Lancaster County, SC Office buildings for sale

Updated: Dec 1, 2025

Two-Building Medical Office Property

1201 Colonial Commons Court, Lancaster, SC 29720

$975,000

0.82 AC lot

Two professional buildings on a 0.82‑acre property
Building 1 includes approximately 14 rooms, reception, waiting, and file areas
Building 1 has new flooring and a new roof
Building 2 features three curtained areas and a large open space
PO Professional Office zoning per the City of Lancaster

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Updated: Jun 11

Historic Mixed-Use Retail/Office Buildings

209-227 S. Main Street, Lancaster, SC 29720

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29,151 sqft

1930s‑vintage commercial buildings in downtown Lancaster, SC, historically used for retail or office space
Currently vacant and in need of renovation—space offers a value‑add rehabilitation opportunity
Off Highway 521 and about 5 minutes from the Highway 9 intersection
Within 10 miles: population of over 56,000 grew 10% since 2020, with a forecast to grow an additional 16% by 2029
More than $641 million in consumer spending during 2024 within 10 miles

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Downtown Mixed-Use Redevelopment Property

210 S. White Street, Lancaster, SC 29720

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22,251 sqft

Vacant 1930s retail/office buildings in downtown Lancaster offer a renovation-ready canvas for mixed-use redevelopment.

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1930s Retail/Office Building Portfolio

116 Arch Street, Lancaster, SC 29720

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29,444 sqft

Vacant, renovation-needed buildings offering flexible retail or office space in downtown Lancaster with convenient highway access.

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Office Building

312 N Main Street N, Lancaster, SC 29720

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2,706 sqft

Office building with some furnishings staying, and utility split where tenant pays electricity and natural gas.

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Versatile Commercial Building in Lancaster

302 N White St, Lancaster, SC 29720

$325,000

Two-story commercial building with offices in downtown Lancaster, SC.

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Office Building with Live-Work Use

36-305 E Arch St, Lancaster, SC 29720

$250,000

B-2 zoning supports residential occupancy alongside a business, with parking and accessible entry.

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Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 7 Active listings in Lancaster County, SC, we suggest exploring several alternatives: plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Brick Storefront Property

2836 Lynwood Drive, Lancaster, SC 29720

$149,900

0.47 AC lot

Commercial space with central air, electric heat, carpet flooring, and a bathroom.

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Rock Hill Commercial Land Available

2164 Eden Terrace, Rock Hill, SC 29730

$350,000

3.64 AC lot

3.64 acre commercial land parcel in Rock Hill, SC.

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O-I Zoned Commercial Land

2135 Eden Terrace, Rock Hill, SC 29730

$450,000

1.08 AC lot

The parcel is zoned O-I and has public sewer service for commercial land planning.

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Medical Office Development Land

Charles Hunley Lane, Monroe, NC 28112

$1,700,000

7.62 AC lot

Commercial land within a medical and office park, positioned near major highways, healthcare services, restaurants, and businesses.

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Lancaster County, SC Office Buildings Market Trends and Statistics

Explore 7 office buildings for sale in Lancaster County, SC, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 83,552 square feet of properties for sale, with an estimated market value of $1,550,000.

Sale prices for office properties in Lancaster County, SC start at $250,000, averaging $516,666, and reaching up to $975,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.