Edwardsville, IL Office Units for Rent & Lease

$500/Mo

Office Suite For Lease

340 S Fillmore Street, Edwardsville, IL 62025

Single office suite for rent near downtown Edwardsville, Illinois.

All utilities included in monthly rent ($500/month).
Convenient location near downtown Edwardsville.
Access to MCT Bike Trail.
Ample parking available.
Shared kitchen and bath.

Updated: Feb 25

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$19 SF/Yr

950 SF

Professional Office Space Available

9 Junction Dr, Edwardsville, IL

950 SF professional office space for lease.

Convenient access to Rte. 159
Located in Glen Carbon, Illinois
Professional office space with 950 SF
Quality finishes
Located in a Professional Office Complex

Updated: Nov 24, 2025

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$24 SF/Yr

4,624 SF

Downtown Edwardsville Office Space

Prime office space adjacent to Madison County courthouse.

241 N Main, Edwardsville, IL

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Downtown Edwardsville Office/Retail Space

$25 SF/Yr

1,800 SF

Downtown Edwardsville Office/Retail Space

1,800 SF space with frontage and visibility on Main Street.

220 N Main St, Edwardsville, IL

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Downtown Edwardsville Retail/Office Space

$25 SF/Yr

1,029 SF

Downtown Edwardsville Retail/Office Space

Freestanding 1,029 SF retail/office space in downtown Edwardsville.

501 N Main, Edwardsville, IL

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$22 SF/Yr

1,000 SF

Downtown Edwardsville Office/Retail Space

Premier office/retail space in downtown Edwardsville at lighted intersection.

100 N Main St, Edwardsville, IL 62025

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$500/Mo

Office Suite For Rent

Single office suite for rent with utilities included.

340 S Fillmore Street Rear, Edwardsville, IL 62025

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$25 SF/Yr

7,266 SF

Edwardsville Office Suites for Lease

Office suites available in campus-like Mark Twain Plaza.

103 W Vandalia St, Edwardsville, IL 62025

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$9 SF/Yr

Flexible Workspace Solutions Available Now

Global network of workspaces with tailored options for any business.

101 W Vandalia St, Suite 125, Edwardsville, IL 62025

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Edwardsville Mixed-Use Retail/Office Space

$30 SF/Yr

1,932 SF

Edwardsville Mixed-Use Retail/Office Space

New construction mixed-use building with retail, office, and restaurant spaces.

400 N Main St, Edwardsville, IL 62025

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$18 SF/Yr

8,000 SF

Historic Office Space in Edwardsville

Unique creative office space in historic downtown Edwardsville, Illinois.

201 Hillsboro Ave, Edwardsville, IL 62025

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$25 SF/Yr

2,520 SF

Downtown Edwardsville Office Space

2,520 SF office space for lease in downtown Edwardsville.

228 N Main St, Edwardsville, IL 62025

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$25 SF/Yr

4,462 SF

Edwardsville Office Suites For Rent

Office suites available in campus-like Mark Twain Plaza, Edwardsville, IL.

101 W Vandalia St, Edwardsville, IL 62025

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$25 SF/Yr

1,531 SF

Edwardsville Office Suites For Rent

Office suites available in campus-like Mark Twain Plaza, Edwardsville.

105 W Vandalia St, Edwardsville, IL 62025

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$16 SF/Yr

4,000 SF

Edwardsville Office Space For Rent

Office suite available in Sunset Hills Professional Center.

1 Sunset Hills Professional Ctr, Edwardsville, IL 62025

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$25 SF/Yr

7,266 SF

Mark Twain Plaza Office Suites

Office suites available for lease in Mark Twain Plaza.

101 W Vandalia St, Edwardsville, IL 62025

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$20 SF/Yr

5,874 SF

Main Level Office Space Available

Professionally managed office space for lease, convenient location.

1012 Plummer Dr, Edwardsville, IL 62025

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$12 SF/Yr

Office Space Near Mannie Jackson Center

Office space for lease near downtown Edwardsville retail corridor.

1310 N Main St, Edwardsville, IL 62025

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Edwardsville Office/Retail Suites Available

$25 SF/Yr

2,720 SF

Edwardsville Office/Retail Suites Available

Class A office/retail suites available in mixed-use development.

1001-1010 Enclave Blvd, Edwardsville, IL

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$20 SF/Yr

5,874 SF

Professional Office Space Available

5,874 SF office space for lease, professionally managed.

1012 Plummer Dr, Edwardsville, IL 62025

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Premier Mixed-Use Development in Edwardsville

$25 SF/Yr

2,720 SF

Premier Mixed-Use Development in Edwardsville

Mixed-use development with office/retail suites available for lease.

1010 Enclave Blvd, Edwardsville, IL 62025

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$12 SF/Yr

2,100 SF

Edwardsville Office Space For Rent

Professional office building near Sunset Hills Golf Course in Edwardsville, IL.

1 Sunset Hills Professional Centre, Edwardsville, IL 62025

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Based on your search, we've compiled 31 Potential Opportunities for your consideration. Besides 22 Active listings in Edwardsville, IL, we suggest exploring alternatives. Similar 9 Properties for Sales.

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Versatile Commercial Property in Edwardsville

$395,000

2,688 SF

Versatile Commercial Property in Edwardsville

Standout commercial property with high visibility and flexible space.

220 S Buchanan Street, Edwardsville, IL 62025

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$995,000

17,056 SF

Versatile Mixed-Use Commercial Property

17,000+ sq ft Edwardsville property suitable for diverse uses.

201 W High Street, Edwardsville, IL 62025

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Edwardsville, IL Office Units Leasing Opportunities Market Analysis

Explore Office Units leasing options in Edwardsville, IL with 22 listings featured on our commercial real estate exchange. The current inventory includes 65,668 square feet of properties with an estimated lease value of $408 /Mo.

Estimated lease rates for Office Units in Edwardsville, IL begin at $12 SF/Yr, with an average of $22 SF/Yr and extend to $30 SF/Yr.