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    Irvine, CA Medical Office Space for Lease

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    Los Angeles, CA San Diego, CA San Francisco, CA
    6 results
    Medical Office Sublease Opportunity
    $4 SF/Yr
    51,863 SF

    Medical Office Sublease Opportunity

    22 Odyssey, Irvine, CA 92618

    Pharmacy suite available for sublease in prime Orange County location.

    • Prime Orange County location near Hoag Hospital Irvine and Kaiser Permanente.
    • Class A medical building.
    • Excellent access to the 5 & 405 Freeways and the 133 Toll Road.
    • 1,500 SF Pharmacy Suite Available for Sublease.
    • Possible Long Term Lease Available.
    Updated: Jan 26
    View details
    Irvine Medical Office Building
    $3 SF/Yr
    43,000 SF

    Irvine Medical Office Building

    15825 Laguna Canyon Road, Irvine, CA 92618

    Medical office building in Irvine with surgery center availability.

    • Premier medical office building in Irvine with established medical tenants
    • Fully built‑out surgery center
    • Rare availability
    • Strategic location with easy access to major freeways and toll road
    • Proximity to Hoag and Kaiser Hospitals
    Updated: Nov 26, 2025
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    Medical Suites in Prime Location
    $0.99 SF/Yr
    23,732 SF

    Medical Suites in Prime Location

    Medical suites available for lease near John Wayne Airport.

    9 Corporate Park, Irvine, CA 92606
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    Irvine Medical/Office Space For Lease
    Contact for pricing
    34,698 SF

    Irvine Medical/Office Space For Lease

    Medical/office space in Irvine with flexible sizing and ample parking.

    17305 Von Karman Avenue, Irvine, CA 92614
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    Irvine Medical Office Space Available
    Contact for pricing
    58,316 SF

    Irvine Medical Office Space Available

    Premier medical office building in Irvine with convenient freeway access.

    3500 Barranca Pkwy, Irvine, CA 92606
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    Irvine Medical Plaza Office Suites
    Contact for pricing
    114,209 SF

    Irvine Medical Plaza Office Suites

    Medical office suites for lease in Irvine Spectrum submarket.

    114 Pacifica, Irvine, CA 92618
    View details
    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 6 Active listings in Irvine, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Newport Beach Medical Office Space
    Contact for pricing
    3,935 SF

    Newport Beach Medical Office Space

    High-image medical space in desirable Airport Area submarket.

    3701 Birch St, Newport Beach, CA 92660
    View details
    Tustin Medical Office Space Available
    Contact for pricing
    13,952 SF

    Tustin Medical Office Space Available

    Move-in ready medical office space in Tustin Medical Arts Center.

    13420 Newport Avenue, Tustin, CA 92780
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    Medical Office Suites For Lease
    $4 SF/Yr
    23,000 SF

    Medical Office Suites For Lease

    Medical office suites available from 1,750 to 23,000 SF.

    20071 SW Birch St, Newport Beach, CA
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    Medical Office Space Near Hospital
    Contact for pricing

    Medical Office Space Near Hospital

    Medical office space with easy access to freeways and hospital.

    14642 Newport Ave, Tustin, CA 92780
    View details

    Explore Similar Spaces for Sale in Irvine, CA

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Corner Medical Office Clinic in Irvine
    $2,968,000
    63,000 SF

    Corner Medical Office Clinic in Irvine

    Fully built-out medical office suite in a prime location.

    113 Waterworks, Irvine, CA 92618
    View details
    Freestanding Building in Irvine Spectrum
    $3,501,754
    5,846 SF

    Freestanding Building in Irvine Spectrum

    High-image building with polished concrete floors and extensive glass.

    70 Discovery, Irvine, CA 92618
    View details
    Office
    $8,000,000
    13,140 SF

    Office

    Medical Office Space · 13,140 SF

    15751 Rockfield Blvd, Irvine, CA 92618
    View details
    Irvine Spectrum Medical Office Building
    $2,000,000
    63,430 SF

    Irvine Spectrum Medical Office Building

    Class B medical office building in Irvine Spectrum, built in 2008.

    113 Waterworks Way #110, Irvine, CA 92618
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Grand Junction Commercial Land Lease
    $9,656 /Mo

    Grand Junction Commercial Land Lease

    0.74 acre commercial land for lease in Grand Junction.

    Highway 6&50, Grand Junction, CO 81505
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    Grand Junction Commercial Land Opportunity
    $17,728 /Mo

    Grand Junction Commercial Land Opportunity

    1.36 acre commercial land for lease in Grand Junction.

    Sanford Drive, Grand Junction, CO 81505
    View details
    El Paso Commercial Land Lease
    $3,600 /Mo

    El Paso Commercial Land Lease

    Commercial land for lease in a strategic El Paso location.

    5538 E Paisano Drive, El Paso, TX 79905
    View details
    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details

    Irvine, CA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Irvine, CA with 6 listings featured on our commercial real estate exchange. The current inventory includes 0 square feet of properties with an estimated lease value of $9 SF/Yr.

    Estimated lease rates for Medical Office Space in Irvine, CA begin at $0.99 SF/Yr, with an average of $3 SF/Yr and extend to $4 SF/Yr.
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    Browse Medical Office Space for Lease Near Irvine, CA

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    Most Searched ZIP Codes in Irvine, CA

    • 92618
    • 92606
    • 92614

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