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    Spartanburg County, SC Medical Office Space for Sale

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    Columbia, SC Aiken, SC Greenville, SC
    8 results
    Landrum Medical Building For Sale
    Contact for pricing
    2,400 SF

    Landrum Medical Building For Sale

    108 W Rutherford Street, Landrum, SC 29356

    2400 SF medical building in downtown Landrum, South Carolina.

    • Prime location in rapidly growing downtown Landrum, near new homes, businesses, and franchises.
    • 2400 sqft medical building suitable for a single tenant.
    • 8+\/- Exam Rooms, 3 Bathrooms, 2 Lobbies, and 2 Reception Areas.
    • Located across from Bealls shopping center and Landrum Farmers Market.
    • Private parking lot with access to 2 city streets.
    Updated: Mar 26
    View details
    Spartanburg Office Building For Sale
    $1,810,000
    7,200 SF

    Spartanburg Office Building For Sale

    130 Dillon Drive, Spartanburg, SC 29307

    7,200 SF office building near Spartanburg Medical District.

    • Prime location in Spartanburg, SC with excellent visibility.
    • Investment opportunity with a multi‑tenant building.
    • ±4,015 SF available, with ±3,185 SF already leased to Ortho Sport & Spine Physicians.
    • Close proximity to Spartanburg Medical District and other healthcare providers.
    • Ideal for primary care or specialty practices.
    Updated: Nov 26, 2025
    View details
    Medical/Professional Office Space Available
    $775,000
    10,000 SF

    Medical/Professional Office Space Available

    10,000 SF property near Mary Black Regional Hospital.

    125 Dillon Dr, Spartanburg, SC 29307
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    Medical Office Space Available
    $430,000
    4,645 SF

    Medical Office Space Available

    4,645 SF medical office space for lease.

    1241 Boiling Springs Rd, Spartanburg, SC
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    Spartanburg Medical/Office Building For Sale
    $825,000
    9,594 SF

    Spartanburg Medical/Office Building For Sale

    9,594 SF medical/office building near downtown Spartanburg.

    1770 Skylyn Dr, Spartanburg, SC
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    Professional Office/Medical Pads For Sale
    $150,000
    3,500 SF

    Professional Office/Medical Pads For Sale

    Two office/medical pads with utilities, parking, and infrastructure included.

    108 Burton St, Spartanburg, SC
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    11,058 SF Office Building For Sale
    Contact for pricing
    11,058 SF

    11,058 SF Office Building For Sale

    11,058 SF fantastic medical investment opportunity

    480 Floyd Rd, Spartanburg, SC 29307
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    Versatile Commercial Building Near Hospital
    $845,000
    11,925 SF

    Versatile Commercial Building Near Hospital

    Adaptable commercial building suitable for medical, retail, or storage use.

    200 Dillon Cir, Spartanburg, SC 29307
    View details
    Based on your search, we've compiled 275 Potential Opportunities for your consideration. Besides 8 Active listings in Spartanburg County, SC, we suggest exploring several alternatives: similar 263 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Greer, SC Commercial Site
    $219,000
    0.87 Acres

    Greer, SC Commercial Site

    0.87-acre parcel zoned for office and professional uses.

    00 Aaron Tippin Drive, Greer, SC 29650
    View details
    Mauldin Commercial Site For Sale
    $200,000
    1.00 Acre

    Mauldin Commercial Site For Sale

    1+ acre lot approved for medical offices in growing area.

    Corn and Miller Road, Mauldin, SC 29607
    View details
    Prime Commercial Corner Lot Available
    $200,000
    1.00 Acre

    Prime Commercial Corner Lot Available

    1+ acre corner lot in rapidly growing Mauldin, SC.

    Corn and Miller Road, Mauldin, SC 29607
    View details
    High-Visibility Commercial Land For Sale
    $450,000

    High-Visibility Commercial Land For Sale

    0.82 acre commercial land with high traffic exposure.

