Greenville County, SC Office Spaces for Sale

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141 properties

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Updated: Jul 29

Office Building with Available Space

110 Frederick Street, Greenville, SC 29607

$7,950,000

46,028 sqft 4.38 AC lot

52,700 SF office building on a 4.38‑acre site
71% leased to Advanced Technology Services
Lease extends through September 2033
15,200 SF of available space
7/1000 parking ratio

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This listing looks promising.

Here's a quick look at some key insights for

110 Frederick Street, Greenville, SC 29607

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Est. Cap Rate

8.9%
Above avg (5.9%)
Est. NOI

$708K
Annual
Mortgage

$5.75M
Feb 2026
Last Sold

Feb 2026
$7.5M

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Updated: May 4

Renovated Multi-Suite Office Building

554 Memorial Drive Extension, Greer, SC 29651

$1,200,000

0.50 AC lot

Office‑General zoning at 554 Memorial Drive Extension, Greer, SC 29651
0.5‑acre office property with parking at the front and rear
Renovations completed during 2022‑2023
Four separate access points support multiple potential office suites
Lower level renovated from the studs outward

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Single-Level Brick Medical Office

203 S Weston Street, Fountain Inn, SC 29644

$1,500,000

0.59 AC lot

C-1 zoning, an included adjacent lot, and a detached brick outbuilding support flexible medical-office use.

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Mixed-Use Property with Two Buildings

Poinsett Highway, Greenville, SC 29609

$1,400,000

0.72 AC lot

Corner property near downtown Greenville with parking, public water service, and flexible commercial use potential.

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Office/Warehouse with Drive-In Door

9 Ellwood Ct, Greenville, SC 29607

$1,900,000

13,171 sqft 1.20 AC lot

Office warehouse building with assembly space plus both dock and drive-in access for flexible industrial operations.

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Single-Level Office Building

1 Elizabeth Drive, Greenville, SC 29615

$384,900

0.34 AC lot

Refreshed professional office property with flexible work areas, reception space, kitchen, restrooms, and rear storage.

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Multi-Building Office Property

413 Vardry Street, Greenville, SC 29601

$3,499,000

0.75 AC lot

Brick office complex with multiple buildings, dedicated parking, exterior signage, and OD zoning near central Greenville.

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Freestanding Office Building on Corner Lot

106 S Texas Avenue, Greenville, SC 29611

$495,000

0.57 AC lot

Freestanding office building with Office District (OD) zoning and public water service on a prominent corner parcel.

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Single-Story Office Building

121 Edinburgh Ct, Greenville, SC 29607

$1,300,000

5,675 sqft

MX-2-zoned office property with two separate entrances and shared parking.

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Two-Level Office Building

221 Adley Way, Greenville, SC 29607

$475,000

0.06 AC lot

Office property with an occupied lower level, available upper floor, parking, and adaptable professional-use space.

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Freestanding Office Building

106 S Texas Avenue, Greenville, SC 29611

$495,000

0.57 AC lot

Freestanding office building with an executive office, multiple private offices, reception area, and on-site parking.

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Downtown Mixed-Use Property

117 Asbury Ave, Greenville, SC 29601

$519,000

1,732 sqft

Existing infill building with MX-2 zoning, flexible room layout, hardwood floors, and strong natural light.

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Office Building

1601 Rutherford Road, Greenville, SC 29609

$390,000

0.28 AC lot

S-1-zoned office property with linoleum and tile flooring.

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C-2 Office Building

1908 N Pleasantburg Drive, Greenville, SC 29609

$398,500

0.47 AC lot

The property features block construction, carpeted interiors, and natural-gas heating.

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Live-Work and Office Property

906 Augusta Street, Greenville, SC 29605

$1,395,000

0.35 AC lot

MX2 zoned property with a new roof, 12-car parking, and four exterior access doors for flexible live, office, or rental use.

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Freestanding Office Building

106 S Texas Avenue, Greenville, SC 29611

$495,000

2,384 sqft 0.57 AC lot

Mid-century design, private offices, natural light, and a flexible layout support professional occupancy.

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Historic Creative Workspace

300 South St, Simpsonville, SC 29681

$1,750,000

8,082 sqft

Flexible commercial layout with open work areas, private rooms, offices, restrooms, a breakroom, and an outdoor patio.

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Mixed-Use Corner Assemblage

302 W Washington Street, Greenville, SC 29601

$8,500,000

58,662 sqft 2.07 AC lot

Five contiguous parcels combine existing improvements with flexibility for office, institutional, warehouse, or adaptive reuse applications.

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Simpsonville Commercial Building For Sale

313 N Main Street, Simpsonville, SC 29681

$3,995,000

24,000 sqft

24,000 SF building in Simpsonville, SC, renovated in 2013.

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Greenville Flex Facility Near Trail

17 Pinsley Cir, Greenville, SC 29617

$1,600,000

10,000 sqft

10,000 SF flex facility on 2-acre fenced lot.

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Fenced Flex Industrial Property

211 N Pleasantburg Dr, Greenville, SC 29607

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13,188 sqft 1.54 AC lot

Flexible office and warehouse configuration with secured outdoor storage, gated access, and loading capability.

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Flex Space with Secured Yard

211 N Pleasantburg Dr, Greenville, SC 29607

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13,188 sqft 1.54 AC lot

Office, showroom, and warehouse areas support varied commercial operations with gated outdoor storage and direct customer access.

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Office Building with Flexible Occupancy

1247-1251 S Pleasantburg Dr, Greenville, SC 29605

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9,877 sqft 0.51 AC lot

Office property offering a partially leased configuration, available space, and existing cubicles and FF&E that may remain.

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Absolute NNN Dental Office

1173 Ashmore Bridge Rd, Greenville, SC 29605

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4,200 sqft

Newly delivered dental office offered on an Absolute NNN basis with a long-term lease and corporate guarantee.

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Greenville County, SC Office Spaces Market Trends and Statistics

Explore 141 office spaces for sale in Greenville County, SC, showcased through 141 active listings on our real estate platform. These investment opportunities span a total of 1,245,258 square feet of properties for sale, with an estimated market value of $52,673,400.

Sale prices for office spaces in Greenville County, SC start at $265,000, averaging $1,549,217, and reaching up to $8,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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