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    Florence, SC
    Office Building

    Florence, SC Office Buildings for Lease

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    6 properties
    Special-Use Office Building
    Updated: Jun 19
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft 0.58 AC lot
    Special‑use office building totaling 2,560 SF available September 2026
    Former veterinary office layout suitable for medical, professional, service‑based, or specialty office use
    Located on S Cashua Dr in Florence’s 5 Points commercial district in a high‑traffic area
    On‑site parking includes nine lined spaces in front, with additional parking available at the rear
    Set on a 0.58‑acre lot
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    Class A Office Building
    Updated: Apr 21
    Class A Office Building

    301 W Evans St, Florence, SC 29501

    Contact for pricing
    40,000 sqft
    Class A office building in Florence’s downtown corridor, directly adjacent to the Federal, State, and County Courthouses
    30,000–40,000 SF across 3–4 stories
    High‑capacity elevator and controlled‑access building
    Advanced HVAC and fully customizable tenant interiors
    Brick and stucco exterior with expansive storefront glazing for a downtown streetscape presence
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    Three-Story Office Building
    Three-Story Office Building

    186 Dunbarton Drive, Florence, SC 29501

    Contact for pricing
    32,087 sqft

    Three-story office building offering private offices, open workspace, and a ground-floor café-style break room.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans Street, Florence, SC 29501

    $4,500/Mo
    3,000 sqft

    Standalone office building near Downtown Florence with private parking.

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    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans St, Florence, SC 29501

    Contact for pricing
    3,000 sqft

    Standalone office building with private parking near Downtown Florence, SC.

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    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 6 Active listings in Florence, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Freestanding Office Building
    Freestanding Office Building

    1051 Shine Ave, Myrtle Beach, SC 29577

    $10,632/Mo
    6,379 sqft

    The layout includes more than 10 offices, multiple storage rooms, and two restrooms.

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    Interior Office-Retail Building
    Interior Office-Retail Building

    941 Spears Creek Court, Columbia, SC 29229

    Contact for pricing
    10,000 sqft 3.00 AC lot

    Interior-finished space with private offices, conference room, open area, and large entertaining space, plus fenced, gated entry.

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    Professional Office Suite
    Professional Office Suite

    1101 Johnson Avenue Unit 302, Myrtle Beach, SC 29577

    Contact for pricing
    43,323 sqft

    Professional office space in The Offices at Market Common, located between Highway 17 Business and Highway 17 Bypass.

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    Class A Office Building
    Class A Office Building

    140 Wildewood Park Dr, Columbia, SC 29223

    Contact for pricing

    Class A office space offering flexible lease terms and abundant on-site parking for day-to-day operations.

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    Similar Spaces for Sale in Florence, SC

    Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

    Historic Office Building with Parking
    Historic Office Building with Parking

    248-260 W Evans st., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    Historic office building with central air, heat pumps, and over 100 parking spaces in downtown Florence.

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    Wood-Frame Office Building
    Wood-Frame Office Building

    2228 W Palmetto St., Florence, SC 29501

    $225,000
    1,405 sqft 0.31 AC lot

    Wood-frame office building with heat pump heating and central air, positioned on a commercial lot along W Palmetto St.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    260 W Evans St, Florence, SC 29501

    $2,700,000
    16,000 sqft 1.47 AC lot

    A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    248-260 W Evans st., Florence, SC 29506

    Contact for pricing
    16,304 sqft 1.47 AC lot

    Historic office building in downtown Florence with multiple tenant suites and over 100 parking spaces.

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    Freestanding Office Building For Sale
    Freestanding Office Building For Sale

    1221 West Evans Street, Florence, SC 29501

    Contact for pricing
    1,085 sqft

    Leased office building with immediate income potential in Florence.

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    Freestanding Office Building with Parking
    Freestanding Office Building with Parking

    1500 West Evans Street, Florence, SC 29501

    Contact for pricing
    2,523 sqft

    Well-maintained brick office with private offices, reception, open workspace, and paved side and rear parking.

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    Multi-Tenant Office Building
    Multi-Tenant Office Building

    1465 Pamplico Hwy, Florence, SC 29505

    Contact for pricing
    6,768 sqft

    Office building offered for sale with approximately 6,768 SF and a stated 4.92% CAP.

    View details
    Downtown Florence Business Technology Center
    Downtown Florence Business Technology Center

    187 E Evans St, Florence, SC

    Contact for pricing
    119,567 sqft 3.29 AC lot

    Office building in downtown Florence with investment and value-add potential.

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    Historic Downtown Florence Building For Sale
    Historic Downtown Florence Building For Sale

    248,258, and 268 W. Evans St., Florence, SC 29501

    Contact for pricing
    16,304 sqft 1.47 AC lot

    16,000 SF historic building in downtown Florence for sale.

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    Historic Downtown Florence Commercial Property
    Historic Downtown Florence Commercial Property

    329 N Irby St, Florence, SC 29501

    Contact for pricing
    12,411 sqft 1.55 AC lot

    Historic building in downtown Florence, suitable for commercial use.

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    Versatile Office Building For Sale
    Versatile Office Building For Sale

    603 W Palmetto Street, Florence, SC 29501

    Contact for pricing
    2,004 sqft

    Functional office building in high traffic area, ideal for professionals.

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    Office Building with Salon Buildout
    Office Building with Salon Buildout

    604 Second Loop Rd, Florence, SC 29505

    Contact for pricing

    Office building arranged for a hair salon, with seven rooms, two bathrooms, and plenty of parking.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land Build-to-Suit Opportunity
    Commercial Land Build-to-Suit Opportunity

    2683 Henderson Drive, Jacksonville, NC 28546

    $4,000/Mo
    2,400 sqft

    Commercial land available for build-to-suit in Jacksonville, NC.

    View details
    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing
    1.27 AC lot

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details
    Commercial Land Near Retail
    Commercial Land Near Retail

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    GB-zoned commercial parcel with public water and sewer near established retail, dining, medical, and financial services.

    View details
    Cleared Lot in Williston
    Cleared Lot in Williston

    33 NW 3RD St, Williston, FL 32696

    $20,000/Mo

    C2-zoned lot in Williston's central business area for rent.

    View details

    Florence, SC Office buildings Market Trends and Statistics

    Explore Office buildings leasing options in Florence, SC with 6 listings featured on our commercial real estate exchange. The current inventory includes 80,647 square feet of properties with an estimated lease value of $18 SF/Yr.

    Estimated lease rates for Office buildings in Florence, SC average $18 SF/Yr.
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