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Lee County, FL Office Buildings for Sale

40 results
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Office/Medical Office Park Available
Contact for pricing
5.17 Acres

Office/Medical Office Park Available

6831 Palisades Park Ct, Fort Myers, FL 33912

Centrally located office and medical office spaces with ample parking.

  • Fully built‑out medical office space available at 6811 Palisades Park Court, STE 1.
  • Centrally located office/medical office park.
  • Immediate occupancy available at 6811 Palisades Park Court, STE 1.
  • Approved for office and medical office uses.
  • Freestanding surgery center and medical office space available at 6821 Palisades Park Court.
Updated: Sep 4, 2025
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Estero Retail and Office Space
Contact for pricing
0.75 Acres

Estero Retail and Office Space

21740 S Tamiami Trl, Estero, FL 33928

35,000 SF center with retail, office, and medical spaces.

  • Prime Location: Situated on the SW corner of US‑41 and Pelican Sound Drive in Estero.
  • High‑Traffic Area: Adjacent to well‑known tenants like FedEx Office, RE/MAX, Anytime Fitness, Avis Budget, and Jimmy John’s.
  • Proximity to Major Landmarks: Across from Hertz corporate headquarters and Coconut Point Mall.
  • Flexible Zoning: MPD zoning approved for a wide variety of retail, office, and medical office uses.
  • Available Space: STE 107 offers 1,120± SF.
Updated: Dec 26, 2025
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Tamiami Trail Commercial Building
$1,750,000
0.83 Acres

Tamiami Trail Commercial Building

8,126 sq ft commercial building on 0.83 acres.

1357 N Tamiami Trl, North Fort Myers, FL 33903
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Fully Leased Fort Myers Investment
$3,900,000
2.72 Acres

Fully Leased Fort Myers Investment

Turnkey commercial property with immediate income and growth potential.

3900 Broadway, Fort Myers, FL 33901
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Renovated Commercial Building with Expansion
$1,349,000
0.32 Acres

Renovated Commercial Building with Expansion

Move-in-ready building with warehouse, land, and redevelopment potential.

3616 Broadway Pass, Fort Myers, FL 33901
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Commercial Office Building For Sale
$315,000
0.19 Acres

Commercial Office Building For Sale

Commercial office building with tenant in place until April 2027.

2250 Fowler St, Fort Myers, FL 33901
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Fort Myers Live/Work Opportunity
$3,795,000
1.06 Acres

Fort Myers Live/Work Opportunity

Fenced property with security, new roof, and hurricane windows.

3131 E Riverside Dr, Fort Myers, FL 33916
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Professional Office in Key West Style
$593,000
0.06 Acres

Professional Office in Key West Style

Move-in-ready office building in Banyan Creek Business Center.

12855 Banyan Creek Dr, Fort Myers, FL 33908
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Commercial Property Near Beach Access
$2,995,000
0.80 Acres

Commercial Property Near Beach Access

Large commercial property with remodeled building near public beach access.

6061 Estero Blvd, Fort Myers Beach, FL 33931
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Sanibel Commercial Building For Sale
$1,200,000
0.26 Acres

Sanibel Commercial Building For Sale

Commercial building with side street frontage in Sanibel, Florida.

905 Fitzhugh St, Sanibel, FL 33957
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Cape Coral Office Building For Sale
$1,695,969
0.55 Acres

Cape Coral Office Building For Sale

Highly desirable Cape Coral office building with high traffic exposure.

725 Cape Coral Pkwy W, Cape Coral, FL 33914
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Gulf Access Multi-Tenant Office Building
$5,900,000
1.12 Acres

Gulf Access Multi-Tenant Office Building

Two-story office building with Gulf access on a signalized corner.

2804 Del Prado Blvd S, Cape Coral, FL 33904
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Cape Coral Commercial Opportunity
$1,050,000
0.16 Acres

Cape Coral Commercial Opportunity

Versatile commercial property in thriving Cape Coral location.

1213 SE 47Th Ter, Cape Coral, FL 33904
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Cape Coral Professional Office Building
$1,475,000
0.42 Acres

Cape Coral Professional Office Building

Professional office building with long-term tenants in Cape Coral.

1314-1322 Lafayette St, Cape Coral, FL 33904
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Fort Myers Commercial Building For Sale
$1,950,000
1.12 Acres

Fort Myers Commercial Building For Sale

Over 10,000 sq ft building with long-term tenants.

1910 Park Meadows Dr, Fort Myers, FL 33907
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Remodeled Freestanding Building on Bayshore
$1,400,000
0.50 Acres

Remodeled Freestanding Building on Bayshore

Remodeled office building with high visibility and ample parking.

6350 Bayshore Rd, North Fort Myers, FL 33917
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Renovated Office Building in Cape Coral
Pending
$400,000
0.09 Acres

Renovated Office Building in Cape Coral

Fully renovated office building in high-visibility Cape Coral location.

829 SE 47Th Ter, Cape Coral, FL 33904
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Refreshed Olde Florida-Style Office
$1,100,000
0.04 Acres

Refreshed Olde Florida-Style Office

Distinctive office campus with flexible spaces on Sanibel's main artery.

1149 Periwinkle Way, Sanibel, FL 33957
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Fort Myers Office Building For Sale
$3,875,000
1.64 Acres

Fort Myers Office Building For Sale

Commercial property on Cleveland Avenue with steady occupancy and recent updates.

3049 Cleveland Ave, Fort Myers, FL 33901
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St James City Investment Property
$1,775,000
2.79 Acres

St James City Investment Property

Two buildings with income potential in St James City.

8359 Stringfellow Rd, Saint James City, FL 33956
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Bonita Springs Office Space Available
Contact for pricing
4.69 Acres

Bonita Springs Office Space Available

Office space available within the Bonita Bay Club Lifestyle Center.

26800 S Tamiami Trl, Bonita Springs, FL 34134
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Bonita Springs Commercial Opportunity
$1,200,000
2,506 SF

Bonita Springs Commercial Opportunity

Two buildings on US 41 in Bonita Springs.

27831 S Tamiami Trl, Bonita Springs, FL 34134
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Fort Myers Office Building
$3,166,542
13,850 SF

Fort Myers Office Building

Turn-key office building with new roofs and buildouts.

11637 Kelly Rd, Fort Myers, FL 33908
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Estero Office Building For Sale
$1,671,111
6,374 SF

Estero Office Building For Sale

6,374 SF office building available in Estero, Florida.

20270 S Tamiami Trl, Estero, FL 33928
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Lee County, FL Office Buildings Investment Opportunities Market Analysis

Explore 2917 office buildings for sale in Lee County, FL, showcased through 40 active listings on our real estate platform. These investment opportunities span a total of 196,481,072 square feet of properties for sale, with an estimated market value of $1,430,857,969.

Prices for office properties in Lee County, FL start at $50,000, averaging $740,993, and reaching up to $29,670,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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