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Lee County, FL Office Properties & Spaces for Sale

125 results
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Cape Coral Business Park Space
Contact for pricing
1.21 Acres

Cape Coral Business Park Space

4409 SE 16Th St, Cape Coral, FL 33904

Well-located business park with ample parking and recent renovations.

  • Well‑located business park with signalized access to Del Prado Blvd S.
  • Lease rate of $12.00 PSF + NNN (est. $7.95 PSF).
  • Recently renovated with new roof, lighting, landscape enhancements, and fresh paint.
  • Ample parking available.
  • Zoning: SC Local, approved for a wide variety of office, light industrial, and retail uses.
Updated: Nov 19, 2025
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Office/Medical Office Park Available
Contact for pricing
5.17 Acres

Office/Medical Office Park Available

6831 Palisades Park Ct, Fort Myers, FL 33912

Centrally located office and medical office spaces with ample parking.

  • Fully built‑out medical office space available at 6811 Palisades Park Court, STE 1.
  • Centrally located office/medical office park.
  • Immediate occupancy available at 6811 Palisades Park Court, STE 1.
  • Approved for office and medical office uses.
  • Freestanding surgery center and medical office space available at 6821 Palisades Park Court.
Updated: Sep 4, 2025
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Estero Retail and Office Space
Contact for pricing
0.75 Acres

Estero Retail and Office Space

35,000 SF center with retail, office, and medical spaces.

21740 S Tamiami Trl, Estero, FL 33928
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Estero Office Suite with Balcony
Contact for pricing
70.04 Acres

Estero Office Suite with Balcony

Second floor office suite with balcony overlooking Fashion Drive.

23190 Fashion Dr, Estero, FL 33928
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Profitable Fort Myers Investment Opportunity
$2,025,000
0.97 Acres

Profitable Fort Myers Investment Opportunity

Free-standing, fully leased building with diverse tenants and ample parking.

3775 Fowler St, Fort Myers, FL 33901
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Professional Office Suites Available
Contact for pricing
0.07 Acres

Professional Office Suites Available

Flexible office solutions with furnished spaces and professional amenities.

12530 World Plaza Ln, Fort Myers, FL 33907
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Tamiami Trail Commercial Building
$1,750,000
0.83 Acres

Tamiami Trail Commercial Building

8,126 sq ft commercial building on 0.83 acres.

1357 N Tamiami Trl, North Fort Myers, FL 33903
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Fully Leased Fort Myers Investment
$3,900,000
2.72 Acres

Fully Leased Fort Myers Investment

Turnkey commercial property with immediate income and growth potential.

3900 Broadway, Fort Myers, FL 33901
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Renovated Commercial Building with Expansion
$1,349,000
0.32 Acres

Renovated Commercial Building with Expansion

Move-in-ready building with warehouse, land, and redevelopment potential.

3616 Broadway Pass, Fort Myers, FL 33901
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Fort Myers Warehouse with Office
$349,900
0.36 Acres

Fort Myers Warehouse with Office

Warehouse with private office, gated access, near airport and I-75.

3560 Work Dr, Fort Myers, FL 33916
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Renovated Office Condo on Sanibel
$299,000
0.14 Acres

Renovated Office Condo on Sanibel

Completely renovated office condo in the heart of Sanibel Island.

1640 Periwinkle Way, Sanibel, FL 33957
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Commercial Office Building For Sale
$315,000
0.19 Acres

Commercial Office Building For Sale

Commercial office building with tenant in place until April 2027.

2250 Fowler St, Fort Myers, FL 33901
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Bundled Investment Opportunity in Fort Myers
$259,000
0.27 Acres

Bundled Investment Opportunity in Fort Myers

Three office units totaling 1,685 SF for sale.

3949 103, Fort Myers, FL 33901
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Downtown Fort Myers Office Condo
$895,000
0.29 Acres

Downtown Fort Myers Office Condo

Class "A" office condo in the Downtown River District.

2401 1St St, Fort Myers, FL 33901
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Fort Myers Live/Work Opportunity
$3,795,000
1.06 Acres

Fort Myers Live/Work Opportunity

Fenced property with security, new roof, and hurricane windows.

3131 E Riverside Dr, Fort Myers, FL 33916
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Professional Office in Key West Style
$593,000
0.06 Acres

Professional Office in Key West Style

Move-in-ready office building in Banyan Creek Business Center.

12855 Banyan Creek Dr, Fort Myers, FL 33908
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Commercial Property Near Beach Access
$2,995,000
0.80 Acres

Commercial Property Near Beach Access

Large commercial property with remodeled building near public beach access.

6061 Estero Blvd, Fort Myers Beach, FL 33931
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Lehigh Acres Office For Sale
$100,000
1,000 SF

Lehigh Acres Office For Sale

Office space available in Lehigh Acres, Florida.

2211 Orchid Rd, Lehigh Acres, FL 33936
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Fort Myers Commercial Parcel
$1,600,000
2.45 Acres

Fort Myers Commercial Parcel

2.45-acre commercial parcel in Fort Myers, Florida.

15100 Elderberry Ln, Fort Myers, FL 33907
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Sanibel Commercial Building For Sale
$1,200,000
0.26 Acres

Sanibel Commercial Building For Sale

Commercial building with side street frontage in Sanibel, Florida.

905 Fitzhugh St, Sanibel, FL 33957
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Cape Coral Office Building For Sale
$1,695,969
0.55 Acres

Cape Coral Office Building For Sale

Highly desirable Cape Coral office building with high traffic exposure.

725 Cape Coral Pkwy W, Cape Coral, FL 33914
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Waterfront Commercial Property in Matlacha
$750,000
0.21 Acres

Waterfront Commercial Property in Matlacha

Income-producing commercial property with waterfront appeal in Pine Island.

4547 Pine Island Rd NW, Matlacha, FL 33993
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Gulf Access Multi-Tenant Office Building
$5,900,000
1.12 Acres

Gulf Access Multi-Tenant Office Building

Two-story office building with Gulf access on a signalized corner.

2804 Del Prado Blvd S, Cape Coral, FL 33904
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Cape Coral Commercial Opportunity
$1,050,000
0.16 Acres

Cape Coral Commercial Opportunity

Versatile commercial property in thriving Cape Coral location.

1213 SE 47Th Ter, Cape Coral, FL 33904
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Lee County, FL Office Properties & Spaces Investment Opportunities Market Analysis

Explore 3578 office properties & spaces for sale in Lee County, FL, showcased through 125 active listings on our real estate platform. These investment opportunities span a total of 229,395,740 square feet of properties for sale, with an estimated market value of $1,918,908,348.

Prices for office spaces in Lee County, FL start at $50,000, averaging $862,043, and reaching up to $29,670,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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