Lancaster County, SC Office Spaces for sale

Updated: May 4

Kershaw Office Building on Large Lot

104 S Ashe Street, Kershaw, SC 29067

$200,000

1,100 sqft 1.76 AC lot

Large 1.76 acre lot (2 lot parcel) within town limits
Potential for rezoning to residential and remodeling into a home
Existing 1100+ sq ft building suitable for office use
Located in a doctor care area
'Easy walking' within city limits

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Updated: Dec 1, 2025

Two-Building Professional Office Property

1201 Colonial Commons Court, Lancaster, SC 29720

$975,000

0.82 AC lot

Two professional buildings on one property: 1201 and 1203 Colonial Commons Ct
1201 Colonial Commons Ct set up as a medical office with ~14 rooms, reception, waiting room, and wired for an X‑ray room
1203 Colonial Commons Ct includes reception and waiting room areas, file room, three curtained areas, large open space, and upper‑level work stations
PO (Professional Office) zoning per the City of Lancaster zoning chart
Building 1 received new flooring and a new roof

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Former Medical Office Space

110 South Cleveland Street, Kershaw, SC 29067

$150,000

3,550 sqft

3,350 SF medical office with 11 parking spaces.

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Historic Mixed-Use Retail/Office Buildings

209-227 S. Main Street, Lancaster, SC 29720

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29,151 sqft

Vacant 1930s buildings offer retail or office space and renovation opportunity in downtown Lancaster, South Carolina.

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Downtown Mixed-Use Building for Renovation

229 S. Main Street, Lancaster, SC 29720

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15,266 sqft

Vacant 1930s mixed-use property in downtown Lancaster, built for retail or office re-activation with renovation underway.

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Downtown Mixed-Use Redevelopment Property

210 S. White Street, Lancaster, SC 29720

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22,251 sqft

Vacant 1930s retail/office buildings in downtown Lancaster offer a renovation-ready canvas for mixed-use redevelopment.

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1930s Retail/Office Building Portfolio

116 Arch Street, Lancaster, SC 29720

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29,444 sqft

Vacant, renovation-needed buildings offering flexible retail or office space in downtown Lancaster with convenient highway access.

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Flex Office Space with Storage

116 Hampton Street, Kershaw, SC 29067

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3,600 sqft

Well-maintained flex space with private office, storage back room, and one restroom, plus recent HVAC and roofing updates.

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Medical Office Buildings Near MUSC

1201 Colonial Commons Ct, Lancaster, SC 29720

$975,000

Two professional buildings suitable for medical or office use.

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Versatile Commercial Building in Lancaster

302 N White St, Lancaster, SC 29720

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Two-story commercial building with offices in downtown Lancaster, SC.

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Medical Office Building

1370 W Meeting Street, Lancaster, SC 29720

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Large medical office building with exam rooms, nurses stations, lab space, and ample parking.

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Prime Retail and Commercial Development

9425 Charlotte Highway, Indian Land, SC 29707

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Retail and commercial development in a high-traffic area.

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Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 12 Active listings in Lancaster County, SC, we suggest exploring several alternatives: similar 60 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land in Lancaster, SC

2836 Lynwood Drive, Lancaster, SC 29720

$149,900

0.47 AC lot

Commercial land suitable for various business ventures.

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Light Industrial Land For Sale

00 Fork Hill Road, Kershaw, SC 29067

$90,000

Land zoned for light industrial use with possible residential rezoning.

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Commercial Land in Pageland, SC

605 E Mcgregor Street, Pageland, SC 29728

$495,000

1.91 AC lot

Two parcels totaling 1.91 acres zoned for commercial and residential use.

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Prime Development Land in Pageland

510 Van Lingle Mungo Boulevard, Pageland, SC 29728

$255,000

2.69 AC lot

2.6+/- acre development site on high-traffic corridor in Pageland.

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Off-Market Properties in Lancaster County, SC

Consider similar Off-Market properties in Lancaster County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.