    4108 Old Buncombe Road, Greenville, SC 29617
    View details

    Explore Off-Market Properties in Spartanburg County, SC

    Consider similar Off-Market properties in Spartanburg County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    3610 Moore Duncan Hwy

    3610 Moore Duncan Hwy

    MEDICAL BUILDING • 5,176 SF
    Value Estimation
    $685,000
    3610 Moore Duncan Hwy, Moore, SC 29369-9414
    View details
    654 Arlington Rd

    654 Arlington Rd

    MEDICAL BUILDING • 4,624 SF
    Value Estimation by Request
    654 Arlington Rd, Greer, SC 29651-1544
    View details
    1770 Skylyn Dr

    1770 Skylyn Dr

    MEDICAL BUILDING • 9,594 SF
    Value Estimation
    $565,000
    1770 Skylyn Dr, Spartanburg, SC 29307-1045
    View details
    2740 Hwy 14

    2740 Hwy 14

    MEDICAL BUILDING • 18.43 Acres
    Value Estimation
    $22,000,000
    2740 Hwy 14, Greer, SC 29650-4922
    View details
    391 Henry St

    391 Henry St

    MEDICAL BUILDING • 5,279 SF
    Value Estimation
    $800,000
    391 Henry St, Spartanburg, SC 29302-2639
    View details
    397 Serpentine Dr Ste A

    397 Serpentine Dr Ste A

    MEDICAL BUILDING • 6,807 SF
    Value Estimation by Request
    397 Serpentine Dr Ste A, Spartanburg, SC 29303-3067
    View details
    397 Serpentine Dr Ste B

    397 Serpentine Dr Ste B

    MEDICAL BUILDING • 3,272 SF
    Value Estimation by Request
    397 Serpentine Dr Ste B, Spartanburg, SC 29303-3067
    View details
    735 Main St

    735 Main St

    MEDICAL BUILDING • 3,941 SF
    Value Estimation by Request
    735 Main St, Spartanburg, SC 29302-1281
    View details
    1526 John B White Sr Blvd

    1526 John B White Sr Blvd

    MEDICAL BUILDING • 1,770 SF
    Value Estimation by Request
    1526 John B White Sr Blvd, Spartanburg, SC 29301
    View details
    1526 John B White Sr Blvd

    1526 John B White Sr Blvd

    MEDICAL BUILDING • 2,363 SF
    Value Estimation by Request
    1526 John B White Sr Blvd, Spartanburg, SC 29301
    View details
    2555 Boiling Spgs Rd

    2555 Boiling Spgs Rd

    MEDICAL BUILDING • 13,374 SF
    Value Estimation
    $1,660,000
    2555 Boiling Spgs Rd, Boiling Springs, SC 29316-5351
    View details
    601 Georgia St

    601 Georgia St

    MEDICAL BUILDING • 3,515 SF
    Value Estimation by Request
    601 Georgia St, Woodruff, SC 29388-1953
    View details
    900 Rutherford St

    900 Rutherford St

    MEDICAL BUILDING • 1,200 SF
    Value Estimation by Request
    900 Rutherford St, Landrum, SC 29356-1725
    View details
    5052 Hwy 9th 9

    5052 Hwy 9th 9

    MEDICAL BUILDING • 4,597 SF
    Value Estimation
    $2,350,000
    5052 Hwy 9th 9, Inman, SC 29349
    View details
    153 Oakwood Ave

    153 Oakwood Ave

    MEDICAL BUILDING • 8,724 SF
    Value Estimation by Request
    153 Oakwood Ave, Spartanburg, SC 29302
    View details
    2755 Hwy 14

    2755 Hwy 14

    MEDICAL BUILDING • 2,038 SF
    Value Estimation by Request
    2755 Hwy 14, Greer, SC 29650-4926
    View details

    Spartanburg County, SC Medical Office Space Investment Opportunities Market Analysis

    Explore 271 medical office space for sale in Spartanburg County, SC, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 13,467,763 square feet of properties for sale, with an estimated market value of $122,595,000.

    Sale prices for medical spaces in Spartanburg County, SC start at $70,000, averaging $965,314, and reaching up to $10,190,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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