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    Florence, SC Commercial Real Estate for Sale

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    Hotel Concept Development Land
    Hotel Concept Development Land

    2423 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    7,000 sqft

    Concept development includes an approximate 90-room select-service hotel and a 5,000–7,000 SF flexible commercial/restaurant pad.

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    Downtown Florence Business Technology Center
    Downtown Florence Business Technology Center

    187 E Evans St, Florence, SC

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    119,567 sqft 3.29 AC lot

    Office building in downtown Florence with investment and value-add potential.

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    Florence Commercial Development Opportunity
    Florence Commercial Development Opportunity

    2621 West Palmetto Street, Florence, SC 29501

    Contact for pricing
    4.54 AC lot

    4.54 acre commercial parcel on high-traffic corridor.

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    See what stands out in Florence County

    We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

    We check every listing here. A few are worth a second look.

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    Multi-Height Warehouse Facility
    Multi-Height Warehouse Facility

    200 Lawson Street, Florence, SC 29501

    Contact for pricing
    10,000 sqft

    Warehouse offers 20', 15', and 18' ceiling heights with multiple high doors and a 10' loading dock door.

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    Large Church Facility
    Large Church Facility

    1200 N Irby, Florence, SC 29501

    Contact for pricing
    68,000 sqft 9.50 AC lot

    Church facility with sanctuary, offices, classrooms, nursery, and an industrial kitchen.

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    Howard Johnson Hotel with On-Site Residence
    Howard Johnson Hotel with On-Site Residence

    2038 W Lucas St, Florence, SC 29501

    Contact for pricing
    3.73 AC lot

    Two-story limited-service property with infrastructure upgrades and a newly renovated two-bedroom, one-bathroom residence.

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    Manufacturing Facility with Crane
    Manufacturing Facility with Crane

    1500 E National Cemetery Rd, Florence, SC 29506

    Contact for pricing
    90,600 sqft

    Industrial property with concrete flooring, heavy lifting equipment, and available utilities.

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    Commercial Land Corner Development
    Commercial Land Corner Development

    1949 W Darlington St, Florence, SC 29501

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    1.53 AC lot

    Corner commercial land offering parking and potential for multi-tenant or single-tenant development.

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    Corner Commercial Development Lot
    Corner Commercial Development Lot

    700 N CASHUA DR, Florence, SC 29501

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    1.45 AC lot

    Signalized corner lot with water and sewer access and convenient entry from two streets.

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    NNN Leased Plasma Investment Property
    NNN Leased Plasma Investment Property

    1933 2nd Loop Rd, Florence, SC 29501

    Contact for pricing
    17,174 sqft

    NNN leased investment property in Florence, South Carolina.

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    B-3 Office Building with Private Offices
    B-3 Office Building with Private Offices

    1205 W Evans St, Florence, SC 29501

    Contact for pricing
    2,290 sqft

    Configured for professional services with a lobby, private offices, open workspace, and support areas.

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    Historic Downtown Florence Commercial Property
    Historic Downtown Florence Commercial Property

    329 N Irby St, Florence, SC 29501

    Contact for pricing
    12,411 sqft 1.55 AC lot

    Historic building in downtown Florence, suitable for commercial use.

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    Commercial Land For Sale
    Commercial Land For Sale

    2819 E Palmetto Street, Florence, SC 29501

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    1.98 AC lot

    1.98 acre commercial land with utilities in Florence, SC.

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    South Irby Street Commercial Lot
    South Irby Street Commercial Lot

    623 South Irby Street, Florence, SC 29501

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    0.46 AC lot

    0.46 acre lot suitable for retail or office development.

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    Freestanding Restaurant Building with Parking
    Freestanding Restaurant Building with Parking

    137 East Palmetto Street, Florence, SC 29506

    Contact for pricing

    Corner restaurant building with parking and expansion potential.

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    Versatile Office Building For Sale
    Versatile Office Building For Sale

    603 W Palmetto Street, Florence, SC 29501

    Contact for pricing
    2,004 sqft

    Functional office building in high traffic area, ideal for professionals.

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    Wendy’s Restaurant in Florence, SC
    Wendy’s Restaurant in Florence, SC

    624 S Irby St, Florence, SC

    Contact for pricing
    2,202 sqft 0.69 AC lot

    Wendy’s restaurant for sale on high-traffic retail corridor.

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    Wendy's Restaurant For Sale
    Wendy's Restaurant For Sale

    4010 E Palmetto St, Florence, SC

    Contact for pricing
    2,058 sqft 1.10 AC lot

    Wendy’s in Florence, South Carolina, leased for 20 years.

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    Vacant Convenience Store and Gas Station
    Vacant Convenience Store and Gas Station

    4011 E Palmetto St, Florence, SC 29506

    Contact for pricing
    2,957 sqft

    Vacant 2,957 SF c-store paired with a 76-branded gas station at 4011 E Palmetto St in Florence, SC.

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    Warehouse with High-Clearance Space
    Warehouse with High-Clearance Space

    904 North Douglas, Florence, SC 29501

    Contact for pricing
    400,000 sqft 31.00 AC lot

    Industrial property offers expansive open interiors, modern lighting, truck-accessible entry points, and dual-street access.

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    Commercial Land with Highway Frontage
    Commercial Land with Highway Frontage

    4020 East Palmetto Street, Florence, SC 29506

    Contact for pricing

    CMU-zoned commercial land with public utilities and direct exposure along a major commercial corridor.

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    Vacant Commercial Development Land
    Vacant Commercial Development Land

    1714 W 2nd Loop Rd., Florence, SC 29501

    Contact for pricing

    A 4.04-acre vacant parcel zoned Farm Vacant (FV) with convenient access to W 2nd Loop Road.

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    Commercial Land with Curb Cut
    Commercial Land with Curb Cut

    621 S Irby Street, Florence, SC 29501

    Contact for pricing

    Three-parcel commercial land assemblage with curb-cut access in downtown Florence.

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    Evans Street Commercial Redevelopment Opportunity
    Evans Street Commercial Redevelopment Opportunity

    617 W Evans St, Florence, SC 29501

    Contact for pricing
    1,200 sqft 0.75 AC lot

    Standalone building on Evans Street with redevelopment potential.

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