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    Roanoke, VA
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    Roanoke, VA Commercial Real Estate for Lease

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    Vinton, VA Salem, VA Hollins, VA
    146 results
    Bank-Converted Office Building
    $15 SF/Yr
    6,631 SF

    Bank-Converted Office Building

    301 McClanahan Street SW, Roanoke, VA 24014

    Converted for office or medical use with renovated second-floor space and on-site parking for convenient access.

    • Former Wells Fargo bank branch with ~3,300 SF on two floors (total 6,631 SF).
    • Second‑floor office space was recently renovated and is ready for use.
    • First floor includes office space and a drive‑thru option if desired.
    • 34 on‑site parking spaces for employees and visitors.
    • Multiple ingress/egress points for access flexibility.
    Updated: Jun 1
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    Spacious Open Floorplan Office Space
    $3 SF/Yr
    18,200 SF

    Spacious Open Floorplan Office Space

    3441 Brandon Ave SW, Roanoke, VA 24018

    Large office space with flexible layout on Brandon Avenue.

    • High‑traffic location on Brandon Ave, ideal for businesses serving Southwest County, Downtown Roanoke, and surrounding areas.
    • Large ±18,200 sf space with a mostly open floorplan.
    • Flexible space that can be demised to fit various business needs.
    • Multiple bathrooms.
    • Owner willing to discuss tenant improvements at an adjusted lease rate.
    Updated: Mar 6
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    Brambleton Avenue Commercial Space Available
    $22 SF/Yr
    1,700 SF

    Brambleton Avenue Commercial Space Available

    1,700 SF space suitable for medical, office, or retail.

    5002 Brambleton Ave, Roanoke, VA 24018
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    Downtown Roanoke Office or Retail
    $10 SF/Yr
    2,600 SF

    Downtown Roanoke Office or Retail

    Office or retail space in downtown Roanoke.

    9 Franklin Rd SW, Roanoke, VA 24011
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    Retail/Office Space on Brambleton Ave
    $12 SF/Yr
    7,260 SF

    Retail/Office Space on Brambleton Ave

    Well-maintained retail/office space with excellent road visibility.

    Roanoke, VA 24018
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    Retail Space on Melrose Avenue
    $11 SF/Yr
    8,316 SF

    Retail Space on Melrose Avenue

    8,316 SF retail space with excellent visibility in Roanoke.

    4160 Melrose Avenue Northwest, Roanoke, VA 24017
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    Downtown Roanoke Office Space
    $15 SF/Yr
    1,550 SF

    Downtown Roanoke Office Space

    Professional office space in a beautifully restored historic building.

    120 Day Ave SW, Roanoke, VA
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    Roanoke Office Space for Rent
    $12 SF/Yr
    2,000 SF

    Roanoke Office Space for Rent

    Updated office space with hardwood floors and dedicated parking.

    1524 Patrick Rd NE, Roanoke, VA
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    Warehouse and Office Space Available
    $5 SF/Yr
    25,050 SF

    Warehouse and Office Space Available

    25,050 SF warehouse and 7,500 SF office space for lease.

    2240 Shenandoah Ave NW, Roanoke, VA 24017
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    Accessible Office Space Near Downtown
    $12 SF/Yr
    7,544 SF

    Accessible Office Space Near Downtown

    Office space with easy access and close to downtown Roanoke.

    Roanoke, VA 24016
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    Downtown Roanoke Office Space Available
    $18 SF/Yr
    306 SF

    Downtown Roanoke Office Space Available

    Historic building with professional office space in downtown Roanoke.

    304 Market St SE, Roanoke, VA
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    Professional Office at McVitty Center
    $20 SF/Yr
    853 SF

    Professional Office at McVitty Center

    853 SF office condo in well-established professional park.

    2758 Electric Rd, Roanoke, VA
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    North Roanoke Plaza Retail/Office Space
    $14 SF/Yr
    875 SF

    North Roanoke Plaza Retail/Office Space

    Retail and office spaces available in North Roanoke Plaza.

    3100 Peters Creek Rd, Roanoke, VA
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    Retail Space in West Village
    $20 SF/Yr
    3,925 SF

    Retail Space in West Village

    Flexible retail spaces available for lease in a visible center.

    3555 Electric Rd, Roanoke, VA
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    Prime Commercial Space in Roanoke
    $12 SF/Yr
    10,923 SF

    Prime Commercial Space in Roanoke

    Modern, versatile office space in Roanoke's Innovation Corridor.

    2727 Franklin Rd, Roanoke, VA
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    Retail Space in High-Traffic Area
    $12 SF/Yr
    1,750 SF

    Retail Space in High-Traffic Area

    Retail space with high visibility and strong residential base.

    631-635 Peters Creek Rd NW, Roanoke, VA
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    Renovated Office Space in Roanoke
    $12 SF/Yr
    2,000 SF

    Renovated Office Space in Roanoke

    Turnkey office space with modern updates and convenient location.

    1524 Patrick Rd NE, Roanoke, VA 24012
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    Modern Office Warehouse Building
    $13 SF/Yr

    Modern Office Warehouse Building

    A modern office-warehouse facility with abundant on-site parking, well-suited for businesses needing flexible work and storage space.

    442 Rutherford Ave NE, Roanoke, VA 24016
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    Retail Space Near Valley View
    Contact for pricing
    6,900 SF

    Retail Space Near Valley View

    Endcap space for sale or lease near Valley View Mall.

    1920 Valley View Blvd NW, Roanoke, VA 24012
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    Refreshed Office Space Available
    $14 SF/Yr
    91,500 SF

    Refreshed Office Space Available

    Modern office space in Roanoke's revitalized central business district.

    34 Campbell Ave SW, Roanoke, VA 24011
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    Renovated Office Space Available
    $16 SF/Yr
    1,577 SF

    Renovated Office Space Available

    Newly renovated office space with flexible layout and great location.

    4728 Starkey Rd, Roanoke, VA
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    Premier Office Space For Lease
    Contact for pricing
    4,700 SF

    Premier Office Space For Lease

    Modern, renovated office space with excellent visibility and easy access.

    5363 Peters Creek Rd NW, Roanoke, VA 24019
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    Premium Office Space Available
    $15 SF/Yr
    6,150 SF

    Premium Office Space Available

    Premium office space for lease in Roanoke Valley.

    5251 S Concourse Dr, Roanoke, VA
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    Office Space Off Interstate
    $12 SF/Yr

    Office Space Off Interstate

    Office leasing opportunity with convenient access just off 581 for a range of professional uses.

    1125 South Jefferson St., Roanoke, VA 24016
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    Roanoke, VA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Roanoke, VA with 146 listings featured on our commercial real estate exchange. The current inventory includes 858,041 square feet of properties with an estimated lease value of $1,561 /Mo.

    Estimated lease rates for Commercial real estate in Roanoke, VA begin at $1.95 SF/Yr, with an average of $16 SF/Yr and extend to $229 SF/Yr.
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