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    Madison County, IL Medical Office Space for Sale

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    Multi-Tenant Office Building
    Updated: Jun 15
    Multi-Tenant Office Building

    3723 Nameoki Road, Granite City, IL 62040

    $275,000
    3,372 sqft · 0.29 AC lot
    High‑traffic location on Nameoki Road
    Multi‑tenant office building with established tenants (State Farm & law firm)
    One fully built‑out 1,700 SF suite available for lease or owner occupancy
    Renovated in 2022
    Includes 22 surface parking spaces
    View details
    Updated Office Building
    Updated: Jun 26
    Updated Office Building

    3704 Pontoon Road, Granite City, IL 62040

    $120,000
    945 sqft · 0.30 AC lot
    Commercial office with approximately 7,950 vehicles per day (AADT) passing by
    Updated building with new roof and new HVAC system; central air and natural gas heating
    Floor plan includes two private offices (potential for a third), lobby, large restroom, and kitchenette
    New carpeting installed in 2026
    On‑site parking for up to five vehicles plus a garage for additional parking and/or storage
    View details
    Medical Office Building with Parking
    Medical Office Building with Parking

    1 Professional Drive, Alton, IL 62002

    $4,000,000
    64,800 sqft · 4.33 AC lot

    Two floors plus lower level medical office with significant parking and available first-floor space under NNN terms.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Commercial Office Property on Acreage
    Commercial Office Property on Acreage

    2911 N Center Street, Maryville, IL 62062

    $399,000
    7.23 AC lot

    Two thousand-plus-square-foot building on a wooded lot with commercial zoning, offering flexibility for office or wellness uses.

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    Professional Office Building
    Professional Office Building

    440 S Prairie Street, Bethalto, IL 62010

    $209,000
    0.31 AC lot

    Office building with multiple rooms, reception space, and a large conference room plus ample parking.

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    Corner Office Building with Parking
    Corner Office Building with Parking

    203 S 6th Street, Wood River, IL 62095

    $399,900
    8,000 sqft

    A corner office building with patient rooms, enclosed vault-door rooms, and ample parking, recently roofed and repainted.

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    Versatile Medical/Athletic Facility For Sale
    Versatile Medical/Athletic Facility For Sale

    1117 Washington St, Highland, IL

    $449,000
    5,375 sqft · 0.16 AC lot

    5,375 SF building suitable for medical, athletic, or office use.

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    Standalone Office Building
    Standalone Office Building

    4 Sunset Hills Professional Center, Edwardsville, IL 62025

    $750,000
    3,290 sqft

    Standalone office building with private offices and conference space, positioned off IL-157 in an established office/medical corridor.

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    Renovated Medical Office Condo
    Renovated Medical Office Condo

    3165 Myrtle Ave, Granite City, IL

    $149,000
    3,021 sqft · 0.36 AC lot

    3,021 SF medical office condo for sale, renovated in 2024.

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    Office Building with Patient Rooms
    Office Building with Patient Rooms

    203 S 6th St, Wood River, IL 62095

    $399,900
    8,000 sqft

    Configured for medical or professional use with main-level exam/offices, enclosed vault rooms, and 26+ parking spaces.

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    Alton Medical Office Building For Sale
    Alton Medical Office Building For Sale

    1 Professional Drive , 20120, Alton, IL 62002

    $4,000,000
    64,800 sqft

    64,800 SF medical office building with investment potential.

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    Alton Medical Campus Opportunity
    Alton Medical Campus Opportunity

    915 E 5th St, Alton, IL

    Contact for pricing
    221,754 sqft · 2.37 AC lot

    Vacant medical campus in historic Alton, Illinois.

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 12 Active listings in Madison County, IL, we suggest exploring several alternatives: similar 4 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Lake St. Louis Development Site
    Lake St. Louis Development Site

    Lot 7 Hawk Ridge Circle, Lake St Louis, MO 63367

    $2,763,882
    12.69 AC lot

    12.69-acre commercial land near planned Costco.

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    Commercial Building Lot with Highway Access
    Commercial Building Lot with Highway Access

    2 Cedric Station, Cedar Hill, MO 63016

    $291,740
    0.80 AC lot

    Build-to-suit commercial site near Highway 30, offering convenient access and visibility for retail, restaurant, or medical use.

    View details
    Springfield Commercial Land Opportunity
    Springfield Commercial Land Opportunity

    W WABASH Avenue, Springfield, IL 62711

    $7,900,000
    28.79 AC lot

    28+ acres of commercial land ready for development.

    View details
    Versatile Commercial Building Near I-55
    Versatile Commercial Building Near I-55

    5598 Us Highway 61 North, Jackson, MO 63755

    $549,900
    3,096 sqft · 0.64 AC lot

    High-traffic location, built in 2017, suitable for diverse businesses.

    View details

    Off-Market Properties in Madison County, IL

    Consider similar Off-Market properties in Madison County, IL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1608 Eastport Plaza Dr
    Office Units

    1608 Eastport Plaza Dr, Collinsville, IL 62234

    Value Estimation by Request
    20,000 sqft
    View details
    1336 Mercantile Dr
    Medical Office Space

    1336 Mercantile Dr, Highland, IL 62249

    Value Estimation by Request
    25,000 sqft
    View details
    101 Vandalia St
    Office Units

    101 Vandalia St, Edwardsville, IL 62025

    Value Estimation by Request
    View details
    850 Vandalia St
    Office Units

    850 Vandalia St, Collinsville, IL 62234

    Value Estimation by Request
    2,112 sqft
    View details

    Madison County, IL Medical Office Space Market Trends and Statistics

    Explore 16 medical office space for sale in Madison County, IL, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 161,603 square feet of properties for sale, with an estimated market value of $10,542,800.

    Sale prices for medical spaces in Madison County, IL start at $120,000, averaging $1,171,422, and reaching up to $4,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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