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    Lexington County, SC Mixed-use Properties for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    13 results
    Mixed-Use Property in Cayce, SC
    $825/Mo
    7,541 SF

    Mixed-Use Property in Cayce, SC

    528-532 Knox Abbott Dr, Cayce, SC 29033

    Mixed-use property suitable for redevelopment, retail, or office use.

    • Excellent redevelopment, retail, or office opportunity with 8,100 sq ft of flexible space.
    • Prime location across the river from downtown Columbia, SC.
    • High visibility and easy access to I‑77 and I‑26.
    • Located in Cayce, a growing and diverse market.
    • Ideal for businesses seeking retail exposure or office space.
    Updated: Apr 15
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    Historic Mixed-Use Building on Main
    $14 SF/Yr
    64,799 SF

    Historic Mixed-Use Building on Main

    1350 Main Street, Columbia, SC 29201

    Mixed-use building in Columbia's Central Business District.

    • Prime location in Columbia's Central Business District (CBD) on Main Street.
    • Walking distance to the State House, Courthouse, and the University of South Carolina.
    • Flexible floor plans & lease terms.
    • Landlord pays for up to three parking spaces in adjacent garage.
    • Full Service lease structure.
    Updated: Nov 26, 2025
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    Class-A Mixed-Use Development For Rent
    Contact for pricing
    15,000 SF

    Class-A Mixed-Use Development For Rent

    New mixed-use development with commercial and residential spaces available for rent.

    351 Meeting Street, West Columbia, SC 29169
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    Updated Mixed-Use Commercial Space
    Contact for pricing
    2,201 SF

    Updated Mixed-Use Commercial Space

    Updated mixed-use space with parking and high-speed internet in Columbia.

    746 Harden St., Columbia, SC 29205
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    Retail Space on Forest Drive
    Contact for pricing
    1,920 SF

    Retail Space on Forest Drive

    Retail space available in mixed-use development on Forest Drive.

    4609 Forest Dr, Columbia, SC
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    Planned Mixed-Use Development Opportunity
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    Planned Mixed-Use Development Opportunity

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

    565 Chapin Rd, Chapin, SC 29036
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    Planned Mixed-Use Development Opportunity
    Contact for pricing

    Planned Mixed-Use Development Opportunity

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

    573 Chapin Rd, Chapin, SC 29036
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    9,000 SF Office Building For Lease
    $8 SF/Yr

    9,000 SF Office Building For Lease

    9,000 SF Office Building For Lease +$8/sqft

    110 Sparkman Dr, Columbia, SC 29209
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    5,225 SF Industrial Building For Lease
    $10 SF/Yr

    5,225 SF Industrial Building For Lease

    5,225 SF Industrial Multiuse Building For Lease

    1457 Bella Vista Dr, Columbia, SC 29223
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    Redeveloped Mixed-Use Space in Cayce
    Contact for pricing
    8,100 SF

    Redeveloped Mixed-Use Space in Cayce

    Flexible retail or office space in a growing area.

    528-532 Knox Abbott Dr, Cayce, SC 29033
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    New Mixed-Use Building For Lease
    Contact for pricing
    14,660 SF

    New Mixed-Use Building For Lease

    New mixed-use building in thriving retail corridor available for lease.

    1514 Brentwood Dr, Columbia, SC 29206
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    Urban Redevelopment Mixed-Use Lifestyle District
    Contact for pricing

    Urban Redevelopment Mixed-Use Lifestyle District

    Vibrant mixed-use district in Columbia, SC, with commercial and residential spaces.

    2180 Pickens St, Columbia, SC 29201
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    Retail Space in BullStreet District
    Contact for pricing

    Retail Space in BullStreet District

    Vibrant retail space in Columbia's dynamic BullStreet District.

    2151 Pickens St, Columbia, SC 29201
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    Based on your search, we've compiled 33 Potential Opportunities for your consideration. Besides 13 Active listings in Lexington County, SC, we suggest exploring alternatives. Similar 16 Properties for Sales.

    Similar Spaces for Sale in Lexington County, SC

    Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

    Versatile Commercial Property on Edmund Highway
    $799,000
    4,090 SF

    Versatile Commercial Property on Edmund Highway

    Commercial property with restaurant and warehouse in Lexington, SC.

