Alone Office Building For Sale
    $250,000
    1,722 SF

    Stand-Alone Office Building For Sale

    Stand-alone office building with immediate occupancy in Lake City, SC.

    215 John St, Lake City, SC
    View details
    Lake City Agricultural Land
    $221,000
    52.00 Acres

    Lake City Agricultural Land

    52 acre agricultural land with hunting and wildlife potential.

    52 Acres-TBD Vox Hwy., Lake City, SC 29560
    View details
    Vacant Restaurant with Drive-Thru
    $850,000
    2,819 SF

    Vacant Restaurant with Drive-Thru

    2,819 SF vacant restaurant with drive-thru for sale.

    147 S Ron McNair Blvd, Lake City, SC 29560
    View details
    Lake City Industrial Warehouse
    $5,900,000
    157,800 SF

    Lake City Industrial Warehouse

    Industrial warehouse property available for sale in Lake City.

    1051 E Main St, Lake City, SC
    View details

    Lake City, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Lake City, SC with 2 listings featured on our commercial real estate exchange. The current inventory includes 12,200 square feet of properties with an estimated lease value of $22 SF/Yr.

    Estimated lease rates for Commercial real estate in Lake City, SC begin at $10 SF/Yr, with an average of $11 SF/Yr and extend to $12 SF/Yr.
    List
    Map

    Browse Commercial real estate for Lease Near Lake City, SC

    Popular Searches in Lake City, SC

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!