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    South Carolina Live-work Space for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    Myrtle Beach Mixed-Use Office Space
    $21 SF/Yr
    4,135 SF
    Myrtle Beach Mixed-Use Office Space

    1101 Johnson Ave, Myrtle Beach, SC

    Office space in vibrant Myrtle Beach district with live-work-play lifestyle.
    • Exceptional location in Myrtle Beach's vibrant district, surrounded by retail, dining, and entertainment.
    • Live‑work‑play lifestyle with upscale residential units above, fostering a built‑in community and foot traffic.
    • Attractive amenities including landscaping, walkable streets, open seating, interactive fountains, and a village‑like atmosphere.
    • Dynamic year‑round events, including cultural festivals and family gatherings.
    Updated: Jul 30, 2025
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    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF
    Historic Mill Office Space Available

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

    Creative office space in a vibrant mixed-use community.
    • Located in Drayton Mills Marketplace, a successful adaptive‑reuse mixed‑use community.
    • ±3,934 SF office suite with restored historic mill character including exposed brick, high ceilings, and large windows.
    • Walkable access to restaurants, coffee shops, retail, fitness studio, and salons.
    • Connected to Drayton Mills’ trail network for walking, biking, and tenant events.
    • Flexible space suitable for office, creative studio, co‑working, or boutique professional services.
    Updated: Nov 25, 2025
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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 2 Active listings in South Carolina, we suggest exploring alternatives. Similar 18 Properties for Sales.

    Similar Spaces for Sale in South Carolina

    Consider Similar Space for Sale. We found 18 Spaces matching your search parameters.

    Redevelopment Opportunity in Beaufort, SC
    $2,495,000
    6,500 SF
    Redevelopment Opportunity in Beaufort, SC

    Rare mixed-use redevelopment site with high visibility and trail access.

    12 Neil Road, Beaufort, SC 29906

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    Versatile Commercial Property, Cleveland SC
    $650,000
    3,355 SF
    Versatile Commercial Property, Cleveland SC

    Two well-maintained buildings on 1.89 acres with mountain views.

    4033 Geer Highway, Cleveland, SC 29635

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    Live-Work Flex Building with Overhead Doors
    $675,000
    4,500 SF
    Live-Work Flex Building with Overhead Doors

    Stud-framed live-work building with open shop, office space, lifts, and multiple overhead doors on a nearly 3-acre tract.

    5229 Augusta Highway, Leesville, SC 29070

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    Live-Work Flex Building With Shop
    $675,000
    2.96 Acres
    Live-Work Flex Building With Shop

    Stud-framed commercial building with office and living quarters, multiple overhead doors, and covered storage on nearly 3 acres.

    5229 Augusta Highway A, Leesville, SC 29070

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    Historic Aiken Mixed-Use Property
    $2,500,000
    8,070 SF
    Historic Aiken Mixed-Use Property

    Unique mixed-use property in downtown Aiken with income potential.

    150 Fairfield Street SE, Aiken, SC 29801

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    Live-Work Commercial Building
    $146,000
    800 SF
    Live-Work Commercial Building

    Updated office and studio apartment setup with fenced yard, mini-splits, and room for expansion on Highway 38.

    5045 Highway 38, Blenheim, SC 29516

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    Restaurant/Convenience Store with Living Area
    $175,000
    1,500 SF
    Restaurant/Convenience Store with Living Area

    Commercial restaurant/convenience store with living area in Cross Anchor, SC.

    701 Union Highway, Cross Anchor, SC 29335

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    Zoned C-2 Brick Ranch with Basement
    $449,000
    1,875 SF
    Zoned C-2 Brick Ranch with Basement

    C-2 zoned brick ranch with road frontage on two streets and an unfinished basement for storage or expansion.

    1504 E Rutherford Street, Landrum, SC 29356

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    Historic Building on Main Street
    $265,000
    Historic Building on Main Street

    Historic building in downtown Union with retail/restaurant potential.

    208 E Main Street, Union, SC 29379

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    Versatile Downtown Greenwood Commercial Space
    $390,000
    1,817 SF
    Versatile Downtown Greenwood Commercial Space

    Unique mixed-use opportunity in the heart of downtown Greenwood.

    327 Main St (Floors 6 & 8), Greenwood, SC 29646

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    Versatile Downtown Commercial Building
    $390,000
    1,800 SF
    Versatile Downtown Commercial Building

    Floors 6 & 8 offer versatile space in downtown Greenwood.

    327 Main St, Greenwood, SC 29646

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    Zoned Downtown Brick Ranch Property
    $449,000
    1.59 Acres
    Zoned Downtown Brick Ranch Property

    Brick ranch on 1.59 acres with road frontage on two streets and an unfinished basement for expansion or workspace use.

    1504 E Rutherford Street, Landrum, SC 29356

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    Versatile Commercial Space in Greenwood
    $195,000
    1,817 SF
    Versatile Commercial Space in Greenwood

    Floors 6 & 8 of The Grier Building in downtown.

    327 Main St (Floors 6 or 8), Greenwood, SC 29646

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    Versatile Mixed-Use Commercial Property
    $750,000
    0.48 Acres
    Versatile Mixed-Use Commercial Property

    Over 5,000 sq ft commercial property with residential area.

    4327 Old Mill Road, Anderson, SC 29623

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    Residential Office with In-Law Suite
    $395,000
    Residential Office with In-Law Suite

    Brick home with finished basement, second kitchen, and separate entrance, offering flexible live/work and professional office potential.

    510 E Calhoun Street, Anderson, SC 29621

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    Renovated Office and Living Space
    $925,000
    4,138 SF
    Renovated Office and Living Space

    Two-story building with flexible floorplan near Downtown Columbia.

    132 Stonemark Ln, Columbia, SC

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    Live-Work Home with Detached Garage
    $297,900
    891 SF
    Live-Work Home with Detached Garage

    Charming home with heated, insulated garage and 3-phase power.

    11 Bainbridge Dr, Greenville, SC 29611

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    Prosperity SC Acreage For Sale
    $75,000
    1.50 Acres
    Prosperity SC Acreage For Sale

    1.5 acre lot zoned for residential or commercial use.

    Brown Street, Prosperity, SC 29127

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    South Carolina Live-work space Leasing Opportunities Market Analysis

    Explore Live-work space leasing options in South Carolina with 2 listings featured on our commercial real estate exchange. The current inventory includes 57,706 square feet of properties with an estimated lease value of $49 SF/Yr.

    Estimated lease rates for Live-work space in South Carolina begin at $21 SF/Yr, with an average of $24 SF/Yr and extend to $28 SF/Yr.
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