Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent / SF / Yr
    $
    $
    Rent / Mo
    $
    $
    Size
    Property size / sq.ft.
    Mixed-Use
    Clear All

    Meet Realmo: The Largest Hub
    of Commercial Real     Estate in the US

    Over 1 million active listings and over 150 million property profiles

    Columbia, SC Mixed-use Properties for Lease

    Notify Me
    List
    Map
    Greenville, SC Charleston, SC Spartanburg, SC
    8 results
    Historic Mixed-Use Building on Main
    $14 SF/Yr
    64,799 SF

    Historic Mixed-Use Building on Main

    1350 Main Street, Columbia, SC 29201

    Mixed-use building in Columbia's Central Business District.

    • Prime location in Columbia's Central Business District (CBD) on Main Street.
    • Walking distance to the State House, Courthouse, and the University of South Carolina.
    • Flexible floor plans & lease terms.
    • Landlord pays for up to three parking spaces in adjacent garage.
    • Full Service lease structure.
    Updated: Nov 26, 2025
    View details
    Updated Mixed-Use Commercial Space
    Contact for pricing
    2,201 SF

    Updated Mixed-Use Commercial Space

    746 Harden St., Columbia, SC 29205

    Updated mixed-use space with parking and high-speed internet in Columbia.

    • Prime location in the heart of Five Points on the corner of Harden and Greene Street.
    • Versatile mixed‑use commercial space with ± 1,932 SF of updated second‑floor space and 269 SF mezzanine storage.
    • Includes LED branded front signage overlooking Five Points fountain.
    • New Electric (Energy Star), HVAC with air purification, and Plumbing including Commercial Shower.
    • Two dedicated on‑site parking spots with EV level 2 charging capability.
    Updated: Jan 27
    View details
    Retail Space on Forest Drive
    Contact for pricing
    1,920 SF

    Retail Space on Forest Drive

    Retail space available in mixed-use development on Forest Drive.

    4609 Forest Dr, Columbia, SC
    View details
    9,000 SF Office Building For Lease
    $8 SF/Yr

    9,000 SF Office Building For Lease

    9,000 SF Office Building For Lease +$8/sqft

    110 Sparkman Dr, Columbia, SC 29209
    View details
    5,225 SF Industrial Building For Lease
    $10 SF/Yr

    5,225 SF Industrial Building For Lease

    5,225 SF Industrial Multiuse Building For Lease

    1457 Bella Vista Dr, Columbia, SC 29223
    View details
    New Mixed-Use Building For Lease
    Contact for pricing
    14,660 SF

    New Mixed-Use Building For Lease

    New mixed-use building in thriving retail corridor available for lease.

    1514 Brentwood Dr, Columbia, SC 29206
    View details
    Urban Redevelopment Mixed-Use Lifestyle District
    Contact for pricing

    Urban Redevelopment Mixed-Use Lifestyle District

    Vibrant mixed-use district in Columbia, SC, with commercial and residential spaces.

    2180 Pickens St, Columbia, SC 29201
    View details
    Retail Space in BullStreet District
    Contact for pricing

    Retail Space in BullStreet District

    Vibrant retail space in Columbia's dynamic BullStreet District.

    2151 Pickens St, Columbia, SC 29201
    View details
    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 8 Active listings in Columbia, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

    Explore Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Mixed-Use Property in Cayce, SC
    $825/Mo
    7,541 SF

    Mixed-Use Property in Cayce, SC

    Mixed-use property suitable for redevelopment, retail, or office use.

    528-532 Knox Abbott Dr, Cayce, SC 29033
    View details
    Planned Mixed-Use Development Opportunity
    Contact for pricing

    Planned Mixed-Use Development Opportunity

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

    565 Chapin Rd, Chapin, SC 29036
    View details
    Planned Mixed-Use Development Opportunity
    Contact for pricing

    Planned Mixed-Use Development Opportunity

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

    573 Chapin Rd, Chapin, SC 29036
    View details
    Redeveloped Mixed-Use Space in Cayce
    Contact for pricing
    8,100 SF

    Redeveloped Mixed-Use Space in Cayce

    Flexible retail or office space in a growing area.

    528-532 Knox Abbott Dr, Cayce, SC 29033
    View details

    Explore Similar Spaces for Sale in Columbia, SC

    Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

    Versatile Commercial Opportunity in Columbia
    $550,000
    3,960 SF

    Versatile Commercial Opportunity in Columbia

    Prime commercial site with existing structure and redevelopment potential.