    6196 Edmund Highway, Lexington, SC 29073
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    Versatile Commercial Opportunity in Columbia
    $550,000
    3,960 SF

    Versatile Commercial Opportunity in Columbia

    Prime commercial site with existing structure and redevelopment potential.

    123 Lawand Drive, Columbia, SC 29210
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    Columbia, SC Mixed-Use Investment Opportunity
    $2,999,000
    1.74 Acres

    Columbia, SC Mixed-Use Investment Opportunity

    Mixed-use commercial property with gas station, retail, and residential components.

    1332 Broad River, Columbia, SC 29210
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    Downtown Lexington Commercial Office Opportunity
    $400,000
    1,190 SF

    Downtown Lexington Commercial Office Opportunity

    Well-located office space near Lexington County Courthouse and Main Street.

    110 N Lake Dr, Lexington, SC 29072
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    Commercial Opportunity in Lexington, SC
    $480,000
    1,600 SF

    Commercial Opportunity in Lexington, SC

    Well-located commercial property suitable for various uses in Lexington, SC.

    108 N Lake Dr, Lexington, SC 29072
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    Mixed-Use Building on Large Lot
    $1,850,000
    9,261 SF

    Mixed-Use Building on Large Lot

    Freestanding mixed-use building with highway frontage and redevelopment potential.

    3905 Fernandina Rd, Columbia, SC 29210
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    Two Notch Road Commercial Property
    $239,000
    15,600 SF

    Two Notch Road Commercial Property

    Highly visible commercial property with flexible use opportunities.

    4949 Two Notch Rd, Columbia, SC 29204
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    Renovated Office and Living Space
    $925,000
    4,138 SF

    Renovated Office and Living Space

    Two-story building with flexible floorplan near Downtown Columbia.

    132 Stonemark Ln, Columbia, SC
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    Office/Retail Building with Warehouse Space
    Contact for pricing
    4,891 SF

    Office/Retail Building with Warehouse Space

    Well-maintained office/retail building with warehouse space and convenient location.

    115 Clark Street, Chapin, SC 29036
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    Retail/Flex Building in Downtown
    Contact for pricing
    7,500 SF

    Retail/Flex Building in Downtown

    Multi-tenant building with retail, showroom, office, and warehouse space.

    300 Huger Street, Columbia, SC 29201
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    Historic Vista Building with Parking
    Contact for pricing
    12,170 SF

    Historic Vista Building with Parking

    Historic mixed-use building in The Vista with parking lot.

    925 Gervais St. & 1217 Park St., Columbia, SC 29201
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Atlanta Land for Lease
    $1,850/Mo

    Atlanta Land for Lease

    3-acre commercial land available for lease in Atlanta, GA.

    1057 Constitution Road SW, Atlanta, GA 30315
    View details
    Prime Commercial Acres For Lease
    $6,000/Mo

    Prime Commercial Acres For Lease

    4.12 acres of commercial land for lease in Rainsville, AL.

    4.12 Acres Al Highway 35, Rainsville, AL 35986
    View details
    MidTown Corner Lot For Rent
    Contact for pricing

    MidTown Corner Lot For Rent

    Corner lot with high visibility in growing Nashville neighborhood.

    1811 Charlotte Avenue, Nashville, TN 37203
    View details
    Prime Land in Jarrettsville Corridor
    Contact for pricing

    Prime Land in Jarrettsville Corridor

    1.55 acre parcel in Jarrettsville's business corridor.

    1753, Jarrettsville, MD 21084
    View details

    Lexington County, SC Mixed-use properties Leasing Opportunities Market Analysis

    Explore Mixed-use properties leasing options in Lexington County, SC with 13 listings featured on our commercial real estate exchange. The current inventory includes 72,340 square feet of properties with an estimated lease value of $15 SF/Yr.

    Estimated lease rates for Mixed-use properties in Lexington County, SC begin at $1.31 SF/Yr, with an average of $7 SF/Yr and extend to $14 SF/Yr.
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    Mixed-use properties by market

    Browse Mixed-use properties for Lease Near Lexington, SC

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