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    Florence, SC Office Buildings for Lease

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    Darlington, SC Timmonsville, SC Hartsville, SC
    Special-Use Office Building
    Contact for pricing
    2,560 SF
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Well-positioned special-use office building with on-site parking and established visibility for medical or professional use.
    • Special‑use office building totaling 2,560 SF available September 2026
    • Former veterinary office layout suitable for medical, professional, service‑based, or specialty office use
    • Located on S Cashua Dr in Florence’s 5 Points commercial district in a high‑traffic area
    • On‑site parking includes nine lined spaces in front, with additional parking available at the rear
    • Set on a 0.58‑acre lot
    Updated: Jun 19
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    Office Building with I-95 Visibility
    Contact for pricing
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.
    • Office building in a professional business park with visibility from I‑95
    • Convenient access to both I‑95 and I‑20
    • On‑site parking includes 28 front spaces, with additional parking at the rear
    Updated: May 29
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    Refreshed Office Building For Lease
    $216 SF/Yr
    3,000 SF
    Refreshed Office Building For Lease

    Standalone office building with private parking near Downtown Florence, SC.

    620 W Evans St, Florence, SC 29501

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 3 Active listings in Florence, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Class A Office Building For Rent
    $18 SF/Yr
    57,000 SF
    Class A Office Building For Rent

    Unique atrium-style office building with suites available for immediate occupancy.

    115 Atrium Way, Columbia, SC 29223

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    Class A Office Building
    Contact for pricing
    Class A Office Building

    Class A office space offering flexible lease terms and abundant on-site parking for day-to-day operations.

    140 Wildewood Park Dr, Columbia, SC 29223

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    Freestanding Office Building in Myrtle Beach
    Contact for pricing
    Freestanding Office Building in Myrtle Beach

    Office building in The Market Common District for rent.

    1051 Shine Ave, Myrtle Beach, SC 29577

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    Class A Office Building
    $27 SF/Yr
    45,000 SF
    Class A Office Building

    Professional office building in the Founders Centre Corporate Campus.

    611 Burroughs and Chapin Blvd, Myrtle Beach, SC 29577

    View details

    Similar Spaces for Sale in Florence, SC

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Historic Downtown Office Building
    $2,700,000
    16,304 SF
    Historic Downtown Office Building

    Historic office building with multiple suites and ample on-site parking in downtown Florence.

    248-260 W Evans st., Florence, SC 29501

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    Downtown Florence Business Technology Center
    $12,000,000
    119,567 SF
    Downtown Florence Business Technology Center

    Office building in downtown Florence with investment and value-add potential.

    187 E Evans St, Florence, SC

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    Freestanding Office Building For Sale
    $199,000
    1,085 SF
    Freestanding Office Building For Sale

    Leased office building with immediate income potential in Florence.

    1221 West Evans Street, Florence, SC 29501

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    Historic Downtown Florence Building For Sale
    $2,800,000
    16,304 SF
    Historic Downtown Florence Building For Sale

    16,000 SF historic building in downtown Florence for sale.

    248,258, and 268 W. Evans St., Florence, SC 29501

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    Historic Downtown Florence Commercial Property
    $1,100,000
    12,411 SF
    Historic Downtown Florence Commercial Property

    Historic building in downtown Florence, suitable for commercial use.

    329 N Irby St, Florence, SC 29501

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    Versatile Office Building For Sale
    $262,500
    2,004 SF
    Versatile Office Building For Sale

    Functional office building in high traffic area, ideal for professionals.

    603 W Palmetto Street, Florence, SC 29501

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    Office Building Near Downtown Florence
    Contact for pricing
    2,481 SF
    Office Building Near Downtown Florence

    Office building with private offices, conference room, and parking.

    604 S Coit, Florence, SC 29501

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land Build-to-Suit Opportunity
    $4,000/Mo
    2,400 SF
    Commercial Land Build-to-Suit Opportunity

    Commercial land available for build-to-suit in Jacksonville, NC.

    2683 Henderson Drive, Jacksonville, NC 28546

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    Prime Development Opportunity in Greenville
    Contact for pricing
    Prime Development Opportunity in Greenville

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    39 Airpark Ct, Greenville, SC 29607

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    Commercial Land with Build-Out Opportunity
    $1,200/Mo
    1,000 SF
    Commercial Land with Build-Out Opportunity

    Parcel zoned B/C with an unfinished interior, allowing a tenant to tailor build-out to their business.

    3709 Trent Road, New Bern, NC 28562

    View details
    Prime Commercial Lot For Lease
    $7,500/Mo
    Prime Commercial Lot For Lease

    0.66 acre commercial lot in high-traffic area.

    Tift Avenue N, Tifton, GA 31794

    View details

    Florence, SC Office buildings Market Trends and Statistics

    Explore Office buildings leasing options in Florence, SC with 3 listings featured on our commercial real estate exchange. The current inventory includes 3,000 square feet of properties with an estimated lease value of $216 SF/Yr.

    Estimated lease rates for Office buildings in Florence, SC begin at $216 SF/Yr, with an average of $216 SF/Yr and extend to $216 SF/Yr.
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