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    Lancaster County, SC Office Properties & Spaces for Sale

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    Columbia, SC Aiken, SC Greenville, SC
    10 results
    Two Professional Buildings Near MUSC
    $975,000
    0.82 Acres

    Two Professional Buildings Near MUSC

    1201 Colonial Commons Court, Lancaster, SC 29720

    Two professional office buildings near MUSC in Lancaster, South Carolina.

    • Prime location minutes from MUSC (Medical University of South Carolina).
    • Two professional office buildings on one property.
    • Zoned "PO" Professional Office by the City of Lancaster.
    • Building 1 features a medical office layout with 14 rooms and a wired X‑ray room.
    • New flooring and new roof installed in Building 1.
    Updated: Dec 1, 2025
    View details
    Versatile Commercial Building in Lancaster
    $349,000

    Versatile Commercial Building in Lancaster

    302 N White St, Lancaster, SC 29720

    Two-story commercial building with offices in downtown Lancaster, SC.

    • Prime location in the heart of downtown Lancaster's growing business district.
    • Versatile commercial building suitable for multiple businesses or a single expanding operation.
    • Two floors, each with four offices and a half bath.
    • Total of 16 rooms and four half baths.
    • Excellent accessibility for clients and employees.
    Updated: Mar 13
    View details
    Medical Office Buildings Near MUSC
    $975,000

    Medical Office Buildings Near MUSC

    Two professional buildings suitable for medical or office use.

    1201 Colonial Commons Ct, Lancaster, SC 29720
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    Former Medical Office Space
    $150,000
    3,550 SF

    Former Medical Office Space

    3,350 SF medical office with 11 parking spaces.

    110 South Cleveland Street, Kershaw, SC 29067
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    Mixed-Use Commercial Property For Sale
    $450,000

    Mixed-Use Commercial Property For Sale

    Four buildings with six potential rental opportunities on 1.6 acres.

    2415 Pineview Drive, Lancaster, SC 29720
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    Lancaster Light Industrial Facility
    $299,000
    3,400 SF

    Lancaster Light Industrial Facility

    3,400 SF facility on 2 acres near Rock Hill.

    1537 Lynwood Drive, Lancaster, SC 29720
    View details
    Versatile Flex, Office, Warehouse Space
    $11,615,750
    92,926 SF

    Versatile Flex, Office, Warehouse Space

    92,926 SF flex, office, and warehouse space for sale.

    11632 Harrisburg Rd, Indian Land, SC
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    Prime Retail and Commercial Development
    $900,000

    Prime Retail and Commercial Development

    Retail and commercial development in a high-traffic area.

    9425 Charlotte Highway, Indian Land, SC 29707
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    Lancaster Medical/Office Space Available
    $875,000
    6,900 SF

    Lancaster Medical/Office Space Available

    Versatile space near MUSC Health Lancaster Medical Center.

    980 N Woodland Dr, Lancaster, SC
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    12.4 Acres Assemblage in Indian Land
    Contact for pricing

    12.4 Acres Assemblage in Indian Land

    12.4 acres in Indian Land, South Carolina for sale.

    Charlotte Hwy, Indian Land, SC 29707
    View details
    Based on your search, we've compiled 264 Potential Opportunities for your consideration. Besides 10 Active listings in Lancaster County, SC, we suggest exploring several alternatives: similar 250 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Land on Charlotte Highway
    $2,200,000
    15.55 Acres

    Prime Development Land on Charlotte Highway

    15.55 acres with high traffic, development potential.

    2383 Charlotte Highway, Lancaster, SC 29720
    View details
    Prime Development Land on Charlotte Highway
    $2,200,000
    15.55 Acres

    Prime Development Land on Charlotte Highway

    Development opportunity on a high-traffic corridor near residential developments.

    2383 Charlotte Highway, Lancaster, SC 29720
    View details
    Monroe Commercial Land For Sale
    $1,700,000
    7.62 Acres

    Monroe Commercial Land For Sale

    Commercial land available in high-traffic Monroe location.

    Charles Hunley Lane, Monroe, NC 28112
    View details
    Vacant Land in Fort Mill
    $1,000,000
    2.25 Acres

    Vacant Land in Fort Mill

    2.25 acres of commercial land with development potential.

    2876 Old Nation Road, Fort Mill, SC 29715
    View details

    Explore Off-Market Properties in Lancaster County, SC

    Consider similar Off-Market properties in Lancaster County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    979 University Dr

    979 University Dr

    OFFICE (GENERAL) • 1,584 SF
    Value Estimation by Request
    979 University Dr, Lancaster, SC 29720
    View details
    713 Main St

    713 Main St

    OFFICE (GENERAL) • 1,128 SF
    Value Estimation by Request
    713 Main St, Lancaster, SC 29720-3644
    View details
    312 Miller St

    312 Miller St

    OFFICE (GENERAL) • 1,467 SF
    Value Estimation by Request
    312 Miller St, Lancaster, SC 29720
    View details
    Hwy 914

    Hwy 914

    OFFICE (GENERAL) • 2,586 SF
    Value Estimation by Request
    Hwy 914, Lancaster, SC 29720
    View details
    503 Meeting St

    503 Meeting St

    OFFICE (GENERAL) • 1,210 SF
    Value Estimation by Request
    503 Meeting St, Lancaster, SC 29720-2323
    View details
    1320 Hwy 9th W Byp

    1320 Hwy 9th W Byp

    MEDICAL BUILDING • 1,320 SF
    Value Estimation by Request
    1320 Hwy 9th W Byp, Lancaster, SC 29720-4712
    View details
    312 Main St

    312 Main St

    OFFICE (GENERAL) • 5,644 SF
    Value Estimation
    $535,000
    312 Main St, Lancaster, SC 29720-2132
    View details
    9160 Northfield Dr

    9160 Northfield Dr

    OFFICE (GENERAL) • 6,670 SF
    Value Estimation
    $890,000
    9160 Northfield Dr, Fort Mill, SC 29707-6540
    View details
    2583 Kershaw Camden Hwy

    2583 Kershaw Camden Hwy

    OFFICE (GENERAL) • 8,060 SF
    Value Estimation by Request
    2583 Kershaw Camden Hwy, Lancaster, SC 29720-6855
    View details
    1104 Lockwood Ln

    1104 Lockwood Ln

    OFFICE (GENERAL) • 2,240 SF
    Value Estimation by Request
    1104 Lockwood Ln, Lancaster, SC 29720-6217
    View details
    Catawba St

    Catawba St

    OFFICE (GENERAL) • 3,128 SF
    Value Estimation by Request
    Catawba St, Lancaster, SC 29720
    View details
    419 Meeting St

    419 Meeting St

    MEDICAL BUILDING • 4,600 SF
    Value Estimation
    $750,000
    419 Meeting St, Lancaster, SC 29720-2321
    View details
    1091 Rebound Rd

    1091 Rebound Rd

    OFFICE (GENERAL) • 1,994 SF
    Value Estimation by Request
    1091 Rebound Rd, Lancaster, SC 29720
    View details
    1629 Springdale Rd

    1629 Springdale Rd

    OFFICE (GENERAL) • 952 SF
    Value Estimation by Request
    1629 Springdale Rd, Lancaster, SC 29720-2253
    View details

    Lancaster County, SC Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 260 office properties & spaces for sale in Lancaster County, SC, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 106,776 square feet of properties for sale, with an estimated market value of $12,939,750.

    Sale prices for office spaces in Lancaster County, SC start at $150,000, averaging $3,234,937, and reaching up to $11,615,750 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Browse Office properties & Spaces for Sale Near Lancaster, SC

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