Laguna Hills, CA Medical Office Space for Rent & Lease

Updated: Nov 26, 2025

Medical/Office Building Near Irvine Spectrum

22921, 22931 & 22941 Triton Way, Laguna Hills, CA 92653

Contact for pricing

6,800 sqft

Prime South Orange County location
Excellent access to the 405, 133 & 5 Freeways and Toll Roads
Major renovations just completed
Near Irvine Spectrum Center
Near newly developed luxury residential

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Updated: Nov 21, 2025

Renovated Medical Office Building

24953 Paseo De Valencia Bldg C, Laguna Hills, CA 92653

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21,300 sqft

Recently renovated exterior with a modern, upscale design.
Convenient and abundant patient parking.
Professionally managed medical office building.
Located near Saddleback Memorial Medical Center.
Great natural light inside the suites.

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Medical Office Space For Rent

24401 Calle De La Louisa, Laguna Hills, CA 92653

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40,000 sqft

New medical office space adjacent to Saddleback Memorial Hospital.

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Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 3 Active listings in Laguna Hills, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Single-Story Medical Office Building

70 Discovery, Irvine, CA 92618

Contact for pricing

5,846 sqft

Single-story freestanding office building with extensive interior and exterior glass and flexible space including lab area.

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Two-Story Medical Office Building

23591 El Toro Road, Lake Forest, CA 92630

$24 SF/Yr

Two-story suites with medical use approved, featuring shared lobby, lounge, courtyard seating, and private mailboxes.

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Medical Building with High Visibility

23321 El Toro Rd., Lake Forest, CA 92630

Contact for pricing

9,300 sqft

Single-story medical building with ample parking and freeway access.

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Irvine Medical Plaza Office Suites

114 Pacifica, Irvine, CA 92618

Contact for pricing

114,209 sqft

Medical office suites for lease in Irvine Spectrum submarket.

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Similar Spaces for Sale in Laguna Hills, CA

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

Furnished Second-Floor Office Condo

23232 PERALTA DR, Laguna Hills, CA 92653

$98,000

1,234 sqft

Turnkey second-floor office condo includes three private offices and a reception/work area with furnishings included.

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Laguna Hills Office Condo

23232 Peralta Drive 117, Laguna Hills, CA 92653

$49,900

574 sqft 0.01 AC lot

Office condo for sale or lease in Laguna Hills.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land for Long-Term Lease

5538 E Paisano Drive, El Paso, TX 79905

$5,950/Mo

Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft

1.7 acre corner lot zoned for commercial, medical, residential.

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Prime Lexington Outlot Opportunity

3330 Partner Place, Lexington, KY 40503

Contact for pricing

Outlot for ground lease or build-to-suit in South Lexington.

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Laguna Hills, CA Medical Office Space for Lease

22921, 22931 & 22941 Triton Way, Laguna Hills, CA 92653

24953 Paseo De Valencia Bldg C, Laguna Hills, CA 92653

24401 Calle De La Louisa, Laguna Hills, CA 92653