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    Lee County, FL Mixed-use Properties for Sale

    10 results
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    Fort Myers Live/Work Opportunity
    $3,795,000
    1.06 Acres

    Fort Myers Live/Work Opportunity

    3131 E Riverside Dr, Fort Myers, FL 33916

    Fenced property with security, new roof, and hurricane windows.

    • River Front property with waterfront office sections.
    • Previously approved for PUD high‑rise development by the City.
    • New 175mph hurricane resistant windows with lifetime warranty.
    • New Firestone TPO roof with remaining multi‑year warranty.
    • Completely fenced‑in with security lighting and electronic security coded gate access.
    Updated: Dec 10, 2025
    View details
    Cape Coral Mixed-Use Duplex
    $575,000
    0.23 Acres

    Cape Coral Mixed-Use Duplex

    2828 Santa Barbara Blvd, Cape Coral, FL 33914

    Mixed-use duplex in Cape Coral, ideal for live/work setup.

    • Mixed‑use duplex zoned MR (Marketplace Residential) offering live/work/investment potential.
    • Turn‑key commercial space currently operating as a successful pet grooming and daycare business, including equipment and client list.
    • Comfortable residential unit suitable for owner occupancy or rental income.
    • Flexible MR zoning allows for various business uses including pet services, veterinary clinic, daycare, offices, or residential.
    • Prime Cape Coral location with excellent visibility, convenient parking, and a welcoming layout.
    Updated: Dec 10, 2025
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    Mixed-Use Redevelopment Opportunity, Fort Myers
    $3,900,000
    0.42 Acres

    Mixed-Use Redevelopment Opportunity, Fort Myers

    Mixed-use redevelopment opportunity in the heart of Fort Myers Beach.

    440 Old San Carlos Blvd, Fort Myers Beach, FL 33931
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    Prime Sanibel Commercial Landmark
    $3,295,000
    0.49 Acres

    Prime Sanibel Commercial Landmark

    Versatile property on Periwinkle Way with business, investment, and lifestyle potential.

    1446 Periwinkle Way, Sanibel, FL 33957
    View details
    Mixed-Use Development Site with Plans
    $28,750,000
    0.33 Acres

    Mixed-Use Development Site with Plans

    Mixed-use development site with approved plans in downtown Cape Coral.

    1415 Cape Coral Pkwy E, Cape Coral, FL 33904
    View details
    Cape Coral Mixed-Use Development
    $2,150,000
    1.33 Acres

    Cape Coral Mixed-Use Development

    78 Units, Entitled Land, High ROI

    3727 15Th Pl, Cape Coral, FL 33904
    View details
    Prime Fort Myers Beach Flex Space
    $4,250,000
    13,250 SF

    Prime Fort Myers Beach Flex Space

    13,250 SF building, 2.23 acres, Gulf access

    17651 San Carlos Blvd, Fort Myers Beach, FL 33931
    View details
    Fort Myers Mixed-Use Investment
    $5,950,000
    24,900 SF

    Fort Myers Mixed-Use Investment

    24-unit multifamily, retail complex, high ROI.

    2741 1St St, Fort Myers, FL 33916
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    Riverside Drive Industrial Property
    $4,795,000
    24,700 SF

    Riverside Drive Industrial Property

    Fort Myers flex space, riverfront location.

    3131 Riverside Dr, Fort Myers, FL 33916
    View details
    Prime Cape Coral Mixed-Use Redevelopment
    $2,200,000
    24,125 SF

    Prime Cape Coral Mixed-Use Redevelopment

    Downtown Cape Coral, 24,125 SF, Owner Financing

    4712 15Th Ave, Cape Coral, FL 33904
    View details
    Based on your search, we've compiled 201 Potential Opportunities for your consideration. Besides 10 Active listings in Lee County, FL, we suggest exploring several alternatives: similar 187 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Cape Coral Commercial Lots
    $299,900
    0.14 Acres

    Cape Coral Commercial Lots

    Two commercial lots near Cape Coral Parkway, zoned SC Mixed-Use.

    819 Lafayette St, Cape Coral, FL 33904
    View details
    Prime Corner Cape Coral Location
    $899,000
    0.25 Acres

    Prime Corner Cape Coral Location

    Commercial lot in the heart of Cape Coral.

