Sanibel, FL Commercial Real Estate for Sale

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Historic Sanibel Building in Prime Location

$1,500,000

0.43 Acres

Historic Sanibel Building in Prime Location

520 Tarpon Bay Rd, Sanibel, FL 33957

Iconic Sanibel building, reimagined for modern use in high-traffic location.

Prime, high‑traffic location directly across from the upcoming Bailey's Shopping Plaza and adjacent to Doc Ford's Rum Bar & Grille.
Flexible Town Center General zoning allows for a wide range of commercial or creative uses.
Historic building (built in 1913) with a rich past, offering a unique and iconic presence on Sanibel Island.
Fully remediated and modernized structure with recent upgrades including new roof, HVAC, plumbing, electrical, flooring, and more.
Freestanding building offering high visibility and accessibility.

Updated: Dec 10, 2025

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$299,000

0.14 Acres

Renovated Office Condo on Sanibel

1640 Periwinkle Way, Sanibel, FL 33957

Completely renovated office condo in the heart of Sanibel Island.

Prime location on Periwinkle Way in the heart of Sanibel Island.
Completely renovated in 2024 with luxury vinyl plank flooring, pristine white cabinetry, and built‑in workspaces.
Flexible 987 sq ft office condo suitable for various business types.
Includes multiple offices, waiting area, receptionist/assistant space, and restroom within the unit.
Equipped with two sinks, washer, dryer, and full‑sized refrigerator.

Updated: Dec 30, 2025

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$1,200,000

0.26 Acres

Sanibel Commercial Building For Sale

Commercial building with side street frontage in Sanibel, Florida.

905 Fitzhugh St, Sanibel, FL 33957

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$5,500,000

3.00 Acres

Prime Commercial Property on Periwinkle

Commercial property with excellent exposure and road frontage on 3 acres.

1551 Periwinkle Way, Sanibel, FL 33957

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Sanibel Island Income-Producing Commercial Property

$5,400,000

0.84 Acres

Sanibel Island Income-Producing Commercial Property

Income-producing commercial property on Sanibel Island with high visibility.

1039 Periwinkle Way, Sanibel, FL 33957

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$3,295,000

0.49 Acres

Prime Sanibel Commercial Landmark

Versatile property on Periwinkle Way with business, investment, and lifestyle potential.

1446 Periwinkle Way, Sanibel, FL 33957

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$415,000

0.03 Acres

Sanibel Island Office Condo

Turnkey, stabilized office condo on Periwinkle Way, Sanibel Island.

1101 Periwinkle Way, Sanibel, FL 33957

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$1,100,000

0.04 Acres

Refreshed Olde Florida-Style Office

Distinctive office campus with flexible spaces on Sanibel's main artery.

1149 Periwinkle Way, Sanibel, FL 33957

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$1,200,000

0.49 Acres

Sanibel Island Commercial Property

Commercial property on Sanibel Island with frontage on Periwinkle Way.

1544 Periwinkle Way, Sanibel, FL 33957

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$795,000

0.04 Acres

Prime Commercial Space on Periwinkle

Commercial building with high visibility on a high-traffic island corridor.

1025 Periwinkle Way, Sanibel, FL 33957

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$1,200,000

Established Sanibel Restaurant and Retail

Iconic Sanibel restaurant and retail business for sale.

1551 Periwinkle Way, Sanibel, FL 33957

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$5,950,000

0.94 Acres

Sanibel Island Investment Portfolio

Four Prime Properties, Gulf Access

4819 Tradewinds Dr, Sanibel, FL 33957

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$1,350,250

3,014 SF

Sanibel Office Condo - Prime Location

Vacant Office, 3,014 sq ft, High Visibility

1149 Periwinkle Way, Sanibel, FL 33957

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Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

$325,000

0.16 Acres

Waterfront Lot with Private Dock

Waterfront lot with dock, boat lift, and utilities in place.

2480 Sycamore St, St James City, FL 33956

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$419,000

0.23 Acres

Waterfront Property Ready for Remodel

Remodel-ready waterfront property with approved permits and boat lifts.

2560 Baybreeze St, St James City, FL 33956

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$475,000

0.23 Acres

Waterfront Double Lot Paradise

Two contiguous buildable lots with direct Gulf access.

3977 Coconut Dr, Saint James City, FL 33956

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$375,000

0.09 Acres

Waterfront Lot with Gulf Access

Waterfront lot with boat lifts and plunge pool.

3783 Cherry Ln, Saint James City, FL 33956

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Sanibel Island Mixed-Use Development Opportunity

$4,750,000

3.82 Acres

Sanibel Island Mixed-Use Development Opportunity

Approved development for restaurant and eight residential dwellings in Sanibel.

