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    Lancaster County, SC Commercial Real Estate for Sale

    239 results
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    Two Professional Buildings Near MUSC
    $975,000
    0.82 Acres

    Two Professional Buildings Near MUSC

    1201 Colonial Cmns Ct, Lancaster, SC 29720

    Two professional office buildings near MUSC in Lancaster, South Carolina.

    • Prime location minutes from MUSC (Medical University of South Carolina).
    • Two professional office buildings on one property.
    • Zoned "PO" Professional Office by the City of Lancaster.
    • Building 1 features a medical office layout with 14 rooms and a wired X‑ray room.
    • New flooring and new roof installed in Building 1.
    Updated: Dec 1, 2025
    View details
    Updated Condo in Active Community
    $374,900
    1,554 SF

    Updated Condo in Active Community

    44429 Oriole Dr, Indian Land, SC 29707

    Updated condo in amenity-rich, active adult community with water views.

    • Enjoy the convenience of walking distance to clubhouse, shopping, restaurants, library, banks, and more.
    • Amenity‑rich active adult community with multiple pools, studios, sports courts, hiking trails, and numerous interest groups.
    • Updated condo with new kitchen featuring quartz countertops and stainless steel appliances.
    • First‑floor unit with water views.
    • Primary bedroom with ensuite bath and walk‑in closet with built‑ins.
    Updated: Apr 10, 2025
    View details
    Kershaw Commercial Corner Lots
    $250,000
    1.10 Acres

    Kershaw Commercial Corner Lots

    Prime Kershaw location, ready to build!

    602/604 Hampton St, Kershaw, SC 29067
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    Lancaster Commercial Property - $149,900
    $149,900
    1,248 SF

    Lancaster Commercial Property - $149,900

    Versatile Commercial Space, High-Traffic Area

    2836 Lynwood Dr, Lancaster, SC 29720
    View details
    High-Visibility Lancaster Commercial Land
    $275,000
    2.39 Acres

    High-Visibility Lancaster Commercial Land

    Prime Lancaster location, high traffic, 2.39 acres.

    00 Highway 9 Byp, Lancaster, SC 29720
    View details
    Highway 200 Commercial Land Opportunity
    $1,147,000
    6.30 Acres

    Highway 200 Commercial Land Opportunity

    6.3 Acres, Prime Lancaster Location

    0000 Hwy 200 Hwy, Lancaster, SC 29720
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    Lancaster Commercial Property - 6 Acres
    $650,000
    6.10 Acres

    Lancaster Commercial Property - 6 Acres

    Versatile Commercial Space, Ample Parking

    1180 Garnette Rd, Lancaster, SC 29720
    View details
    Lancaster Commercial Land Opportunity
    $599,000
    3.49 Acres

    Lancaster Commercial Land Opportunity

    High-Visibility 3.5-Acre Parcel, Prime Location

    00 Charlotte Hwy, Lancaster, SC 29720
    View details
    Kershaw Commercial Property - 5 Acres
    $199,000
    5.00 Acres

    Kershaw Commercial Property - 5 Acres

    High-traffic location, two buildings, development potential.

    7595 Flat Creek Rd, Kershaw, SC 29067
    View details
    Lancaster Medical Office Complex
    $1,100,000
    0.82 Acres

    Lancaster Medical Office Complex

    Dual-Building Property, High-Income Potential

    1201 Colonial Cmns Ct, Lancaster, SC 29720
    View details
    Fort Mill Industrial Property
    $12,900,000
    92,926 SF

    Fort Mill Industrial Property

    92,926 SF Flex/Warehouse, $12.9M

    11632 Harrisburg Rd, Fort Mill, SC 29707
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    Lancaster, SC Walgreens Investment
    $5,460,000
    14,820 SF

    Lancaster, SC Walgreens Investment

    High-yield NNN Walgreens, strong tenant.

    1101 Highway 9 Byp, Lancaster, SC 29720
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    Versatile Flex, Office, Warehouse Space
    $11,615,750
    92,926 SF

    Versatile Flex, Office, Warehouse Space

    92,926 SF flex, office, and warehouse space for sale.

    11632 Harrisburg Rd, Indian Land, SC 29707
    View details
    Two Professional Buildings Near MUSC
    $1,100,000
    8,482 SF

    Two Professional Buildings Near MUSC

    Two professional buildings on one property near the Medical University.