    1725 Cape Coral Pkwy E, Cape Coral, FL 33904
    View details
    Cape Coral Commercial Lot Opportunity
    $1,300,000
    0.26 Acres

    Cape Coral Commercial Lot Opportunity

    Vacant commercial lot in high-visibility Cape Coral Parkway location.

    429 Cape Coral Pkwy E, Cape Coral, FL 33904
    View details
    Commercial Lot in Cape Coral
    $269,000
    0.61 Acres

    Commercial Lot in Cape Coral

    Development opportunity in rapidly growing Cape Coral, Florida.

    1808 Skyline Blvd, Cape Coral, FL 33991
    View details

    Explore Off-Market Properties in Lee County, FL

    Consider similar Off-Market properties in Lee County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    & Coral Pt Dr

    & Coral Pt Dr

    Retail properties • 125,108 SF
    Value Estimation by Request
    0 & Coral Pt Dr, Cape Coral, FL 33990
    View details
    2741 1St St

    2741 1St St

    Individual retail properties • 24,900 SF
    Value Estimation by Request
    2741 1St St, Fort Myers, FL 33916
    View details
    735 19Th St

    735 19Th St

    Industrial properties
    Value Estimation by Request
    735 19Th St, Cape Coral, FL 33909
    View details
    135 Mango St

    135 Mango St

    Mixed-use properties • 2,546 SF
    Value Estimation by Request
    135 Mango St, Fort Myers Beach, FL 33931
    View details
    512 Estero Blvd

    512 Estero Blvd

    STORE/OFFICE (MIXED USE) • 924 SF
    Value Estimation by Request
    512 Estero Blvd, Fort Myers Beach, FL 33931-2019
    View details
    7010 Granada Lks Dr

    7010 Granada Lks Dr

    STORE/OFFICE (MIXED USE) • 2,088 SF
    Value Estimation by Request
    7010 Granada Lks Dr, Fort Myers, FL 33967-6079
    View details
    787 Pondella Rd

    787 Pondella Rd

    STORE/OFFICE (MIXED USE) • 2,268 SF
    Value Estimation
    $250,000
    787 Pondella Rd, North Fort Myers, FL 33903-5761
    View details
    4200 Pne Is NW Rd

    4200 Pne Is NW Rd

    STORE/OFFICE (MIXED USE) • 1,608 SF
    Value Estimation
    $210,000
    4200 Pne Is NW Rd, Matlacha, FL 33993-9775
    View details
    720 Pondella Rd

    720 Pondella Rd

    STORE/OFFICE (MIXED USE) • 3,701 SF
    Value Estimation
    $360,000
    720 Pondella Rd, North Fort Myers, FL 33903-5760
    View details
    1793 Fowler St

    1793 Fowler St

    STORE/OFFICE (MIXED USE) • 1,280 SF
    Value Estimation
    $360,000
    1793 Fowler St, Fort Myers, FL 33901-3002
    View details
    1130 Main St

    1130 Main St

    STORE/OFFICE (MIXED USE) • 3,480 SF
    Value Estimation by Request
    1130 Main St, Fort Myers Beach, FL 33931-2212
    View details
    421 Park Ave

    421 Park Ave

    STORE/OFFICE (MIXED USE) • 1,977 SF
    Value Estimation
    $4,245,000
    421 Park Ave, Boca Grande, FL 33921-1000
    View details
    431 Park Ave

    431 Park Ave

    STORE/OFFICE (MIXED USE) • 1,920 SF
    Value Estimation by Request
    431 Park Ave, Boca Grande, FL 33921-1000
    View details
    473 Marsh Ave

    473 Marsh Ave

    STORE/OFFICE (MIXED USE) • 2,953 SF
    Value Estimation
    $235,000
    473 Marsh Ave, Fort Myers, FL 33905
    View details

    Lee County, FL Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 194 mixed-use properties for sale in Lee County, FL, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 18,171,328 square feet of properties for sale, with an estimated market value of $194,778,512.

    Prices for multi use buildings in Lee County, FL start at $70,000, averaging $1,352,628, and reaching up to $28,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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    Mixed-use properties by market

    Browse Mixed-use properties for Sale Near Lee, FL

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