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    Madison County, IL Medical Office Space for Lease

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    Chicago, IL Springfield, IL Hoffman Estates, IL
    8 results
    Alton Office Space for Lease
    $700 /Mo
    30,980 SF

    Alton Office Space for Lease

    307 Henry St., Alton, IL 62002

    Office space available in full-service building with parking.

    • Full‑service lease includes taxes, utilities, insurance, CAM, and light janitorial services.
    • Located in a HUB Zone.
    • Suitable for medical, legal, or other professional/personal services.
    • Building elevator provides access to all four floors.
    • Ample parking available.
    Updated: Sep 30, 2025
    View details
    Collinsville Office Space for Lease
    $16 SF/Yr
    13,003 SF

    Collinsville Office Space for Lease

    1616 Eastport Plaza Dr, Collinsville, IL

    13,000+ SF office space available in Collinsville's Eastport District.

    • 13,000+ SF of contiguous office space available in Collinsville's thriving Eastport District.
    • Easy access from I‑255 (Exit 26) & I‑55/I‑70 (Exit 11).
    • Excellent location minutes from Downtown St. Louis, centered between Madison & St. Clair Counties, IL.
    • Suite 1616 offers specialized lab features including Mass Spectrometry Room, Exhaust Tubes, Nitrogen Tank Pad, Emergency Shower System, Server Room, and Walk‑In Cooler.
    • Suite 1622 offers 6,368 SF with 13 individual offices, reception area, conference room, kitchen, and storage.
    Updated: Jun 23, 2025
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    Highland Retail/Office/Medical Spaces For Lease
    $14 SF/Yr
    1,775 SF

    Highland Retail/Office/Medical Spaces For Lease

    Office, retail, and medical spaces available for lease in Highland.

    12603 State Rte 143, Highland, IL 62249
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    Turnkey Medical Office For Lease
    $13 SF/Yr
    3,600 SF

    Turnkey Medical Office For Lease

    3,600 SF medical office with easy highway access.

    101 United Dr, Collinsville, IL
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    Medical Office Building For Lease
    $17 SF/Yr
    8,000 SF

    Medical Office Building For Lease

    Highly visible medical office building with easy highway access.

    4273 S State Rte 159, Glen Carbon, IL
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    Granite City Office Space Available
    $9 SF/Yr
    2,050 SF

    Granite City Office Space Available

    Office space for rent near Maryville Rd. and Pontoon Rd.

    3908 Maryville Rd, Granite City, IL
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    Remodeled Medical Office Suite
    $10 SF/Yr
    3,040 SF

    Remodeled Medical Office Suite

    3,040 SF remodeled medical office suite for lease.

    1628-1336 Mercantile Dr, Highland, IL
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    Remodeled Medical Office Suite
    Contact for pricing
    3,040 SF

    Remodeled Medical Office Suite

    Newly remodeled medical office suite in Woodcrest Plaza, Highland, IL.

    1336 Mercantile Dr, Highland, IL 62249
    View details
    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 8 Active listings in Madison County, IL, we suggest exploring alternatives. Similar 9 Properties for Sales.

    Explore Similar Spaces for Sale in Madison County, IL

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Edwardsville Professional Office Opportunity
    $750,000
    6,580 SF

    Edwardsville Professional Office Opportunity

    3,290 SF office space in Sunset Hills Professional Center.

    4 Sunset Hills Professional Center, Edwardsville, IL 62025
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    Versatile Office Space in Wood River
    $399,900
    8,000 SF

    Versatile Office Space in Wood River

    8000 sq ft office space suitable for various businesses.

    203 S 6th Street, Wood River, IL 62095
    View details
    Granite City Commercial Office Building
    $199,000
    2,624 SF

    Granite City Commercial Office Building

    Commercial building in Granite City, suitable for medical or office.

    2412 Corporate Center, Granite City, IL 62040
    View details
    Medical Office Building For Sale
    $4,000,000
    64,800 SF

    Medical Office Building For Sale

    64,800 SF medical office building on 4.3 acres.

    1 Professional Drive, Alton, IL 62002
    View details
    Versatile Medical/Athletic Facility For Sale
    $449,000
    5,375 SF

    Versatile Medical/Athletic Facility For Sale

    5,375 SF building suitable for medical, athletic, or office use.

    1117 Washington St, Highland, IL
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    Renovated Medical Office Condo
    $149,000
    3,021 SF

    Renovated Medical Office Condo

    3,021 SF medical office condo for sale, renovated in 2024.

    3165 Myrtle Ave, Granite City, IL
    View details
    Alton Medical Office Building For Sale
    $4,000,000
    64,800 SF

    Alton Medical Office Building For Sale

    64,800 SF medical office building with investment potential.

    1 Professional Drive , 20120, Alton, IL 62002
    View details
    Alton Medical Campus Opportunity
    Contact for pricing
    221,754 SF

    Alton Medical Campus Opportunity

    Vacant medical campus in historic Alton, Illinois.

    915 E 5th St, Alton, IL
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    New Office Space Available
    Contact for pricing
    1,855 SF

    New Office Space Available

    Newly constructed office space near St. Joseph's Hospital.

    5-25 Apex Dr, Highland, IL
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
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    Prime Commercial Lot For Rent
    $7,500 /Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
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    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    Winter Park Mixed-Use Opportunity
    $8,500 /Mo
    23,056 SF

    Winter Park Mixed-Use Opportunity

    Double commercial lot in Winter Park, FL, for lease.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details

    Madison County, IL Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Madison County, IL with 8 listings featured on our commercial real estate exchange. The current inventory includes 1,110,475,080 square feet of properties with an estimated lease value of $57 SF/Yr.

    Estimated lease rates for Medical Office Space in Madison County, IL begin at $10 SF/Yr, with an average of $14 SF/Yr and extend to $17 SF/Yr.
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    Medical Office Space by market

    Browse Medical Office Space for Lease Near Madison, IL

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