2163 Periwinkle Way, Sanibel, FL 33957

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Sanibel Development Opportunity on Periwinkle

$2,999,000

2.29 Acres

Sanibel Development Opportunity on Periwinkle

Iconic Sanibel property with frontage on Periwinkle Way.

1223 Periwinkle Way, Sanibel, FL 33957

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Sanibel Commercial/Residential Opportunity

$1,795,000

0.50 Acres

Sanibel Commercial/Residential Opportunity

Rare 0.498 acre commercial/residential parcel on West Gulf Drive.

2761 W Gulf Dr, Sanibel, FL 33957

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Explore Off-Market Properties in Sanibel, FL

Consider similar Off-Market properties in Sanibel, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

4150 Dingman Dr

Multifamily properties

Value Estimation by Request

4150 Dingman Dr, Sanibel, FL 33957

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610 Donax St

Residential income properties

Value Estimation by Request

610 Donax St, Sanibel, FL 33957

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Wildlife Preserve

WASTE DISPOSAL, SEWAGE • 7.00 Acres

Value Estimation

$335,000

Wildlife Preserve, Sanibel, FL 33957

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Bay Dr

WASTE DISPOSAL, SEWAGE • 19.16 Acres

Value Estimation

$300,000

Bay Dr, Sanibel, FL 33957

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2505 Is Inn Rd

WASTE DISPOSAL, SEWAGE • 0.33 Acres

Value Estimation

$225,000

2505 Is Inn Rd, Sanibel, FL 33957

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Sanibel, FL 33957

WASTE DISPOSAL, SEWAGE • 1.00 Acre

Value Estimation

$255,000

Sanibel, FL 33957

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Sanibel, FL 33957

WASTE DISPOSAL, SEWAGE • 11.00 Acres

Value Estimation

$335,000

Sanibel, FL 33957

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Sanibel, FL 33957

WASTE DISPOSAL, SEWAGE • 5.00 Acres

Value Estimation

$330,000

Sanibel, FL 33957

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1349 Bay Dr

WASTE DISPOSAL, SEWAGE • 0.31 Acres

Value Estimation

$5,995,000

1349 Bay Dr, Sanibel, FL 33957-3513

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2495 Coconut Dr

WAREHOUSE, STORAGE • 2,542 SF

Value Estimation

$295,000

2495 Coconut Dr, Sanibel, FL 33957-2007

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2361 Periwinkle Way

MINI-WAREHOUSE, STORAGE • 3,457 SF

Value Estimation

$345,000

2361 Periwinkle Way, Sanibel, FL 33957

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Sanibel, FL Commercial Real Estate Investment Opportunities Market Analysis

Explore 246 commercial real estate investment opportunities in Sanibel, FL with 90 listings featured on our commercial real estate marketplace. The current inventory includes 14,590,564 square feet of properties with an estimated value of $226,271,800.

Estimated prices for commercial real estate in Sanibel, FL begin at $70,000, with an average of $1,087,845 and extend to $21,000,000.

In Sanibel, FL, current investment values show:

Office Properties & Spaces positioned at $391,925
Land measuring $1,808,260
Office buildings assessed at $348,606
Residential land & home lots calculated at $1,442,392

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Sanibel, FL Commercial Real Estate for Sale

Historic Sanibel Building in Prime Location

Iconic Sanibel building, reimagined for modern use in high-traffic location.

Renovated Office Condo on Sanibel

Completely renovated office condo in the heart of Sanibel Island.

Sanibel Commercial Building For Sale

Prime Commercial Property on Periwinkle

Sanibel Island Income-Producing Commercial Property

Prime Sanibel Commercial Landmark

Sanibel Island Office Condo

Refreshed Olde Florida-Style Office

Sanibel Island Commercial Property

Prime Commercial Space on Periwinkle

Established Sanibel Restaurant and Retail

Sanibel Island Investment Portfolio

Sanibel Office Condo - Prime Location

Explore Opportunities in Nearby Cities

Waterfront Lot with Private Dock

Waterfront Property Ready for Remodel

Waterfront Double Lot Paradise

Waterfront Lot with Gulf Access

Potential Development Sites for Consideration

Sanibel Island Mixed-Use Development Opportunity

Sanibel Development Opportunity on Periwinkle

Sanibel Commercial/Residential Opportunity

Explore Off-Market Properties in Sanibel, FL

4150 Dingman Dr

610 Donax St

Wildlife Preserve

Bay Dr

2505 Is Inn Rd

Sanibel, FL 33957

Sanibel, FL 33957

Sanibel, FL 33957

1349 Bay Dr

2495 Coconut Dr

2361 Periwinkle Way

Sanibel, FL Commercial Real Estate Investment Opportunities Market Analysis

In Sanibel, FL, current investment values show:

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