San Ysidro, CA Commercial Real Estate for Sale

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342 properties

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Updated: Mar 11

Three-Story Mixed-Use Building

2368 2nd AVE, San Diego, CA 92101

$2,669,000

3,800 sqft 0.13 AC lot

3‑story mixed‑use building with approximately 3,800 square feet
0.1251‑acre parcel at 2368 2nd AVE, San Diego, CA 92101
Independent access to each floor supports separate occupancy or leasing
Mixed‑use zoning accommodates commercial and residential configurations
Mills Act property with tax benefits for qualified owners

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Updated: Sep 10

Multifamily Property With Detached Units

4159 38th St, San Diego, CA 92105

$1,099,000

1,386 sqft 0.08 AC lot

Three detached living spaces on a 0.0804‑acre lot
1,386 square feet with 3 bedrooms, 1.5 bathrooms, and in‑unit laundry in the primary residence
Additional dwellings include 1 bedroom and 1 bathroom each
RM‑2‑5 zoning
Built in 1926 with a composition roof

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26-Unit Apartment Building

4017 42nd St, San Diego, CA 92105

$8,995,000

9,112 sqft

Commercially zoned apartment property with private bathrooms and an existing NNN master lease.

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Full-Floor Furnished Office Units

1350 Columbia St, San Diego, CA 92101

$3,875,000

6,678 sqft

Designer-furnished office suite with private elevator access, collaborative work areas, conference space, and integrated technology infrastructure.

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Upgraded Mixed-Use Property

110 Maple, San Diego, CA 92103

$4,890,000

3,750 sqft 0.13 AC lot

Five-unit corner asset combines professional office space with remodeled residential units and shared landscaped courtyard.

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Mixed-Use Storefront Property

3275 Euclid, San Diego, CA 92105

$900,000

0.11 AC lot

Corner-lot commercial property with storefront space and separate entrances.

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Commercial Infill Land Parcel

47th St, San Diego, CA 92102

$500,000

0.14 AC lot

Vacant commercial-zoned parcel with existing curbs and access to surrounding neighborhoods, businesses, and major roadways.

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Freestanding Office Building

5050 Federal Boulevard, San Diego, CA 92102

$3,300,000

9,930 sqft 0.58 AC lot

Renovated commercial office property with flexible rooms, accessible facilities, gated parking, and an adjoining apartment.

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Live-Work Space with Two Offices

2487 Kettner Blvd, San Diego, CA 92101

$1,149,000

1,610 sqft 0.02 AC lot

Commercially zoned property with two kitchens, an upgraded full bath, and mixed-use flexibility for office or residential use.

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8-Unit Apartment Building

2934 F Street, San Diego, CA 92102

$3,250,000

6,245 sqft 0.16 AC lot

Fully occupied multifamily property with one- and two-bedroom apartments under month-to-month tenancies.

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Freestanding Office Building

6334 University Ave, San Diego, CA 92115

$950,000

2,273 sqft

Functional office configuration with reception areas, private rooms, monument signage, rear access, and on-site parking.

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Remodeled 4-Unit Quadplex

6979-85 Lisbon St, San Diego, CA 92114

$1,450,000

0.09 AC lot

All four residences are occupied and professionally managed, with remodeled interiors and central heating and air conditioning.

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Two-Structure Flex Property

3946 La Salle St, San Diego, CA 92110

$1,500,000

Street-facing retail or office space is paired with an open shop area for flexible commercial use.

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Medical Office Condominium Building

11770 Bernardo Plaza Ct, San Diego, CA 92128

$2,113,852

88,872 sqft 3.05 AC lot

Well-maintained four-story medical office building with upgraded interiors and common areas, positioned for healthcare operators.

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Freestanding Office Building with Parking

6334 University Avenue, San Diego, CA 92115

$950,000

Freestanding office building operating as a mortuary, with chapel/viewing space and rear access plus on-site parking.

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Retail Storefront with Bonus Studio

4975 Newport Ave., San Diego, CA 92107

$2,250,000

0.08 AC lot

CC-4-2 zoning and access from both Newport Avenue and the rear alley support flexible commercial use.

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Ground-Floor Office Condo Suite

3740 Park Boulevard Cu1, San Diego, CA 92103

$2,100,000

2,360 sqft

Modern ground-floor office condo built in 2007 with private offices, reception, open work areas, and multiple entrances.

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Dry-Cleaning Storefront Business

1031 Market Street, San Diego, CA 92101

$379,000

Operating dry-cleaning business with established customers, transferable permits, and leased locations.

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Freestanding Office Building

1501 5th Ave, San Diego, CA 92101

$8,500,000

43,670 sqft

Freestanding office asset offering immediate occupancy, customization flexibility, and access to downtown amenities and public transportation.

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Flex Space with Loading Dock

3065 Beyer Boulevard, San Diego, CA 92154

$1,990,000

Flexible industrial space includes office reception, central air, and rear loading access.

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Updated Mixed-Use Office-Retail Building

3675 Voltaire St, San Diego, CA 92106

$4,500,000

11,060 sqft

Retail space at grade is paired with offices above in a flexible commercial layout.

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Renovated Coworking Office Space

4526-38 CASS STREET, San Diego, CA 92109

Contact for pricing

0.17 AC lot

Private and semi-private offices offer flexible month-to-month occupancy with furnished options and shared business amenities.

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City Heights Redevelopment Opportunity

4228 El Cajon Blvd, San Diego, CA 92105

$2,950,000

6,752 sqft 0.28 AC lot

Redevelopment site with existing retail and multifamily potential.

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Second-Floor Office Units

7060 Miramar Rd, San Diego, CA 92121

Contact for pricing

Two updated suites provide flexible layouts within a shopping center with shared restrooms, monument signage, and on-site parking.

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San Ysidro, CA Commercial Real Estate Market Trends and Statistics

Explore 342 commercial real estate for sale in San Ysidro, CA, showcased through 342 active listings on our real estate platform. These investment opportunities span a total of 3,301,451 square feet of properties for sale, with an estimated market value of $381,309,358.

Sale prices for business properties in San Ysidro, CA start at $75,000, averaging $3,315,733, and reaching up to $23,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 27K

Population Growth (5Y) -16.8%

Median Household Income $65,865

College Educated 7.2%

High-Yield Neighborhoods for Investment

Identify San Ysidro submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
92173	$10.2M

Taxes & Financing

Tax Rate (average for all types) 0.94%

Property Tax per SF $14.23 per SF

Tax Rate vs County Average 0.24 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in San Diego County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in San Ysidro fall within the 100,000+ square foot range.

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