    123 Lawand Drive, Columbia, SC 29210
    View details
    Columbia, SC Mixed-Use Investment Opportunity
    $2,999,000
    1.74 Acres

    Columbia, SC Mixed-Use Investment Opportunity

    Mixed-use commercial property with gas station, retail, and residential components.

    1332 Broad River, Columbia, SC 29210
    View details
    Downtown Columbia Mixed-Use Opportunity
    $90,000
    0.10 Acres

    Downtown Columbia Mixed-Use Opportunity

    Mixed-use lot in downtown Columbia near amenities and highways.

    617 Richland Street, Columbia, SC 29201
    View details
    Mixed-Use Building on Large Lot
    $1,850,000
    9,261 SF

    Mixed-Use Building on Large Lot

    Freestanding mixed-use building with highway frontage and redevelopment potential.

    3905 Fernandina Rd, Columbia, SC 29210
    View details
    Two Notch Road Commercial Property
    $239,000
    15,600 SF

    Two Notch Road Commercial Property

    Highly visible commercial property with flexible use opportunities.

    4949 Two Notch Rd, Columbia, SC 29204
    View details
    Renovated Office and Living Space
    $925,000
    4,138 SF

    Renovated Office and Living Space

    Two-story building with flexible floorplan near Downtown Columbia.

    132 Stonemark Ln, Columbia, SC
    View details
    Retail/Flex Building in Downtown
    Contact for pricing
    7,500 SF

    Retail/Flex Building in Downtown

    Multi-tenant building with retail, showroom, office, and warehouse space.

    300 Huger Street, Columbia, SC 29201
    View details
    Historic Vista Building with Parking
    Contact for pricing
    12,170 SF

    Historic Vista Building with Parking

    Historic mixed-use building in The Vista with parking lot.

    925 Gervais St. & 1217 Park St., Columbia, SC 29201
    View details
    Downtown Columbia Redevelopment Opportunity
    Contact for pricing
    21,434 SF

    Downtown Columbia Redevelopment Opportunity

    One-acre redevelopment site at a prominent downtown intersection.

    1600 Bull Street, Columbia, SC 29201
    View details
    Multifamily Conversion Opportunity
    $850,000
    20,000 SF

    Multifamily Conversion Opportunity

    Two-story buildings ideal for residential conversion in Columbia, SC.

    800 Dutch Square Blvd, Columbia, SC 29210
    View details
    Historic Building in The Vista
    $2,300,000
    12,170 SF

    Historic Building in The Vista

    Historic building with parking lot suitable for mixed-use development.

    925 Gervais St. & 1217 Park St, Columbia, SC 29201
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Atlanta Land for Lease
    $1,850/Mo

    Atlanta Land for Lease

    3-acre commercial land available for lease in Atlanta, GA.

    1057 Constitution Road SW, Atlanta, GA 30315
    View details
    Prime Commercial Acres For Lease
    $6,000/Mo

    Prime Commercial Acres For Lease

    4.12 acres of commercial land for lease in Rainsville, AL.

    4.12 Acres Al Highway 35, Rainsville, AL 35986
    View details
    MidTown Corner Lot For Rent
    Contact for pricing

    MidTown Corner Lot For Rent

    Corner lot with high visibility in growing Nashville neighborhood.

    1811 Charlotte Avenue, Nashville, TN 37203
    View details
    Prime Land in Jarrettsville Corridor
    Contact for pricing

    Prime Land in Jarrettsville Corridor

    1.55 acre parcel in Jarrettsville's business corridor.

    1753, Jarrettsville, MD 21084
    View details

    Columbia, SC Mixed-use properties Leasing Opportunities Market Analysis

    Explore Mixed-use properties leasing options in Columbia, SC with 8 listings featured on our commercial real estate exchange. The current inventory includes 64,799 square feet of properties with an estimated lease value of $14 SF/Yr.

    Estimated lease rates for Mixed-use properties in Columbia, SC begin at $14 SF/Yr, with an average of $14 SF/Yr and extend to $14 SF/Yr.
    List
    Map

    Browse Mixed-use properties for Lease Near Columbia, SC

    Popular Searches in Columbia, SC

    Popular Categories

    Most Searched ZIP Codes in Columbia, SC

    • 29201
    • 29205
    • 29206
    • 29209
    • 29223

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!