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    Madison County, IL Medical Office Space for Lease

    14 results
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    Alton Office Space for Lease
    $700 / Mo
    30,980 SF

    Alton Office Space for Lease

    307 Henry St, Alton, IL 62002

    Office space available in full-service building with parking.

    • Full‑service lease includes taxes, utilities, insurance, CAM, and light janitorial services.
    • Located in a HUB Zone.
    • Suitable for medical, legal, or other professional/personal services.
    • Building elevator provides access to all four floors.
    • Ample parking available.
    Updated: Sep 30, 2025
    View details
    Remodeled Medical Office Suite
    $10 SF/Yr
    3,040 SF

    Remodeled Medical Office Suite

    1628-1336 Mercantile Dr, Highland, IL 62249

    3,040 SF remodeled medical office suite for lease.

    • Newly remodeled 3,040 SF medical office suite.
    • Features a staff lounge with kitchenette, waiting room with reception desk, (7) exam rooms, (1) lab/documentation area, and restrooms.
    • Strategically situated in Highland, IL, just off Highway 40 for easy access.
    • Proximity to St. Louis, MO (30 miles).
    • Well‑appointed space ideal for efficient and versatile office operations.
    View details
    Turnkey Medical Office For Lease
    $13 SF/Yr
    3,600 SF

    Turnkey Medical Office For Lease

    3,600 SF medical office with easy highway access.

    101 United Dr, Collinsville, IL
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    New Office Space Available
    $18 SF/Yr
    1,855 SF

    New Office Space Available

    Newly constructed office space near St. Joseph's Hospital.

    5-25 Apex Dr, Highland, IL 62249
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    Medical Office Building For Lease
    $17 SF/Yr
    8,000 SF

    Medical Office Building For Lease

    Highly visible medical office building with easy highway access.

    4273 S State Route 159, Glen Carbon, IL 62034
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    Collinsville Office Space for Lease
    $16 SF/Yr
    13,003 SF

    Collinsville Office Space for Lease

    13,000+ SF office space available in Collinsville's Eastport District.

    1616 Eastport Plaza Dr, Collinsville, IL 62234
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    Granite City Office Space Available
    Contact for pricing
    2,050 SF

    Granite City Office Space Available

    Office space for rent near Maryville Rd. and Pontoon Rd.

    3908 Maryville Rd, Granite City, IL 62040
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    Highland Medical Office Space
    $14 SF/Yr
    25,070 SF

    Highland Medical Office Space

    Prime Retail Location, Multiple Suites Available

    12603 State Route 143, Highland, IL 62249
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    Maryville Medical Office Space
    $15 SF/Yr
    10,800 SF

    Maryville Medical Office Space

    Class B, 10,800 SF, High Visibility

    2921 Center St, Maryville, IL 62062
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    Godfrey, IL Office Space
    $9 SF/Yr
    96,921 SF

    Godfrey, IL Office Space

    Multiple suites, 1,104-6,301 sq ft.

    5771 Godfrey Rd, Godfrey, IL 62035
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    Highland Medical Office Space for Sale
    $10 SF/Yr
    25,000 SF

    Highland Medical Office Space for Sale

    Prime 3,040 SF medical office, newly renovated.

    1336 Mercantile Dr, Highland, IL 62249
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    Edwardsville Office Space Available
    $9 SF/Yr
    6,249 SF

    Edwardsville Office Space Available

    Flexible Offices, Coworking & More

    101 Vandalia St, Edwardsville, IL 62025
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    Eastport Plaza Drive Office/Warehouse
    Contact for pricing
    20,000 SF

    Eastport Plaza Drive Office/Warehouse

    Collinsville, IL Build-to-Suit Opportunity

    1608 Eastport Plaza Dr, Collinsville, IL 62234
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    Highland Retail/Office/Medical Spaces For Lease
    $14 SF/Yr
    1,775 SF

    Highland Retail/Office/Medical Spaces For Lease

    Office, retail, and medical spaces available for lease in Highland.

    12603 State Route 143, Highland, IL 62249
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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 14 Active listings in Madison County, IL, we suggest exploring alternatives. Similar 6 Properties for Sales.

    Explore Similar Spaces for Sale in Madison County, IL

    Consider Similar Space for Sale. We found 6 Spaces in Nearby Locations matching your search parameters.

    Granite City Commercial Office Building
    $220,000
    2,624 SF

    Granite City Commercial Office Building

    Commercial office building in Granite City, 15 minutes from St. Louis.

    2412 Corporate Ctr, Granite City, IL 62040
    View details
    Medical Office Building For Sale
    $4,000,000
    64,800 SF

    Medical Office Building For Sale

    64,800 SF medical office building on 4.3 acres.

    1 Professional Dr, Alton, IL 62002
    View details
    Versatile Office Space in Wood River
    $399,900
    8,000 SF

    Versatile Office Space in Wood River

    8000 sq ft office space suitable for various businesses.

    203 S 6Th St, Wood River, IL 62095
    View details
    Alton Medical Campus Opportunity
    Contact for pricing
    221,754 SF

    Alton Medical Campus Opportunity

    Vacant medical campus in historic Alton, Illinois.

    915 E 5Th St, Alton, IL 62002
    View details
    Renovated Medical Office Condo
    Contact for pricing
    3,021 SF

    Renovated Medical Office Condo

    3,021 SF medical office condo for sale, renovated in 2024.

    3165 Myrtle Ave, Granite City, IL 62040
    View details
    Versatile Medical/Athletic Facility For Sale
    Contact for pricing
    5,375 SF

    Versatile Medical/Athletic Facility For Sale

    5,375 SF building suitable for medical, athletic, or office use.

    1117 Washington St, Highland, IL 62249
    View details

    Madison County, IL Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Madison County, IL with 20 listings featured on our commercial real estate exchange. The current inventory includes 8,507,834,280 square feet of properties with an estimated lease value of $145 SF/Yr.

    Estimated lease rates for Medical Office Space in Madison County, IL begin at $9 SF/Yr, with an average of $13 SF/Yr and extend to $18 SF/Yr.
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    Medical Office Space by market

    Browse Medical Office Space for Lease Near Madison, IL

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