Add Listing
    Illinois
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Madison County, IL Medical Office Space for Lease

    Notify Me
    List
    Map
    Chicago, IL Springfield, IL Naperville, IL
    13 results
    Alton Retail/Office Space Available
    $13 SF/Yr
    8,872 SF

    Alton Retail/Office Space Available

    215 E Center Drive, Alton, IL 62002

    Desirable retail/office space with high visibility near Alton Square Mall.

    • High traffic and visibility location across from Alton Square Mall and adjacent to Homer Adams Parkway.
    • Available for immediate occupancy.
    • Approximately 2,799 s.f. retail/office space.
    • Prior use was a Dental Office, with existing reception area, handicap bathroom, office space, lab space, kitchenette, and storage area.
    • Anchor tenants include Quest Diagnostics, Jackson Hewitt, C.J. Schlosser, Great Rivers Animal Hospital and Southwestern Hearing Center.
    Updated: May 1
    View details
    Granite City Office Building
    $1,700/Mo
    3,372 SF

    Granite City Office Building

    3723 Nameoki Road, Granite City, IL 62040

    Well-maintained office building with high visibility and strong tenants.

    • High‑visibility location on Nameoki Road, a major commercial corridor.
    • Well‑maintained 1,700 SF suite available for lease or owner occupancy.
    • Property underwent comprehensive renovation in 2022.
    • Two long‑standing tenants provide stable income.
    • Suitable for various uses: co‑working, professional office, medical, conference, or service‑based.
    Updated: Mar 21
    View details
    Alton Office Space for Lease
    $700/Mo
    30,980 SF

    Alton Office Space for Lease

    Office space available in full-service building with parking.

    307 Henry St., Alton, IL 62002
    View details
    Glen Carbon Lower Level Suite
    $18 SF/Yr
    5,145 SF

    Glen Carbon Lower Level Suite

    5,145 SF unfinished suite ideal for office or retail.

    2160 S State Route 157, Glen Carbon, IL 62034
    View details
    Highland Retail/Office/Medical Spaces For Lease
    $14 SF/Yr
    1,775 SF

    Highland Retail/Office/Medical Spaces For Lease

    Office, retail, and medical spaces available for lease in Highland.

    12603 State Rte 143, Highland, IL 62249
    View details
    Collinsville Office Space for Lease
    $16 SF/Yr
    13,003 SF

    Collinsville Office Space for Lease

    13,000+ SF office space available in Collinsville's Eastport District.

    1616 Eastport Plaza Dr, Collinsville, IL
    View details
    Turnkey Medical Office For Lease
    $13 SF/Yr
    3,600 SF

    Turnkey Medical Office For Lease

    3,600 SF medical office with easy highway access.

    101 United Dr, Collinsville, IL
    View details
    Medical Office Building For Lease
    $17 SF/Yr
    8,000 SF

    Medical Office Building For Lease

    Highly visible medical office building with easy highway access.

    4273 S State Rte 159, Glen Carbon, IL
    View details
    Glen Carbon Lower Level Suite
    Contact for pricing
    5,145 SF

    Glen Carbon Lower Level Suite

    Unfinished 5,145 SF suite ideal for office or retail.

    2160 South State Route 157, Glen Carbon, IL 62034
    View details
    New Office Space Available
    $18 SF/Yr
    1,855 SF

    New Office Space Available

    Newly constructed office space near St. Joseph's Hospital.

    5-25 Apex Dr, Highland, IL
    View details
    Remodeled Medical Office Suite
    $10 SF/Yr
    3,040 SF

    Remodeled Medical Office Suite

    3,040 SF remodeled medical office suite for lease.

    1628-1336 Mercantile Dr, Highland, IL
    View details
    Remodeled Medical Office Suite
    $10 SF/Yr
    3,040 SF

    Remodeled Medical Office Suite

    Newly remodeled medical office suite in Woodcrest Plaza, Highland, IL.

