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    Florence, SC Retail Properties & Spaces for Sale

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    Timmonsville, SC Darlington, SC Effingham, SC
    31 results
    Remodeled Commercial Building Near Downtown
    $320,000
    2,165 SF

    Remodeled Commercial Building Near Downtown

    910 W Evans st, Florence, SC 29501

    Turnkey commercial property in prime location with excellent visibility.

    • Completely remodeled/rebuilt from the ground up with new roof, HVAC, electrical, and plumbing.
    • Prime location minutes from downtown Florence with excellent visibility and access.
    • Turnkey property suitable for a medical office, salon, law firm, or small business.
    • Five spacious rooms that can serve as private offices or treatment spaces.
    • Modern kitchen with brand‑new cabinets and granite countertops.
    Updated: Apr 24
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    Historic Downtown Florence Commercial Building
    $2,700,000
    16,304 SF

    Historic Downtown Florence Commercial Building

    248-260 W Evans st., Florence, SC 29501

    16,000 SF historic building in thriving downtown Florence.

    • Prime downtown Florence location in a thriving area.
    • Large 16,000 sq ft historic building with limitless potential.
    • Significant parking available (over 100 spaces), rare for downtown.
    • Versatile space currently configured with multiple tenants (Law Firm, H&R Block, Hair Studio).
    • Spacious 1.47‑acre lot allows for growth and development.
    Updated: Mar 9
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    Prime Commercial Property on Palmetto
    $250,000
    1,405 SF

    Prime Commercial Property on Palmetto

    High-visibility commercial property on a high-traffic street in Florence.

    2228 W Palmetto St., Florence, SC 29501
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    Fully Occupied Retail Center
    $1,650,000
    15,450 SF

    Fully Occupied Retail Center

    Retail center in good condition with high traffic count.

    823-817 S Cashua Drive, Florence, SC 29501
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    Florence Commercial Building on Evans
    $79,000
    1,200 SF

    Florence Commercial Building on Evans

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
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    Florence Commercial Development Opportunity
    $1,200,000
    4.54 Acres

    Florence Commercial Development Opportunity

    4.54 acre commercial parcel on high-traffic corridor.

    2621 West Palmetto Street, Florence, SC 29501
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    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF

    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501
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    Showroom and Warehouse on Irby
    $500,000
    6,120 SF

    Showroom and Warehouse on Irby

    Single tenant building with showroom and warehouse on 1.09-acre lot.

    511 Irby Street, Florence, SC 29501
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    NNN Leased Plasma Investment Property
    $3,370,000
    17,174 SF

    NNN Leased Plasma Investment Property

    NNN leased investment property in Florence, South Carolina.

    1933 2nd Loop Rd, Florence, SC 29501
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    Standalone Industrial Building on Harrell
    $189,000
    40,000 SF

    Standalone Industrial Building on Harrell

    Industrial building suitable for fabrication, automotive, contractor, or storage.

    120 N Guerry St, Florence, SC 29501
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    Office/Retail Conversion Opportunity
    $400,000
    2,600 SF

    Office/Retail Conversion Opportunity

    2600 SF residence on 1.6 acres, suitable for conversion.

    2901 W Palmetto Street, Florence, SC 29501
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    Evans Street Commercial Redevelopment Opportunity
    $79,000
    1,200 SF

    Evans Street Commercial Redevelopment Opportunity

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
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    Former Convenience Store Investment Property
    $125,000
    2,400 SF

    Former Convenience Store Investment Property

    Fixer-upper retail property with 150' frontage, great investment potential.

    1134 E Howe Springs Road, Florence, SC 29505
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    8,000 SF Retail Opportunity
    $1,521,444
    8,000 SF

    8,000 SF Retail Opportunity

    Family Dollar retail property for sale in Florence, SC.

    3216 E Palmetto St, Florence, SC 29506
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    Walgreens
    $4,750,000
    14,500 SF

    Walgreens

    Opportunity to acquire an absolute NNN Leased Walgreens located in Florence, SC

    2498 2nd Loop Rd, Florence, SC 29501
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    Turnkey Fish Market Opportunity
    $250,900
    2,499 SF

    Turnkey Fish Market Opportunity

    Profitable, equipped fish market for sale in Florence, SC.

    1401 W Darlington Street, Florence, SC 29501
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    Historic Downtown Florence Building For Sale
    $2,800,000
    16,304 SF

    Historic Downtown Florence Building For Sale

    16,000 SF historic building in downtown Florence for sale.

    248,258, and 268 W. Evans St., Florence, SC 29501
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    South Irby Street Commercial Lot
    $255,000
    0.46 Acres

    South Irby Street Commercial Lot

    0.46 acre lot suitable for retail or office development.

    623 South Irby Street, Florence, SC 29501
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    Wendy's Restaurant For Sale
    Contact for pricing
    2,058 SF

    Wendy's Restaurant For Sale

    Wendy’s in Florence, South Carolina, leased for 20 years.

    4010 E Palmetto St, Florence, SC
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    Wendy’s Restaurant in Florence, SC
    Contact for pricing
    2,202 SF

    Wendy’s Restaurant in Florence, SC

    Wendy’s restaurant for sale on high-traffic retail corridor.

    624 S Irby St, Florence, SC
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    Versatile Office Building For Sale
    $262,500
    2,004 SF

    Versatile Office Building For Sale

    Functional office building in high traffic area, ideal for professionals.

    603 W Palmetto Street, Florence, SC 29501
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    Retail, Special Purpose
    $400,000
    3,375 SF

    Retail, Special Purpose

    Retail space · 3,375 SF

    710 S Barringer St, Florence, SC 29501
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    Corner Commercial Property For Sale
    $200,000
    1,520 SF

    Corner Commercial Property For Sale

    Commercial property with block building near downtown Florence and hospitals.

    702 S Barringer St, Florence, SC 29501
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    Mechanic/Auto Body Shop For Sale
    $200,000
    1,350 SF

    Mechanic/Auto Body Shop For Sale

    Two metal shops with high traffic location near downtown.

    726 Barringer St, Florence, SC 29501
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    Florence, SC Retail Properties & Spaces Investment Opportunities Market Analysis

    Explore 72 retail properties & spaces for sale in Florence, SC, showcased through 31 active listings on our real estate platform. These investment opportunities span a total of 225,958 square feet of properties for sale, with an estimated market value of $20,946,744.

    Sale prices for stores in Florence, SC start at $79,000, averaging $952,124, and reaching up to $4,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Shopping centers 7
    Grocery and convenience stores 5
    Automotive properties 4
    Auto shops 3
    Showrooms 3

    Demographics Overview

    Population 92K
    Population Growth (5Y) -1.5%
    Median Household Income $61,793
    College Educated 17.4%

    High-Yield Neighborhoods for Investment

    Identify Florence submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    29505 $125K
    29501 $813.9K
    29506 $1.1M

    Taxes & Financing

    Average Loan-to-Value 65.0%

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