Roanoke, VA Medical Office Space for Lease

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Updated: Jun 1

Bank-Converted Office Building

301 McClanahan Street SW, Roanoke, VA 24014

$15 SF/Yr

6,631 sqft · $8,288/Mo

Former Wells Fargo bank branch with ~3,300 SF on two floors (total 6,631 SF).
Second‑floor office space was recently renovated and is ready for use.
First floor includes office space and a drive‑thru option if desired.
34 on‑site parking spaces for employees and visitors.
Multiple ingress/egress points for access flexibility.

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Updated: Jul 29, 2025

Prime Commercial Space in Roanoke

2727 Franklin Rd, Roanoke, VA

$12 SF/Yr

10,923 sqft · $11,605/Mo

Prime location in Roanoke's Innovation Corridor, near medical, research, and professional facilities.
Excellent connectivity with direct access to I‑581 and U.S. 220.
High visibility on Franklin Road with approximately 28,000 AADT.
Ample parking for clients and employees.
Modern and versatile space with customizable floor plans.

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Office Space Off Interstate

1125 South Jefferson St., Roanoke, VA 24016

$12 SF/Yr

Office leasing opportunity with convenient access just off 581 for a range of professional uses.

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Retail Space Near Valley View

1920 Valley View Blvd NW, Roanoke, VA 24012

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6,900 sqft

Endcap space for sale or lease near Valley View Mall.

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New Class A Office Space

3090 Electric Rd, Roanoke, VA

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6,500 sqft

Newly constructed medical/professional office space for lease in Roanoke County.

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Medical/Office Building in Roanoke County

5303 Indian Grave Rd, Roanoke, VA

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5,678 sqft

5,678 SF medical/office building on 1.15 acre site.

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First Floor Office Suite

5304 Indian Grave Rd, Roanoke, VA

$16 SF/Yr

3,000 sqft · $4,000/Mo

Office suite for rent with high visibility and ample parking.

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Office Space in Prime Location

3241 Electric Rd, Roanoke, VA

$15 SF/Yr

2,023 sqft · $2,528/Mo

Ready-to-use office suites in a demographically affluent Roanoke neighborhood.

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Roanoke Office Space For Lease

3247 Electric Rd, Roanoke, VA

$11 SF/Yr

1,912 sqft · $1,752/Mo

Ready-to-use office suites in a well-located Roanoke office park.

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Professional Office Space For Lease

3243 Electric Rd, Roanoke, VA

$12 SF/Yr

957 sqft · $957/Mo

Customizable office suites in affluent Roanoke neighborhood, recently renovated.

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Medical/Professional Office Space Available

375 Hershberger Rd, Roanoke, VA

$19 SF/Yr

3,000 sqft · $4,750/Mo

3,000 SF medical/professional office space for lease.

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Office or Medical Space Available

4633 Brambleton Ave, Roanoke, VA

$17 SF/Yr

1,800 sqft · $2,550/Mo

Office or medical space for lease in Roanoke, Virginia.

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Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 12 Active listings in Roanoke, VA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Building with Parking

401 Depot St NW, Christiansburg, VA 24073

$14 SF/Yr

Flexible office and treatment-room layout with reception, kitchenette, and dedicated parking for daily client access.

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Medical Office Space Available

825 Davis Street, Blacksburg, VA 24060

$25 SF/Yr

9,900 sqft · $20,625/Mo

9,900 SF medical office space for lease.

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Christiansburg Professional Park Office Space

90 College St, Christiansburg, VA

$16 SF/Yr

2,200 sqft · $2,933/Mo

Office space available in Christiansburg Professional Park.

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Medical Office Suites in Professional Park

200 PROFESSIONAL PARK DR SE, Blacksburg, VA 24060

Contact for pricing

2,960 sqft

Flexible two-suite medical office setup with shared reception and multiple restrooms for efficient client visits.

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Similar Spaces for Sale in Roanoke, VA

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Medical Office Building with Mobile Shelving

2118 Rosalind Ave SW, Roanoke, VA 24014

$1,300,000

0.44 AC lot

Medical office property with full build-out, two conference rooms, and paved parking for 28 vehicles.

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Storefront with New Roof

1217 Salem Ave Sw, Roanoke, VA 24016

$105,000

Blank-canvas storefront suited for retail, health services, or repair use, with a new roof installed in 2024.

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South Roanoke Office/Medical Opportunity

301 McClanahan St - SW, Roanoke, VA

$1,750,000

6,631 sqft · 0.72 AC lot

Office or medical building near Carilion Roanoke Memorial Hospital.

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Medical/Office Building Near Valley View

4910 Valley View Boulevard Northwest, Roanoke, VA 24012

Contact for pricing

60,055 sqft

60,055 RSF medical/office building adjacent to Valley View Mall.

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Medical Office Building For Rent

5100-5104 Bernard Dr, Roanoke, VA

$1,150,000

3,391 sqft · 0.36 AC lot

Southwest County medical office building with two suites available.

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Roanoke Office Building with Views

7851-7857 Enon Dr, Roanoke, VA

$1,350,000

10,129 sqft · 3.10 AC lot

10,129 SF office building with valley views for sale.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Development Opportunity in Greenville

39 Airpark Ct, Greenville, SC 29607

Contact for pricing

1.27 acre interstate-visible land for ground lease or build-to-suit.

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Commercial Land Parcel with Utilities

2585 Maple Lane, Pittsburgh, PA 15241

$50,000 SF/Yr

Level, fully serviced commercial parcel with approvals in place and signage permitted up to 20 sq ft.

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Prime Lexington Outlot Opportunity

3330 Partner Place, Lexington, KY 40503

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Outlot for ground lease or build-to-suit in South Lexington.

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Beaumont Centre Outparcel Opportunity

3199 Beaumont Centre Circle, Lexington, KY 40513

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Outparcel opportunity in established shopping center for ground lease.

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Roanoke, VA Medical Office Space Market Trends and Statistics

Explore Medical Office Space leasing options in Roanoke, VA with 12 listings featured on our commercial real estate exchange. The current inventory includes 30,246 square feet of properties with an estimated lease value of $117 SF/Yr.

Estimated lease rates for Medical Office Space in Roanoke, VA begin at $11 SF/Yr, with an average of $14 SF/Yr and extend to $19 SF/Yr.

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