    1336 Mercantile Dr, Highland, IL 62249
    View details
    Granite City Office Space Available
    $9 SF/Yr
    2,050 SF

    Granite City Office Space Available

    Office space for rent near Maryville Rd. and Pontoon Rd.

    3908 Maryville Rd, Granite City, IL
    View details
    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 13 Active listings in Madison County, IL, we suggest exploring alternatives. Similar 9 Properties for Sales.

    Similar Spaces for Sale in Madison County, IL

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Edwardsville Professional Office Opportunity
    $750,000
    6,580 SF
    Edwardsville Professional Office Opportunity

    3,290 SF office space in Sunset Hills Professional Center.

    4 Sunset Hills Professional Center, Edwardsville, IL 62025

    View details
    Versatile Office Space in Wood River
    $399,900
    8,000 SF
    Versatile Office Space in Wood River

    8000 sq ft office space suitable for various businesses.

    203 S 6th Street, Wood River, IL 62095

    View details
    Granite City Office Building
    $290,000
    3,372 SF
    Granite City Office Building

    Multi-tenant office building with established tenants and available suite.

    3723 Nameoki Road, Granite City, IL 62040

    View details
    Granite City Commercial Office Building
    $199,000
    2,624 SF
    Granite City Commercial Office Building

    Commercial building in Granite City, suitable for medical or office.

    2412 Corporate Center, Granite City, IL 62040

    View details
    Medical Office Building For Sale
    $4,000,000
    64,800 SF
    Medical Office Building For Sale

    64,800 SF medical office building on 4.3 acres.

    1 Professional Drive, Alton, IL 62002

    View details
    Versatile Medical/Athletic Facility For Sale
    $449,000
    5,375 SF
    Versatile Medical/Athletic Facility For Sale

    5,375 SF building suitable for medical, athletic, or office use.

    1117 Washington St, Highland, IL

    View details
    Renovated Medical Office Condo
    $149,000
    3,021 SF
    Renovated Medical Office Condo

    3,021 SF medical office condo for sale, renovated in 2024.

    3165 Myrtle Ave, Granite City, IL

    View details
    Alton Medical Office Building For Sale
    $4,000,000
    64,800 SF
    Alton Medical Office Building For Sale

    64,800 SF medical office building with investment potential.

    1 Professional Drive , 20120, Alton, IL 62002

    View details
    Alton Medical Campus Opportunity
    Contact for pricing
    221,754 SF
    Alton Medical Campus Opportunity

    Vacant medical campus in historic Alton, Illinois.

    915 E 5th St, Alton, IL

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office Development Land For Lease
    Contact for pricing
    4,000 SF

    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401
    View details
    Kingery Highway Commercial Development Opportunity
    $85,000 SF/Yr

    Kingery Highway Commercial Development Opportunity

    High-visibility land for retail, car wash, or medical development.

    8501 & 8511 Kingery Highway, Willowbrook, IL 60527
    View details
    Beaumont Centre Outparcel Opportunity
    Contact for pricing

    Beaumont Centre Outparcel Opportunity

    Outparcel opportunity in established shopping center for ground lease.

    3199 Beaumont Centre Circle, Lexington, KY 40513
    View details
    Prime Lexington Outlot Opportunity
    Contact for pricing

    Prime Lexington Outlot Opportunity

    Outlot for ground lease or build-to-suit in South Lexington.

    3330 Partner Place, Lexington, KY 40503
    View details

    Madison County, IL Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Madison County, IL with 13 listings featured on our commercial real estate exchange. The current inventory includes 46,752 square feet of properties with an estimated lease value of $108 SF/Yr.

    Estimated lease rates for Medical Office Space in Madison County, IL begin at $6 SF/Yr, with an average of $12 SF/Yr and extend to $17 SF/Yr.
    List
    Map

    Medical Office Space by market

    Browse Medical Office Space for Lease Near Madison, IL

    Popular Categories

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!