    1201-1203 Colonial Commons Ct, Lancaster, SC 29720
    View details
    Lancaster Light Industrial Facility
    $325,000
    3,400 SF

    Lancaster Light Industrial Facility

    3,400 SF facility on 2 acres near Rock Hill.

    1537 Lynwood Dr, Lancaster, SC 29720
    View details
    Mixed-Use Investment Opportunity
    $1,150,000
    20,606 SF

    Mixed-Use Investment Opportunity

    Multi-tenant property with retail, office, industrial, and storage units.

    979-987 University Dr, Lancaster, SC 29720
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Land on Charlotte Highway
    $2,200,000
    15.55 Acres

    Prime Commercial Land on Charlotte Highway

    15.55 acres with high traffic and development potential.

    2383 Charlotte Hwy, Lancaster, SC 29720
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    Prime Development Land Lancaster, SC
    $2,200,000
    15.55 Acres

    Prime Development Land Lancaster, SC

    Development opportunity on a high-traffic corridor near residential developments.

    2383 Charlotte Hwy, Lancaster, SC 29720
    View details
    Lancaster Commercial Opportunity For Sale
    $279,000
    0.57 Acres

    Lancaster Commercial Opportunity For Sale

    General Business zoned land in high-traffic Lancaster location.

    2537 Charlotte Hwy, Lancaster, SC 29720
    View details
    Lancaster Land with Highway Frontage
    $1,600,000
    25.00 Acres

    Lancaster Land with Highway Frontage

    25 acres of land ideal for development or investment.

    3080 Charlotte Hwy, Lancaster, SC 29720
    View details

    Explore Off-Market Properties in Lancaster County, SC

    Consider similar Off-Market properties in Lancaster County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    945-973 Highway 9 Byp

    945-973 Highway 9 Byp

    Restaurants • 12,800 SF
    Value Estimation by Request
    945-973 Highway 9 Byp, Lancaster, SC 29720
    View details
    9955 Charlotte Hwy

    9955 Charlotte Hwy

    Retail properties • 16,450 SF
    Value Estimation by Request
    9955 Charlotte Hwy, Indian Land, SC 29707
    View details
    Airport Rd And Barton Rd

    Airport Rd And Barton Rd

    Restaurants • 44,350 SF
    Value Estimation by Request
    0 Airport Rd And Barton Rd, Lancaster, SC 29720
    View details
    in Expanding Lancaster County! Restaurant For Sale With Real Est

    in Expanding Lancaster County! Restaurant For Sale With Real Est

    Restaurants • 2,814 SF
    Value Estimation by Request
    in Expanding Lancaster County! Restaurant For Sale With Real Est, Lancaster, SC 29720
    View details
    Hubbard Rd

    Hubbard Rd

    Commercial real estate • 5.13 Acres
    Value Estimation by Request
    Hubbard Rd, Lancaster, SC 29020
    View details
    000 Hubbard Rd

    000 Hubbard Rd

    Commercial real estate • 7.02 Acres
    Value Estimation by Request
    000 Hubbard Rd, Lancaster, SC 29720
    View details
    209 Main St

    209 Main St

    Restaurants • 96,454 SF
    Value Estimation by Request
    209 Main St, Lancaster, SC 29720
    View details
    9931-9955 Charlotte Hwy

    9931-9955 Charlotte Hwy

    Retail properties • 16,450 SF
    Value Estimation by Request
    9931-9955 Charlotte Hwy, Indian Land, SC 29707
    View details

    Lancaster County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 1759 commercial real estate investment opportunities in Lancaster County, SC with 239 listings featured on our commercial real estate marketplace. The current inventory includes 2,150,247,333 square feet of properties with an estimated value of $597,637,617.

    Estimated prices for commercial real estate in Lancaster County, SC begin at $33,900, with an average of $625,143 and extend to $13,935,000.

    In Lancaster County, SC, current investment values show:

    • Retail properties positioned at $439,332
    • Other commercial real estate measuring $872,334
    • Individual retail properties assessed at $329,136
    • Office Properties & Spaces calculated at $580,814
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    Commercial real estate by market

    Browse Commercial real estate for Sale Near Lancaster, SC

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