Add Listing
    Roanoke, VA
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Roanoke, VA Medical Office Space for Lease

    Notify Me
    List
    Map
    Vinton, VA Salem, VA Hollins, VA
    11 results
    Brambleton Avenue Commercial Space Available
    $22 SF/Yr
    1,700 SF

    Brambleton Avenue Commercial Space Available

    5002 Brambleton Ave, Roanoke, VA 24018

    1,700 SF space suitable for medical, office, or retail.

    • High‑traffic location on Brambleton Ave with 26,000 vehicles per day
    • Versatile 1,700 SF space suitable for medical, professional office, or retail use
    • Previously a dental office, featuring 4 operatories, reception area, 2 bathrooms, office, sterilization area, and break room
    • Close proximity to the new Publix site and established neighborhoods
    • Located in a desirable area of southwest county
    Updated: Mar 6
    View details
    Prime Commercial Space in Roanoke
    $12 SF/Yr
    10,923 SF

    Prime Commercial Space in Roanoke

    2727 Franklin Rd, Roanoke, VA

    Modern, versatile office space in Roanoke's Innovation Corridor.

    • Prime location in Roanoke's Innovation Corridor, near medical, research, and professional facilities.
    • Excellent connectivity with direct access to I‑581 and U.S. 220.
    • High visibility on Franklin Road with approximately 28,000 AADT.
    • Ample parking for clients and employees.
    • Modern and versatile space with customizable floor plans.
    Updated: Jul 29, 2025
    View details
    Retail Space Near Valley View
    Contact for pricing
    6,900 SF

    Retail Space Near Valley View

    Endcap space for sale or lease near Valley View Mall.

    1920 Valley View Blvd NW, Roanoke, VA 24012
    View details
    Roanoke Office and Medical Space
    $16 SF/Yr
    1,152 SF

    Roanoke Office and Medical Space

    Office and medical space in Roanoke's growth corridor.

    1315 2nd St SW, Roanoke, VA
    View details
    New Class A Office Space
    Contact for pricing
    6,500 SF

    New Class A Office Space

    Newly constructed medical/professional office space for lease in Roanoke County.

    3090 Electric Rd, Roanoke, VA
    View details
    First Floor Office Suite
    $14 SF/Yr
    3,000 SF

    First Floor Office Suite

    Office suite for rent with high visibility and ample parking.

    5304 Indian Grave Rd, Roanoke, VA
    View details
    Office Space in Prime Location
    $15 SF/Yr
    2,023 SF

    Office Space in Prime Location

    Ready-to-use office suites in a demographically affluent Roanoke neighborhood.

    3241 Electric Rd, Roanoke, VA
    View details
    Medical/Professional Office Space Available
    $19 SF/Yr
    3,000 SF

    Medical/Professional Office Space Available

    3,000 SF medical/professional office space for lease.

    375 Hershberger Rd, Roanoke, VA
    View details
    Roanoke Office Space For Lease
    $11 SF/Yr
    1,912 SF

    Roanoke Office Space For Lease

    Ready-to-use office suites in a well-located Roanoke office park.

    3247 Electric Rd, Roanoke, VA
    View details
    Professional Office Space For Lease
    $12 SF/Yr
    957 SF

    Professional Office Space For Lease

    Customizable office suites in affluent Roanoke neighborhood, recently renovated.

    3243 Electric Rd, Roanoke, VA
    View details
    Office or Medical Space Available
    $17 SF/Yr
    1,800 SF

    Office or Medical Space Available

    Office or medical space for lease in Roanoke, Virginia.

    4633 Brambleton Ave, Roanoke, VA
    View details
    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 11 Active listings in Roanoke, VA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Move-in Ready Medical Office Condo
    $1.00 SF/Yr

    Move-in Ready Medical Office Condo

    Former dental/medical office space with existing infrastructure in Staunton, VA.

    1557 COMMERCE AVE, Staunton, VA 24401
    View details
    Move-in Ready Medical Office Condo
    $1.00 SF/Yr

    Move-in Ready Medical Office Condo

    Former dental/medical office space with existing infrastructure.

    1557 COMMERCE AVE, Staunton, VA 24401
    View details
    North Greensboro Office/Medical Space
    $14 SF/Yr
    1,760 SF

    North Greensboro Office/Medical Space

    Office or medical space for lease in north Greensboro.

    2704-2722 N Church St, Greensboro, NC
    View details
    Medical Office Space Available
    Contact for pricing

    Medical Office Space Available

    Medical office space for rent with easy highway access.

    3200 Horse Pen Creek Rd, Greensboro, NC 27410
    View details

    Similar Spaces for Sale in Roanoke, VA

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Updated Commercial Space with Parking
    $299,950
    0.22 Acres
    Updated Commercial Space with Parking

    Remodeled commercial space with parking near airport and retail.

    5111 Airport Rd NW, Roanoke, VA 24012

    View details
    Medical/Office Building Near Valley View
    Contact for pricing
    60,055 SF
    Medical/Office Building Near Valley View

    60,055 RSF medical/office building adjacent to Valley View Mall.

    4910 Valley View Boulevard Northwest, Roanoke, VA 24012

    View details
    Medical/Office Building in Roanoke County
    $1,250,000
    5,678 SF
    Medical/Office Building in Roanoke County

    5,678 SF medical/office building on 1.15 acre site.

    5303 Indian Grave Rd, Roanoke, VA

    View details
    South Roanoke Office/Medical Opportunity
    $1,750,000
    6,631 SF
    South Roanoke Office/Medical Opportunity

    Office or medical building near Carilion Roanoke Memorial Hospital.

    301 McClanahan St - SW, Roanoke, VA

    View details
    South Roanoke Office/Medical Building For Sale
    $1,750,000
    6,631 SF
    South Roanoke Office/Medical Building For Sale

    Office or medical building in South Roanoke with parking.

    301 McClanahan St SW, Roanoke, VA 24014

    View details
    Medical Office Building For Rent
    $1,150,000
    3,391 SF
    Medical Office Building For Rent

    Southwest County medical office building with two suites available.

    5100-5104 Bernard Dr, Roanoke, VA

    View details
    Roanoke Office Building with Views
    $1,350,000
    10,129 SF
    Roanoke Office Building with Views

    10,129 SF office building with valley views for sale.

    7851-7857 Enon Dr, Roanoke, VA

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Corner Lot on Highway 72
    $5,000/Mo
    1,875 SF

    Corner Lot on Highway 72

    1.7 acre corner lot zoned for commercial, medical, residential.

    30472 Highway 72, Madison, AL 35756
    View details
    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    WINTER PARK Land Lease Opportunity
    $8,500/Mo
    23,056 SF

    WINTER PARK Land Lease Opportunity

    Commercial land lease opportunity in Winter Park, Florida.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details

    Roanoke, VA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Roanoke, VA with 11 listings featured on our commercial real estate exchange. The current inventory includes 26,467 square feet of properties with an estimated lease value of $139 SF/Yr.

    Estimated lease rates for Medical Office Space in Roanoke, VA begin at $11 SF/Yr, with an average of $15 SF/Yr and extend to $22 SF/Yr.
    List
    Map

    Popular Searches in Roanoke, VA

    Popular Categories

    Most Searched ZIP Codes in Roanoke, VA

    • 24012
    • 24018

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!