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    Irvine, CA Medical Office Space for Lease

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    6 properties
    Ground-Floor Medical Office Suite
    Updated: May 27
    Ground-Floor Medical Office Suite

    22 Odyssey, Irvine, CA 92618

    $6,915/Mo
    Sublease office space at 22 Odyssey, Suite 135, Irvine, CA
    1,500 SF open concept suite with a professional reception/entry area
    Move‑in ready suite with convenient ground‑floor access and a well‑maintained layout
    Configured for pharmacy use with client‑facing operations
    Central air; high‑speed internet and telecommunications readiness reported
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    Turnkey Open-Plan Medical Office
    Updated: May 28
    Turnkey Open-Plan Medical Office

    135-22 Odyssey, Irvine, CA 92618

    $6,915/Mo
    1,500 sqft
    1,500 SF ground‑floor office suite for sublease at 22 Odyssey, Suite 135 (Irvine, CA)
    Open floor plan configured for pharmacy/medical office with client‑facing operations
    Move‑in ready suite with convenient ground‑floor access and ample parking availability
    Professional entry/reception area plus open workspace suitable for client‑facing use
    High‑speed internet and telecommunications readiness
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    Single-Story Medical Office Building
    Single-Story Medical Office Building

    70 Discovery, Irvine, CA 92618

    Contact for pricing
    5,846 sqft

    Single-story freestanding office building with extensive interior and exterior glass and flexible space including lab area.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Ground-Floor Medical Office Suite
    Ground-Floor Medical Office Suite

    113 Waterworks Way, Irvine, CA 92618

    Contact for pricing
    1,402 sqft

    Ground-floor suite with four exam rooms, storage, and two entrances for patient and private physician access.

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    Irvine Medical Office Space Available
    Irvine Medical Office Space Available

    3500 Barranca Pkwy, Irvine, CA 92606

    $66 SF/Yr
    58,316 sqft

    Premier medical office building in Irvine with convenient freeway access.

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    Irvine Medical Plaza Office Suites
    Irvine Medical Plaza Office Suites

    114 Pacifica, Irvine, CA 92618

    Contact for pricing
    114,209 sqft

    Medical office suites for lease in Irvine Spectrum submarket.

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 6 Active listings in Irvine, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Versatile Flex Commercial Condominium
    Versatile Flex Commercial Condominium

    26150 Enterprise Way, Lake Forest, CA 92630

    $4,800/Mo

    Flexible flex unit suited for office, medical, showroom, training, or light industrial use with convenient freeway access.

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    Medical/Office Building Near Irvine Spectrum
    Medical/Office Building Near Irvine Spectrum

    22921, 22931 & 22941 Triton Way, Laguna Hills, CA 92653

    Contact for pricing
    6,800 sqft

    Two-story medical and office building with recent renovations and ample parking.

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    Medical Building with High Visibility
    Medical Building with High Visibility

    23321 El Toro Rd., Lake Forest, CA 92630

    Contact for pricing
    9,300 sqft

    Single-story medical building with ample parking and freeway access.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    24401 Calle De La Louisa, Laguna Hills, CA 92653

    Contact for pricing
    40,000 sqft

    New medical office space adjacent to Saddleback Memorial Hospital.

    View details

    Similar Spaces for Sale in Irvine, CA

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Turnkey Corner Medical Office Suite
    Turnkey Corner Medical Office Suite

    113 Waterworks, Irvine, CA 92618

    $2,968,000

    Fully built-out medical suite with a dedicated procedure room and reception-to-care workflow for outpatient specialty use.

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    Office
    Office

    15751 Rockfield Blvd, Irvine, CA 92618

    $8,000,000
    13,140 sqft

    Medical Office Space · 13,140 SF

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    Leased Medical Office Tower
    Leased Medical Office Tower

    16300 Sand Canyon Avenue, Irvine, CA 92618

    Contact for pricing
    115,791 sqft

    Medical office tower currently 90% leased, positioned front row to Hoag’s $1B expansion.

    View details
    Irvine Spectrum Medical Office Building
    Irvine Spectrum Medical Office Building

    113 Waterworks Way #110, Irvine, CA 92618

    $2,000,000
    63,430 sqft

    Class B medical office building in Irvine Spectrum, built in 2008.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land for Long-Term Lease
    Commercial Land for Long-Term Lease

    5538 E Paisano Drive, El Paso, TX 79905

    $5,950/Mo

    Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

    View details
    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details

    Irvine, CA Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Irvine, CA with 6 listings featured on our commercial real estate exchange. The current inventory includes 59,816 square feet of properties with an estimated lease value of $121.32 SF/Yr.

    Estimated lease rates for Medical Office Space in Irvine, CA begin at $55.32 SF/Yr, with an average of $60.66 SF/Yr and extend to $66 SF/Yr.
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    Most Searched ZIP Codes in Irvine, CA

    • 92618
    • 92606

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