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    Irvine, CA Commercial Real Estate for Lease

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    Open-Plan Office Suite
    Updated: May 27
    Open-Plan Office Suite

    22 Odyssey, Irvine, CA 92618

    $6,915/Mo
    1,500‑square‑foot office suite in Suite 135
    Open floor plan with current pharmacy use
    Ground‑floor location at 22 Odyssey
    Central Air cooling
    One block from Hoag Hospital
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    Office Building for Lease
    Updated: Jun 17, 2025
    Office Building for Lease

    2020 Main Street, Irvine, CA 92614

    $4,593/Mo
    Central air conditioning
    Year built: 1999
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    Ground-Floor Medical Office Suite
    Ground-Floor Medical Office Suite

    22 Odyssey Unit 135, Irvine, CA 92618

    $6,915/Mo
    1,500 sqft

    Open-plan professional space with pharmacy-related client-facing configuration and convenient access to major transportation routes.

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    Turnkey Open-Plan Medical Office
    Turnkey Open-Plan Medical Office

    135-22 Odyssey, Irvine, CA 92618

    $6,915/Mo
    1,500 sqft

    Move-in ready ground-floor suite with an open workspace for client-facing medical operations and convenient parking.

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    Second-Floor Office Unit
    Second-Floor Office Unit

    950 Roosevelt, Irvine, CA 92620

    $1.00 SF/Yr
    4,960 sqft

    Adaptable office space offers individual rooms and landlord-supported floor plan changes for varied professional uses.

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    Serviced Offices with Business Support at Spaces The Quad. Contact us today to book a tour!
    Serviced Offices with Business Support at Spaces The Quad. Contact us today to book a tour!

    530 Technology Dr, Irvine, CA 92618

    15 available spaces from 11 to 2,027 sqft
    $129-$24,665/Mo per office

    Find fully flexible work and meeting space in Spaces The Quad. Book a tour & get info

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    Flexible Offices and Coworking at Irvine Spectrum. Contact us today to book a tour!
    Flexible Offices and Coworking at Irvine Spectrum. Contact us today to book a tour!

    300 Spectrum Center Dr, Unit 400, Irvine, CA 92618

    16 available spaces from 11 to 2,012 sqft
    $119-$20,924/Mo per office

    Flexible workspace in Irvine Spectrum. Book a tour & get info

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    Cost-Efficient Office Space at Spaces Intersect. Contact us today to book a tour!
    Cost-Efficient Office Space at Spaces Intersect. Contact us today to book a tour!

    17875 Von Karman Ave, Irvine, CA 92614

    15 available spaces from 11 to 2,001 sqft
    $129-$22,818/Mo per office

    Find fully flexible work and meeting space in Spaces Intersect. Book a tour & get info

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    Serviced Office Space for Rent at Irvine Center Drive. Contact us today to book a tour!
    Serviced Office Space for Rent at Irvine Center Drive. Contact us today to book a tour!

    7545 Irvine Center Dr, Unit 200, Irvine, CA 92618

    16 available spaces from 11 to 2,042 sqft
    $129-$24,537/Mo per office

    Flexible workspace in Irvine Center Drive. Book a tour & get info

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    Single-Story Medical Office Building
    Single-Story Medical Office Building

    70 Discovery, Irvine, CA 92618

    Contact for pricing
    5,846 sqft

    Single-story freestanding office building with extensive interior and exterior glass and flexible space including lab area.

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    Furnished Office Suite with Parking
    Furnished Office Suite with Parking

    300 Spectrum Center Dr, Irvine, CA 92618

    Contact for pricing
    4,999 sqft

    Fully furnished suite in Spectrum Center with covered parking, conference space, and on-site café and gym.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    17672 Cowan, Irvine, CA 92614

    Contact for pricing
    3,350 sqft

    Multi-tenant office setting with six private offices and restrooms.

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    Contiguous Second-Floor Office Suites
    Contiguous Second-Floor Office Suites

    17780 Fitch, Irvine, CA 92614

    Contact for pricing
    12,500 sqft

    Second-floor office space with contiguous suites 210, 215, and 220 totaling 12,500 SF.

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    Office Unit with On-Site Amenities
    Office Unit with On-Site Amenities

    7595 Irvine Center Drive 150, Irvine, CA 92618

    Contact for pricing
    3,687 sqft

    Class B office space supports general office and research-and-development uses, subject to applicable approvals.

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    Two-Story Office Suite
    Two-Story Office Suite

    150-7595 Irvine Center Dr, Irvine, CA 92604

    Contact for pricing
    3,687 sqft

    Class B workspace includes fitness, food service, EV charging, and Wi-Fi amenities.

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    Fully Furnished Plug-and-Play Office Suite
    Fully Furnished Plug-and-Play Office Suite

    300 Spectrum Center Drive, Suite 1120, Irvine, CA 92618

    Contact for pricing
    8,147 sqft

    Sublease office suite with conference center and covered parking for an efficient, move-in-ready setup.

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    Ground-Floor Office Suite
    Ground-Floor Office Suite

    1100 Main St, Irvine, CA 92614

    Contact for pricing
    6,140 sqft

    Ground-floor suite with 17 offices, including corner offices, plus reception, kitchen, copy, and utility rooms.

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    Class A Three-Story Office Building
    Class A Three-Story Office Building

    17900 Von Karman Avenue, Irvine, CA 92614

    Contact for pricing
    71,864 sqft

    Surface parking supports a three-level workplace in Irvine’s master planned business district.

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    Office Flex Suite with Warehouse
    Office Flex Suite with Warehouse

    18001 Sky Park Circle, Unit H, Irvine, CA 92614

    Contact for pricing
    2,144 sqft

    Sublease suite combines private offices, shared workspace, conference space, restrooms, and dedicated warehouse area.

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    Corner Flex Space
    Corner Flex Space

    23 Mauchly, Suite 110, Irvine, CA 92618

    Contact for pricing
    2,390 sqft

    Air-conditioned corner suite combines finished offices with an open work area for flexible business operations.

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    Office Unit with On-Site Amenities
    Office Unit with On-Site Amenities

    7595 Irvine Center Dr Unit 150, Irvine, CA 92618

    Contact for pricing
    44,194 sqft

    Two-story Class B property supports general office and research-and-development use, subject to applicable approvals.

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    Creative Campus With Outdoor Workspaces
    Creative Campus With Outdoor Workspaces

    16845 Von Karman Avenue, Irvine, CA 92606

    Contact for pricing
    9,263 sqft 24.00 AC lot

    Office interiors are complemented by on-site lifestyle amenities and outdoor areas for work, wellness, and social use.

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    Sublease Office Space
    Sublease Office Space

    2515 McCabe Way, Irvine, CA 92614

    Contact for pricing
    7,671 sqft

    Office space is available on a sublease basis with an in-place sublease term through 2029.

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    Creative Campus Office Space
    Creative Campus Office Space

    16755 Von Karman Avenue, Irvine, CA 92606

    Contact for pricing
    12,249 sqft 24.00 AC lot

    Connected workplace campus with office interiors and outdoor areas for wellness, work, and social use.

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    Irvine, CA Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Irvine, CA with 290 listings featured on our commercial real estate exchange. The current inventory includes 10,923,257 square feet of properties with an estimated lease value of $241.20.

    Estimated lease rates for Commercial real estate in Irvine, CA begin at $21.12 SF/Yr, with an average of $40.20 SF/Yr and extend to $55.32 SF/Yr.
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    Most Searched ZIP Codes in Irvine, CA

    • 92618
    • 92614
    • 92612
    • 92606
    • 92604
    • 92602
    • 92620
    • 37318

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