Spartanburg, SC Mixed-use properties for Rent & Lease

Updated: Nov 25, 2025

Historic Mill Office Space Available

1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

$16 SF/Yr

53,571 sqft

Located in Drayton Mills Marketplace, a successful adaptive‑reuse mixed‑use community.
±3,934 SF office suite with restored historic mill character including exposed brick, high ceilings, and large windows.**
Walkable access to restaurants, coffee shops, retail, fitness studio, and salons.
Connected to Drayton Mills’ trail network for walking, biking, and tenant events.
Flexible space suitable for office, creative studio, co‑working, or boutique professional services.

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Updated: Oct 21, 2025

Spartanburg Flexible Space For Rent

1201 Union, Spartanburg, SC

Contact for pricing

34,053 sqft 4.14 AC lot

±34,000‑SF Flexible Space suitable for retail/mixed‑use.
Direct access and street frontage on Union St.
Located minutes from Downtown Spartanburg.
Abundant parking.
Adjacent concrete slab ideal for development.

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Historic Spartanburg Mixed-Use Retail Space

174 E Main St, Spartanburg, SC 29306

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4,709 sqft

Retail space available in historic mixed-use building in downtown Spartanburg.

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Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 3 Active listings in Spartanburg, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

Mixed-use properties for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Renovated Mixed-Use Property

219 Amboy Rd, Asheville, NC 28806

$3,500/Mo

4,535 sqft

Flexible commercial space combines bar, restaurant, office, commissary kitchen, courtyard, patio, and onsite parking.

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Two Lower-Level Storefront Suites

140-244 Short Coxe Ave, Asheville, NC 28801

$3,125/Mo

Renovated commercial suites offer modern amenities, on-site parking, and access to downtown Asheville activity.

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Two-Story Mixed-Use Property

761 Verdae Blvd, Greenville, SC 29607

Contact for pricing

Warm-lit shell suitable for high-end retail or a tailored office user.

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Topgolf-Anchored Mixed-Use Property

315 Tanner Price Way, Greenville, SC 29615

Contact for pricing

15,000 sqft

Zoned for restaurant, hotel, industrial, and entertainment uses along Pelham Road’s major retail corridor.

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Similar Spaces for Sale in Spartanburg, SC

Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

Commercial Kitchen Property with Basement

850 Falling Creek Road, Spartanburg, SC 29301

$380,000

1,879 sqft 0.53 AC lot

Commercial property with an open meeting area, kitchen infrastructure, storage, and parking capacity on a half-acre lot.

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Mixed-Use Commercial Building

180 John B White Sr Boulevard, Spartanburg, SC 29306

$525,000

0.23 AC lot

Interior renovation is underway in a versatile commercial building with paved parking.

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Rare Redevelopment Opportunity 7 Retail Properties

127-163 E Main St, Spartanburg, SC 29306

$8,950,000

8,256 sqft 0.19 AC lot

7 Retail Properties Rare Downtown Spartanburg Development Opportunity

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Mixed-Use Specialty Facility

501 Willis Rd, Spartanburg, SC 29301

Contact for pricing

61,289 sqft

PR-zoned property suited to pickleball, tennis, or an activity center.

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Mixed-Use Property with Highway Frontage

9139 Warren H Abernathy Hwy, Spartanburg, SC 29301

Contact for pricing

1,500 sqft 1.20 AC lot

Commercial site with on-site parking, gas service, public water, and septic infrastructure.

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Mixed-Use Property With Renovated Buildings

8861 Warren B Abernathy Highway, Spartanburg, SC 29301

$850,000

2.19 AC lot

Renovated buildings, a separate shop, and public water create a flexible commercial property setting.

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Historic Mixed-Use Property For Sale

571 E Main St, Spartanburg, SC 29302

Contact for pricing

4,688 sqft 0.48 AC lot

4,688 SF mixed-use property in Converse Heights neighborhood.

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Land Near Wofford College Campus

577 N CHURCH ST, Spartanburg, SC 29306

Contact for pricing

Mixed-use land for sale near downtown and Wofford College.

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Renovated Flex Space with Yard

872 W Main St, Spartanburg, SC 29301

Contact for pricing

1.00 AC lot

Updated commercial building with outdoor areas supporting flexible business operations.

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Prime Land on E. Main

2700 E Main St, Spartanburg, SC 29307

Contact for pricing

10,000 sqft 7.76 AC lot

7.76 acres on a busy commercial corridor, redevelopment opportunity.

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Spartanburg Eastside Mixed-Use Development Opportunity

2910 E Main St, Spartanburg, SC 29307

Contact for pricing

11.56 AC lot

11.56 acres for mixed-use development in Spartanburg's Eastside.

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Land, Mixed Use

2052 Southport Rd, Spartanburg, SC 29306

Contact for pricing

Mixed-use properties

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Spartanburg, SC Mixed-use properties Lease Rates & Market Statistics

Explore 3 Mixed-use properties for lease in Spartanburg, SC on Realmo, a commercial real estate exchange covering the Spartanburg area. The current inventory totals 92,333 square feet of properties.

Mixed-use properties lease rates in Spartanburg range from $16 SF/Yr at the entry level to $16 SF/Yr at the top of the market, averaging $16 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $16 SF/Yr is 15% below the South Carolina state average of $18.87 SF/Yr.

Spartanburg accounts for 60% of the 5 mixed-use properties currently available across Spartanburg County, where nearby markets include Cowpens and Wellford.

Featured Spartanburg Real Estate Agencies

Realmo connects you with licensed Spartanburg CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

Keller Williams Realty Spartanburg Partners

1707 John B White Sr Blvd, Suite E Spartanburg, SC 29301

Phone: 18645746000

www.kwspartanburg.com

Better Homes and Gardens Young & Company

8291 Warren H. Abernathy Highway Spartanburg, SC 29301

Phone: 19706605323

bhgyoung.com

Agent Pros Realty

2992 Reidville Rd Spartanburg, SC 29301

Phone: 18645999907

agentprosrealty.com