San Ysidro, CA Commercial real estate for sale

Updated: Sep 25

Mixed-Use Property with Residence

2971 Imperial Avenue, San Diego, CA 92102

$1,080,000

1,775 sqft 0.13 AC lot

Remodeled detached residence with 3 bedrooms and 2.5 bathrooms
Separate commercial building faces Imperial Avenue
Approximately 5,600‑square‑foot lot zoned CN‑1‑3
Complete Communities Housing Solutions Tier 3 area; qualifying projects may offer up to 6.5 FAR
Covered patio and gated driveway with alley access

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Updated: Oct 5

26-Unit Apartment Building

4017 42nd St, San Diego, CA 92105

$8,995,000

9,112 sqft

26 residential units, each with a private bathroom
7,000‑square‑foot lot
Master NNN lease with House of Metamorphosis
Tenant operator has approximately 50 years in business

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Mixed-Use Building with Retail Space

3580 Adams Ave, San Diego, CA 92116

$2,600,000

3,690 sqft 0.15 AC lot

Retail space and five apartments share the property, with alley access and on-site parking.

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Office Building with Covered Patio

2419 El Cajon, San Diego, CA 92104

$2,500,000

5,000 sqft 0.16 AC lot

An existing architectural office pairs open work areas and a glass-walled conference room with outdoor space beneath a pergola.

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Office Building with Covered Patio

2419 El Cajon, San Diego, CA 92104

$2,500,000

0.16 AC lot

An open-plan interior pairs gallery and work areas with a glass conference room and sheltered outdoor space.

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Mixed-Use Storefront Property

3275 Euclid, San Diego, CA 92105

$900,000

0.11 AC lot

Corner-lot commercial property with storefront space and separate entrances.

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Remodeled 4-Unit Quadplex

6979-85 Lisbon St, San Diego, CA 92114

$1,400,000

0.09 AC lot

All four residences are occupied and professionally managed, with remodeled interiors and central heating and air conditioning.

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Two-Story Medical Office Building

4710 Ruffner St, San Diego, CA 92111

$3,250,000

10,000 sqft 0.35 AC lot

Four first-floor suites include two vacant spaces, with each unit separately metered.

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Live-Work Space with Two Offices

2487 Kettner Blvd, San Diego, CA 92101

$1,149,000

1,610 sqft 0.02 AC lot

Commercially zoned property with two kitchens, an upgraded full bath, and mixed-use flexibility for office or residential use.

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Commercial Infill Land Parcel

47th St, San Diego, CA 92102

$450,000

0.14 AC lot

Vacant commercial-zoned parcel with existing curbs and access to surrounding neighborhoods, businesses, and major roadways.

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Penthouse Office Suite

1350 Columbia St, San Diego, CA 92101

$3,875,000

6,678 sqft

The ninth-floor workspace includes collaborative seating, a glass-enclosed conference room, phone pods, and a hospitality bar.

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Dry-Cleaning Storefront Business

1031 Market Street, San Diego, CA 92101

$250,000

Operating dry-cleaning business with established customers, transferable permits, and leased locations.

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Leased Auto Repair Shop

4491 Park Boulevard, San Diego, CA 92116

$2,500,000

The current tenant has occupied the property since 2005, with the lease running through June 30, 2030.

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Freestanding Office Building

4394 30th, San Diego, CA 92104

$1,649,000

1,735 sqft 0.07 AC lot

Five private offices, a conference room, reception area, kitchen, and two restrooms support a functional workplace layout.

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Two-Structure Flex Property

3946 La Salle St, San Diego, CA 92110

$1,500,000

Street-facing retail or office space is paired with an open shop area for flexible commercial use.

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Two-Unit Industrial Warehouse

2345 Via Segundo, San Ysidro, CA 92173

$1,680,000

Separate front entrances and rear alley loading access support distinct warehouse operations.

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Mixed-Use Property with Residence

2971 Imperial Ave, San Diego, CA 92102

$1,080,000

700 sqft 0.13 AC lot

A detached home and separate Imperial Ave commercial building occupy a gated site with alley access.

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Flex Space with Loading Dock

3065 Beyer Boulevard, San Diego, CA 92154

$1,990,000

A separate front entry accommodates an office or reception area, with industrial zoning.

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Auto Repair Shop with Equipment

301 16th St, San Diego, CA 92101

$1,492,000

1,926 sqft 0.10 AC lot

The existing automotive service setup includes repair equipment, three-phase power, and on-site parking.

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Second-Floor Office Units

7060 Miramar Rd, San Diego, CA 92121

Contact for pricing

Two updated suites provide flexible layouts within a shopping center with shared restrooms, monument signage, and on-site parking.

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Mixed-Use Building with Storefront

4741 Point Loma, San Diego, CA 92107

$2,295,000

3,376 sqft

Two commercial spaces occupy the lower level, with a four-bedroom residence above.

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Retail Showroom Suite

7050 Miramar, San Diego, CA 92121

Contact for pricing

Front-facing retail space with showroom presentation, monument signage, and parking at Miramar Crossings.

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Freestanding Office Building

5050 Federal Boulevard, San Diego, CA 92102

$3,300,000

9,930 sqft 0.58 AC lot

Renovated commercial office property with flexible rooms, accessible facilities, gated parking, and an adjoining apartment.

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Flex Space with Loading Door

10050 Via De La Amistad, San Diego, CA 92154

$749,000

Industrial zoning and two-level workspace combine warehouse capacity with office and conference areas.

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San Ysidro, CA Commercial Real Estate Market Trends and Statistics

Explore 324 commercial real estate for sale in San Ysidro, CA, showcased through 324 active listings on our real estate platform. These investment opportunities span a total of 2,925,896 square feet of properties for sale, with an estimated market value of $402,362,358.

Sale prices for business properties in San Ysidro, CA start at $75,000, averaging $3,193,352, and reaching up to $42,220,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

San Ysidro, CA CRE market trends — vacancy, lease rates and price per SF, updated monthly

Neighborhood	Average Price
92173	$13.2M

Neighborhood

Average Price

92173

$13.2M