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    Florence County, SC Commercial Real Estate for Sale

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    Retail Storefront with Storage
    Retail Storefront with Storage

    114 Seaboard Ave., Johnsonville, SC 29555

    Contact for pricing
    2,150 sqft

    Retail storefront includes multiple rooms, 1.5 baths, and a separate back storage building with cement flooring.

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    Florence Commercial Development Opportunity
    Florence Commercial Development Opportunity

    2621 West Palmetto Street, Florence, SC 29501

    Contact for pricing
    4.54 AC lot

    4.54 acre commercial parcel on high-traffic corridor.

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    Multi-Height Warehouse Facility
    Multi-Height Warehouse Facility

    200 Lawson Street, Florence, SC 29501

    Contact for pricing
    10,000 sqft

    Warehouse offers 20', 15', and 18' ceiling heights with multiple high doors and a 10' loading dock door.

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    See what stands out in Florence County

    We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

    We check every listing here. A few are worth a second look.

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    Large Church Facility
    Large Church Facility

    1200 N Irby, Florence, SC 29501

    Contact for pricing
    68,000 sqft 9.50 AC lot

    Church facility with sanctuary, offices, classrooms, nursery, and an industrial kitchen.

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    Howard Johnson Hotel with On-Site Residence
    Howard Johnson Hotel with On-Site Residence

    2038 W Lucas St, Florence, SC 29501

    Contact for pricing
    3.73 AC lot

    Two-story limited-service property with infrastructure upgrades and a newly renovated two-bedroom, one-bathroom residence.

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    Zoned NZ Development Land
    Zoned NZ Development Land

    Pygatt Rd/ 2222 1/2 W Cummings Rd, Effingham, SC 29541

    $170,000

    Commercial land zoned NZ, offering flexible development possibilities for land and office-oriented endeavors.

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    Manufacturing Facility with Crane
    Manufacturing Facility with Crane

    1500 E National Cemetery Rd, Florence, SC 29506

    Contact for pricing
    90,600 sqft

    Industrial property with concrete flooring, heavy lifting equipment, and available utilities.

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    Commercial Land Corner Development
    Commercial Land Corner Development

    1949 W Darlington St, Florence, SC 29501

    Contact for pricing
    1.53 AC lot

    Corner commercial land offering parking and potential for multi-tenant or single-tenant development.

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    Corner Commercial Development Lot
    Corner Commercial Development Lot

    700 N CASHUA DR, Florence, SC 29501

    Contact for pricing
    1.45 AC lot

    Signalized corner lot with water and sewer access and convenient entry from two streets.

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    NNN Leased Plasma Investment Property
    NNN Leased Plasma Investment Property

    1933 2nd Loop Rd, Florence, SC 29501

    Contact for pricing
    17,174 sqft

    NNN leased investment property in Florence, South Carolina.

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    Historic Vineyard Estate with Winery
    Historic Vineyard Estate with Winery

    701 Truluck Vineyards Rd, Lake City, SC 29560

    $4,950,000

    Move-in ready vineyard estate featuring a fully appointed winery building, tasting room, production areas, and guest cottage.

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    B-3 Office Building with Private Offices
    B-3 Office Building with Private Offices

    1205 W Evans St, Florence, SC 29501

    Contact for pricing
    2,290 sqft

    Configured for professional services with a lobby, private offices, open workspace, and support areas.

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    Wooded Acreage Property
    Wooded Acreage Property

    791 Moulds Rd, Lake City, SC 29560

    $60,000
    5.35 AC lot

    Secluded wooded acreage is accessed from Moulds Rd for a private setting near Lake City, SC.

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    Historic Downtown Florence Commercial Property
    Historic Downtown Florence Commercial Property

    329 N Irby St, Florence, SC 29501

    Contact for pricing
    12,411 sqft 1.55 AC lot

    Historic building in downtown Florence, suitable for commercial use.

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    Commercial Land For Sale
    Commercial Land For Sale

    2819 E Palmetto Street, Florence, SC 29501

    Contact for pricing
    1.98 AC lot

    1.98 acre commercial land with utilities in Florence, SC.

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    Farmland with Mature Woods
    Farmland with Mature Woods

    1002 Sam Lee Road, Scranton, SC 29591

    $419,155

    Rural acreage combines open agricultural ground, timber, and paved road access for farming, recreation, or a future homesite.

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    South Irby Street Commercial Lot
    South Irby Street Commercial Lot

    623 South Irby Street, Florence, SC 29501

    Contact for pricing
    0.46 AC lot

    0.46 acre lot suitable for retail or office development.

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    Freestanding Restaurant Building with Parking
    Freestanding Restaurant Building with Parking

    137 East Palmetto Street, Florence, SC 29506

    Contact for pricing

    Corner restaurant building with parking and expansion potential.

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    Versatile Office Building For Sale
    Versatile Office Building For Sale

    603 W Palmetto Street, Florence, SC 29501

    Contact for pricing
    2,004 sqft

    Functional office building in high traffic area, ideal for professionals.

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    Timmonsville Medical Office Building
    Timmonsville Medical Office Building

    101 W Market St, Timmonsville, SC 29161

    Contact for pricing
    1,978 sqft

    Well-maintained building suitable for medical or business office.

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    Wendy’s Restaurant in Florence, SC
    Wendy’s Restaurant in Florence, SC

    624 S Irby St, Florence, SC

    Contact for pricing
    2,202 sqft 0.69 AC lot

    Wendy’s restaurant for sale on high-traffic retail corridor.

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    Wendy's Restaurant For Sale
    Wendy's Restaurant For Sale

    4010 E Palmetto St, Florence, SC

    Contact for pricing
    2,058 sqft 1.10 AC lot

    Wendy’s in Florence, South Carolina, leased for 20 years.

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    Vacant Convenience Store and Gas Station
    Vacant Convenience Store and Gas Station

    4011 E Palmetto St, Florence, SC 29506

    Contact for pricing
    2,957 sqft

    Vacant 2,957 SF c-store paired with a 76-branded gas station at 4011 E Palmetto St in Florence, SC.

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    Warehouse with High-Clearance Space
    Warehouse with High-Clearance Space

    904 North Douglas, Florence, SC 29501

    Contact for pricing
    400,000 sqft 31.00 AC lot

    Industrial property offers expansive open interiors, modern lighting, truck-accessible entry points, and dual-street access.

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