San Ysidro, CA Mixed-use properties for sale

Updated: Sep 25

Mixed-Use Property with Residence

2971 Imperial Avenue, San Diego, CA 92102

$1,080,000

1,775 sqft 0.13 AC lot

Remodeled detached residence with 3 bedrooms and 2.5 bathrooms
Separate commercial building faces Imperial Avenue
Approximately 5,600‑square‑foot lot zoned CN‑1‑3
Complete Communities Housing Solutions Tier 3 area; qualifying projects may offer up to 6.5 FAR
Covered patio and gated driveway with alley access

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Updated: Oct 16

Mixed-Use Building with Retail Space

3580 Adams Ave, San Diego, CA 92116

$2,600,000

3,690 sqft 0.15 AC lot

Five apartments: three 1 Bed / 1 Bath units, one studio, and one 2 Bed / 1 Bath unit
Approximately 2,000 SF of retail space with a bathroom
3,690 square feet of total property area
53' x 123' lot with alley access
Five or more parking spaces

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Mixed-Use Storefront Property

3275 Euclid, San Diego, CA 92105

$900,000

0.11 AC lot

Corner-lot commercial property with storefront space and separate entrances.

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Mixed-Use Building with Storefront

4741 Point Loma, San Diego, CA 92107

$2,295,000

3,376 sqft

Two commercial spaces occupy the lower level, with a four-bedroom residence above.

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Live-Work Space with Two Offices

2487 Kettner Blvd, San Diego, CA 92101

$1,149,000

1,610 sqft 0.02 AC lot

Commercially zoned property with two kitchens, an upgraded full bath, and mixed-use flexibility for office or residential use.

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Four-Story Mixed-Use Building

920 Kline Street, La Jolla, CA 92037

$5,800,000

20,000 sqft 1.50 AC lot

Mixed retail and office occupancy is supported by an updated elevator and private baths in many suites.

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Mixed-Use Property with Alley Access

1434-44 Garnet Ave, San Diego, CA 92109

$1,695,000

1,622 sqft 0.14 AC lot

Retail/office space includes a detached studio and rear open area.

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Mixed-Use Building with Live-Work Layout

3236 National Ave, San Diego, CA 92113

$979,000

1,730 sqft

Commercial space occupies the lower level, with shopkeeper quarters above.

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Mixed-Use Property with Retail Frontage

3783-89 Park Blvd, San Diego, CA 92103

$3,750,000

7,310 sqft

Eight residences include studios, cottages, and duplex units, with an on-site laundry room serving the property.

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Retail Strip Center with Monument Signage

7878 CLAIREMONT MESA BLVD, San Diego, CA 92111

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13,671 sqft

A mix of established tenants occupies the center, with parking around the building and several entry and exit points.

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Corner-Lot Mixed-Use Building

2754 Imperial Avenue, San Diego, CA 92102

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4,272 sqft 0.13 AC lot

Private offices, four restrooms, a kitchenette, and on-site parking accommodate flexible commercial occupancy.

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Mixed-Use Property with Residence

4741 Point Loma Ave, San Diego, CA 92106

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3,376 sqft

Three-part configuration combines commercial suites with a two-level upper residence.

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10-Unit Mixed-Use Property

1041-47 6th Ave, San Diego, CA 92101

$2,500,000

10,962 sqft

This downtown San Diego building combines residential and commercial space and is fully occupied.

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Mixed-Use Development Site

4210 40 th Street, San Diego, CA 92105

$1,100,000

1,128 sqft

CUPD-CU-2-4 zoning supports residential, commercial, and mixed-use development.

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Single-Tenant Mixed-Use Building

2317 Hotel Circle South, San Diego, CA 92108

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9,240 sqft 1.86 AC lot

Two-story retail and office asset with CO-2-2 zoning and on-site parking.

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Freestanding Mixed-Use Lab Building

9955 Mesa Rim Rd, San Diego, CA 92121

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15,853 sqft 5.45 AC lot

Renovation plans include facade and landscaping upgrades, with warehouse and laboratory infrastructure already in place.

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Renovated Mixed-Use Portfolio

3131-57 Adams Avenue, San Diego, CA 92116

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7,520 sqft 0.35 AC lot

Two adjacent properties combine apartments, retail suites, and updated residential interiors.

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Mixed-Use Investment in La Playa

1051-65 Rosecrans Street, San Diego, CA 92106

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7,600 sqft

Mixed-use property in Point Loma with retail and residential units.

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Mixed-Use Property with Apartments

561-565 E San Ysidro Blvd, San Ysidro, CA 92173

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5,959 sqft

The property brings together street-facing commercial space and four residential units at the rear.

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Mixed-Use Development Opportunity

2135 University Avenue, San Diego, CA 92104

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880 sqft

Current automotive repair shop in San Diego’s Transit Priority Zone, with plans outlined for retail below and multifamily above.

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Mixed-Use Property with Parking Garage

1023 Fourth Avenue, San Diego, CA 92101

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39,329 sqft

Three connected buildings pair residential lofts and retail space with secured garage parking in downtown San Diego.

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Corner Mixed-Use Commercial Space

875 G St 108, San Diego, CA 92101

$1,039,900

Ground-floor space offers an open layout, entrances on two streets, storefront windows and two bathrooms.

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Corner Lot with Development Potential

3665 Imperial Ave, San Diego, CA 92113

$624,000

0.14 AC lot

High-traffic corner lot suitable for commercial or residential development.

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Mixed-Use Building with Residential Units

4702-4714 University Ave, San Diego, CA 92105

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11,517 sqft 0.45 AC lot

Mixed-use improvements include four vacant one-bedroom, one-bath residential units.

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San Ysidro, CA Mixed-Use Properties Market Trends and Statistics

Explore 44 mixed-use properties for sale in San Ysidro, CA, showcased through 44 active listings on our real estate platform. These investment opportunities span a total of 250,545 square feet of properties for sale, with an estimated market value of $56,796,895.

Sale prices for multi use buildings in San Ysidro, CA start at $624,000, averaging $2,271,875, and reaching up to $5,800,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.