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Irvine, CA Office Spaces for Lease

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Open-Plan Office Suite
Updated: May 27
Open-Plan Office Suite

22 Odyssey, Irvine, CA 92618

$6,915/Mo
1,500‑square‑foot office suite in Suite 135
Open floor plan with current pharmacy use
Ground‑floor location at 22 Odyssey
Central Air cooling
One block from Hoag Hospital
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Office Building for Lease
Updated: Jun 17, 2025
Office Building for Lease

2020 Main Street, Irvine, CA 92614

$4,593/Mo
Central air conditioning
Year built: 1999
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Turnkey Open-Plan Medical Office
Turnkey Open-Plan Medical Office

135-22 Odyssey, Irvine, CA 92618

$6,915/Mo
1,500 sqft

Move-in ready ground-floor suite with an open workspace for client-facing medical operations and convenient parking.

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Second-Floor Office Unit
Second-Floor Office Unit

950 Roosevelt, Irvine, CA 92620

$1.00 SF/Yr
4,960 sqft

Adaptable office space offers individual rooms and landlord-supported floor plan changes for varied professional uses.

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Serviced Offices with Business Support at Spaces The Quad. Contact us today to book a tour!
Serviced Offices with Business Support at Spaces The Quad. Contact us today to book a tour!

530 Technology Dr, Irvine, CA 92618

15 available spaces from 11 to 2,027 sqft
$129-$24,665/Mo per office

Find fully flexible work and meeting space in Spaces The Quad. Book a tour & get info

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Flexible Offices and Coworking at Irvine Spectrum. Contact us today to book a tour!
Flexible Offices and Coworking at Irvine Spectrum. Contact us today to book a tour!

300 Spectrum Center Dr, Unit 400, Irvine, CA 92618

16 available spaces from 11 to 2,012 sqft
$119-$20,924/Mo per office

Flexible workspace in Irvine Spectrum. Book a tour & get info

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Cost-Efficient Office Space at Spaces Intersect. Contact us today to book a tour!
Cost-Efficient Office Space at Spaces Intersect. Contact us today to book a tour!

17875 Von Karman Ave, Irvine, CA 92614

15 available spaces from 11 to 2,001 sqft
$129-$22,818/Mo per office

Find fully flexible work and meeting space in Spaces Intersect. Book a tour & get info

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Serviced Office Space for Rent at Irvine Center Drive. Contact us today to book a tour!
Serviced Office Space for Rent at Irvine Center Drive. Contact us today to book a tour!

7545 Irvine Center Dr, Unit 200, Irvine, CA 92618

16 available spaces from 11 to 2,042 sqft
$129-$24,537/Mo per office

Flexible workspace in Irvine Center Drive. Book a tour & get info

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Single-Story Medical Office Building
Single-Story Medical Office Building

70 Discovery, Irvine, CA 92618

Contact for pricing
5,846 sqft

Single-story freestanding office building with extensive interior and exterior glass and flexible space including lab area.

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Furnished Office Suite with Parking
Furnished Office Suite with Parking

300 Spectrum Center Drive, Suite 1120, Irvine, CA 92618

Contact for pricing
8,147 sqft

Fully furnished suite in Spectrum Center with covered parking, conference space, and on-site café and gym.

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Second-Floor Office Suite
Second-Floor Office Suite

17672 Cowan, Irvine, CA 92614

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3,350 sqft

Multi-tenant office setting with six private offices and restrooms.

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Fully Furnished Plug-and-Play Office Suite
Fully Furnished Plug-and-Play Office Suite

300 Spectrum Center Drive, Suite 1120, Irvine, CA 92618

Contact for pricing
8,147 sqft

Sublease office suite with conference center and covered parking for an efficient, move-in-ready setup.

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Ground-Floor Office Suite
Ground-Floor Office Suite

1100 Main St, Irvine, CA 92614

Contact for pricing
6,140 sqft

Ground-floor suite with 17 offices, including corner offices, plus reception, kitchen, copy, and utility rooms.

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Office Suite with Reception
Office Suite with Reception

28 Hammond, Irvine, CA 92618

Contact for pricing
4,753 sqft

Office suite includes reception, three private offices, two restrooms, and two open areas with 100% HVAC.

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Class A Three-Story Office Building
Class A Three-Story Office Building

17900 Von Karman Avenue, Irvine, CA 92614

Contact for pricing
71,864 sqft

Surface parking supports a three-level workplace in Irvine’s master planned business district.

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Furnished Office Suite in Irvine
Furnished Office Suite in Irvine

2020 Main St 360, Irvine, CA 92614

$8,754/Mo

Move-in-ready office suite with reception, offices, conference room, kitchen.

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Corner Flex Space
Corner Flex Space

23 Mauchly, Suite 110, Irvine, CA 92618

Contact for pricing
2,390 sqft

Air-conditioned corner suite combines finished offices with an open work area for flexible business operations.

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Sublease Office Space
Sublease Office Space

2515 McCabe Way, Irvine, CA 92614

Contact for pricing
7,671 sqft

Office space is available on a sublease basis with an in-place sublease term through 2029.

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Ground-Floor Medical Office
Ground-Floor Medical Office

15785 Laguna Canyon Rd, Irvine, CA 92618

Contact for pricing
2,388 sqft

Move-in-ready medical office with exam rooms, two restrooms, a kitchen, and lab space.

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Flex Space with Ground-Level Doors
Flex Space with Ground-Level Doors

15291-15301 Barranca Pkwy, Irvine, CA 92618

Contact for pricing
9,266 sqft

Two-story office component with ground-level loading and access to major freeways.

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Office Suite in Business Park
Office Suite in Business Park

6 Morgan, Ste 125, Irvine, CA 92618

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2,823 sqft

Available for rent as Suite 125 within Alton Business Park, offering 2,823 square feet of office space.

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Flex Space with Private Offices
Flex Space with Private Offices

23 Mauchly, Irvine, CA 92618

Contact for pricing
2,390 sqft

Flexible commercial suite combining office space with a dedicated work area and two restrooms.

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Flex Space with Ground-Level Door
Flex Space with Ground-Level Door

12 Mauchly, Irvine, CA 92618

Contact for pricing
4,304 sqft

R&D and industrial condominium offering warehouse functionality with office component and a full sprinkler system.

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Freestanding Single-Story Retail Facility
Freestanding Single-Story Retail Facility

17361 Armstrong Ave, Irvine, CA 92614

Contact for pricing
11,331 sqft

Freestanding single-story retail facility with a 4:1 parking ratio available for lease in Irvine.

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Irvine, CA Office Spaces Lease Rates & Market Statistics

Browse 184 Office Spaces for lease in Irvine, CA on Realmo, a commercial real estate marketplace serving the Irvine area. The current inventory totals 5,893,535 square feet of properties — an average of ~32,050 SF per listing.

Office Spaces lease rates in Irvine range from $21.12 SF/Yr at the entry level to $55.32 SF/Yr at the top of the market, averaging $39.12 SF/Yr. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $39.12 SF/Yr, the local average runs 57% above California's state average of $24.90 SF/Yr.

Irvine accounts for 20% of the 939 office spaces currently available across Orange County, where nearby markets include Newport Beach and Santa Ana. By space type, the market includes 120 office units, 44 office buildings and 15 coworking space listings.

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