South Carolina Commercial Real Estate for Lease

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Greenville, SC Columbia, SC Charleston, SC North Charleston, SC Myrtle Beach, SC Spartanburg, SC Rock Hill, SC Summerville, SC
2,672 properties
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Retail Strip Center Space
Retail Strip Center Space

1675 E Main St, Duncan, SC 29334

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Lease opportunity along E Main Street (HWY 290) near established national retail operators.

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Industrial Suite with Office Space
Industrial Suite with Office Space

9481 Industrial Center Drive, Ladson, SC 29456

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2,805 sqft

Flex space with warehouse and office, available April 1, 2026.

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Medical Office Space Available
Medical Office Space Available

3221, 3223, 3225, & 3231 Sunset Blvd., West Columbia, SC 29169

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39,722 sqft

Accessible medical office space in a growing Columbia corridor.

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Retail Space with Ample Parking
Retail Space with Ample Parking

2768 E S Decker Blvd, Columbia, SC 29206

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1,550 sqft

Retail space zoned GC-General Commercial with ample on-site parking near major Columbia corridors.

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Renovated Class B Office Units
Renovated Class B Office Units

601 E Mcbee Ave, Greenville, SC 29601

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Flexible suites near downtown amenities with on-site parking and tenant improvement package negotiable.

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Clinton Retail Opportunity Near I-26
Clinton Retail Opportunity Near I-26

18812-18860 Hwy 72 E, Clinton, SC 29325

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3,600 sqft

Retail or QSR build-to-suit/ground lease opportunity near Interstate 26.

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Office Building with Prominent Signage
Office Building with Prominent Signage

3875 Faber Place Dr, North Charleston, SC 29405

Contact for pricing
19,669 sqft

Quick access to I-526 with excellent visibility, prominent building signage, and abundant free surface parking.

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Industrial Warehouse with Dock Doors
Industrial Warehouse with Dock Doors

218 Evans Rd, Lugoff, SC 29078

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99,096 sqft

Industrial warehouse space features eight dock-high doors, dry sprinkler system, 20' clear height, and fully fenced perimeter.

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Rock Hill Warehouse/Manufacturing Facility
Rock Hill Warehouse/Manufacturing Facility

911 E. White St, Rock Hill, SC 29730

$8.95 SF/Yr

Recently renovated warehouse/manufacturing facility with heavy power and rail siding.

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Office/Medical Suite
Office/Medical Suite

1264 Ribaut Rd, Beaufort, SC 29902

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1,484 sqft

Suite offers a large open work area, two offices, data room, and one bathroom, plus washer/dryer hookups.

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Single-Tenant Retail Space
Single-Tenant Retail Space

2101 Enterprise Dr, Mullins, SC 29574

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1,200 sqft

Single-tenant retail space offered for rent with approximately 1,200 SF of retail area.

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Waterfront Commercial Land for Lease
Waterfront Commercial Land for Lease

4400 Clemson Boulevard, Anderson, SC 29621

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3,000 sqft 2.20 AC lot

2.2 acres of waterfront commercial land with dock.

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Flex Space with Roll-Up Doors
Flex Space with Roll-Up Doors

4330 Cheyenne St, North Charleston, SC 29405

$14.50 SF/Yr

Flex space with conditioned office, roll-up doors, secured parking.

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North Charleston Office Building For Sale
North Charleston Office Building For Sale

2170 Ashley Phosphate Road, North Charleston, SC 29406

$20.50 SF/Yr

Second-generation office space with open and private workspaces available.

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Grocery-Anchored Shopping Center
Grocery-Anchored Shopping Center

25-123 US Highway 321 Bypass, Winnsboro, SC 29180

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Retail center positioned along two major thoroughfares with grocery-store anchoring.

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Renovated First-Floor Office Suite
Renovated First-Floor Office Suite

8 Lafayette Pl, Hilton Head Island, SC 29926

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3,025 sqft

Recently updated workspace with reception, private offices, conference room, kitchenette, and lobby access.

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Freestanding Retail Building
Freestanding Retail Building

1200 Charleston Hwy, West Columbia, SC 29169

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15,000 sqft

Freestanding retail building offered for sale or lease on Charleston Hwy in West Columbia.

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Retail Space in Johns Island
Retail Space in Johns Island

3874 Savannah Hwy, Johns Island, SC

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1,200 sqft 1.34 AC lot

Retail space for lease in a bustling commercial district.

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Retail Space with Open Layout
Retail Space with Open Layout

1901 Rosewood Dr, Columbia, SC

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5,429 sqft 0.35 AC lot

Retail space featuring an open floor plan and high visibility.

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Retail Center in York, SC
Retail Center in York, SC

1075-1095 Filbert Highway, York, SC 29745

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56,352 sqft

Established retail center anchored by Food Lion in York, SC.

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Office Units with Fenced Parking
Office Units with Fenced Parking

7880-7890 Dorchester Rd, North Charleston, SC 29418

Contact for pricing
6,600 sqft

6,600 SF office units with fenced parking and handicap accessibility, ready with fresh exterior updates.

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West Columbia Flex Space Available
West Columbia Flex Space Available

560 Chris Dr, West Columbia, SC 29169

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2,391 sqft

Flex space available for lease in West Columbia, South Carolina.

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Climate-Controlled Warehouse Space
Climate-Controlled Warehouse Space

1033 Wappoo Rd, Charleston, SC 29407

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7,511 sqft

Climate-controlled warehouse space with 13' ceiling heights, offering 3,751 to 7,511 SF while improvements are underway.

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Industrial Warehouse for Lease
Industrial Warehouse for Lease

15 Burty Rd, Greenville, SC 29605

Contact for pricing
20,000 sqft

Industrial warehouse space is available for lease at 15 Burty Rd in Greenville, SC.

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