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San Ysidro, CA Office Spaces for Sale

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Kearny Mesa Multi-Tenant Office Building
Updated: Jun 1
Kearny Mesa Multi-Tenant Office Building

4565 Ruffner St, San Diego, CA 92111

$4,750,000
15,974 sqft
Prime Kearny Mesa location adjacent to Convoy Street with immediate access to Interstate 805
Stable in‑place income of $237,116 annual NOI at a 5.00% CAP rate
Significant rental upside with in‑place rents at $23.62/SF compared to submarket comps at $29.55/SF
100% occupied 15,974 SF multi‑tenant office building
Historically high occupancy with the building not dropping below 90% occupancy in over 10 years
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4565 Ruffner St, San Diego, CA 92111

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Corner-Lot Mixed-Use Property
Updated: Jul 7
Corner-Lot Mixed-Use Property

3275 Euclid, San Diego, CA 92105

$900,000
0.11 AC lot
1,380 SF mixed‑use property on a 4,802 SF corner lot
Commercial storefront suited to retail, office, medical, or creative use
Separate entrances for business operations and residential/private access
Dual‑address identity: 3275 Euclid Ave & 4769 Thorn St
Located along a transit corridor in San Diego’s Islenair Historic District
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Live-Work Office Flex Space
Live-Work Office Flex Space

2487 Kettner Blvd, San Diego, CA 92101

$1,149,000
1,610 sqft 0.02 AC lot

Two office suites plus a flex garage space, upgraded full bath and two kitchens; no HOA.

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Mixed-Use Office and Retail Units
Mixed-Use Office and Retail Units

825-829 Washington St., San Diego, CA 92103

$1,189,000
1,778 sqft 0.03 AC lot

Three remodeled office and retail units at 825-829 Washington St. offer extensive exterior and systems upgrades.

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Ground-Floor Office Condo Suite
Ground-Floor Office Condo Suite

3740 Park Boulevard Cu1, San Diego, CA 92103

$2,100,000
2,360 sqft

Modern ground-floor office condo built in 2007 with private offices, reception, open work areas, and multiple entrances.

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Mixed-Use Property with Courtyard
Mixed-Use Property with Courtyard

110 Maple St, San Diego, CA 92103

$4,890,000
0.13 AC lot

A corner commercial asset combines a leased office component with remodeled residences and a landscaped shared outdoor area.

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Two-Structure Flex Property
Two-Structure Flex Property

3946 La Salle St, San Diego, CA 92110

$1,650,000

Street-facing retail or office space is paired with an open shop area for flexible commercial use.

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Freestanding Office Building with Parking
Freestanding Office Building with Parking

6334 University Avenue, San Diego, CA 92115

$950,000

Freestanding office building operating as a mortuary, with chapel/viewing space and rear access plus on-site parking.

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Three-Story Mixed-Use Building
Three-Story Mixed-Use Building

2368 2nd Ave, San Diego, CA 92101

$2,669,000
3,800 sqft

Three-story mixed-use building features independently accessible floors with private in- and egress and onsite parking.

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Flex Space with Loading Dock
Flex Space with Loading Dock

3065 Beyer Boulevard, San Diego, CA 92154

$1,990,000

Flexible industrial space includes office reception, central air, and rear loading access.

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Renovated Coworking Space
Renovated Coworking Space

4526-38 CASS STREET, San Diego, CA 92109

Contact for pricing
0.17 AC lot

Flexible private and semi-private offices include shared business amenities with month-to-month availability.

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Mixed-Use Property in Opportunity Zone
Mixed-Use Property in Opportunity Zone

4170 Fairmount Ave, San Diego, CA 92105

$999,000
1,404 sqft

Mixed-use property with high foot traffic in City Heights.

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Ground-Floor Office/Medical Condo
Ground-Floor Office/Medical Condo

3740 Park Boulevard Unit CU1, San Diego, CA 92103

$2,100,000
2,360 sqft

Ground-floor condo in the DECA building offers private offices, reception space, and multiple entrances with eight dedicated parking spaces.

