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    Alton, IL Medical Office Space for Lease

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    Godfrey, IL Wood River, IL Saint Louis, MO
    Alton Retail/Office Space Available
    $13 SF/Yr
    8,872 SF
    Alton Retail/Office Space Available

    215 E Center Drive, Alton, IL 62002

    Desirable retail/office space with high visibility near Alton Square Mall.
    • High traffic and visibility location across from Alton Square Mall and adjacent to Homer Adams Parkway.
    • Available for immediate occupancy.
    • Approximately 2,799 s.f. retail/office space.
    • Prior use was a Dental Office, with existing reception area, handicap bathroom, office space, lab space, kitchenette, and storage area.
    • Anchor tenants include Quest Diagnostics, Jackson Hewitt, C.J. Schlosser, Great Rivers Animal Hospital and Southwestern Hearing Center.
    Updated: May 1
    View details
    Alton Office Space for Lease
    $700/Mo
    30,980 SF
    Alton Office Space for Lease

    307 Henry St., Alton, IL 62002

    Office space available in full-service building with parking.
    • Full‑service lease includes taxes, utilities, insurance, CAM, and light janitorial services.
    • Located in a HUB Zone.
    • Suitable for medical, legal, or other professional/personal services.
    • Building elevator provides access to all four floors.
    • Ample parking available.
    Updated: Sep 30, 2025
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    Fourth-Floor Office Suite
    $665/Mo
    500 SF
    Fourth-Floor Office Suite

    Fourth-floor professional suite offers elevator access and full-service leasing with utilities and CAM included.

    407-307 Henry St, Alton, IL 62002

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    Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 3 Active listings in Alton, IL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Renovated Multi-Tenant Office Building
    $1,700/Mo
    3,372 SF
    Renovated Multi-Tenant Office Building

    Renovated office building on a major corridor, offering a fully built-out suite that can be divided into two offices.

    3723 Nameoki Road, Granite City, IL 62040

    View details
    Glen Carbon Lower Level Suite
    $18 SF/Yr
    5,145 SF
    Glen Carbon Lower Level Suite

    5,145 SF unfinished suite ideal for office or retail.

    2160 S State Route 157, Glen Carbon, IL 62034

    View details
    Glen Carbon Lower Level Suite
    Contact for pricing
    5,145 SF
    Glen Carbon Lower Level Suite

    Unfinished 5,145 SF suite ideal for office or retail.

    2160 South State Route 157, Glen Carbon, IL 62034

    View details
    Granite City Office Space Available
    $9 SF/Yr
    2,050 SF
    Granite City Office Space Available

    Office space for rent near Maryville Rd. and Pontoon Rd.

    3908 Maryville Rd, Granite City, IL

    View details

    Similar Spaces for Sale in Alton, IL

    Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

    Medical Office Building For Sale
    $4,000,000
    64,800 SF
    Medical Office Building For Sale

    64,800 SF medical office building on 4.3 acres.

    1 Professional Drive, Alton, IL 62002

    View details
    Alton Medical Office Building For Sale
    $4,000,000
    64,800 SF
    Alton Medical Office Building For Sale

    64,800 SF medical office building with investment potential.

    1 Professional Drive , 20120, Alton, IL 62002

    View details
    Alton Medical Campus Opportunity
    Contact for pricing
    221,754 SF
    Alton Medical Campus Opportunity

    Vacant medical campus in historic Alton, Illinois.

    915 E 5th St, Alton, IL

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office Development Land For Lease
    Contact for pricing
    4,000 SF
    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401

    View details
    Kingery Highway Commercial Development Opportunity
    $85,000 SF/Yr
    Kingery Highway Commercial Development Opportunity

    High-visibility land for retail, car wash, or medical development.

    8501 & 8511 Kingery Highway, Willowbrook, IL 60527

    View details
    Beaumont Centre Outparcel Opportunity
    Contact for pricing
    Beaumont Centre Outparcel Opportunity

    Outparcel opportunity in established shopping center for ground lease.

    3199 Beaumont Centre Circle, Lexington, KY 40513

    View details
    Prime Lexington Outlot Opportunity
    Contact for pricing
    Prime Lexington Outlot Opportunity

    Outlot for ground lease or build-to-suit in South Lexington.

    3330 Partner Place, Lexington, KY 40503

    View details

    Alton, IL Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Alton, IL with 3 listings featured on our commercial real estate exchange. The current inventory includes 9,372 square feet of properties with an estimated lease value of $28 SF/Yr.

    Estimated lease rates for Medical Office Space in Alton, IL begin at $13 SF/Yr, with an average of $14 SF/Yr and extend to $15 SF/Yr.
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