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    Florence, SC Commercial Real Estate for Sale

    140 results
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    Established Auto Body Business For Sale
    $1,305,000
    4,125 SF

    Established Auto Body Business For Sale

    803 Ranch Rd, Florence, SC 29506

    Turn-key auto body business with equipment, client roster, and real estate.

    • Established auto body business operating for over 30 years.
    • Turn‑key operation including all equipment, signage, business name, phone number, and client roster.
    • High‑visibility location with a long‑standing customer base.
    • Includes real estate and a profitable business.
    • Features 6 bays (2 upfront, 4 in the back).
    Updated: Jan 12
    View details
    Commercial Property on S Cashua Drive
    $638,800
    13,801 SF

    Commercial Property on S Cashua Drive

    818 Delmae Dr, Florence, SC 29501

    Three buildings on three lots near Walmart in Florence, SC.

    • Three combined lots on S Cashua Drive, near Walmart.
    • Includes three buildings: two houses, a large garage, and a renovated tobacco barn. One building currently operates as a day care center.
    • Three separate tax map ID numbers.
    • Includes "Bathroom 1" and "Bathroom 2".
    • One house built in 1962.
    Updated: Dec 17, 2025
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    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    Office building with 7,517 square feet of space in Florence.

    1706 2Nd Loop Rd, Florence, SC 29501
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    Florence Commercial Space - Irby St.
    Contact for pricing
    0.05 Acres

    Florence Commercial Space - Irby St.

    High-traffic location, 2000 sq ft office.

    1811 Irby St, Florence, SC 29505
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    Florence Commercial Building - Great Location
    $195,000
    3,332 SF

    Florence Commercial Building - Great Location

    Prime Commercial Space, 3,332 sq ft, 0.25 acre lot

    111 111 Laurel St, Florence, SC 29501
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    Prime Florence Office Building
    Contact for pricing
    0.23 Acres

    Prime Florence Office Building

    Downtown location, 2481 sq ft, 14 parking spaces

    604 Coit St, Florence, SC 29501
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    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive)
    $200,000
    1,520 SF

    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive)""""}"""

    Florence Commercial Corner Property

    702 Barringer St, Florence, SC 29506
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    Prime Florence Commercial Space
    $520,000
    3,900 SF

    Prime Florence Commercial Space

    High-traffic location, 3900 sq ft.

    181 181 Palmetto, Florence, SC 29506
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    Florence Commercial Property - High Traffic Area
    $400,000
    3,375 SF

    Florence Commercial Property - High Traffic Area

    Prime Commercial Land, Warehouse, & More

    710 Barringer St, Florence, SC 29506
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    Florence Commercial Space - Palmetto St.
    Contact for pricing
    0.04 Acres

    Florence Commercial Space - Palmetto St.

    High-traffic location, excellent visibility. Great for retail or office.

    1565 Palmetto St, Florence, SC 29501
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    Prime Florence Commercial Building
    $375,000
    3,000 SF

    Prime Florence Commercial Building

    Updated Bank Facility, 3000 sq ft, 0.72 acres

    1937 1937 Palmetto, Florence, SC 29501
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    Florence Commercial Redevelopment Opportunity
    $275,000
    7,700 SF

    Florence Commercial Redevelopment Opportunity

    High-potential 7,700 SF building on 1.08 acres.

    4617 4617 Palmetto St, Florence, SC 29506
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    Prime Florence Office Building
    Contact for pricing
    0.07 Acres

    Prime Florence Office Building

    Downtown Florence Office Space Available

    620 Evans St, Florence, SC 29501
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    Florence Commercial Building - Great Investment
    $199,000
    1,340 SF

    Florence Commercial Building - Great Investment

    High-traffic location, excellent income potential.

    603 603 Dargan St, Florence, SC 29506
    View details
    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive).
    $200,000
    1,350 SF

    McLeod Hospital (less than 1 mile) as well as MUSC Hospital and Florence Regional Airport (both less than a 3 mile drive).""""}"""

    Florence Commercial Property - High Traffic Area

    726 Barringer St, Florence, SC 29506
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    Prime Florence Commercial Property
    Contact for pricing
    2,250 SF

    Prime Florence Commercial Property

    Established Business, High Traffic Area

    1416 Pamplico Hwy, Florence, SC 29505
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    Downtown Florence Commercial Space
    Contact for pricing
    0.03 Acres

    Downtown Florence Commercial Space

    Prime Location, Lease Opportunity

    181 Dargan St, Florence, SC 29501
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    Florence Warehouse - I-95 Access
    Contact for pricing
    0.11 Acres

    Florence Warehouse - I-95 Access

    Large Warehouse, Excellent Location, Immediate Occupancy

    180 Freight Rd, Florence, SC 29501
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    Prime Florence Commercial Land
    $2,750,000
    1 SF

    Prime Florence Commercial Land

    7.96 Acres Near Hospital & Airport

    1700 Palmetto St, Florence, SC 29506
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    High-Traffic Florence Commercial Lot
    $90,000
    0.34 Acres

    High-Traffic Florence Commercial Lot

    Prime Commercial Land, High Visibility

    732 Barringer St, Florence, SC 29506
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    Walgreens Investment Opportunity
    $4,750,000
    14,500 SF

    Walgreens Investment Opportunity

    NNN Leased Walgreens in Florence, SC

    2498 2nd Loop Rd, Florence, SC 29501
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    Florence Retail Investment Opportunity
    $400,000
    3,375 SF

    Florence Retail Investment Opportunity

    High-traffic location, 3 buildings, .82 acres

    710 Barringer St, Florence, SC 29501
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    Florence Industrial Warehouse For Sale
    $16,000,000
    400,000 SF

    Florence Industrial Warehouse For Sale

    Massive warehouse, 300,000+ rentable SF

    901 Douglas St, Florence, SC 29501
    View details
    Florence Mixed-Use Investment Opportunity
    $500,000
    1.38 Acres

    Florence Mixed-Use Investment Opportunity

    High-traffic SC-327 Retail & Restaurant Space

    0 Sc-327, Florence, SC 29506
    View details

    Florence, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 2505 commercial real estate investment opportunities in Florence, SC with 140 listings featured on our commercial real estate marketplace. The current inventory includes 250,227,782 square feet of properties with an estimated value of $722,940,621.

    Estimated prices for commercial real estate in Florence, SC begin at $31,000, with an average of $717,915 and extend to $16,000,000.

    In Florence, SC, current investment values show:

    • Retail properties positioned at $689,349
    • Office Properties & Spaces measuring $655,721
    • Office buildings assessed at $659,490
    • Individual retail properties calculated at $892,368
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    Most Searched ZIP Codes in Florence, SC

    • 29501
    • 29506
    • 29505
    • 29161

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