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Medical Office Condominium Building
Medical Office Condominium Building

11770 Bernardo Plaza Ct, San Diego, CA 92128

$493,750
88,872 sqft 3.05 AC lot

Well-maintained four-story medical office building with upgraded interiors and common areas, positioned for healthcare operators.

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Old Town San Diego Investment
Old Town San Diego Investment

4062 Harney St, San Diego, CA 92110

$1,799,000
2,052 sqft

Versatile commercial property in high-demand Old Town San Diego.

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Turn-Key Penthouse Office Floor
Turn-Key Penthouse Office Floor

1350 Columbia St, San Diego, CA 92101

$3,875,000
6,678 sqft

Designer-furnished, open-concept office with panoramic windows and secure elevator access on a full top floor.

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Freestanding Office Building
Freestanding Office Building

6334 University Ave, San Diego, CA 92115

$1,055,000
2,273 sqft

Functional office configuration with reception areas, private rooms, monument signage, rear access, and on-site parking.

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New Retail Condominiums in San Diego
New Retail Condominiums in San Diego

4473 30th St Unit 103, San Diego, CA 92116

$679,000
679 sqft

New construction commercial retail condominiums in San Diego's premier urban district.

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Four-Story Medical Office Building
Four-Story Medical Office Building

11770 Bernardo Plaza Ct, San Diego, CA 92128

Contact for pricing
4,266 sqft 3.05 AC lot

Four-story medical office building on 3.05 acres with elevators, central courtyard, and ample surface and covered parking.

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Corner-Lot Mixed-Use Building
Corner-Lot Mixed-Use Building

2754 Imperial Avenue, San Diego, CA 92102

Contact for pricing
4,272 sqft 0.13 AC lot

Private offices, four restrooms, a kitchenette, and on-site parking accommodate flexible commercial occupancy.

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Mixed-Use Creative and Wellness Property
Mixed-Use Creative and Wellness Property

3065 Reynard Way, San Diego, CA 92103

$1,975,000
6,222 sqft 0.33 AC lot

Two-parcel property with existing improvements and current tenant occupancy in a CN-1-3 zone with Complete Communities Tier 3 overlay.

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Medical Office Condo Suites
Medical Office Condo Suites

11770 Bernardo Plaza Ct, San Diego, CA 92128

Contact for pricing
7,146 sqft

Condo-owned medical office suites with flexible sizing ranging from 791 to 8,516 square feet.

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Four-Story Medical Office Building
Four-Story Medical Office Building

11770 Bernardo Plaza Ct, San Diego, CA 92128

Contact for pricing
1,169 sqft 3.05 AC lot

Four-story medical office building on 3.05 acres along Interstate 15 with two elevators, a landscaped courtyard, and ample parking.

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Four-Story Medical Office Building
Four-Story Medical Office Building

11770 Bernardo Plaza Ct, San Diego, CA 92128

Contact for pricing
1,267 sqft 3.05 AC lot

Four-story medical office building with recently upgraded systems, two elevators, and structured amenities.

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San Ysidro, CA Office Spaces Market Trends and Statistics

Explore 153 office spaces for sale in San Ysidro, CA, showcased through 153 active listings on our real estate platform. These investment opportunities span a total of 1,841,558 square feet of properties for sale, with an estimated market value of $51,244,575.

Sale prices for office spaces in San Ysidro, CA start at $458,500, averaging $1,897,947, and reaching up to $5,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Office buildings 1

Demographics Overview

Population 27K
Population Growth (5Y) -16.8%
Median Household Income $65,865
College Educated 7.2%

High-Yield Neighborhoods for Investment

Identify San Ysidro submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood Average Price
92173 $2.6M

Taxes & Financing

Tax Rate (average for all types) 0.94%
Property Tax per SF $14.23 per SF
Tax Rate vs County Average 0.24 pp below county avg
Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in San Diego County

New Delisted

Total CRE Inventory on Market (SF)

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