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    Sanibel, FL Mixed-use Properties for Sale

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    Prime Sanibel Commercial Landmark
    $3,295,000
    0.49 Acres

    Prime Sanibel Commercial Landmark

    1446 Periwinkle Way, Sanibel, FL 33957

    Versatile property on Periwinkle Way with business, investment, and lifestyle potential.

    • Prime Periwinkle Way frontage with 150 feet in a high‑traffic commercial corridor.
    • Versatile property featuring a retail building (2,358 sq ft), a residence (2,390 sq ft, 4 bed/2 bath), and a workshop with apartment.
    • Significant income potential through rental of the apartment and/or commercial space.
    • Flexible usage options: retail, office, wellness center, or mixed commercial/residential.
    • Established landmark site with a history of success as the Island Trading Post.
    Updated: Dec 10, 2025
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    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 1 Active listings in Sanibel, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 15 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Redevelopment Opportunity, Fort Myers
    $3,900,000
    0.42 Acres

    Mixed-Use Redevelopment Opportunity, Fort Myers

    Mixed-use redevelopment opportunity in the heart of Fort Myers Beach.

    440 Old San Carlos Blvd, Fort Myers Beach, FL 33931
    View details
    Gulf Access Commercial Property
    $8,900,000
    0.74 Acres

    Gulf Access Commercial Property

    Commercial property on Estero Blvd, Fort Myers Beach, gulf access.

    1207 Estero Blvd, Fort Myers Beach, FL 33931
    View details
    Entitled Land Parcel in Cape Coral
    $1,150,000
    0.69 Acres

    Entitled Land Parcel in Cape Coral

    Mixed-use development opportunity with approved plans for apartments and commercial space.

    430 SW 47Th Ter, Cape Coral, FL 33914
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    Cape Coral Mixed-Use Development
    $1,450,000

    Cape Coral Mixed-Use Development

    39 Units + 8,300 SF Commercial

    430 47Th Ter, Cape Coral, FL 33914
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Sanibel Development Opportunity on Periwinkle
    $2,999,000
    2.29 Acres

    Sanibel Development Opportunity on Periwinkle

    Iconic Sanibel property with frontage on Periwinkle Way.

    1223 Periwinkle Way, Sanibel, FL 33957
    View details

    Explore Off-Market Properties in Sanibel, FL

    Consider similar Off-Market properties in Sanibel, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1609 Periwinkle Way

    1609 Periwinkle Way

    STORE/OFFICE (MIXED USE) • 1,650 SF
    Value Estimation by Request
    1609 Periwinkle Way, Sanibel, FL 33957-4402
    View details
    2422 Palm Rdg Rd

    2422 Palm Rdg Rd

    STORE/OFFICE (MIXED USE) • 1,744 SF
    Value Estimation
    $410,000
    2422 Palm Rdg Rd, Sanibel, FL 33957-3202
    View details
    1157 Periwinkle Way

    1157 Periwinkle Way

    STORE/OFFICE (MIXED USE) • 1,500 SF
    Value Estimation by Request
    1157 Periwinkle Way, Sanibel, FL 33957-4701
    View details
    905 Fitzhugh St, Unit 911

    905 Fitzhugh St, Unit 911

    STORE/OFFICE (MIXED USE) • 1,500 SF
    Value Estimation
    $290,000
    905 Fitzhugh St, Sanibel, FL 33957-4503
    View details
    2402 Palm Rdg Rd

    2402 Palm Rdg Rd

    STORE/OFFICE (MIXED USE) • 2,656 SF
    Value Estimation by Request
    2402 Palm Rdg Rd, Sanibel, FL 33957-3222
    View details
    1506 Periwinkle Way

    1506 Periwinkle Way

    STORE/OFFICE (MIXED USE) • 991 SF
    Value Estimation
    $365,000
    1506 Periwinkle Way, Sanibel, FL 33957-4514
    View details
    2400 Palm Rdg Rd

    2400 Palm Rdg Rd

    STORE/OFFICE (MIXED USE) • 1,500 SF
    Value Estimation by Request
    2400 Palm Rdg Rd, Sanibel, FL 33957-3237
    View details
    1167 Buttonwood Ln

    1167 Buttonwood Ln

    STORE/OFFICE (MIXED USE) • 3,462 SF
    Value Estimation by Request
    1167 Buttonwood Ln, Sanibel, FL 33957-7303
    View details
    2340 Periwinkle Way, Unit R1

    2340 Periwinkle Way, Unit R1

    STORE/OFFICE (MIXED USE) • 747 SF
    Value Estimation
    $255,000
    2340 Periwinkle Way, Sanibel, FL 33957-3203
    View details
    1571 Periwinkle Way

    1571 Periwinkle Way

    STORE/OFFICE (MIXED USE) • 2,455 SF
    Value Estimation
    $905,000
    1571 Periwinkle Way, Sanibel, FL 33957-4513
    View details
    1554 Periwinkle Way

    1554 Periwinkle Way

    STORE/OFFICE (MIXED USE) • 1,612 SF
    Value Estimation
    $285,000
    1554 Periwinkle Way, Sanibel, FL 33957-4519
    View details
    708 Tarpon Bay Rd

    708 Tarpon Bay Rd

    STORE/OFFICE (MIXED USE) • 1,376 SF
    Value Estimation by Request
    708 Tarpon Bay Rd, Sanibel, FL 33957-3114
    View details
    2359 Periwinkle Way

    2359 Periwinkle Way

    STORE/OFFICE (MIXED USE) • 805 SF
    Value Estimation
    $340,000
    2359 Periwinkle Way, Sanibel, FL 33957-3208
    View details
    3889 Sanibel Captiva Rd

    3889 Sanibel Captiva Rd

    STORE/OFFICE (MIXED USE) • 2,112 SF
    Value Estimation by Request
    3889 Sanibel Captiva Rd, Sanibel, FL 33957-3021
    View details
    3333 Sanibel Captiva Rd, Unit 3399

    3333 Sanibel Captiva Rd, Unit 3399

    STORE/OFFICE (MIXED USE) • 5,422 SF
    Value Estimation
    $525,000
    3333 Sanibel Captiva Rd, Sanibel, FL 33957-3100
    View details

    Sanibel, FL Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 16 mixed-use properties for sale in Sanibel, FL on our real estate platform. These investment opportunities span a total of 9,345,179 square feet of properties for sale, with an estimated market value of $5,830,000.

    Prices for multi use buildings in Sanibel, FL start at $180,000, averaging $647,777, and reaching up to $3,295,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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    Most Searched ZIP Codes in Sanibel, FL

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