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    Columbia, SC
    Mixed-Use

    Columbia, SC Mixed-use Properties for Lease

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    Cayce, SC West Columbia, SC Lexington, SC Irmo, SC Hopkins, SC Blythewood, SC Gaston, SC Elgin, SC
    Historic Mixed-Use Building on Main
    Updated: Nov 26, 2025
    Historic Mixed-Use Building on Main

    1350 Main Street, Columbia, SC 29201

    Contact for pricing
    64,799 sqft
    Prime location in Columbia's Central Business District (CBD) on Main Street.
    Walking distance to the State House, Courthouse, and the University of South Carolina.
    Flexible floor plans & lease terms.
    Landlord pays for up to three parking spaces in adjacent garage.
    Full Service lease structure.
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    Retail or Medical Office Suite
    Updated: Jul 26, 2024
    Retail or Medical Office Suite

    1514 Brentwood Dr, Columbia, SC 29206

    Contact for pricing
    5,680 sqft
    New construction mixed‑use building at 1514 Brentwood Drive with 14,660 SF total building size
    Adjacent to Rigby Square and includes 11 new luxury townhomes
    Located on the Forest Acres retail corridor between Beltline Boulevard and Trenholm Road
    Visible from Forest Drive with approximately 27,600 vehicles passing by daily
    Suitable for high‑end retail or medical office/office users
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    New Mixed-Use Building For Lease
    New Mixed-Use Building For Lease

    1514 Brentwood Dr, Columbia, SC 29206

    Contact for pricing
    14,660 sqft

    New mixed-use building in thriving retail corridor available for lease.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 3 Active listings in Columbia, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Turn-Key Office/Mixed-Use Space
    Turn-Key Office/Mixed-Use Space

    413 Main Street S, New Ellenton, SC 29809

    $1,100/Mo
    840 sqft

    Move-in ready office or mixed-use space available on an NNN lease in downtown New Ellenton.

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    Build-Out Ready Office/Mixed-Use Space
    Build-Out Ready Office/Mixed-Use Space

    413 Main Street S, New Ellenton, SC 29809

    $800/Mo
    510 sqft

    Build-out ready office and mixed-use space available on a NNN lease in New Ellenton.

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    Planned Mixed-Use Development Opportunity
    Planned Mixed-Use Development Opportunity

    573 Chapin Rd, Chapin, SC 29036

    Contact for pricing

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

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    Planned Mixed-Use Development Opportunity
    Planned Mixed-Use Development Opportunity

    565 Chapin Rd, Chapin, SC 29036

    Contact for pricing

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

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    Similar Spaces for Sale in Columbia, SC

    Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

    Mixed-Use Building on Large Lot
    Mixed-Use Building on Large Lot

    3905 Fernandina Rd, Columbia, SC 29210

    Contact for pricing
    9,261 sqft 1.23 AC lot

    Freestanding mixed-use building with highway frontage and redevelopment potential.

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    Office/Warehouse Space on Lake Murray
    Office/Warehouse Space on Lake Murray

    1682 Lake Murray Boulevard, Columbia, SC 29212

    Contact for pricing
    5,384 sqft 1.05 AC lot

    Functional office and warehouse space with convenient access to amenities.

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    Renovated Office and Living Space
    Renovated Office and Living Space

    132 Stonemark Ln, Columbia, SC

    Contact for pricing
    4,138 sqft 0.60 AC lot

    Two-story building with flexible floorplan near Downtown Columbia.

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    Downtown Columbia Redevelopment Opportunity
    Downtown Columbia Redevelopment Opportunity

    1600 Bull Street, Columbia, SC 29201

    Contact for pricing
    21,434 sqft

    One-acre redevelopment site at a prominent downtown intersection.

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    Historic Building in The Vista
    Historic Building in The Vista

    925 Gervais St. & 1217 Park St, Columbia, SC 29201

    Contact for pricing
    12,170 sqft 0.50 AC lot

    Historic building with parking lot suitable for mixed-use development.

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    Multifamily Conversion Opportunity
    Multifamily Conversion Opportunity

    800 Dutch Square Blvd, Columbia, SC 29210

    Contact for pricing
    20,000 sqft

    Two-story buildings ideal for residential conversion in Columbia, SC.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Atlanta Land for Lease
    Atlanta Land for Lease

    1057 Constitution Road SW, Atlanta, GA 30315

    $1,850/Mo

    3-acre commercial land available for lease in Atlanta, GA.

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    Commercial Land with Highway Access
    Commercial Land with Highway Access

    4.12 Acres Al Highway 35, Rainsville, AL 35986

    $6,000/Mo

    Prime commercial land on Highway 35 in Rainsville with an ALDOT-approved entrance and sewer available.

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    Prime Land in Jarrettsville Corridor
    Prime Land in Jarrettsville Corridor

    1753, Jarrettsville, MD 21084

    Contact for pricing

    1.55 acre parcel in Jarrettsville's business corridor.

    View details
    Harrisburg Redevelopment Site For Rent
    Harrisburg Redevelopment Site For Rent

    2150 Herr Street, Harrisburg, PA 17103

    Contact for pricing
    11,000 sqft

    5.85-acre redevelopment site approved for 92 residential units.

    View details

    Columbia, SC Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Columbia, SC with 3 listings featured on our commercial real estate exchange. The current inventory includes 85,139 square feet of properties.
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